Androgens, oestrogens and endometrium: a fine balance between perfection and pathology
Open accessAbstract
The endometrium is a complex multicellular tissue that is exquisitely sensitive to the actions of sex steroids synthesised in the ovary (endocrine system). Recent studies have highlighted a previously under-appreciated role for local (intracrine) metabolism in fine-tuning tissue function in both health and disease. In this review we have focused on the impact of oestrogens and androgens on endometrial function summarising data from studies on normal endometrial physiology and disorders including infertility, endometriosis and cancer. We consider the evidence that expression of enzymes including aromatase, sulphatase and AKR1C3 by endometrial cells plays an important role in tissue function and malfunction and discuss results from studies using drugs targeting intracrine pathways to treat endometrial disorders. We summarise studies exploring the spatial and temporal expression of oestrogen receptors (ERalpha/ESR1, ERbeta/ESR2 and GPER) and their role in mediating the impact of endogenous and synthetic ligands on cross-talk between vascular, immune, epithelial and stromal cells. There is a single androgen receptor gene and androgens play a key role in stromal-epithelial cross-talk, scar-free healing of endometrium during menstruation and regulation of cell proliferation. The development of new receptor-selective drugs (SERMs, SARMs, SARDs) has reinvigorated interest in targeting receptor subtypes in treatment of disorders including endometriosis and endometrial cancer and some show promise as novel therapies. In summary, understanding the mechanisms regulated by sex steroids provides the platform for improved personalised treatment of endometrial disorders as well as novel insights into the impact of steroids on processes such as tissue repair and regeneration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Potential sources of altered androgen metabolism in endometriosis could be the lesions themselves, as endometrial cells have been shown to have the capacity to express the full complement of the steroidogenic genes involved in androgen and estrogen synthesis.
“Potential sources of altered androgen metabolism in endometriosis could be the lesions themselves, as endometrial cells have been shown to have the capacity to express the full complement of the steroidogenic genes involved in androgen and estrogen synthesis.28”
From Steroid hormone profiling reveals altered adrenal androgen production in endometriosis (2026) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Yaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090 · see citing works
Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81717-1 · Cited by 2,726 · see citing works
ESHRE guideline: management of women with endometriosis
Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D'Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., et al. (2014) · Human Reproduction · doi:10.1093/humrep/det457 · Cited by 2,211 · see citing works
Nuclear Receptor Coregulators: Cellular and Molecular Biology
McKenna, N. J., Lanz, R. B., & O’Malley, B. W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0366 · Cited by 1,905 · see citing works
Carroll, J. S., Liu, X. S., Brodsky, A. S., Li, W., Meyer, C. A., Szary, A. J., Eeckhoute, J., Shao, W., Hestermann, E. V., Geistlinger, T. R., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.008 · Cited by 1,384 · see citing works
Genome-wide analysis of estrogen receptor binding sites
Carroll, J. S., Meyer, C. A., Song, J. S., Li, W., Geistlinger, T., Eeckhoute, J., Brodsky, A. S., Keeton, E. K., Fertuck, K. C., Hall, G., et al. (2006) · Nature Genetics · doi:10.1038/ng1901 · Cited by 1,368 · see citing works
Principles for modulation of the nuclear receptor superfamily
Gronemeyer, H., Gustafsson, J.-Å., & Laudet, V. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1551 · Cited by 1,228 · see citing works
Noyes, R. W., Hertig, A. T., & Rock, J. (1975) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)33500-1 · Cited by 941 · see citing works
Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844 · see citing works
Tamoxifen: a most unlikely pioneering medicine
Jordan, V. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1031 · Cited by 832 · see citing works
(2020) · OncoTargets and Therapy · doi:10.2147/ott · Cited by 787 · see citing works
Burney, R. O., Talbi, S., Hamilton, A. E., Vo, K. C., Nyegaard, M., Nezhat, C. R., Lessey, B. A., & Giudice, L. C. (2007) · Endocrinology · doi:10.1210/en.2006-1692 · Cited by 735 · see citing works
Lessey, B. A., Killam, A. P., METZGER, D. A., Haney, A. F., Greene, G. L., & McCarty, K. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-334 · Cited by 647 · see citing works
Carmeci, C., Thompson, D. A., Ring, H. Z., Francke, U., & Weigel, R. J. (1997) · Genomics · doi:10.1006/geno.1997.4972 · Cited by 590 · see citing works
Decidualization of the Human Endometrium: Mechanisms, Functions, and Clinical Perspectives
Gellersen, B., Brosens, I., & Brosens, J. J. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-991042 · Cited by 587 · see citing works
Estrogen receptor phosphorylation.
Lannigan, D. (2003) · Steroids · doi:10.1016/s0039-128x(02)00110-1 · Cited by 490 · see citing works
Extranuclear Steroid Receptors: Nature and Actions
Hammes, S. R., & Levin, E. R. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0022 · Cited by 475 · see citing works
Is dehydroepiandrosterone a hormone?
