The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Postbiotics and paraprobiotics: From concepts to applications
Abstract
In recent years, new probiotic-related concepts such as postbiotics and paraprobiotics have been used to describe non-viable microorganisms or bacterial-free extracts that may provide benefits to the host by offering bioactivities additional to probiotics. However, several aspects related to these postbiotics and paraprobiotics bioactivities remain unexplored or are poorly understood. Therefore, the aim of this work is to provide an overview of the general aspects and emerging trends of postbiotics and paraprobiotics, such as conceptualization of terms, production, characterization, bioactivities, health-promoting effects, bioengineering approaches, and applications. In vitro and in vivo studies have demonstrated that some postbiotics and paraprobiotics exhibit bioactivities such as anti-inflammatory, immunomodulatory, anti-proliferative, antioxidant, and antimicrobial. These bioactivities could be involved in health-promoting effects observed in human and clinical trials, but despite the scientific evidence available, the mechanisms of action and the signaling pathways involved have not been fully elucidated. Nevertheless, paraprobiotics and postbiotics possess valuable potential for the development of biotechnological products with functional ingredients for the nutraceutical industry.
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“A safer and more practical approach would be to use inactivated microbial cells, cell fractions, or soluble products and metabolites of probiotics, known as postbiotics [12–14].”
From Coaggregation of oral pathogens by postbiotic lactobacilli (2025) · cites this paper as [14]
Citations
Cites
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592
Probiotics, gut microbiota, and their influence on host health and disease
Sánchez, B., Delgado, S., Blanco‐Míguez, A., Lourenço, A., Gueimonde, M., & Margolles, A. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600240 · Cited by 1,104
Postbiotics: An Evolving Term within the Functional Foods Field
Aguilar-Toalá, J. E., Garcia-Varela, R., Garcia, H. S., Mata-Haro, V., González-Córdova, A. F., Vallejo-Cordoba, B., & Hernández-Mendoza, A. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.03.009 · Cited by 1,078
Self-citationThe Prolongation of Life: Optimistic Studies
Metchnikoff, É. (2003) · Cited by 874
Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities
Amaretti, A., Nunzio, M. D., Pompei, A., Raimondi, S., Rossi, M., & Bordoni, A. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4241-7 · Cited by 532
de Almada, C. N., de Almada, C. N., Martinez, R. C. R., & Sant’Ana, A. S. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.09.011 · Cited by 425
Paraprobiotics and postbiotics: Concepts and potential applications in dairy products
Barros, C. P., Guimarães, J. T., Esmerino, E. A., Duarte, M. C. K., Silva, M. C., Silva, R., Ferreira, B. M., Sant’Ana, A. S., Freitas, M. Q., & Cruz, A. G. (2020) · Current Opinion in Food Science · doi:10.1016/j.cofs.2019.12.003 · Cited by 345
Tiptiri-Kourpeti, A., Spyridopoulou, K., Santarmaki, V., Aindelis, G., Tompoulidou, E., Lamprianidou, E., Saxami, G., Ypsilantis, P., Lampri, E. S., Simopoulos, C. E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147960 · Cited by 327
Gao, J., Li, Y., Wan, Y., Hu, T., Liu, L., Yang, S., Gong, Z., Zeng, Q., Wei, Y., Yang, W., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00477 · Cited by 311
Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood
Penders, J., Gerhold, K., Stobberingh, E. E., Thijs, C. T., Zimmermann, K., Lau, S., & Hamelmann, E. H. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.05.043 · Cited by 304
Research works printed but not linked: 1
- Ray, 2010, Cell wall lysed probiotic tincture decreases immune response to pathogenic enteric bacteria and improves symptoms in autistic and immune compromised children, Explore, 19, 1
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Sorted by citations
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Esfehani, R. J., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 586
Teame, T., Wang, A., Xie, M., Zhang, Z., Yang, Y., Ding, Q., Gao, C., Olsen, R. E., Ran, C., & Zhou, Z. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.570344 · Cited by 428
Postbiotics: Current Trends in Food and Pharmaceutical Industry
Thorakkattu, P., Khanashyam, A. C., Shah, K., Babu, K. S., Mundanat, A. S., Deliephan, A., Deokar, G. S., Santivarangkna, C., & Nirmal, N. P. (2022) · Foods · doi:10.3390/foods11193094 · Cited by 438
Postbiotics produced by lactic acid bacteria: The next frontier in food safety
Moradi, M., Kousheh, S. A., Almasi, H., Alizadeh, A., Guimarães, J. T., YILMAZ, N., & Javid, A. L. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12613 · Cited by 398
Paraprobiotics: A New Perspective for Functional Foods and Nutraceuticals
Siciliano, R. A., Reale, A., Mazzeo, M. F., Morandi, S., Silvetti, T., & Brasca, M. (2021) · Nutrients · doi:10.3390/nu13041225 · Cited by 270
Metadata
- Authors
- Cuevas-González, P. F., Liceaga, A. M., & Aguilar-Toalá, J. E.
- Affiliations
- Universidad Tecnologica de Tijuana (MX)
- Purdue University West Lafayette (US)
- Corresponding author
- Liceaga, A.M.
- Aguilar-Toalá, J.E.
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 136
- Pages
- 109502
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W3038698648
- Cited by
- 431
- References
- 109
- Citations by year
- 2026: 70 · 2025: 90 · 2024: 84 · 2023: 73 · 2022: 54 · 2021: 53 · 2020: 6
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- postbiotics, paraprobiotics, bacterial extracts, bioactive compounds, anti-inflammatory activity, immunomodulation, antioxidant activity, antimicrobial activity, health-promoting properties, nutraceuticals, functional food ingredients
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Humans, Dietary Supplements, Probiotics
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