Valuable compounds in macroalgae extracts

Andrade, Paula B.; Barbosa, Mariana; Matos, Rui Pedro; Lopes, Graciliana; Vinholes, Juliana; Mouga, Teresa; Valentão, Patrícia

doi:10.1016/j.foodchem.2012.11.081

Cited by 188Seaweed-derived Bioactive CompoundsMarine and coastal plant biologyPhytochemistry and Biological Activities

Valuable compounds in macroalgae extracts

Andrade, Paula B., Barbosa, Mariana, Matos, Rui Pedro, Lopes, Graciliana, Vinholes, Juliana, Mouga, Teresa, Valentão, Patrícia·2013·Food Chemistry

DOI 10.1016/j.foodchem.2012.11.081

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Abstract

Bioactive compounds present in ethanolic extracts from 18 macroalgae of the Portuguese coast were analysed by gas chromatography-mass spectrometry (GC-MS), leading to the characterization of 14 compounds: proline, phloroglucinol, mannitol, 8 fatty acids and 3 sterols. A dose-dependent response against enzymes with biological significance (α-glucosidase, acetylcholinesterase and butyrylcholinesterase) and free radicals (DPPH, nitric oxide, superoxide and hydroxyl) was found, Phaeophyta being the most promising group. A PCA analysis was performed and allowed the establishment of a correlation between the algae chemical composition and the biological activity. Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus are among the most active species, which is in accordance with their higher contents in phloroglucinol, mannitol, oleic, arachidonic and eicosapentaenoic acids, and fucosterol. The results point to the potential interest of the use of Phaeophyta species as food additives, due to their potent antiradical activities, and especially highlights the importance of F. spiralis in the food chain of Mediterranean countries. Moreover, the incorporation of the extracts of these species in food products, nutraceutical and pharmaceutical preparations for human health should also be instigated, since they can suppress hyperglycemia and inhibit cholinesterases.

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Macroalgae produce a large range of primary and secondary metabolites used in food, cosmetic, pharmaceutical, and other industries.
“macroalgae are responsible for the production of a large range of primary and secondary metabolites that can be used for different applications in food, cosmetic, pharmaceutical, and other industries [108].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [108]
Many compounds from macroalgae have antiinflammatory, antimutagenic, antitumor, antidiabetic, hepatoprotective, free radical scavenger, anticoagulant, thrombolytic, and antihypertensive properties.
“Many of these compounds have well-established antiinflammatory, antimutagenic, antitumor, antidiabetic, hepatoprotective, free radical scavengers, anticoagulants, thrombolytic, and antihyperthensive properties [108,109].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [108]
Macroalgae contain larger amounts of unsaturated fatty acids than saturated, and because of that, they exhibit acetylcholinesterase inhibition, which can provide protection from neurodegenerative disorders.
“Macroalgae contain larger amount of unsaturated fatty acids than saturated [23,24], and because of that, they exhibit acetylcholinesterase inhibition, which means that they can provide protection from neurodegenerative disorders [25].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [25]

