Postbiotics: An Evolving Term within the Functional Foods Field

Aguilar-Toalá, J.E.; Garcia-Varela, R.; Garcia, H.S.; Mata-Haro, V.; González-Córdova, A.F.; Vallejo-Cordoba, B.; Hernández-Mendoza, A.

doi:10.1016/j.tifs.2018.03.009

Cited by 1,078Probiotics and Fermented FoodsProtein Hydrolysis and Bioactive PeptidesMicrobial Metabolites in Food Biotechnology

Postbiotics: An Evolving Term within the Functional Foods Field

Aguilar-Toalá, J.E., Garcia-Varela, R., Garcia, H.S., Mata-Haro, V., González-Córdova, A.F., Vallejo-Cordoba, B., Hernández-Mendoza, A.·2018·Trends in Food Science & Technology

DOI 10.1016/j.tifs.2018.03.009

Open this paper in CoChat — free account

Abstract

It has been recognized that a number of mechanisms mediating the health benefits of beneficial bacterial cells do require viability. However, new terms such as paraprobiotic or postbiotic have emerged to denote that non-viable microbial cells, microbial fractions, or cell lysates might also offer physiological benefits to the host by providing additional bioactivity.This review provides an overview of the postbiotic concept, evidence of their health benefits and possible signaling pathways involved in their protective effects, as well as perspectives for applications in foods and pharmaceuticals.Postbiotics refers to soluble factors (products or metabolic byproducts), secreted by live bacteria, or released after bacterial lysis, such as enzymes, peptides, teichoic acids, peptidoglycan-derived muropeptides, polysaccharides, cell surface proteins, and organic acids. These postbiotics have drawn attention because of their clear chemical structure, safety dose parameters, long shelf life and the content of various signaling molecules which may have anti-inflammatory, immunomodulatory, anti-obesogenic, antihypertensive, hypocholesterolemic, anti-proliferative, and antioxidant activities. These properties suggest that postbiotics may contribute, to the improvement of host health by improving specific physiological functions, even though the exact mechanisms have not been entirely elucidated.

Integrity signals

Registry

Crossref · 10.1016/j.tifs.2018.03.009

Cites

129 of 129 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Postbiotics are metabolic byproducts released by living bacteria or by bacterial lysis that can have beneficial effects on the host.
“Postbiotics are metabolic byproducts released by living bacteria or by bacterial lysis that can have beneficial effects on the host [6].”
From Analysis of Chemical Structure and Antibiofilm Properties of Exopolysaccharides from Lactiplantibacillus plantarum EIR/IF-1 Postbiotics (2022) · cites this paper as [6]

