First effective mHealth nutrition and lifestyle coaching program for subfertile couples undergoing in vitro fertilization treatment: a single-blinded multicenter randomized controlled trial
Open accessAbstract
Objective To study compliance and effectiveness of the mHealth nutrition and lifestyle coaching program Smarter Pregnancy in couples undergoing in vitro fertilization (IVF) treatment with or without intracytoplasmic sperm injection (ICSI).Design Multicenter, single-blinded, randomized controlled trial, conducted from July 2014 to March 2017.Setting IVF clinics.Patient(s) A total of 626 women undergoing IVF treatment with or without ICSI and 222 male partners.Interventions(s) Couples were randomly assigned to the light (control group) or regular (intervention group) Smarter Pregnancy program. Both groups filled out a baseline screening questionnaire on nutrition and lifestyle behaviors, and the intervention group received coaching tailored to inadequate behaviors during the 24-week period.Main outcome measure(s) Difference in improvement of a composite dietary and lifestyle risk score for the intake of vegetables, fruits, folic acid supplements, smoking, and alcohol use after 24 weeks of the program.Result(s) Compared with control subjects, women and men in the intervention group showed a significantly larger improvement of inadequate nutrition behaviors after 24 weeks of coaching. At the same time, the women also showed a significantly larger improvement of inadequate lifestyle behaviors.Conclusion(s) The mHealth coaching program Smarter Pregnancy is effective and improves the most important nutritional and lifestyle behaviors among couples undergoing IVF/ICSI treatment. International multicenter randomized trials are recommended to study the effect of using Smarter Pregnancy on pregnancy, live birth, and neonatal outcome.Netherlands trial register number NTR4150.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oostingh 2020 reported an RR of 0.92 (95% CI 0.81 to 1.05) for clinical pregnancy in 626 participants.
“Oostingh 2020 reported an RR of 0.92 (95% CI 0.81 to 1.05) in 626 participants.”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Oostingh 2020
Preconception lifestyle advice on a combination of topics may result in little to no difference in the proportion of women not smoking (RR 1.01, 95% CI 0.98 to 1.04; 1 RCT, 606 participants; low-quality evidence).
“Preconception lifestyle advice on a combination of topics may result in little to no difference in the proportion of women not smoking (RR 1.01, 95% CI 0.98 to 1.04; 1 RCT, 606 participants; low-quality evidence).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Oostingh 2020
The effect of preconception lifestyle advice on a combination of topics on the number of men not smoking is uncertain (RR 1.01, 95% CI 0.91 to 1.12; 1 RCT, 212 participants; very low-quality evidence).
“We are uncertain whether preconception lifestyle advice on a combination of topics affects the number of men not smoking (RR 1.01, 95% CI 0.91 to 1.12; 1 RCT, 212 participants; very low-quality evidence).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Oostingh 2020
The review included only one study that had invited male participants (Oostingh 2020).
“In our review, we included only one study that had invited male participants (Oostingh 2020).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Oostingh 2020
In Oostingh 2020, at 6 months, men in the experimental group had a higher rate of adequate fruit intake (>2 pieces/d) than control, with a risk ratio of 1.57 (95% CI 1.21 to 2.04).
“Men: 67/103 in experimental group 46/111 in control group RR 1.57, 95% CI 1.21 to 2.04”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Oostingh 2020
In Oostingh 2020, at 6 months, women in the experimental group had a higher rate of adequate vegetable intake (>200 g/d) than control, with a risk ratio of 1.46 (95% CI 1.17 to 1.82).
“Women: 124/299 in experimental group 89/313 in control group RR 1.46, 95% CI 1.17 to 1.82”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Oostingh 2020
In Oostingh 2020, at 6 months, women in the experimental group had a higher rate of adequate fruit intake (>2 pieces/d) than control, with a risk ratio of 1.18 (95% CI 1.05 to 1.33).
“Women: 207/299 in experimental group 182/311 in control group RR 1.18, 95% CI 1.05 to 1.33”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Oostingh 2020
In Oostingh 2020, at 6 months, men in the experimental group had a higher rate of adequate vegetable intake (>200 g/d) than control, with a risk ratio of 1.42 (95% CI 0.96 to 2.08).
“Men: 40/103 in experimental group 31/113 in control group RR 1.42, 95% CI 0.96 to 2.08”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Oostingh 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1993) · doi:10.1007/978-1-4899-4541-9 · Cited by 21,230 · see citing works
The Transtheoretical Model of Health Behavior Change.