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Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage
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Anti-diabetic Potential of a Stigmasterol From the Seaweed Gelidium spinosum and Its Application in the Formulation of Nanoemulsion Conjugate for the Development of Functional Biscuits
Poulose, N., Sajayan, A., Ravindran, A., Chandran, A., Priyadharshini, G. B., Selvin, J., & Kiran, G. S. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.694362 · Cited by 65 · see citing works
Phytoestrogens and mycoestrogens in surface waters — Their sources, occurrence, and potential contribution to estrogenic activity
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Phytosterols in Seaweeds: An Overview on Biosynthesis to Biomedical Applications
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Cystoseira algae (Fucaceae): update on their chemical entities and biological activities
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Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds
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Marine green macroalgae: A source of natural compounds with mineralogenic and antioxidant activities
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Influence of Codium tomentosum Extract in the Properties of Alginate and Chitosan Edible Films
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Photoprotection properties of marine photosynthetic organisms grown in high ultraviolet exposure areas: Cosmeceutical applications
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Distribution of natural ingredients suggests a complex network of metabolic transport between source and sink tissues in the brown alga Fucus vesiculosus
Birkemeyer, C., Osmolovskaya, N., Kuchaeva, L., & Tarakhovskaya, E. (2018) · Planta · doi:10.1007/s00425-018-3009-4 · Cited by 62 · see citing works
Phytochemical study of the headspace volatile organic compounds of fresh algae and seagrass from the Adriatic Sea (single point collection)
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Overview of 3 year precommercial seafarming of Macrocystis pyrifera along the Chilean coast
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Edible Brown Seaweed in Gluten-Free Pasta: Technological and Nutritional Evaluation
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Methanol extracts from Cystoseira tamariscifolia and Cystoseira nodicaulis are able to inhibit cholinesterases and protect a human dopaminergic cell line from hydrogen peroxide-induced cytotoxicity
Custódio, L. M. B., Silvestre, L., Rocha, M. I., Rodrigues, M. J., Vizetto‐Duarte, C., Pereira, H., Barreira, L. A., & Varela, J. C. S. (2016) · Pharmaceutical Biology · doi:10.3109/13880209.2015.1123278 · Cited by 58 · see citing works
Distinct fatty acid profile of ten brown macroalgae
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Browning inhibition of plant extracts on fresh‐cut fruits and vegetables—A review
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Extraction of sterols in brown macroalgae from Antarctica and their identification by liquid chromatography coupled with tandem mass spectrometry
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Beneficial impacts and health benefits of macroalgae phenolic molecules on fish production
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Antioxidant screening and phenolic content of ethanol extracts of selected Baja California Peninsula macroalgae
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Antibacterial and Antioxidant Metabolites of Diaporthe spp. Isolated from Flowers of Melodorum fruticosum
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The Remarkable Antioxidant and Anti-Inflammatory Potential of the Extracts of the Brown Alga Cystoseira amentacea var. stricta
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Nonenzymatic α-Linolenic Acid Derivatives from the Sea: Macroalgae as Novel Sources of Phytoprostanes
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Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer based on network pharmacology and molecular docking
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Feasibility of bioplastic production using micro- and macroalgae- A review
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Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol through Integrated System Pharmacology and In Silico Analysis
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Evaluation of seaweed extracts functionality as post-harvest treatment for minimally processed Fuji apples
Augusto, A., Simões, T., Pedrosa, R., & Silva, S. (2015) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2015.10.004 · Cited by 45 · see citing works
Domesticated Populations of Codium tomentosum Display Lipid Extracts with Lower Seasonal Shifts than Conspecifics from the Wild—Relevance for Biotechnological Applications of this Green Seaweed
Rey, F., Cartaxana, P., Melo, T., Calado, R., Pereira, R., Abreu, H., Domingues, P. M., Cruz, S., & Domingues, M. R. (2020) · Marine Drugs · doi:10.3390/md18040188 · Cited by 44 · see citing works
Improved phylogeny of brown algae Cystoseira (Fucales) from the Atlantic-Mediterranean region based on mitochondrial sequences
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Multi-Step Subcritical Water Extracts of Fucus vesiculosus L. and Codium tomentosum Stackhouse: Composition, Health-Benefits and Safety
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Toxicity in vitro and in Zebrafish Embryonic Development of Gold Nanoparticles Biosynthesized Using Cystoseira Macroalgae Extracts
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Extraction and Purification of Biopolymers from Marine Origin Sources Envisaging Their Use for Biotechnological Applications
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Phytoestrogens and sterols in waters with cyanobacterial blooms - Analytical methods and estrogenic potencies
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The biotechnological potential of Asparagopsis armata: What is known of its chemical composition, bioactivities and current market?
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Bifurcaria bifurcata: a key macro‐alga as a source of bioactive compounds and functional ingredients
Alves, C., Pintéus, S., Simões, T., Horta, A., Silva, J., Tecelão, C., & Pedrosa, R. (2016) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13135 · Cited by 39 · see citing works
Analysis of functional components and radical scavenging activity of 21 algae species collected from the Japanese coast
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Characterization of the lipid profile of Antarctic brown seaweeds and their endophytic fungi by gas chromatography–mass spectrometry (GC–MS)
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Lactic acid fermentation in the development of a seaweed sauerkraut‐style product: Microbiological, physicochemical, and sensory evaluation
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Quality Characteristics and Functional and Antioxidant Capacities of Algae-Fortified Fish Burgers Prepared from Common Barbel ( Barbus barbus )
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Bioaccessibility of Antioxidants and Fatty Acids from Fucus Spiralis
