Cited by 676Mobile Health and mHealth ApplicationsCardiac Health and Mental HealthMobile Learning in Education

Effect of Lifestyle-Focused Text Messaging on Risk Factor Modification in Patients With Coronary Heart Disease: A Randomized Clinical Trial

Chow, Clara K., Redfern, Julie, Hillis, Graham S., Thakkar, Jay, Santo, Karla, Hackett, Maree L., Jan, Stephen, Graves, Nicholas +7 more·2015·JAMA

Abstract

IMPORTANCE: Cardiovascular disease prevention, including lifestyle modification, is important but underutilized. Mobile health strategies could address this gap but lack evidence of therapeutic benefit. OBJECTIVE: To examine the effect of a lifestyle-focused semipersonalized support program delivered by mobile phone text message on cardiovascular risk factors. DESIGN AND SETTING: The Tobacco, Exercise and Diet Messages (TEXT ME) trial was a parallel-group, single-blind, randomized clinical trial that recruited 710 patients (mean age, 58 [SD, 9.2] years; 82% men; 53% current smokers) with proven coronary heart disease (prior myocardial infarction or proven angiographically) between September 2011 and November 2013 from a large tertiary hospital in Sydney, Australia. INTERVENTIONS: Patients in the intervention group (n = 352) received 4 text messages per week for 6 months in addition to usual care. Text messages provided advice, motivational reminders, and support to change lifestyle behaviors. Patients in the control group (n=358) received usual care. Messages for each participant were selected from a bank of messages according to baseline characteristics (eg, smoking) and delivered via an automated computerized message management system. The program was not interactive. MAIN OUTCOMES AND MEASURES: The primary end point was low-density lipoprotein cholesterol (LDL-C) level at 6 months. Secondary end points included systolic blood pressure, body mass index (BMI), physical activity, and smoking status. RESULTS: At 6 months, levels of LDL-C were significantly lower in intervention participants, with concurrent reductions in systolic blood pressure and BMI, significant increases in physical activity, and a significant reduction in smoking. The majority reported the text messages to be useful (91%), easy to understand (97%), and appropriate in frequency (86%). [table: see text]. CONCLUSIONS AND RELEVANCE: Among patients with coronary heart disease, the use of a lifestyle-focused text messaging service compared with usual care resulted in a modest improvement in LDL-C level and greater improvement in other cardiovascular disease risk factors. The duration of these effects and hence whether they result in improved clinical outcomes remain to be determined. TRIAL REGISTRATION: anzctr.org.au Identifier: ACTRN12611000161921.

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Crossref · 10.1001/jama.2015.10945

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Authors
Chow, C. K., Redfern, J., Hillis, G. S., Thakkar, J., Santo, K., Hackett, M. L., Jan, S., Graves, N., de Keizer, L., Barry, T., Bompoint, S., Stepien, S., Whittaker, R., Rodgers, A., & Thiagalingam, A.
Affiliations
  • The University of Sydney (AU)
  • Queensland University of Technology (AU)
  • The George Institute for Global Health, University of Sydney, Sydney, Australia
  • Westmead Hospital (AU)
  • University of Auckland (NZ)
Venue
JAMA
Published
2015-09-22
Volume
314
Issue
12
Pages
1255
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W1854618833
Cited by
676
References
29
Citations by year
2026: 36 · 2025: 43 · 2024: 50 · 2023: 47 · 2022: 63 · 2021: 93 · 2020: 69 · 2019: 71 · 2018: 71 · 2017: 67 · 2016: 53 · 2015: 11 · 2014: 1
FWCI
122.83
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders
National Health and Medical Research Council (2014-17)
Topics
  • Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Physical Sciences › Computer Science › Information Systems › Mobile Learning in Education
Keywords
coronary artery disease, mobile health, text messaging, lifestyle modification, cardiovascular risk factors, LDL cholesterol, smoking cessation, physical activity, blood pressure, body mass index
MeSH terms
Blood Pressure, Coronary Disease, Female, Humans, Life Style, Cholesterol, LDL, Male, Middle Aged, Risk Factors, Smoking, Time Factors, Program Evaluation, Exercise, Body Mass Index, Single-Blind Method, Reminder Systems, Text Messaging

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