Labrie, F., Luu-The, V., Bèlanger, A., Lin, S.-X., Simard, J., Pelletier, G., & Labrie, C. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06264 · Cited by 454 · see citing works
Diagnosing adenomyosis: an integrated clinical and imaging approach
Chapron, C., Vannuccini, S., Santulli, P., Abrão, M. S., Carmona, F., Fraser, I. S., Gordts, S., Guo, S., Just, P., Noël, J., et al. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmz049 · Cited by 439 · see citing works
Flouriot, G., Brand, H., Denger, S., Métivier, R., Koš, M., Reid, G., Sonntag‐Buck, V., & Gannon, F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4688 · Cited by 419 · see citing works
Dalton, J. T., Barnette, K. G., Bohl, C. E., Hancock, M. L., Rodriguez, D., Dodson, S. T., Morton, R. A., & Steiner, M. S. (2011) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-011-0034-6 · Cited by 403 · see citing works
Alternatively spliced androgen receptor variants
Dehm, S. M., & Tindall, D. J. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0141 · Cited by 380 · see citing works
Jung, C. K., Little, M. P., Lubin, J. H., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2503 · Cited by 344 · see citing works
Naftalin, J., Hoo, W., Pateman, K., Mavrelos, D., Holland, T., & Jurkovic, D. (2012) · Human Reproduction · doi:10.1093/humrep/des332 · Cited by 337 · see citing works
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity
Dennis, M. K., Field, A. S., Burai, R., Ramesh, C., Petrie, W. K., Bologa, C., Oprea, T. I., Yamaguchi, Y., Hayashi, S., Sklar, L. A., et al. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.07.002 · Cited by 312 · see citing works
Role of Estrogen Receptor-β in Endometriosis
Bulun, S., Monsavais, D., Pavone, M., Dyson, M., Xue, Q., Attar, E., Tokunaga, H., & Su, E. (2012) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1299596 · Cited by 307 · see citing works
Lessey, B. A., & Kim, J. J. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.05.031 · Cited by 286 · see citing works
Nuclear Receptors and Their Selective Pharmacologic Modulators
Burris, T. P., Solt, L. A., Wang, Y., Crumbley, C., Banerjee, S., Griffett, K., Lundåsen, T., Hughes, T., & Kojetin, D. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006833 · Cited by 285 · see citing works
Asherman’s syndrome: current perspectives on diagnosis and management
Dreisler, E., & Kjer, J. J. (2019) · International Journal of Women s Health · doi:10.2147/ijwh.s165474 · Cited by 284 · see citing works
Whitaker, L. H. R., & Critchley, H. (2015) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2015.11.012 · Cited by 274 · see citing works
Zhu, B. T., Han, G.-Z., Shim, J.-Y., Wen, Y., & Jiang, X.-R. (2006) · Endocrinology · doi:10.1210/en.2006-0113 · Cited by 271 · see citing works
Oestrogen receptor knockout mice: roles for oestrogen receptors α and β in reproductive tissues
Hewitt, S. C., & Korach, K. S. (2003) · Reproduction · doi:10.1530/rep.0.1250143 · Cited by 261 · see citing works
Aromatase and other steroidogenic genes in endometriosis: translational aspects.
Attar, E., & Bulun, S. E. (2006) · Human Reproduction Update · doi:10.1093/humupd/dmi034 · Cited by 255 · see citing works
Burney, R. O., Hamilton, A. E., Aghajanova, L., Vo, K. C., Nezhat, C. N., Lessey, B. A., & Giudice, L. C. (2009) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gap068 · Cited by 254 · see citing works
Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand
Horard, B., & Vanacker, J.-M. (2003) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0310349 · Cited by 251 · see citing works
Development of selective androgen receptor modulators (SARMs)
Narayanan, R., Coss, C. C., & Dalton, J. T. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.06.013 · Cited by 251 · see citing works
Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis
Bulun, S., Cheng, Y.-H., Pavone, M., Xue, Q., Attar, E., Trukhacheva, E., Tokunaga, H., Utsunomiya, H., Yin, P., Luo, X., et al. (2010) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1242991 · Cited by 243 · see citing works
Frasor, J. M., Barnett, D., Danes, J. M., Hess, R., Parlow, A. F., & Katzenellenbogen, B. S. (2003) · Endocrinology · doi:10.1210/en.2002-0143 · Cited by 232 · see citing works
Role of medical therapy in the management of uterine adenomyosis
Vannuccini, S., Luisi, S., Tosti, C., Sorbi, F., & Petraglia, F. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.013 · Cited by 231 · see citing works
Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)
Gao, W., & Dalton, J. T. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.01.003 · Cited by 216 · see citing works
GPR30: a novel indicator of poor survival for endometrial carcinoma