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048 · see citing works
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Bacterial competition: surviving and thriving in the microbial jungle
Hibbing, M. E., Fuqua, C., Parsek, M. R., & Peterson, S. B. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2259 · Cited by 2,658 · see citing works
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298 · see citing works
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
Kimura, I., Ozawa, K., Inoue, D., Imamura, T., Kimura, K., Maeda, T., Terasawa, K., Kashihara, D., Hirano, K., Tani, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2852 · Cited by 1,512 · see citing works
Probiotic Mechanisms of Action
Bermúdez-Brito, M., Plaza‐Díaz, J., Muñoz‐Quezada, S., Gómez‐Llorente, C., & Gil, Á. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000342079 · Cited by 1,276 · see citing works
Risk and safety of probiotics
Doron, S., & Snydman, D. R. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ085 · Cited by 942 · see citing works
The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept)
Taverniti, V., & Guglielmetti, S. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0218-x · Cited by 703 · see citing works
Bacteriocins and their food applications
And, H. C., & Hoover, D. G. (2003) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2003.tb00016.x · Cited by 550 · see citing works
Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities
Amaretti, A., Nunzio, M. D., Pompei, A., Raimondi, S., Rossi, M., & Bordoni, A. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4241-7 · Cited by 532 · see citing works
Two antioxidative lactobacilli strains as promising probiotics
Kullisaar, T., Zilmer, M., Mikelsaar, M., Vihalemm, T., Annuk, H., Kairane, Č., & Kilk, A. (2002) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(01)00674-2 · Cited by 525 · see citing works
Probiotics
Williams, N. T. (2010) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp090168 · Cited by 522 · see citing works
Antioxidant activity of Lactobacillus plantarum strains isolated from traditional Chinese fermented foods
Li, S., Zhao, Y., Zhang, L., Zhang, X., Huang, L., Li, D., Niu, C., Yang, Z., & Wang, Q. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.06.048 · Cited by 450 · see citing works
Paraprobiotics: Evidences on their ability to modify biological responses, inactivation methods and perspectives on their application in foods
de Almada, C. N., de Almada, C. N., Martinez, R. C. R., & Sant’Ana, A. S. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.09.011 · Cited by 425 · see citing works
Spray drying of probiotics and other food-grade bacteria: A review
Huang, S., Vignolles, M.-L., Chen, X. D., Loir, Y. L., Jan, G., Schuck, P., & Jeantet, R. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.02.007 · Cited by 402 · see citing works
Postbiotics: what else?
Tsilingiri, K., & Rescigno, M. (2012) · Beneficial Microbes · doi:10.3920/bm2012.0046 · Cited by 396 · see citing works
Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters
Netzker, T., Fischer, J., Weber, J., Mattern, D. J., König, C. C., Valiante, V., Schroeckh, V., & Brakhage, A. A. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00299 · Cited by 393 · see citing works
Antioxidative Effect of Intestinal Bacteria Bifidobacterium longum ATCC 15708 and Lactobacillus acidophilus ATCC 4356
Lin, M., & Chang, F.-J. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005577330695 · Cited by 384 · see citing works
Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model
Tsilingiri, K., Barbosa, T., Penna, G., Caprioli, F., Sonzogni, A., Viale, G., & Rescigno, M. (2012) · Gut · doi:10.1136/gutjnl-2011-300971 · Cited by 364 · see citing works
Lipoteichoic Acids from Lactobacillus Strains Elicit Strong Tumor Necrosis Factor Alpha-Inducing Activities in Macrophages through Toll-Like Receptor 2
Matsuguchi, T., Takagi, A., Matsuzaki, T., Nagaoka, M., Ishikawa, K., Yokokura, T., & Yoshikai, Y. (2003) · Clinical Diagnostic Laboratory Immunology · doi:10.1128/cdli.10.2.259-266.2003 · Cited by 328 · see citing works
Lactobacillus casei Exerts Anti-Proliferative Effects Accompanied by Apoptotic Cell Death and Up-Regulation of TRAIL in Colon Carcinoma Cells
