Cited by 138Tannin, Tannase and Anticancer ActivitiesPhytochemicals and Antioxidant ActivitiesLignin and Wood Chemistry

Biological and pharmacological aspects of tannins and potential biotechnological applications

Open access
Melo, Luciana Fentanes Moura de, Aquino-Martins, Verônica Giuliani de Queiroz, Silva, Ariana Pereira da, Oliveira Rocha, Hugo Alexandre, Scortecci, Katia Castanho·2023·Food Chemistry

Abstract

Secondary metabolites are divided into three classes: phenolic, terpenoid, and nitrogenous compounds. Phenolic compounds are also known as polyphenols and include tannins, classified as hydrolysable or condensed. Herein, we explored tannins for their ROS reduction characteristics and role in homeostasis. These activities are associated with the numbers and degree of polymerisation of reactive hydroxyl groups present in the phenolic rings of tannins. These characteristics are associated with anti-inflammatory, anti-aging, and anti-proliferative health benefits. Tannins can reduce the risk of cancer and neurodegenerative diseases, such as cardiovascular diseases and Alzheimer's, respectively. These biomolecules may be used as nutraceuticals to maintain good gut microbiota. Industrial applications include providing durability to leather, anti-corrosive properties to metals, and substrates for 3D printing and in bio-based foam manufacture. This review updates regarding tannin-based research and highlights its biological and pharmacological relevance and potential applications.

Integrity signals

Registry

Crossref · 10.1016/j.foodchem.2023.135645

Cites

136 of 136 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

2 retracted

Flagged first, then by citations

4 of the 140 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Melo, L. F. M. D., Aquino-Martins, V. G. D. Q., Silva, A. P. D., Oliveira Rocha, H. A., & Scortecci, K. C.
Affiliations
Universidade Federal do Rio Grande do Norte (BR)
Venue
Food Chemistry
Publisher
Elsevier BV
Published
2023-07
Volume
414
Pages
135645
ISSN
0308-8146 (ISSN-L)
OpenAlex
W4319320211
Cited by
137
References
140
Citations by year
2026: 34 · 2025: 45 · 2024: 43 · 2023: 15
FWCI
2.65
Type
journal article
Language
en
Open access
Locations
  • Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Tannin, Tannase and Anticancer Activities
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Physical Sciences › Engineering › Biomedical Engineering › Lignin and Wood Chemistry
Keywords
tannins, hydrolysable tannins, proanthocyanidins, polyphenols, reactive oxygen species scavenging, antioxidant activity, anti-inflammatory activity, anti-aging, antiproliferative activity, cancer prevention, neurodegenerative diseases, cardiovascular disease, nutraceuticals, gut microbiota, leather tanning, corrosion protection, 3D printing, bio-based foams
MeSH terms
Phenols, Plant Extracts, Tannins, Dietary Supplements, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review