Effect of Lifestyle-Focused Text Messaging on Risk Factor Modification in Patients With Coronary Heart Disease: A Randomized Clinical Trial
Abstract
IMPORTANCE: Cardiovascular disease prevention, including lifestyle modification, is important but underutilized. Mobile health strategies could address this gap but lack evidence of therapeutic benefit. OBJECTIVE: To examine the effect of a lifestyle-focused semipersonalized support program delivered by mobile phone text message on cardiovascular risk factors. DESIGN AND SETTING: The Tobacco, Exercise and Diet Messages (TEXT ME) trial was a parallel-group, single-blind, randomized clinical trial that recruited 710 patients (mean age, 58 [SD, 9.2] years; 82% men; 53% current smokers) with proven coronary heart disease (prior myocardial infarction or proven angiographically) between September 2011 and November 2013 from a large tertiary hospital in Sydney, Australia. INTERVENTIONS: Patients in the intervention group (n = 352) received 4 text messages per week for 6 months in addition to usual care. Text messages provided advice, motivational reminders, and support to change lifestyle behaviors. Patients in the control group (n=358) received usual care. Messages for each participant were selected from a bank of messages according to baseline characteristics (eg, smoking) and delivered via an automated computerized message management system. The program was not interactive. MAIN OUTCOMES AND MEASURES: The primary end point was low-density lipoprotein cholesterol (LDL-C) level at 6 months. Secondary end points included systolic blood pressure, body mass index (BMI), physical activity, and smoking status. RESULTS: At 6 months, levels of LDL-C were significantly lower in intervention participants, with concurrent reductions in systolic blood pressure and BMI, significant increases in physical activity, and a significant reduction in smoking. The majority reported the text messages to be useful (91%), easy to understand (97%), and appropriate in frequency (86%). [table: see text]. CONCLUSIONS AND RELEVANCE: Among patients with coronary heart disease, the use of a lifestyle-focused text messaging service compared with usual care resulted in a modest improvement in LDL-C level and greater improvement in other cardiovascular disease risk factors. The duration of these effects and hence whether they result in improved clinical outcomes remain to be determined. TRIAL REGISTRATION: anzctr.org.au Identifier: ACTRN12611000161921.
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Current evidence on digital health interventions is disproportionately concerned with high-income countries and hospital settings.
“Current evidence on digital health interventions is disproportionately concerned with high-income countries and hospital settings.”
From Digital health interventions for non-communicable disease management in primary health care in low-and middle-income countries (2023) · cites this paper as [16]
Most original studies and reviews on digital health interventions focused on high-income countries, hospital settings, or fields other than NCDs.
“However, most of these original studies and reviews focused on high-income countries, hospital settings, or fields other than NCDs15,16,19–22.”
From Digital health interventions for non-communicable disease management in primary health care in low-and middle-income countries (2023) · cites this paper as [16]
A lifestyle-focused text messaging service resulted in improvements in various CVD risk factors in CAD patients.
“Chow et al. 101 demonstrated that a lifestyle-focused text messaging service resulted in improvements in various CVD risk factors in CAD patients.”
Among the health issues in the current meta-analysis, only 4 studies focused on health-related quality of life.
“Among the health issues in the current meta-analysis, only 4 studies focused on health-related quality of life [47,61,72,112].”
From The Comparative Effectiveness of Mobile Phone Interventions in Improving Health Outcomes: Meta-Analytic Review (2019) · cites this paper as [61]
Social presentation engagement type has been applied in only 4 studies.
“both the social presentation [7,48,61,68] and social referencing [7,8,48,85] engagement types have been applied in only 4 studies.”
From The Comparative Effectiveness of Mobile Phone Interventions in Improving Health Outcomes: Meta-Analytic Review (2019) · cites this paper as [61]
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“A lifestyle-focused text messaging program promoted risk factor modification among patients with coronary heart disease [28].”
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“44 Combined, these studies informed the delivery of the SMART text messages, including the length, language, and frequency of text messages, as well as their interactive and personalisation features.”
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- Authors
- Chow, C. K., Redfern, J., Hillis, G. S., Thakkar, J., Santo, K., Hackett, M. L., Jan, S., Graves, N., de Keizer, L., Barry, T., Bompoint, S., Stepien, S., Whittaker, R., Rodgers, A., & Thiagalingam, A.
- Affiliations
- The University of Sydney (AU)
- Queensland University of Technology (AU)
- The George Institute for Global Health, University of Sydney, Sydney, Australia
- Westmead Hospital (AU)
- University of Auckland (NZ)
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2015-09-22
- Volume
- 314
- Issue
- 12
- Pages
- 1255
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1854618833
- Cited by
- 676
- References
- 29
- Citations by year
- 2026: 36 · 2025: 43 · 2024: 50 · 2023: 47 · 2022: 63 · 2021: 93 · 2020: 69 · 2019: 71 · 2018: 71 · 2017: 67 · 2016: 53 · 2015: 11 · 2014: 1
- FWCI
- 122.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- National Health and Medical Research Council (2014-17)
- Topics
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Physical Sciences › Computer Science › Information Systems › Mobile Learning in Education
- Keywords
- coronary artery disease, mobile health, text messaging, lifestyle modification, cardiovascular risk factors, LDL cholesterol, smoking cessation, physical activity, blood pressure, body mass index
- MeSH terms
- Blood Pressure, Coronary Disease, Female, Humans, Life Style, Cholesterol, LDL, Male, Middle Aged, Risk Factors, Smoking, Time Factors, Program Evaluation, Exercise, Body Mass Index, Single-Blind Method, Reminder Systems, Text Messaging
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