Tiptiri-Kourpeti, A., Spyridopoulou, K., Santarmaki, V., Aindelis, G., Tompoulidou, E., Lamprianidou, E., Saxami, G., Ypsilantis, P., Lampri, E. S., Simopoulos, C. E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147960 · Cited by 320 · see citing works
Antioxidant activities of different fractions of polysaccharide conjugates from green tea (Camellia Sinensis)
Chen, H., Zhang, M., Qu, Z., & Xie, B. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.06.040 · Cited by 314 · see citing works
Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro
Choi, S. S., Kim, Y., Han, K. S., You, S., Oh, S., & Kim, S. H. (2006) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.01913.x · Cited by 292 · see citing works
Addressing the Antibiotic Resistance Problem with Probiotics: Reducing the Risk of Its Double-Edged Sword Effect
Imperial, I. C. V. J., & Ibana, J. A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01983 · Cited by 284 · see citing works
Probiotics: definition, scope and mechanisms of action
Reid, G. (2015) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2015.12.001 · Cited by 273 · see citing works
Comparison of the Immunomodulatory Properties of Three Probiotic Strains of Lactobacilli Using Complex Culture Systems: Prediction for In Vivo Efficacy
Mileti, E., Matteoli, G., Iliev, I. D., & Rescigno, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007056 · Cited by 272 · see citing works
Structural elucidation and antioxidant activities of exopolysaccharides from Lactobacillus helveticus MB2-1
Li, W., Ji, J., Chen, X., Jiang, M., Rui, X., & Dong, M. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.11.053 · Cited by 271 · see citing works
Effect of Antibiotic Treatment on the Intestinal Metabolome
Antunes, L. C. M., Han, J., Ferreira, R. B. R., Lolić, P., Borchers, C. H., & Finlay, B. B. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01664-10 · Cited by 271 · see citing works
Probiotics, Prebiotics, and Synbiotics: Gut and Beyond
Vyas, U., & Ranganathan, N. (2012) · Gastroenterology Research and Practice · doi:10.1155/2012/872716 · Cited by 258 · see citing works
Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4
Cavallari, J. F., Fullerton, M. D., Duggan, B. M., Foley, K. P., Denou, E., Smith, B. K., Desjardins, E. M., Henriksbo, B. D., Kim, K. J., Tuinema, B. R., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.021 · Cited by 231 · see citing works
Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides
Liu, C., Tseng, K., Chiang, S., Lee, B., Hsu, W., & Pan, T. (2011) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.4456 · Cited by 230 · see citing works
Quantification of Uronic Acids in Tea Polysaccharide Conjugates and Their Antioxidant Properties
Chen, H., Zhang, M., & Xie, B. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0349679 · Cited by 229 · see citing works
Immunomodulatory and antitumor effects in vivo by the cytoplasmic fraction of Lactobacillus casei and Bifidobacterium longum
Lee, J. W., Shin, J. G., Kim, E. H., Kang, H. E., Yim, I. B., Kim, J. Y., Joo, H. G., & Woo, H. J. (2004) · Journal of Veterinary Science · doi:10.4142/jvs.2004.5.1.41 · Cited by 218 · see citing works
Therapeutic Use of Prebiotics, Probiotics, and Postbiotics to Prevent Necrotizing Enterocolitis
Patel, R. M., & Denning, P. W. (2013) · Clinics in Perinatology · doi:10.1016/j.clp.2012.12.002 · Cited by 218 · see citing works
Metabiotics: novel idea or natural development of probiotic conception
Ba, S. (2013) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v24i0.20399 · Cited by 212 · see citing works
Antioxidant Activity of an Exopolysaccharide Purified from Lactococcus lactis subsp. lactis 12
Pan, D., & Mei, X. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.01.005 · Cited by 211 · see citing works
Biopolymers from Lactic Acid Bacteria. Novel Applications in Foods and Beverages
Torino, M. I., Font de Valdez, G., & Mozzi, F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00834 · Cited by 201 · see citing works
The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs
Güngör, N. D., & Yürüdü, N. Ö. Ş. (2015) · Cited by 199 · see citing works
Cell-Free Supernatants from Probiotic Lactobacillus casei and Lactobacillus rhamnosus GG Decrease Colon Cancer Cell Invasion In Vitro