Smith, H. O., Leslie, K. K., Singh, M., Qualls, C., Revankar, C. M., Joste, N. E., & Prossnitz, E. R. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.01.004 · Cited by 214 · see citing works
Danazol for pelvic pain associated with endometriosis
Farquhar, C., Prentice, A., Singla, A. A., & Selak, V. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000068.pub2 · Cited by 210 · see citing works
Critchley, H. O. D., Brenner, R. M., Henderson, T. A., Williams, K., Nayak, N. R., Slayden, O. D., Millar, M. R., & Saunders, P. T. K. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7317 · Cited by 210 · see citing works
Self-citationStructure of the homodimeric androgen receptor ligand-binding domain
Nadal, M., Prekovic, S., Gallastegui, N., Helsen, C., Abella, M., Zielinska, K., Gay, M., Vilaseca, M., Taulès, M., Houtsmuller, A. B., et al. (2017) · Nature Communications · doi:10.1038/ncomms14388 · Cited by 193 · see citing works
Adenomyosis: a systematic review of medical treatment
Pontis, A., D’Alterio, M. N., Pirarba, S., de Angelis, C., Tinelli, R., & Angioni, S. L. (2016) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1197200 · Cited by 190 · see citing works
Young, S. L. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.06.010 · Cited by 177 · see citing works
Greaves, E., Cousins, F., Murray, A., Esnal-Zufiaurre, A., Fassbender, A., Horne, A., & Saunders, P. (2014) · American Journal of Pathology · doi:10.1016/j.ajpath.2014.03.011 · Cited by 170 · see citing works
Self-citationAghajanova, L., Hamilton, A., Kwintkiewicz, J., Vo, K. C., & Giudice, L. C. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.070300 · Cited by 168 · see citing works
G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth
Petrie, W. K., Dennis, M. K., Hu, C., Dai, D. D., Arterburn, J. B., Smith, H. O., Hathaway, H. J., & Prossnitz, E. R. (2013) · Obstetrics and Gynecology International · doi:10.1155/2013/472720 · Cited by 166 · see citing works
Mehasseb, M. K., Panchal, R., Taylor, A. H., Brown, L., Bell, S. C., & Habiba, M. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.02.051 · Cited by 165 · see citing works
Chenevix‐Trench, G., Fearnley, E., Marquart, L., Spurdle, A. B., Weinstein, P., & Webb, P. M. (2010) · Cancer Causes & Control · doi:10.1007/s10552-010-9658-7 · Cited by 161 · see citing works
What have we learned about GPER function in physiology and disease from knockout mice
Prossnitz, E. R., & Hathaway, H. J. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.06.014 · Cited by 157 · see citing works
LECCE, G., Méduri, G., Ancelin, M., Bergeron, C., & Perrot‐Applanat, M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7322 · Cited by 153 · see citing works
The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function
Meyer, M. R., Prossnitz, E. R., & Barton, M. (2011) · Vascular Pharmacology · doi:10.1016/j.vph.2011.06.003 · Cited by 153 · see citing works
Estrogen metabolism and action in endometriosis
Rižner, T. L. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.03.022 · Cited by 153 · see citing works
Progesterone Resistance in Endometriosis: an Acquired Property?
McKinnon, B. D., Mueller, M. D., & Montgomery, G. W. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.05.006 · Cited by 153 · see citing works
Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women
Lessey, B. A., Palomino, W. A., Apparao, K. B. C., Young, S. L., & Lininger, R. A. (2006) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-4-s1-s9 · Cited by 145 · see citing works
Estrogen receptor β: the guardian of the endometrium
Hapangama, D. K., Kamal, A. M., & Bulmer, J. N. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmu053 · Cited by 145 · see citing works
Petz, L. N., Ziegler, Y., Schultz, J. R., Kim, H., Kemper, J. K., & Nardulli, A. M. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.11.008 · Cited by 142 · see citing works
Communication between genomic and non-genomic signaling events coordinate steroid hormone actions
Wilkenfeld, S. R., Lin, C., & Frigo, D. E. (2017) · Steroids · doi:10.1016/j.steroids.2017.11.005 · Cited by 141 · see citing works
Horie, K., Takakura, K., Imai, K., Liao, S., & Mori, T. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137595 · Cited by 140 · see citing works
Garry, R., Hart, R. J., Karthigasu, K. A., & Burke, C. (2009) · Human Reproduction · doi:10.1093/humrep/dep036 · Cited by 140 · see citing works
Aromatase inhibitors for the treatment of endometriosis
Pavone, M. E., & Bulun, S. E. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.053 · Cited by 138 · see citing works
Uterine pathology in transmasculine persons on testosterone: a retrospective multicenter case series
Grimstad, F. W., Fowler, K. G., New, E. P., Ferrando, C. A., Pollard, R. R., Chapman, G. C., Gomez‐Lobo, V., & Gray, M. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.12.021 · Cited by 134 · see citing works
