Protective effect of sea cucumber (Acaudina molpadioides) fucoidan against ethanol-induced gastric damage
Abstract
Sea cucumber is a nutritional aquatic food that is widely consumed in East Asian countries. Employing a rat model of ethanol-induced gastric ulcer, we examined the protective effect of sea cucumber fucoidan (SC-FUC) extracted from Acaudina molpadioides and explored the related mechanisms. Oral administration with 100mg/kg body weight SC-FUC for 5days can significantly prevent the formation of gastric ulcer. Moreover, SC-FUC pretreatment could alleviate ethanol-induced histological damage, reverse changes in tissue oxidation and antioxidase activities, and regulate the signalling pathways of mitogen-activated protein kinases and matrix metalloproteinases. This study investigated the ethanol-induced gastric ulcer protective effect of SC-FUC for the first time, and elucidated that the protective mechanisms included anti-oxidation, gastric matrix hydrolysis suppression, and anti-inflammation.
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SC-FUC pretreatment could alleviate ethanol-induced histological damage, reverse changes in tissue oxidation and antioxidase activities, and regulate the signaling pathways of mitogen-activated protein kinases and matrix metalloproteinases.
“Moreover, SC-FUC pretreatment could alleviate ethanol-induced histological damage, reverse changes in tissue oxidation and antioxidase activities, and regulate the signaling pathways of mitogen-activated protein kinases and matrix metalloproteinases [153].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [153]
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Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189 · see citing works
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- Authors
- Wang, Y., Su, W., Zhang, C., Xue, C., Chang, Y., Wu, X., Tang, Q., & Wang, J.
- Affiliations
- Ocean University of China (CN)
- Corresponding author
- Chang, Yaoguang
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 133
- Issue
- 4
- Pages
- 1414-1419
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2111175994
- Cited by
- 92
- References
- 57
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 9 · 2015: 9 · 2014: 6 · 2013: 8 · 2012: 1
- FWCI
- 11.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Keywords
- Acaudina molpadioides, ethanol-induced gastric injury, gastroprotection, oxidative stress, antioxidant enzymes, matrix metalloproteinases, mitogen-activated protein kinase, anti-inflammatory activity
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