Prochaska, J. O., & Velicer, W. F. (1997) · American Journal of Health Promotion · doi:10.4278/0890-1171-12.1.38 · Cited by 7,782 · see citing works
Health promotion from the perspective of Social Cognitive Theory
Bandura, A. (1998) · Psychology & Health · doi:10.1080/08870449808407422 · Cited by 3,087 · see citing works
Mascarenhas, M., Flaxman, S. R., Boerma, T., Vanderpoel, S., & Stevens, G. A. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001356 · Cited by 2,357 · see citing works
Stephenson, J., Heslehurst, N., Hall, J., Schoenaker, D. A. J. M., Hutchinson, J., Cade, J. E., Poston, L., Barrett, G., Crozier, S. R., Barker, M., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30311-8 · Cited by 1,222 · see citing works
Free, C., Phillips, G., Watson, L., Galli, L., Felix, L., Edwards, P., Patel, V., & Haines, A. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001363 · Cited by 1,187 · see citing works
Chow, C. K., Redfern, J., Hillis, G. S., Thakkar, J., Santo, K., Hackett, M. L., Jan, S., Graves, N., de Keizer, L., Barry, T., et al. (2015) · JAMA · doi:10.1001/jama.2015.10945 · Cited by 676 · see citing works
Quinn, C. C., Shardell, M. D., Terrin, M. L., Barr, E. A., Ballew, S. H., & Gruber-Baldini, A. L. (2011) · Diabetes Care · doi:10.2337/dc11-0366 · Cited by 650 · see citing works
Homan, G. F., Davies, M., & Norman, R. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml056 · Cited by 546 · see citing works
Free, C., Phillips, G., Felix, L., Galli, L., Patel, V., & Edwards, P. (2010) · BMC Research Notes · doi:10.1186/1756-0500-3-250 · Cited by 539 · see citing works
Intervention strategies to improve nutrition and health behaviours before conception
Barker, M., Dombrowski, S. U., Colbourn, T., Fall, C. H. D., Kriznik, N. M., Lawrence, W. T., Norris, S. A., Ngaiza, G., Patel, D., Skordis-Worrall, J., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30313-1 · Cited by 377 · see citing works
Self-citationRizvi, S. L., Dimeff, L. A., Skutch, J., Carroll, D., & Linehan, M. M. (2011) · Behavior Therapy · doi:10.1016/j.beth.2011.01.003 · Cited by 271 · see citing works
Johansen, M. Y., MacDonald, C. S., Hansen, K. B., Karstoft, K., Christensen, R., Pedersen, M., Hansen, L. S., Zacho, M., Wedell-Neergaard, A.-S., Nielsen, S. T., et al. (2017) · JAMA · doi:10.1001/jama.2017.10169 · Cited by 244 · see citing works
Overdijkink, S. B., Velu, A. V., Rosman, A. N., van Beukering, M. D. M., Kok, M., & Steegers‐Theunissen, R. P. M. (2018) · JMIR mhealth and uhealth · doi:10.2196/mhealth.8834 · Cited by 197 · see citing works
Self-citationMcLernon, D. J., Maheshwari, A., Lee, A. J., & Bhattacharya, S. (2016) · Human Reproduction · doi:10.1093/humrep/dev336 · Cited by 160 · see citing works
Chiu, Y., Williams, P. L., Gillman, M. W., Gaskins, A. J., Mínguez‐Alarcón, L., Souter, I. C., Toth, T. L., Ford, J. B., Hauser, R. B., Chavarro, J. E., et al. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.5038 · Cited by 138 · see citing works
Twigt, J. M., Bolhuis, M. E. C., Steegers, E. A. P., Hammiche, F., van Inzen, W. G., Laven, J. S. E., & Steegers‐Theunissen, R. P. M. (2012) · Human Reproduction · doi:10.1093/humrep/des157 · Cited by 134 · see citing works
Self-citationA Summary of Pathways or Mechanisms Linking Preconception Maternal Nutrition with Birth Outcomes
King, J. C. (2016) · Journal of Nutrition · doi:10.3945/jn.115.223479 · Cited by 134 · see citing works
Dietary patterns and outcomes of assisted reproduction
Gaskins, A. J., Nassan, F. L., Chiu, Y., Arvizu, M., Williams, P. L., Keller, M. G., Souter, I. C., Hauser, R. B., & Chavarro, J. E. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.02.004 · Cited by 129 · see citing works
Hammiche, F., Laven, J. S. E., Mil, N. H. G., de Cock, M., de Vries, J. H. M., Lindemans, J. W., Steegers, E., & Steegers‐Theunissen, R. P. M. (2011) · Human Reproduction · doi:10.1093/humrep/der225 · Cited by 128 · see citing works
Self-citationvan Dijk, M. R., Huijgen, N. A., Willemsen, S. P., Laven, J. S. E., Steegers, E. A. P., & Steegers‐Theunissen, R. P. M. (2016) · JMIR mhealth and uhealth · doi:10.2196/mhealth.5197 · Cited by 115 · see citing works
Self-citationLan, L., Harrison, C. L., Misso, M., Hill, B., Teede, H. J., Mol, B. W., & Moran, L. J. (2017) · Human Reproduction · doi:10.1093/humrep/dex241 · Cited by 91 · see citing works
Cumulative live birth rates in low-prognosis women
Leijdekkers, J. A., Eijkemans, M. J. C., van Tilborg, T. C., Oudshoorn, S. C., van Golde, R. J. T., Hoek, A., Lambalk, C. B., de Bruin, J. P., Fleischer, K., Mochtar, M. H., et al. (2019) · Human Reproduction · doi:10.1093/humrep/dez051 · Cited by 87 · see citing works