Hormone receptor dynamics in a receptive human endometrium
Critchley, H. O. D., & Saunders, P. T. K. (2009) · Reproductive Sciences · doi:10.1177/1933719108331121 · Cited by 133 · see citing works
Self-citationRaloxifene: A Selective Estrogen Receptor Modulator (SERM) with Multiple Target System Effects
Muchmore, D. B. (2000) · The Oncologist · doi:10.1634/theoncologist.5-5-388 · Cited by 133 · see citing works
Das, A., Mantena, S. R., Kannan, A., Evans, D. B., Bagchi, M. K., & Bagchi, I. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901647106 · Cited by 131 · see citing works
Top ten endometriosis research priorities in the UK and Ireland
Horne, A. W., Saunders, P. T. K., Abokhrais, I. M., & Hogg, L. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31344-2 · Cited by 131 · see citing works
Self-citationSteroid sulfatase inhibitors for estrogen- and androgen-dependent cancers
Purohit, A., & Foster, P. A. (2012) · Journal of Endocrinology · doi:10.1530/joe-11-0266 · Cited by 126 · see citing works
Cousins, F. L., Murray, A. A., Esnal‐Zufiaurre, A., Gibson, D. A., Critchley, H., & Saunders, P. T. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086378 · Cited by 124 · see citing works
Self-citationGATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex
He, B., Lanz, R. B., Fiskus, W. C., Geng, C., Yi, P., Hartig, S. M., Rajapakshe, K., Shou, J., Wei, L., Shah, S. S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421415111 · Cited by 124 · see citing works
Altered Gene Expression Profiling in Endometrium: Evidence for Progesterone Resistance
Aghajanova, L., Velarde, M. C., & Giudice, L. C. (2010) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1242994 · Cited by 122 · see citing works
Horne, A. W., & Saunders, P. T. K. (2019) · Cell · doi:10.1016/j.cell.2019.11.033 · Cited by 120 · see citing works
Self-citationKulak, J., Fischer, C., Komm, B., & Taylor, H. S. (2011) · Endocrinology · doi:10.1210/en.2010-1010 · Cited by 112 · see citing works
Kearbey, J. D., Gao, W., Narayanan, R., Fisher, S. J., Wu, D., Miller, D. D., & Dalton, J. T. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9152-9 · Cited by 110 · see citing works
Anti-estrogen Treatment in Endometrial Cancer: A Systematic Review
van Weelden, W. J., Massuger, L. F. A. G., ENITEC, et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00359 · Cited by 109 · see citing works
Gibson, D. A., Greaves, E., Critchley, H. O. D., & Saunders, P. T. K. (2015) · Human Reproduction · doi:10.1093/humrep/dev067 · Cited by 108 · see citing works
Self-citationEstrogen biosynthesis and signaling in endometriosis
Huhtinen, K., Ståhle, M., Perheentupa, A., & Poutanen, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.022 · Cited by 107 · see citing works
G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal and Abnormal Endometrium
Plante, B. J., Lessey, B. A., Taylor, R. N., Wang, W., Bagchi, M. K., Yuan, L., Scotchie, J. G., Fritz, M. A., & Young, S. L. (2012) · Reproductive Sciences · doi:10.1177/1933719111431000 · Cited by 107 · see citing works
Day, J. M., Foster, P., Tutill, H. J., Parsons, M. F. C., Newman, S. P., Chander, S. K., Allan, G. M., Lawrence, H. R., Vicker, N., Potter, B. V. L., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23350 · Cited by 107 · see citing works
Gibson, D. A., & Saunders, P. T. K. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.026 · Cited by 107 · see citing works
Self-citationGlobal Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis
Herndon, C. N., Aghajanova, L., Balayan, S., Erikson, D., Barragan, F., Goldfien, G., Vo, K. C., Hawkins, S., & Giudice, L. C. (2016) · Reproductive Sciences · doi:10.1177/1933719116650758 · Cited by 106 · see citing works
Fanning, S. W., Jeselsohn, R. M., Dharmarajan, V., Mayne, C. G., Karimi, M., Buchwalter, G., Houtman, R., Toy, W., Fowler, C. E., Han, R., et al. (2018) · eLife · doi:10.7554/elife.37161 · Cited by 100 · see citing works
The important roles of steroid sulfatase and sulfotransferases in gynecological diseases
Rižner, T. L. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00030 · Cited by 98 · see citing works
Expression of androgen receptor splice variants in clinical breast cancers
Hickey, T. E., Irvine, C. M., Dvinge, H., Tarulli, G. A., Hanson, A. R., Ryan, N. K., Pickering, M. A., Birrell, S. N., Hu, D. G., Mackenzie, P. I., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6296 · Cited by 96 · see citing works
Pathogenesis of endometriosis: Look no further than John Sampson
Yovich, J. L., Rowlands, P. K., Lingham, S., Sillender, M., & Srinivasan, S. (2019) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2019.10.007 · Cited by 95 · see citing works
Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?