Escamilla, J., Lane, M. A., & Maitin, V. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.700758 · Cited by 191 · see citing works
The effect of probiotics on immune regulation, acne, and photoaging
Kober, M.-M., & Bowe, W. P. (2015) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2015.02.001 · Cited by 190 · see citing works
Metabiotics: One Step ahead of Probiotics; an Insight into Mechanisms Involved in Anticancerous Effect in Colorectal Cancer
Sharma, M., & Shukla, G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01940 · Cited by 187 · see citing works
Comparative proteomic analysis of Lactobacillus plantarumfor the identification of key proteins in bile tolerance
Hamon, E., Horvatovich, P. L., Izquierdo, E., Bringel, F., Marchioni, E., Werner, D., & Ennahar, S. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-63 · Cited by 174 · see citing works
Inhibitory activity of postbiotic produced by strains of Lactobacillus plantarum using reconstituted media supplemented with inulin
Kareem, K. Y., Foo, H. L., Loh, T. C., Ooi, M. F., & Samsudin, A. A. (2014) · Gut Pathogens · doi:10.1186/1757-4749-6-23 · Cited by 171 · see citing works
Postbiotic Activities of Lactobacilli-derived Factors
Cicenia, A., Scirocco, A., Carabotti, M., Pallotta, L., Marignani, M., & Severi, C. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000231 · Cited by 165 · see citing works
Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 byLactococcus lactisReverses Diabetes in Recent-Onset NOD Mice
Robert, S., Gysemans, C. A., Takiishi, T., Korf, H., Spagnuolo, I., Sebastiani, G., Huynegem, K. V., Steidler, L., Caluwaerts, S., Demetter, P., et al. (2014) · Diabetes · doi:10.2337/db13-1236 · Cited by 161 · see citing works
Relationship Between Oxygen Sensitivity and Oxygen Metabolism of Bifidobacterium Species
Shimamura, S., Abe, F., Ishibashi, N., Miyakawa, H., Yaeshima, T., Araya-Kojima, T., & TOMITA, M. (1992) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(92)78105-3 · Cited by 161 · see citing works
Effects of dietary postbiotic and inulin on growth performance, IGF1 and GHR mRNA expression, faecal microbiota and volatile fatty acids in broilers
Kareem, K. Y., Loh, T. C., Foo, H. L., Akit, H., & Samsudin, A. A. (2016) · BMC Veterinary Research · doi:10.1186/s12917-016-0790-9 · Cited by 157 · see citing works
Functional genomic analyses of the gut microbiota for CRC screening
Konstantinov, S. R., Kuipers, E. J., & Peppelenbosch, M. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.178 · Cited by 145 · see citing works
GanedenBC30™ cell wall and metabolites: anti-inflammatory and immune modulating effects in vitro
Jensen, G. S., Benson, K. F., Carter, S. G., & Endres, J. R. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-15 · Cited by 137 · see citing works
Antihypertensive Effects of Probiotics
Robles‐Vera, I., Toral, M., Romero, M., Jiménez, R., Sánchez, M., Pérez‐Vizcaíno, F., & Duarte, J. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0723-4 · Cited by 137 · see citing works
Proinflammatory Cytokine and Nitric Oxide Induction in Murine Macrophages by Cell Wall and Cytoplasmic Extracts of Lactic Acid Bacteria
Tejada-Simon, M. V., & Pestka, J. J. (1999) · Journal of Food Protection · doi:10.4315/0362-028x-62.12.1435 · Cited by 134 · see citing works
Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome
Compare, D., Rocco, A., Coccoli, P., Angrisani, D., Sgamato, C., Iovine, B., Salvatore, U., & Nardone, G. (2017) · BMC Gastroenterology · doi:10.1186/s12876-017-0605-x · Cited by 133 · see citing works
In vitro and in vivo antioxidant activity of exopolysaccharide fractions from Bifidobacterium animalis RH
Xu, R., Shang, N., & Li, P. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.07.010 · Cited by 127 · see citing works
Lipoteichoic Acids fromLactobacillus johnsoniiStrain La1 andLactobacillus acidophilusStrain La10 Antagonize the Responsiveness of Human Intestinal Epithelial HT29 Cells to Lipopolysaccharide and Gram-Negative Bacteria
Vidal, K., Donnet‐Hughes, A., & Granato, D. (2002) · Infection and Immunity · doi:10.1128/iai.70.4.2057-2064.2002 · Cited by 125 · see citing works
New insights into therapeutic strategies for gut microbiota modulation in inflammatory diseases