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Bioprospecting of Less-Polar Constituents from Endemic Brown Macroalga Fucus virsoides J. Agardh from the Adriatic Sea and Targeted Antioxidant Effects In Vitro and In Vivo (Zebrafish Model)
Jerković, I., Cikoš, A.-M., Babić, S., Čižmek, L., Bojanić, K., Aladić, K., Ul’yanovskii, N. V., Kosyakov, D. S., Lebedev, А. T., Čož‐Rakovac, R., et al. (2021) · Marine Drugs · doi:10.3390/md19050235 · Cited by 37 · see citing works
Effect of an icing medium containing the alga Fucus spiralis on the microbiological activity and lipid oxidation in chilled megrim (Lepidorhombus whiffiagonis)
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Natural Products of Marine Macroalgae from South Eastern Australia, with Emphasis on the Port Phillip Bay and Heads Regions of Victoria
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High-Performance Liquid Chromatography with Fluorescence Detection for Simultaneous Analysis of Phytosterols (Stigmasterol, β-Sitosterol, Campesterol, Ergosterol, and Fucosterol) and Cholesterol in Plant Foods
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Antimicrobial activity of Ulva reticulata and its endophytes
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24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer’s Disease
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Effect of biodegradable film (lyophilised alga F ucus spiralis and sorbic acid) on quality properties of refrigerated megrim ( L epidorhombus whiffiagonis)
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Phlorotannins from Fucales: potential to control hyperglycemia and diabetes-related vascular complications
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Roasting processed oriental melon (Cucumis melo L. var. makuwa Makino) seed influenced the triglyceride profile and the inhibitory potential against key enzymes relevant for hyperglycemia
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Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties
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Evaluation of the volatile composition and fatty acid profile of seven Antarctic macroalgae
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Brown Macroalgae (Phaeophyceae): A Valuable Reservoir of Antimicrobial Compounds on Northern Coast of Spain
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Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources. Part I: Cystoseira barbata (Stackhouse) C. Agardh
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Carbon nanotube production from algal biochar using microwave irradiation technology
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In vitro and in silico evaluation of fucosterol from Sargassum horridum as potential human acetylcholinesterase inhibitor
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Evaluation and characterization of algal biomass applied to the development of fingermarks on glass surfaces
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Carotenoid and Chlorophyll Profiles in Five Species of Malaysian Seaweed as Potential Halal Active Pharmaceutical Ingredient (API)
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Determination of Total Antioxidant Capacities of Algal Pigments in Seaweed by the Combination of High-Performance Liquid Chromatography (HPLC) with A Cupric Reducing Antioxidant Capacity (CUPRAC) Assay
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Environmental life cycle optimization of essential terpene oils produced by the macroalga Ochtodes secundiramea
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Anti-Arthritis Effect through the Anti-Inflammatory Effect of Sargassum muticum Extract in Collagen-Induced Arthritic (CIA) Mice
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Asparagopsis Genus: What We Really Know About Its Biological Activities and Chemical Composition
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Early Embryogenesis of Brown Alga Fucus vesiculosus L. is Characterized by Significant Changes in Carbon and Energy Metabolism
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Chemical profiling of edible seaweed (Ochrophyta) extracts and assessment of their in vitro effects on cell-free enzyme systems and on the viability of glutamate-injured SH-SY5Y cells
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Antimicrobial and antioxidant effect of lyophilized Fucus spiralis addition on gelatin film during refrigerated storage of mackerel
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Isolation and Characterization of a Novel Calcium/Calmodulin-Dependent Protein Kinase, AtCK, from Arabidopsis
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Enhancing Mexican lime (Citrus aurantifolia cv.) shelf life with innovative edible coatings: xanthan gum edible coating enriched with Spirulina platensis and pomegranate seed oils
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Marine invasive species for high-value products' exploration – Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens
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A concise review of the potential utilization based on bioactivity and pharmacological properties of the genus Gelidium (Gelidiales, Rhodophyta)
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Hydrothermal Pretreatments of Macroalgal Biomass for Biorefineries
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Nutraceutical Potential of Five Mexican Brown Seaweeds
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Seaweed polysaccharides as sustainable building blocks for biomaterials in tissue engineering
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Bioprospecting for lipophilic-like components of five Phaeophyta macroalgae from the Portuguese coast
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Marine macroalgae as a dietary source of genoprotection in gilthead seabream (Sparus aurata) against endogenous and exogenous challenges
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Authors: Andrade, P. B., Barbosa, M., Matos, R. P., Lopes, G., Vinholes, J., Mouga, T., & Valentão, P.
Affiliations: Universidade do Porto (PT)
Universidade de Leiria e Oeste (PT)
ORCID: Andrade, Paula B.
Barbosa, Mariana
Lopes, Graciliana
Vinholes, Juliana
Mouga, Teresa
Venue: Food Chemistry
Publisher: Elsevier BV
Published: 2013-06
Volume: 138
Issue: 2-3
Pages: 1819-1828
ISSN: 0308-8146 (ISSN-L)
DOI: 10.1016/j.foodchem.2012.11.081
OpenAlex: W2030477556
Cited by: 188
References: 53
Citations by year: 2026: 10 · 2025: 11 · 2024: 9 · 2023: 14 · 2022: 18 · 2021: 20 · 2020: 21 · 2019: 19 · 2018: 18 · 2017: 13 · 2016: 16 · 2015: 12 · 2014: 4 · 2013: 2
FWCI: 8.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Food Chemistry (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Funders: Fundação para a Ciência e a Tecnologia (FCT) (PEst-C/EQB/LA0006/2011)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords: macroalgae extracts, bioactive compounds, brown algae, Cystoseira, Fucus spiralis, phloroglucinol, mannitol, fatty acids, sterols, fucosterol, anticholinesterase activity, α-glucosidase inhibition, antioxidant activity, free radical scavenging, nutraceuticals, food additives, hyperglycemia
MeSH terms: Acetylcholinesterase, Antioxidants, Butyrylcholinesterase, Chromatography, High Pressure Liquid, Enzyme Inhibitors, Humans, Seaweed, Glycoside Hydrolase Inhibitors

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