Guo, S., & Groothuis, P. G. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy020 · Cited by 93 · see citing works
Critchley, H. O. D., Henderson, T. A., Kelly, R. W., Scobie, G. S., Evans, L. R., Groome, N. P., & Saunders, P. T. K. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020502 · Cited by 87 · see citing works
Self-citationSteroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma
Utsunomiya, H., Ito, K., Suzuki, T., Kitamura, T., Kaneko, C., Nakata, T., Niikura, H., Okamura, K., Yaegashi, N., & Sasano, H. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0040 · Cited by 85 · see citing works
Medical Management of Heavy Menstrual Bleeding
Maybin, J. A., & Critchley, H. (2015) · Women s Health · doi:10.2217/whe.15.100 · Cited by 84 · see citing works
Uterine Epithelial Estrogen Receptor-α Controls Decidualization via a Paracrine Mechanism
Pawar, S., Laws, M. J., Bagchi, I. C., & Bagchi, M. K. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1142 · Cited by 84 · see citing works
Kamal, A. M., Bulmer, J. N., DeCruze, S. B., Stringfellow, H. F., Martin-Hirsch, P., & Hapangama, D. K. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.16 · Cited by 84 · see citing works
Danazol for pelvic pain associated with endometriosis
Selak, V., Farquhar, C. M., Prentice, A., & Singla, A. A. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000068 · Cited by 84 · see citing works
Gibson, D. A., Simitsidellis, I., Cousins, F. L., Critchley, H. O. D., & Saunders, P. T. K. (2016) · Scientific Reports · doi:10.1038/srep19970 · Cited by 82 · see citing works
Self-citationPonnusamy, S., He, Y., Hwang, D., Thiyagarajan, T., Houtman, R., Bocharova, V., Sumpter, B. G., Fernandez, E. J., Johnson, D. L., Du, Z., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1458 · Cited by 81 · see citing works
Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling
Cousins, F. L., Kirkwood, P. M., Saunders, P. T. K., & Gibson, D. A. (2016) · Scientific Reports · doi:10.1038/srep36748 · Cited by 78 · see citing works
Self-citationGreaves, E., Collins, F., Esnal-Zufiaurre, A., Giakoumelou, S., Horne, A. W., & Saunders, P. T. K. (2014) · Endocrinology · doi:10.1210/en.2014-1086 · Cited by 77 · see citing works
Self-citationWhitaker, L. H. R., Murray, A. A., Matthews, R., Shaw, G., Williams, A. R. W., Saunders, P. T. K., & Critchley, H. O. D. (2017) · Human Reproduction · doi:10.1093/humrep/dew359 · Cited by 77 · see citing works
Self-citationDanazol for heavy menstrual bleeding
Beaumont, H. H., Augood, C. A., Duckitt, K., & Lethaby, A. E. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001017.pub2 · Cited by 75 · see citing works
Huhtinen, K., Saloniemi-Heinonen, T., Keski-Rahkonen, P., Desai, R., Laajala, D., Ståhle, M., Häkkinen, M. R., Awosanya, M., Suvitie, P., Kujari, H., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1913 · Cited by 75 · see citing works
Low-Dose Mifepristone Inhibits Endometrial Proliferation and Up-Regulates Androgen Receptor
Narvekar, N. N., Cameron, S. T., Critchley, H., Lin, S., Cheng, L., & Baird, D. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031945 · Cited by 74 · see citing works
Evidence of androgen action in endometrial and ovarian cancers
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2014) · Endocrine-Related Cancer · doi:10.1530/erc-13-0551 · Cited by 73 · see citing works
Self-citationDonnez, J., Donnez, O., & Dolmans, M. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.035 · Cited by 73 · see citing works
Potter, B. V. L. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0045 · Cited by 73 · see citing works
Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103276 · Cited by 70 · see citing works
Self-citationCollins, F., Macpherson, S., Brown, P., Bombail, V., Williams, A. R. W., Anderson, R. A., Jabbour, H. N., & Saunders, P. T. K. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-330 · Cited by 70 · see citing works
Self-citationKitawaki, J., Koshiba, H., Ishihara, H., Kusuki, I., Tsukamoto, K., & Honjo, H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6829 · Cited by 69 · see citing works
Miravet-Valenciano, J., Ruiz-Alonso, M., Gómez, E., & Garcia-Velasco, J. A. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.06.002 · Cited by 69 · see citing works
GSK2881078, a SARM, Produces Dose-Dependent Increases in Lean Mass in Healthy Older Men and Women
Neil, D., Clark, R. V., Magee, M. H., Billiard, J., Chan, A., Xue, Z., & Russell, A. J. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02644 · Cited by 68 · see citing works
Winuthayanon, W., Lierz, S. L., Delarosa, K. C., Sampels, S. R., Donoghue, L. J., Hewitt, S. C., & Korach, K. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-07728-1 · Cited by 67 · see citing works
Marshall, E., Lowrey, J., MacPherson, S., Maybin, J. A., Collins, F., Critchley, H. O. D., & Saunders, P. T. K. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0272 · Cited by 66 · see citing works
Self-citationBrodie, J., & McEwan, I. J. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01723 · Cited by 65 · see citing works
The G protein-coupled estrogen receptor as a modulator of neoplastic transformation
Jacenik, D., Cygankiewicz, A. I., & Krajewska, W. M. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.04.011 · Cited by 65 · see citing works