Vieira, A. T., Fukumori, C., & Ferreira, C. M. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.38 · Cited by 124 · see citing works
Designer probiotics for the prevention and treatment of human diseases
Chua, K. J., Kwok, W. C., Aggarwal, N., Sun, T., & Chang, M. W. (2017) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.04.011 · Cited by 123 · see citing works
Antioxidative activity of lactic acid bacteria in yogurt
Zhang, S. (2011) · African Journal of Microbiology Research · doi:10.5897/ajmr11.997 · Cited by 122 · see citing works
Hypocholesterolemic effect of sonication-killed Bifidobacterium longum isolated from healthy adult Koreans in high cholesterol fed rats
Shin, H. S., Park, S.-Y., Lee, D. K., Kim, S. A., An, H. M., Kim, J. R., Kim, M. J., Gyeong, M., Lee, S. W., Kim, K., et al. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-0917-7 · Cited by 116 · see citing works
Bioactives from probiotics for dermal health: functions and benefits
Lew, L.-C., & Liong, M.-T. (2013) · Journal of Applied Microbiology · doi:10.1111/jam.12137 · Cited by 115 · see citing works
Effects of feeding different postbiotic metabolite combinations produced by Lactobacillus plantarum strains on egg quality and production performance, faecal parameters and plasma cholesterol in laying hens
Loh, T. C., Choe, D. W., Foo, H. L., Sazili, A. Q., & Bejo, M. H. (2014) · BMC Veterinary Research · doi:10.1186/1746-6148-10-149 · Cited by 111 · see citing works
Assessment of commercial probiotic bacterial contents and label accuracy.
Weese, J. S., & Martin, H. (2011) · PubMed Central · Cited by 107 · see citing works
Anti-inflammatory potential of probiotics: lipoteichoic acid makes a difference
Lebeer, S., Claes, I. J. J., & Vanderleyden, J. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.09.004 · Cited by 106 · see citing works
Proteomic Profiling of the Acid Stress Response in Lactobacillus plantarum 423
Heunis, T. D. J., Deane, S. M., Smit, S., & Dicks, L. M. T. (2014) · Journal of Proteome Research · doi:10.1021/pr500353x · Cited by 105 · see citing works
Lactobacillus plantarum lipoteichoic acid down-regulated Shigella flexneri peptidoglycan-induced inflammation
Kim, H. G., Lee, S. Y., Kim, N. R., Lee, H. Y., Ko, M. Y., Jung, B. J., Kim, C. M., Lee, J. M., Park, J. H., Han, S. H., et al. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.07.011 · Cited by 103 · see citing works
Isolation and characterization of a proteinaceous antifungal compound from Lactobacillus plantarum YML007 and its application as a food preservative
Rather, I. A., Seo, B. J., Rejish Kumar, V. J., Choi, U.-H., Choi, K.-H., Lim, J., & Park, Y.-H. (2013) · Letters in Applied Microbiology · doi:10.1111/lam.12077 · Cited by 103 · see citing works
Rational identification of diet-derived postbiotics for improving intestinal microbiota function
Klemashevich, C. L., Wu, C., Howsmon, D. P., Alaniz, R. C., Lee, K., & Jayaraman, A. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.10.006 · Cited by 101 · see citing works
Effects of liquid metabolite combinations produced by Lactobacillus plantarum on growth performance, faeces characteristics, intestinal morphology and diarrhoea incidence in postweaning piglets
Thu, T. V., Loh, T. C., Foo, H. L., et al. (2010) · Tropical Animal Health and Production · doi:10.1007/s11250-010-9655-6 · Cited by 98 · see citing works
Designer Probiotics: Paving the Way to Living Therapeutics
Singh, B., Mal, G., & Marotta, F. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.04.001 · Cited by 98 · see citing works
Egg production, faecal pH and microbial population, small intestine morphology, and plasma and yolk cholesterol in laying hens given liquid metabolites produced by Lactobacillus plantarum strains
Choe, D. W., Loh, T. C., Foo, H. L., Bejo, M. H., & Sazili, A. Q. (2012) · British Poultry Science · doi:10.1080/00071668.2012.659653 · Cited by 97 · see citing works
Modulation of Bax/Bcl-2 and caspases by probiotics during acetaminophen induced apoptosis in primary hepatocytes
Sharma, S., Singh, R. L., & Kakkar, P. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.11.041 · Cited by 94 · see citing works
Fragmented Lactic Acid Bacterial Cells Activate Peroxisome Proliferator-Activated Receptors and Ameliorate Dyslipidemia in Obese Mice
