Cited by 51Analytical chemistry methods developmentIonic liquids properties and applicationsDye analysis and toxicity

Nonionic Surfactants Based Hydrophobic Deep Eutectic Solvents for Liquid–Liquid Microextraction of Sudan Dyes in Tomato Chili Sauces

Chen, Jia, Li, Xiao, Huang, Anqi, Deng, Wenwen, Xiao, Yuxiu·2021·Food Chemistry

Abstract

A new type of high-density hydrophobic deep eutectic solvents (DESs) were synthesized with nonionic surfactants as hydrogen bond acceptors and hexafluoroisopropanol (HFIP) as hydrogen bond donor. Brij-35 was selected as the optimal nonionic surfactant for the preparation of Brij-35-HFIP-DES (molar ratio 1:20). A vortex-assisted DES-based liquid-liquid microextraction method was proposed for determination of Sudan dyes in tomato chili sauces. The whole pretreatment process only needs 5 min and 1.1 mL of organic solvent. The method with HPLC-DAD shows high efficiency (enrichment factors 89-176 and extraction rates 61.0-74.6%) and good performance with linearity (R ≥ 0.9997) in 0.04-2 μg g-1 range, detection limits of 0.0045-0.0118 μg g-1, recoveries of 91.6-104.5% and intra-/inter-day precision below 8.0%. A "DES in water in DES" aggregate microstructure was observed in DES-rich phase. The proposed method is simple, quick, eco-friendly, and suits for the efficient extraction and accurate determination of Sudan dyes in tomato chili sauces.

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Crossref · 10.1016/j.foodchem.2021.130373

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Authors
Chen, J., Li, X., Huang, A., Deng, W., & Xiao, Y.
Affiliations
  • Wenzhou Medical University (CN)
  • Wuhan University (CN)
Corresponding author
Xiao, Yuxiu
Venue
Food Chemistry
Publisher
Elsevier BV
Published
2021-12
Volume
364
Pages
130373
ISSN
0308-8146 (ISSN-L)
OpenAlex
W3168720836
Cited by
51
References
40
Citations by year
2026: 6 · 2025: 9 · 2024: 14 · 2023: 14 · 2022: 7 · 2021: 1
FWCI
4.51
Type
journal article
Language
en
Open access
closed
Locations
  • Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation of Hebei Province (2015CFA139, LF20170838, 81673394, 82073811)
  • Wuhan University (2015CFA139, LF20170838, 81673394, 82073811)
  • Large-Scale Instrument and Equipment Sharing Foundation of Wuhan University (2015CFA139, LF20170838, 81673394, 82073811)
  • National Natural Science Foundation of China (2015CFA139, LF20170838, 81673394, 82073811)
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
  • Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
  • Physical Sciences › Chemistry › Analytical Chemistry › Dye analysis and toxicity
Keywords
hydrophobic deep eutectic solvents, nonionic surfactants, Brij 35, hexafluoroisopropanol, liquid-liquid microextraction, vortex-assisted extraction, Sudan dyes, food dye analysis, HPLC-DAD
MeSH terms
Chromatography, High Pressure Liquid, Coloring Agents, Solvents, Surface-Active Agents, Solanum lycopersicum, Limit of Detection, Liquid Phase Microextraction

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