Paraprobiotics and postbiotics: Concepts and potential applications in dairy products

Barros, Cássia P; Guimarães, Jonas T; Esmerino, Erick A; Duarte, Maria Carmela KH; Silva, Márcia C; Silva, Ramon; Ferreira, Beatriz M; Sant’Ana, Anderson S; Freitas, Monica Q; Cruz, Adriano G

doi:10.1016/j.cofs.2019.12.003

Cited by 345Probiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyProtein Hydrolysis and Bioactive Peptides

Paraprobiotics and postbiotics: Concepts and potential applications in dairy products

Barros, Cássia P, Guimarães, Jonas T, Esmerino, Erick A, Duarte, Maria Carmela KH, Silva, Márcia C, Silva, Ramon, Ferreira, Beatriz M, Sant’Ana, Anderson S +2 more·2020·Current Opinion in Food Science

DOI 10.1016/j.cofs.2019.12.003

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Probiotics can increase the availability of nutrients and produce bioactive soluble factors (postbiotics) beneficial to the host.
“Probiotics can increase the availability of nutrients and produce bioactive soluble factors (byproducts of metabolism) that are beneficial to the host and are referred to as postbiotics [240].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [240]

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Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
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Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works
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Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287 · see citing works
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de Vrese, M., & Schrezenmeir, J. (2008) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2008_097 · Cited by 1,033 · see citing works
Benefaction of probiotics for human health: A review
George Kerry, R., Patra, J. K., Gouda, S., Park, Y., Shin, H.-S., & Das, G. (2018) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.01.002 · Cited by 898 · see citing works
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Taverniti, V., & Guglielmetti, S. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0218-x · Cited by 703 · see citing works
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And, H. C., & Hoover, D. G. (2003) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2003.tb00016.x · Cited by 550 · see citing works
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Quirós, A., Ramos, M., Muguerza, B., Delgado, M. A., Miguel, M., Aleixandre, A., & Recio, I. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2005.12.011 · Cited by 279 · see citing works
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Shao, L., Wu, Z., Zhang, H., Chen, W., Ai, L., & Guo, B. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.02.037 · Cited by 140 · see citing works
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Dash, G., Raman, R. P., Prasad, K. P., Makesh, M., Pradeep, M. A., & Sen, S. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.12.007 · Cited by 118 · see citing works
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Sawada, D., Sugawara, T., Ishida, Y., Aihara, K., Aoki, Y., Takehara, I., Takano, K., & Fujiwara, S. (2015) · Food Research International · doi:10.1016/j.foodres.2015.11.032 · Cited by 104 · see citing works
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Miguel, M., Recio, I., Ramos, M., Delgado, M. A., & Aleixandre, M. A. (2006) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(06)72372-4 · Cited by 96 · see citing works
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Sanz, Y. (2007) · International Dairy Journal · doi:10.1016/j.idairyj.2007.01.016 · Cited by 94 · see citing works
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Nakamura, F., Ishida, Y., Sawada, D., Ashida, N., Sugawara, T., Sakai, M., Goto, T., Kawada, T., & Fujiwara, S. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b05827 · Cited by 91 · see citing works
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Rajoka, M. S. R., Zhao, H., Mehwish, H. M., Li, N., Lu, Y. P., Lian, Z., Shao, D., Jin, M., Li, Q., Zhao, L., et al. (2019) · Food Research International · doi:10.1016/j.foodres.2019.05.002 · Cited by 84 · see citing works
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Salar-Behzadi, S., Wu, S. Q., Toegel, S., et al. (2013) · Food Research International · doi:10.1016/j.foodres.2013.05.024 · Cited by 66 · see citing works
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Domingo, J. J. S. (2017) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2016.12.001 · Cited by 59 · see citing works
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Rodrigues, V. C. D. C., da Silva, L. G. S., Simabuco, F. M., Venema, K., & Antunes, A. E. C. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.01.046 · Cited by 57 · see citing works
Effectiveness and Safety of Lactobacillus LB in the Treatment of Mild Acute Diarrhea in Children
Salazar‐Lindo, E., Figueroa‐Quintanilla, D., Caciano, M. I., et al. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3180375594 · Cited by 55 · see citing works
Probiotical Cell Fragments (PCFs) as “Novel Nutraceutical Ingredients”
Shigwedha, N., Sichel, L. S., Jia, L., & Zhang, L. (2014) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2014.23007 · Cited by 55 · see citing works
Potential anticancer effects of cell wall protein fractions from Lactobacillus paracasei on human intestinal Caco‐2 cell line
Nozari, S., Faridvand, Y., Etesami, S. A., Beiki, M. A. K., Mazrakhondi, S. A. M., & Abdolalizadeh, J. (2019) · Letters in Applied Microbiology · doi:10.1111/lam.13198 · Cited by 51 · see citing works
The enumeration of probiotic issues: From unavailable standardised culture media to a recommended procedure?
Vinderola, G., Reinheimer, J. A., & Salminen, S. (2019) · International Dairy Journal · doi:10.1016/j.idairyj.2019.04.010 · Cited by 48 · see citing works
Whether viable and dead probiotic are equally efficacious?
Sarkar, S. (2018) · Nutrition & Food Science · doi:10.1108/nfs-07-2017-0151 · Cited by 38 · see citing works
Evaluation of Commercial Probiotic Products
Macedo, F., & Fredua‐Agyeman, M. (2016) · British Journal of Pharmacy · doi:10.5920/bjpharm.2016.11 · Cited by 18 · see citing works
Market Assessment and Product Evaluation of Probiotic Containing Dietary Supplements Available in Bangladesh Market
Begum, A. A., Jakaria, D. M., Anisuzzaman, S. M., et al. (2015) · Journal of Pharmaceutics · doi:10.1155/2015/763796 · Cited by 17 · see citing works
Microbiological Considerations for Probiotic Supplemented Foods
Quality Assurance, M. D. L., & Sarkar, S. (2013) · International Journal of Microbiology & Advanced Immunology · doi:10.19070/2329-9967-130001 · Cited by 8 · see citing works

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Authors: Barros, C. P., Guimarães, J. T., Esmerino, E. A., Duarte, M. C. K., Silva, M. C., Silva, R., Ferreira, B. M., Sant’Ana, A. S., Freitas, M. Q., & Cruz, A. G.
Affiliations: Universidade Federal Fluminense (BR)
Universidade Estadual de Campinas (UNICAMP) (BR)
Instituto Federal do Rio de Janeiro (BR)
Corresponding author: Guimarães, Jonas T
ORCID: Barros, Cássia P
Guimarães, Jonas T
Esmerino, Erick A
Silva, Márcia C
Silva, Ramon
Ferreira, Beatriz M
Sant’Ana, Anderson S
Cruz, Adriano G
Venue: Current Opinion in Food Science
Publisher: Elsevier BV
Published: 2020-04
Volume: 32
Pages: 1-8
ISSN: 2214-7993 (ISSN-L)
DOI: 10.1016/j.cofs.2019.12.003
OpenAlex: W2995522736
Cited by: 345
References: 47
Citations by year: 2026: 47 · 2025: 69 · 2024: 61 · 2023: 55 · 2022: 43 · 2021: 39 · 2020: 29 · 2018: 2
FWCI: 2.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Food Science (publishedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico (302763/2014-7, 305804/2017-0)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.339713/2019-00)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
Keywords: paraprobiotics, postbiotics, psychobiotics, dairy products, functional foods, microbial metabolites, health-promoting foods, probiotics

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Paraprobiotics and postbiotics: Concepts and potential applications in dairy products

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