The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
Open accessAbstract
MicroRNAs (miRNAs), through mRNA degradation or repression, act as key regulator of gene expression. Our aim was to identify specific miRNAs that are expressed in endometrium of women with and without endometriosis. We profiled the expression of 287 miRNAs in paired eutopic and ectopic endometrium and isolated endometrial cells using microarray and validated the expression of selected miRNAs using real-time PCR. On the basis of global normalization, 65 of these miRNAs were identified to be expressed above the threshold levels set during the analysis in the endometrium of women without endometriosis with a progressive decline in expression in paired eutopic and ectopic endometrium. Statistical analysis (ANOVA) identified 48 of these miRNAs as differentially expressed among these tissues and 32 miRNAs between isolated endometrial stromal cell (ESC) and glandular epithelial cell (GEC) (P < 0.05). The expression of hsa-miR20a, hsa-miR21, hsa-miR26a, hsa-miR18a, hsa-miR206, hsa-miR181a and hsa-miR142-5p, predicted to target many genes, including TGF-betaR2, ERalpha, ERbeta and PR, respectively, was validated in these tissues and cells using real-time PCR. Treatment of ESC and GEC with 17beta-estradiol and medroxyprogesterone acetate (10(-8) M) differentially regulated the expression of hsa-miR20a, hsa-miR21 and hsa-miR26a, which in part reversed following co-treatment with ICI-182780 and RU-486 (10(-6) M), respectively (P < 0.05). In conclusion, we provided evidence for the expression of a number of differentially expressed miRNAs in eutopic/ectopic endometrium and isolated endometrial cells, opening up the possibility that aberrant/altered expression of some miRNAs whose expression is regulated by the ovarian steroids may influence the expression of specific target genes with central roles in normal endometrial cellular activities and pathogenesis of endometriosis.
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Global differential expression of miRNAs in eutopic compared with ectopic endometrium has been evaluated by several groups.
“Global differential expression of miRNAs in eutopic compared with ectopic endometrium has been evaluated by several groups [120–124].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [120]
Relatively few studies have compared miRNA expression in eutopic endometrium from women with and without surgically confirmed endometriosis.
“In contrast to studies comparing miRNA expression in eutopic versus ectopic endometrium, relatively few studies have compared miRNA expression in eutopic endometrium from women with and without surgically confirmed endometriosis [120, 125, 126].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [120]
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- Authors
- Pan, Q., Luo, X., Toloubeydokhti, T., & Chegini, N.
- Affiliations
- University of Florida Health (US)
- Venue
- Molecular Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08-31
- Volume
- 13
- Issue
- 11
- Pages
- 797-806
- ISSN
- 1360-9947 (ISSN-L)
- 1460-2407
- OpenAlex
- W2140429790
- Cited by
- 261
- References
- 46
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 8 · 2021: 9 · 2020: 11 · 2019: 17 · 2018: 8 · 2017: 13 · 2016: 12 · 2015: 23 · 2014: 25 · 2013: 27 · 2012: 31
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2014-11-13)
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- Molecular Human Reproduction (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37432)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- miRNA expression profiling, endometriosis, endometrium, ovarian steroids, estradiol, medroxyprogesterone acetate, fulvestrant, RU486, endometrial stromal cells, endometrial glandular epithelial cells, estrogen receptor alpha, estrogen receptor beta, progesterone receptor, miRNA target genes
- MeSH terms
- Adult, Endometriosis, Endometrium, Estradiol, Female, Gene Expression Regulation, Humans, Ovary, Steroids, Polymerase Chain Reaction, Medroxyprogesterone Acetate, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs
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