The Expression and Ovarian Steroid Regulation of Endometrial Micro-RNAs
Open accessAbstract
MicroRNAs (miRNAs) which regulate gene expression stability displayed an aberrant expression profile in ectopic endometrium (ECE) as compared to eutopic (EUE) and normal endometrium (NE). We assessed the expression of miR-17-5p, miR-23a, miR-23b and miR-542-3p, their predicted target genes, steroidogenic acute regulatory protein, aromatase and cyclooxygenase-2, and influence of ovarian steroids on their expression in endometrial stromal (ESC) and glandular epithelial cells (GEC). The results indicated a lower expression of miR-23b and miR-542-3p and higher level of miR-17-5p in paired ECE and EUE as compared with NE. These levels were elevated and inversely correlated with the level of expression of their respective target genes in ECE. The expression of these miRNAs and genes was differentially regulated by 17beta- estradiol, medroxyprogesterone acetate, ICI-182780 and RU-486, or their respective combinations in ESC and GEC. We concluded that altered expression of specific miRNAs in ECE, affecting the stability of their target genes expression, has direct implications in pathogenesis of endometriosis.
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Reports of miR-23a expression in eutopic endometrium from women with and without endometriosis showed opposite directions of dysregulation, with one study involving proliferative endometrial specimens and the other including only early to midsecretory samples.
“Notably, the reports of miR-23a expression in eutopic endometrium from women with and without endometriosis showed opposite directions of dysregulation, with one study involving proliferative endometrial specimens and the other including only early to midsecretory samples.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [128]
Other miRNAs and predicted cognate mRNAs demonstrating differential expression in eutopic endometrium from women with and without endometriosis include miR-23a/CYP19A1 and miR-542-3p/COX2, miR-126/CRK and miR23a/NR5A1.
“Other miRNAs and predicted cognate mRNAs demonstrating differential expression in eutopic endometrium from women with and without endometriosis include miR-23a/CYP19A1 and miR-542-3p/COX2 [128], miR-126/CRK [129] and miR23a/NR5A1 [130].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [128]
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- Authors
- Toloubeydokhti, T., Pan, Q., Luo, X., Bukulmez, O., & Chegini, N.
- Affiliations
- University of Florida Health (US)
- Corresponding author
- Chegini, Nasser
- Venue
- Reproductive Sciences
- Published
- 2008-12
- Volume
- 15
- Issue
- 10
- Pages
- 993-1001
- ISSN
- 1933-7191 (ISSN-L)
- 1933-7205
- PMC
- PMC2729333
- OpenAlex
- W1566032609
- Cited by
- 83
- References
- 62
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 8 · 2014: 13 · 2013: 7 · 2012: 7
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Reproductive Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD037432, HD37432)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- microRNA, endometriosis, ectopic endometrium, eutopic endometrium, miR-17-5p, miR-23a, miR-23b, miR-542-3p, steroidogenic acute regulatory protein, aromatase, cyclooxygenase-2, ovarian steroids, estradiol, medroxyprogesterone acetate, fulvestrant, RU486, endometrial stromal cells, endometrial glandular epithelial cells, miRNA target genes
- MeSH terms
- Adult, Cells, Cultured, Endometriosis, Endometrium, Female, Gene Expression Regulation, Humans, Ovary, Gonadal Steroid Hormones, MicroRNAs
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