Konings, G. F. J., Brentjens, L. S., Delvoux, B., Linnanen, T., Cornel, K. M. C., Koskimies, P., Bongers, M. Y., Kruitwagen, R. F. P. M., Xanthoulea, S., & Romano, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00940 · Cited by 65 · see citing works
Mileshkin, L., Edmondson, R. J., O’Connell, R. L., et al. (2019) · Gynecologic Oncology · doi:10.1016/j.ygyno.2019.05.007 · Cited by 65 · see citing works
Kolková, Z., Noskova, V., Ehinger, A., Hansson, S. R., & Casslén, B. G. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq043 · Cited by 64 · see citing works
Mäentausta, O., Sormunen, R. T., ISOMAA, V. V., Lehto, V.-P., Jouppila, P. I., & Vihko, R. (1991) · PubMed · Cited by 64 · see citing works
Catalano, R. D., Wilson, M. R., Boddy, S. C., & Jabbour, H. N. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gaq094 · Cited by 62 · see citing works
Delvoux, B., D'Hooghe, T., Kyama, C., Koskimies, P., Hermans, R. J. J., Dunselman, G. A., & Romano, A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2851 · Cited by 59 · see citing works
Winuthayanon, W., Hewitt, S. C., & Korach, K. S. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.120170 · Cited by 58 · see citing works
Utsunomiya, H., Suzuki, T., Kaneko, C., Takeyama, J., Nakamura, J., Kimura, K., Yoshihama, M., Harada, N., Ito, K., Konno, R., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7661 · Cited by 57 · see citing works
Lash, G. E., Bulmer, J. N., Li, T. C., Innes, B. A., Mariee, N., Patel, G., Sanderson, J., Quenby, S., & Laird, S. M. (2016) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2016.04.290 · Cited by 57 · see citing works
Kieser, K. J., Kim, D. W., Carlson, K. E., Katzenellenbogen, B. S., & Katzenellenbogen, J. A. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100047k · Cited by 56 · see citing works
participants, O. B. O. T. I. T., Palmieri, C., Stein, R. C., Liu, X., Hudson, E., Nicholas, H., Sasano, H., Guestini, F., Holcombe, C., Barrett, S., et al. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4328-z · Cited by 56 · see citing works
Tissue selective estrogen complex (TSEC): a review
Pickar, J. H., Boucher, M., & Morgenstern, D. (2018) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001095 · Cited by 55 · see citing works
Biological and clinical effects of aromatase inhibitors in neoadjuvant therapy
Miller, W. R., Dixon, J. M., Cameron, D., & Anderson, T. J. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00149-2 · Cited by 54 · see citing works
Dorostghoal, M., Ghaffari, H.-O.-A., Moramezi, F., & Keikhah, N. (2018) · PubMed Central · doi:10.22074/ijfs.2018.5118 · Cited by 54 · see citing works
Endocrine therapy in epithelial ovarian cancer
Langdon, S. P., Gourley, C., Gabra, H., et al. (2016) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2017.1272414 · Cited by 53 · see citing works
Omlin, A. G., Jones, R. J., van der Noll, R., Satoh, T., Niwakawa, M., Smith, S. A., Graham, J., Ong, M., Finkelman, R. D., Schellens, J. H. M., et al. (2015) · Investigational New Drugs · doi:10.1007/s10637-015-0235-5 · Cited by 52 · see citing works
Inhibition of steroid sulfatase activity by danazol
Carlström, K., Döberl, A., Pousette, Å., et al. (1984) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348409156994 · Cited by 52 · see citing works
Transcriptome sequencing of adenomyosis eutopic endometrium: A new insight into its pathophysiology
Xiang, Y., Sun, Y., Yang, B. X., Yang, Y., Zhang, Y., Yu, T., Huang, H., Zhang, J., & Xu, H. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14718 · Cited by 52 · see citing works
Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age
Gibson, D. A., Simitsidellis, I., Kelepouri, O., Critchley, H. O. D., & Saunders, P. T. K. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.12.024 · Cited by 51 · see citing works
Self-citationAldo-keto reductase 1C3—Assessment as a new target for the treatment of endometriosis
Rižner, T. L., & Penning, T. M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104446 · Cited by 51 · see citing works
Lavery, D. N., & McEwan, I. J. (2008) · Biochemistry · doi:10.1021/bi702220p · Cited by 50 · see citing works
Kajihara, T., Tochigi, H., Prechapanich, J., Uchino, S., Itakura, A., Brosens, J. J., & Ishihara, O. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.10.017 · Cited by 49 · see citing works
Bombail, V., Macpherson, S., Critchley, H., & Saunders, P. T. K. (2008) · Human Reproduction · doi:10.1093/humrep/den298 · Cited by 49 · see citing works
Self-citationDonnez, J., Dolmans, M.-M., & Fellah, L. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.12.018 · Cited by 49 · see citing works
Inhibition of steroid sulfatase decreases endometriosis in an in vivo murine model
Colette, S., Defrere, S., Lousse, J. C., Van Langendonckt, A., Gotteland, J. P., Loumaye, E., & Donnez, J. (2011) · Human Reproduction · doi:10.1093/humrep/der079 · Cited by 45 · see citing works
Gibson, D. A., McInnes, K. J., Critchley, H. O. D., & Saunders, P. T. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2140 · Cited by 44 · see citing works
Self-citationZhang, L., Xiong, W., Li, N., Liu, H., He, H., Du, Y., Zhang, Z., & Liu, Y. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.11.008 · Cited by 44 · see citing works
