The DOI matches its Crossref record; 152 of the 154 references it cites were found in a registry or an index.
Biomarkers of endometriosis
Open accessAbstract
A noninvasive test for endometriosis would be useful for the early detection of endometriosis in symptomatic women who have pelvic pain and/or subfertility with normal ultrasound results. This would include nearly all cases of minimal-to-mild endometriosis, some cases of moderate-to-severe endometriosis without a clearly visible ovarian endometrioma, and cases with pelvic adhesions and/or other pelvic pathology that might benefit from surgery to improve pelvic pain and/or subfertility. This overview discusses the diagnostic performance of noninvasive or semi-invasive tests for endometriosis, including panels of known peripheral blood biomarkers, protein/peptide markers discovered by proteomics, miRNA, and endometrial nerve fiber density. Tests with high sensitivity and acceptable specificity have been developed; some have been validated in independent populations and are therefore promising. To make real progress, international agreement on biobank development is needed for standard operating procedures for the collection, treatment, storage, and analysis of tissue samples and for detailed clinical phenotyping of these samples. Furthermore, it is necessary to validate the diagnostic accuracy of any promising test prospectively in an independent symptomatic patient population with subfertility and/or pain without clear ultrasound evidence of endometriosis and with a clinical indication for surgery, divided into cases with laparoscopically and histologically confirmed endometriosis and controls with laparoscopically confirmed absence of endometriosis.
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In the citing paper
“At present, such a test does not exist [17, 20].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [17]
In the citing paper
“Putative endometriosis biomarkers are mostly glycoproteins, growth or adhesion factors, hormones, or proteins related to immunology or angiogenesis [17, 23, 30].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [17]
In the citing paper
“Despite extensive research, no single biomarker nor a panel of biomarkers in peripheral blood has been validated as a diagnostic test for endometriosis [17, 20].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [17]
In the citing paper
“These studies have shown promising results; however, proteomics technologies are costly and time-consuming [23], and there is a need for better standardization and reproducibility of proteomic technologies before they can be used reliably in clinical research projects [17].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [17]
In the citing paper
“This can allow researchers to overcome the main pitfalls in the study design and methodology such as small sample size, lack of relevant clinical information inconsistency in sample handling and storage, and technical control of preanalytical sample variability, which contribute to controversial study results in endometriosis research [17].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [17]
In the citing paper
“The adoption of validated, internationally agreed upon standard operating procedures (SOPs) for tissue sample collection, processing and storage, and standardized phenotypic and other patient data collection, are crucial to optimise sample quality, reduce variability, and enable cross-centre studies [17, 113, 148].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [17]
In the citing paper
“Despite the plethora of studies on endometriosis biomarkers, neither a single biomarker nor a panel of biomarkers has been validated for a noninvasive diagnostic test with sufficient sensitivity and specificity [17].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [17]
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Metadata
- Authors
- Fassbender, A., Vodolazkaia, A., Saunders, P., Lebovic, D., Waelkens, E., De Moor, B., & D'Hooghe, T.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- MRC Centre for Reproductive Health (GB)
- University of Wisconsin–Madison (US)
- KU Leuven (BE)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 99
- Issue
- 4
- Pages
- 1135-1145
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2151444028
- Cited by
- 150
- References
- 154
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 10 · 2021: 5 · 2020: 12 · 2019: 14 · 2018: 16 · 2017: 13 · 2016: 17 · 2015: 17 · 2014: 21 · 2013: 7
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, biomarkers, non-invasive diagnosis, peripheral blood biomarkers, proteomics, microRNA, subfertility, pelvic pain, diagnostic accuracy, endometrioma
- MeSH terms
- Endometriosis, Endometrium, Female, Humans, Reproducibility of Results, Biomarkers, Proteomics
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