Self-citationLeijdekkers, J. A., Eijkemans, M. J. C., van Tilborg, T. C., Oudshoorn, S. C., McLernon, D. J., Bhattacharya, S., Mol, B. W., Broekmans, F. J., Torrance, H. L., & OPTIMIST group (2018) · Human Reproduction · doi:10.1093/humrep/dey263 · Cited by 86 · see citing works
Self-citationvan Uitert, E. M., van der Elst-Otte, N., Wilbers, J. J., Exalto, N., Willemsen, S. P., Eilers, P. H. C., Koning, A. H. J., Steegers, E. A. P., & Steegers‐Theunissen, R. P. M. (2013) · Human Reproduction · doi:10.1093/humrep/det375 · Cited by 73 · see citing works
Self-citationGormack, A. A., Peek, J. C., Derraik, J. G. B., Gluckman, P. D., Young, N. L., & Cutfield, W. S. (2015) · Human Reproduction · doi:10.1093/humrep/dev094 · Cited by 71 · see citing works
van Dijk, M. R., Koster, M. P. H., Willemsen, S. P., Huijgen, N. A., Laven, J. S. E., & Steegers‐Theunissen, R. P. M. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.014 · Cited by 60 · see citing works
Self-citationvan Dijk, M. R., Oostingh, E. C., Koster, M. P. H., Willemsen, S. P., Laven, J. S. E., & Steegers‐Theunissen, R. P. M. (2017) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-017-1228-5 · Cited by 57 · see citing works
Self-citationTemel, S., van Voorst, S. F., de Jong‐Potjer, L. C., Waelput, A. J. M., Cornel, M. C., de Weerd, S., Denktaş, S., & Steegers, E. A. P. (2014) · Journal of Community Genetics · doi:10.1007/s12687-014-0204-2 · Cited by 55 · see citing works
Self-citationvan Dijk, M. R., Koster, M. P. H., Rosman, A. N., & Steegers‐Theunissen, R. P. M. (2017) · JMIR mhealth and uhealth · doi:10.2196/mhealth.7834 · Cited by 36 · see citing works
Self-citationGootjes, D. V., van Dijk, M. R., Koster, M. P. H., Willemsen, S. P., Steegers, E. A. P., & Steegers‐Theunissen, R. P. M. (2018) · JMIR mhealth and uhealth · doi:10.2196/11664 · Cited by 31 · see citing works
Self-citationChavarro (2018) · doi:10.1016/j.fertnstert.2018.07.023 · Cited by 19 · see citing works
Huijgen, N. A., van de Kamp, M. E., Twigt, J. M., et al. (2013) · e-SPEN Journal · doi:10.1016/j.clnme.2013.12.001 · Cited by 15 · see citing works
Promoting healthy lifestyle in fertility clinics: an Australian perspective
Homan, G. F., deLacey, S., & Tremellen, K. (2018) · Human Reproduction Open · doi:10.1093/hropen/hox028 · Cited by 10 · see citing works
Couples perception regarding how lifestyle might affect fertility: results of a pilot study
Homan, G., & Norman, R. J. (2009) · Australian journal of advanced nursing · doi:10.37464/2009.264.1753 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Steegers-Theunissen, R. P. M., Wiegel, R. E., Jansen, P. W., Laven, J. S. E., & Sinclair, K. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218211 · Cited by 82 · see citing works
Self-citationPreconception lifestyle advice for people with infertility
Boedt, T., Vanhove, A.-C., Vercoe, M. A., Matthys, C., Dancet, E., & Lie Fong, S. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008189.pub3 · Cited by 66 · see citing works
- Authors
- Oostingh, E. C., Koster, M. P. H., van Dijk, M. R., Willemsen, S. P., Broekmans, F. J. M., Hoek, A., Goddijn, M., Klijn, N. F., van Santbrink, E. J. P., Steegers, E. A. P., Laven, J. S. E., & Steegers-Theunissen, R. P. M.
- Affiliations
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- University Medical Center Groningen (NL)
- Leiden University Medical Center (NL)
- ORCID
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 114
- Issue
- 5
- Pages
- 945-954
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W3046676119
- Cited by
- 50
- References
- 35
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 6 · 2023: 11 · 2022: 8 · 2021: 7 · 2020: 2
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, cc-by)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- ZonMw
- Erasmus Medisch Centrum
- Topics
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- mobile health, nutrition coaching, lifestyle coaching, in vitro fertilization, intracytoplasmic sperm injection, subfertility, couples, dietary behavior, fruit and vegetable intake, folic acid supplementation, smoking, alcohol consumption, mobile health intervention
- MeSH terms
- Mentoring, Adult, Family Characteristics, Female, Fertilization in Vitro, Follow-Up Studies, Humans, Infertility, Male, Netherlands, Pregnancy, Nutrition Assessment, Single-Blind Method, Treatment Outcome, Telemedicine, Risk Reduction Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