Regulation of androgen action during establishment of pregnancy
Gibson, D. A., Simitsidellis, I., & Saunders, P. T. K. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0027 · Cited by 42 · see citing works
Self-citationPautier, P., Vergote, I. B., Joly, F., Melichar, B., Kutarska, E., Hall, G. D., Lisyanskaya, A. S., Reed, N. S., Oaknin, A., Ostapenko, V., et al. (2016) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000862 · Cited by 41 · see citing works
Lindemann, K. Y., Malander, S., Christensen, R. D., Mirza, M. R., Kristensen, G. B., Aavall-Lundqvist, E., Vergote, I. B., Rosenberg, P., Boman, K., & Nordström, B. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-68 · Cited by 40 · see citing works
Remodeling of estrogen-dependent sympathetic nerve fibers seems to be disturbed in adenomyosis
Barcena, M. L., Oldeweme, J., Arnold, J., Schneider, A., & Mechsner, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.013 · Cited by 40 · see citing works
Androgens regulate scarless repair of the endometrial “wound” in a mouse model of menstruation
Cousins, F. L., Kirkwood, P. M., Murray, A. A., Collins, F., Gibson, D. A., & Saunders, P. T. K. (2016) · The FASEB Journal · doi:10.1096/fj.201600078r · Cited by 39 · see citing works
Self-citationTanaka, S., Miki, Y., Hashimoto, C., Takagi, K., Doe, Z., Li, B., Yaegashi, N., Suzuki, T., & Ito, K. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.022 · Cited by 38 · see citing works
The Development of Steroid Sulfatase Inhibitors for Hormone‐Dependent Cancer Therapy
Day, J. M., Purohit, A., Tutill, H. J., Foster, P., Woo, L. W. L., Potter, B. V. L., & Reed, M. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03677.x · Cited by 38 · see citing works
Bombail, V., Gibson, D. A., Collins, F., Macpherson, S., Critchley, H., & Saunders, P. T. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0154 · Cited by 38 · see citing works
Self-citationBombail, V., Collins, F., Brown, P., & Saunders, P. T. K. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.007 · Cited by 37 · see citing works
Self-citationRole of nociceptor estrogen receptor GPR30 in a rat model of endometriosis pain
Álvarez, P., Bogen, O., & Levine, J. D. (2014) · Pain · doi:10.1016/j.pain.2014.09.035 · Cited by 37 · see citing works
Local estrogen metabolism (intracrinology) in endometrial cancer: A systematic review
Cornel, K. M. C., Bongers, M. Y., Kruitwagen, R. F. P. M., & Romano, A. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.10.004 · Cited by 37 · see citing works
Fulvestrant for the treatment of advanced breast cancer
Blackburn, S. A., Parks, R. M., & Cheung, K. (2018) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2018.1473038 · Cited by 36 · see citing works
Ye, R.-S., Pi, M., Nooh, M. M., Bahout, S. W., & Quarles, L. D. (2019) · Molecular Pharmacology · doi:10.1124/mol.118.115014 · Cited by 36 · see citing works
Mori, T., Ito, F., Matsushima, H., Takaoka, O., Tanaka, Y., Koshiba, A., Kusuki, I., & Kitawaki, J. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.01.026 · Cited by 31 · see citing works
Schultze‐Mosgau, M., Waellnitz, K., Nave, R., Klein, S., Kraetzschmar, J., Rautenberg, T., Schmitz, H., & Rohde, B. (2016) · Human Reproduction · doi:10.1093/humrep/dew145 · Cited by 31 · see citing works
ERα-targeted endocrine therapy, resistance and the role of GPER
Pepermans, R. A., & Prossnitz, E. R. (2019) · Steroids · doi:10.1016/j.steroids.2019.108493 · Cited by 31 · see citing works
Ito, K., Miki, Y., Suzuki, T., McNamara, K. M., & Sasano, H. (2016) · Endocrine-Related Cancer · doi:10.1530/erc-15-0470 · Cited by 29 · see citing works
Wangtrakuldee, P., Adeniji, A. O., Zang, T., Duan, L., Khatri, B. B., Twenter, B. M., Estrada, M. A., Higgins, T. F., Winkler, J. D., & Penning, T. M. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.01.001 · Cited by 29 · see citing works
Hormonal therapies in uterine sarcomas, aggressive angiomyxoma, and desmoid-type fibromatosis
Pannier, D., Cordoba, A., Ryckewaert, T., et al. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.08.007 · Cited by 29 · see citing works
ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1
Greaves, E., Collins, F., Critchley, H., & Saunders, P. T. K. (2013) · Human Reproduction · doi:10.1093/humrep/det235 · Cited by 28 · see citing works
Self-citationArcher, D. F., Simon, J. A., Portman, D. J., et al. (2019) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1657008 · Cited by 28 · see citing works
Sierens, J., Scobie, G. A., Wilson, J., & Saunders, P. T. K. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0320703 · Cited by 26 · see citing works
Self-citationMao, X., Dong, B., Gao, M., et al. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s216146 · Cited by 26 · see citing works
Pohl, O., Bestel, E., & Gotteland, J. (2014) · Reproductive Sciences · doi:10.1177/1933719114522526 · Cited by 24 · see citing works
Androgen Receptor Modulators: A Marriage of Chemistry and Biology
McEwan, I. J. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.69 · Cited by 23 · see citing works
Harris, H. A. (2006) · Nuclear Receptor Signaling · doi:10.1621/nrs.04012 · Cited by 22 · see citing works
Chlebowski, R. T., Haque, R., Hedlin, H., et al. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3647-1 · Cited by 22 · see citing works
