Inhibitory effects of laminaran and low molecular alginate against the putrefactive compounds produced by intestinal microflora in vitro and in rats
Abstract
The inhibitory effects of laminaran and low molecular weight sodium alginate (MW = 49,000) against formation of ammonia, indole compounds and phenol compounds, putrefactive and harmful compounds, induced by human fecal microflora, were examined in vitro. Laminaran was fermented to acetate, propionate, n-butyrate and lactate. The alginate was fermented to acetate and propionate. Both of these polysaccharides inhibited formation of the putrefactive compounds. In the case of rats fed diet containing 2% (w/w) laminaran or low molecular alginate, the fermentation pattern agreed with that of the in vitro experiment. Laminaran suppressed indole, p-cresole and sulfide, significantly. These putrefactive compounds, in rats fed low molecular alginate, also tended to be lower. These results suggest that the fermentation of laminaran by intestinal bacteria suppresses the putative risk markers for colon cancer.
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Laminarin supplementation of rats feed enhances the cecal population of bifidobacteria, with no significant effect on lactobacilli.
“In addition, laminarin supplementation of rats feed also enhanced the cecal population of bifidobacteria, with no significant effect on lactobacilli.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [139]
Laminarin suppresses certain putrefactive compounds considered risk markers for colon cancer, such as indole, cresol, and sulfide, and has immunomodulatory properties.
“Moreover, laminarin also suppressed certain putrefactive compounds considered as risk markers for colon cancer, such as indole, cresol, and sulfide, and had immunomodulatory properties [139].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [139]
Polysaccharides were fermented into propionic and butyric acids by intestinal microbiota, similar to prebiotics.
“Polysaccharides were fermented into propionic and butyric acids by intestinal microbiota, similar to the effects of prebiotics.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [88]
Fermentation of laminaran by intestinal bacteria could suppress risk of colorectal cancer.
“These results suggest that the fermentation of laminaran by intestinal bacteria could suppress the risk of colorectal cancer [87,88].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [88]
Laminarans noticeably inhibited formation of putrefactive and harmful compounds such as indoles, p-cresol, ammonia, phenol, and sulfide produced by fecal microflora.
“Laminarans noticeably inhibited the formation of putrefactive and harmful compounds, such as indoles, p-cresol, ammonia, phenol, and sulfide, produced by the fecal microflora.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [88]
In both experiments (laminaran and alginic acid), intestinal bacterial flora of rats was changed.
“In both experiments (with laminaran and with alginic acid) the intestinal bacterial flora of rats was changed.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [88]
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- Authors
- Kuda, T., Yano, T., Matsuda, N., & Nishizawa, M.
- Affiliations
- Tokyo University of Agriculture (JP)
- Corresponding author
- Kuda, Takashi
- ORCID
- Kuda, Takashi
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 91
- Issue
- 4
- Pages
- 745-749
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2046147142
- Cited by
- 96
- References
- 16
- Citations by year
- 2025: 6 · 2024: 7 · 2023: 2 · 2022: 9 · 2021: 2 · 2020: 7 · 2019: 10 · 2018: 5 · 2017: 9 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 5
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- laminarin, gut microbiota, fecal fermentation, indole, p-cresol, sulfide, ammonia, phenolic compounds, dietary polysaccharides, rats
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