Kauppila, A., Isotalo, H., Kivinen, S., et al. (1985) · International Journal of Cancer · doi:10.1002/ijc.2910350203 · Cited by 21 · see citing works
Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus
Simitsidellis, I., Esnal-Zuffiaure, A., Kelepouri, O., O’Flaherty, E. A. A., Gibson, D. A., & Saunders, P. T. K. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0153 · Cited by 21 · see citing works
Self-citationHickey, M., & Marino, J. L. (2019) · Menopause The Journal of The North American Menopause Society · Cited by 19 · see citing works
Sun, F., Duan, H., Wang, S., & Li, J.-J. (2015) · Reproductive Sciences · doi:10.1177/1933719115584447 · Cited by 18 · see citing works
Li, J.-J., Duan, H., Wang, S., Sun, F., Gan, L., Tang, Y., Xu, Q., & Li, T. C. (2017) · BioMed Research International · doi:10.1155/2017/5974693 · Cited by 17 · see citing works
The role of fulvestrant in endometrial cancer
Bogliolo, S., Cassani, C., Dominoni, M., et al. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2016.1244264 · Cited by 14 · see citing works
Ormeloxifene–Looking beyond contraception
Pati, T., Chanania, K., Marandi, S., et al. (2017) · Journal of Mid-life Health · doi:10.4103/jmh.jmh_71_16 · Cited by 14 · see citing works
Hong, D. G., Park, J. Y., Chong, G. O., et al. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1540572 · Cited by 14 · see citing works
The ERβ5 splice variant increases oestrogen responsiveness of ERαpos Ishikawa cells
Collins, F., Itani, N., Esnal‐Zufiaurre, A., Gibson, D. A., Fitzgerald, C., & Saunders, P. T. K. (2020) · Endocrine Related Cancer · doi:10.1530/erc-19-0291 · Cited by 13 · see citing works
Self-citationKhine, Y. M., Taniguchi, F., Nagira, K., Nakamura, K., Ohbayashi, T., Osaki, M., & Harada, T. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.13023 · Cited by 11 · see citing works
Gibson, D. A., Foster, P. A., Simitsidellis, I., Critchley, H. O. D., Kelepouri, O., Collins, F., & Saunders, P. T. K. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0037 · Cited by 10 · see citing works
Self-citationGibson, D. A., Esnal‐Zufiaurre, A., Bajo-Santos, C., Collins, F., Critchley, H., & Saunders, P. T. K. (2020) · Human Reproduction · doi:10.1093/humrep/dez306 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Sanderson PA, Critchley HO, Williams AR, Arends MJ & Saunders PT 2017 New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum Reprod Update 23 232-254.
- Saunders PT, Millar MR, Macpherson S, Irvine DS, Groome NP, Evans LR, Sharpe RM & Scobie GA 2002 ERbeta1 and the ERbeta2 splice variant (ERbetacx/beta2) are expressed in distinct cell populations in the adult human testis. J Clin Endocrinol Metab 87 2706-2715.
- Shaaban AM, Green AR, Karthik S, Alizadeh Y, Hughes TA, Harkins L, Ellis IO, Robertson JF, Paish EC, Saunders PT, et al. 2008 Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients. Clin Cancer Res 14 5228- 5235.
Cited by
Sorted by citations
Stener-Victorin, E., Teede, H., Norman, R. J., Legro, R., Goodarzi, M. O., Dokras, A., Laven, J., Hoeger, K., & Piltonen, T. T. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00511-3 · Cited by 495 · see citing works
Crespi, B. J., & Evans, S. F. (2023) · Journal of Pain Research · doi:10.2147/jpr.s389166 · Cited by 17 · see citing works
“Androgens and Fertility in Women with Endometriosis Optimal levels of serum and ovarian androgens, especially testosterone, play key roles in additional aspects of female reproductive development, functions and disease.(8,9) Testosterone is essential for folliculogenesis,(80) and low levels of testosterone are associa…”
BackgroundAndrogens, Endometriosis and Pain
Evans, S. F., Hull, M. L., Hutchinson, M. R., & Rolan, P. E. (2021) · Frontiers in Reproductive Health · doi:10.3389/frph.2021.792920 · Cited by 14 · see citing works
Steroid hormone profiling reveals altered adrenal androgen production in endometriosis
Simitsidellis, I., Ainslie, R. J., Taylor, A. E., Gilligan, L. C., Shaheen, F., Blanke, S., Anderson, C., Hapangama, D., Arlt, W., Horne, A. W., et al. (2026) · European Journal of Endocrinology · doi:10.1093/ejendo/lvag109 · Cited by 1 · see citing works
Self-citation
- Authors
- Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K.
- Affiliations
- Centre for Inflammation Research (GB)
- Corresponding author
- Saunders, Philippa T K
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2020-09
- Volume
- 246
- Issue
- 3
- Pages
- R75-R93
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W3034379618
- Cited by
- 76
- References
- 181
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 17 · 2023: 15 · 2022: 15 · 2021: 8 · 2020: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Medical Research Council (MR/N024524/1, G1100356/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometrium, sex steroids, estrogen, androgens, aromatase, sulphatase, AKR1C3, oestrogen receptor, androgen receptor, endometriosis, endometrial cancer, infertility, tissue repair, selective estrogen receptor modulators, selective androgen receptor modulators, tissue regeneration
- MeSH terms
- Androgens, Endometriosis, Endometrium, Estrogens, Female, Humans, Estrogen Receptor alpha
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review