Nakamura, F., Ishida, Y., Sawada, D., Ashida, N., Sugawara, T., Sakai, M., Goto, T., Kawada, T., & Fujiwara, S. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b05827 · Cited by 91 · see citing works
Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment of Acetaminophen Hepatotoxicity
Dinić, M., Lukić, J., Đokić, J., Milenković, M., Strahinić, I., Golić, N., & Begović, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00594 · Cited by 91 · see citing works
Identification of Bacilysin, Chlorotetaine, and Iturin A Produced by Bacillus sp. Strain CS93 Isolated from Pozol, a Mexican Fermented Maize Dough
Phister, T. G., O’Sullivan, D. J., & McKay, L. L. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.1.631-634.2004 · Cited by 90 · see citing works
Improvements in Gastrointestinal Symptoms among Children with Autism Spectrum Disorder Receiving the Delpro� Probiotic and Immunomodulator Formulation
Sichel, J. P. (2013) · Journal of Probiotics & Health · doi:10.4172/2329-8901.1000102 · Cited by 89 · see citing works
Selection of lactic acid bacteria with high phytate degrading activity for application in whole wheat breadmaking
Palacios, M. C., Haros, C. M., Sanz, Y., & Rosell, C. M. (2007) · LWT · doi:10.1016/j.lwt.2007.02.005 · Cited by 81 · see citing works
Influence of postbiotic RG14 and inulin combination on cecal microbiota, organic acid concentration, and cytokine expression in broiler chickens
Kareem, K. Y., Loh, T. C., Foo, H. L., Samsudin, A. A., & Akit, H. (2016) · Poultry Science · doi:10.3382/ps/pew362 · Cited by 80 · see citing works
Glutathione Protects Lactobacillus sanfranciscensis against Freeze-Thawing, Freeze-Drying, and Cold Treatment
Zhang, J., Du, G., Zhang, Y., et al. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00026-09 · Cited by 79 · see citing works
Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide
Yang, G., Jiang, Y., Yang, W., Du, F., Yao, Y., Shi, C., & Wang, C. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0394-2 · Cited by 77 · see citing works
How Do We Know When Something Called "Probiotic" Is Really a Probiotic? A Guideline for Consumers and Health Care Professionals
Sanders, M. E. (2009) · Cited by 76 · see citing works
Bacterial Peptidoglycan Stimulates Adipocyte Lipolysis via NOD1
Chi, W., Dao, D., Lau, T. C., Henriksbo, B. D., Cavallari, J. F., Foley, K. P., & Schertzer, J. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097675 · Cited by 75 · see citing works
Antioxidative Activity of Lactobacilli Measured by Oxygen Radical Absorbance Capacity
Saide, J. A. O., & Gilliland, S. E. (2005) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(05)72801-0 · Cited by 75 · see citing works
Lactobacillus gasseri SBT2055 reduces postprandial and fasting serum non-esterified fatty acid levels in Japanese hypertriacylglycerolemic subjects
Ogawa, A., Kadooka, Y., Kato, K., Shirouchi, B., & Sato, M. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-36 · Cited by 72 · see citing works
Postbiotic Modulation of Retinoic Acid Imprinted Mucosal-like Dendritic Cells by Probiotic Lactobacillus reuteri 17938 In Vitro
Haileselassie, Y., Navis, M., Vu, N., Qazi, K. R., Réthi, B., & Sverremark‐Ekström, E. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00096 · Cited by 72 · see citing works
Protective Role of Postbiotic Mediators Secreted by Lactobacillus rhamnosus GG Versus Lipopolysaccharide-induced Damage in Human Colonic Smooth Muscle Cells
Cicenia, A., Santangelo, F., Gambardella, L., Pallotta, L., Iebba, V., Scirocco, A., Marignani, M., Tellan, G., Carabotti, M., Corazziari, E. S., et al. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000681 · Cited by 70 · see citing works
Bioengineered probiotics, a strategic approach to control enteric infections
Amalaradjou, M. A. R., & Bhunia, A. K. (2013) · Bioengineered · doi:10.4161/bioe.23574 · Cited by 69 · see citing works
Engineered Probiotics: Applications and Biological Containment
Sola-Oladokun, B., Culligan, E. P., & Sleator, R. D. (2017) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030216-030256 · Cited by 68 · see citing works
Toward improving technological and functional properties of probiotics in foods
Sánchez, B., Ruíz, L., Gueimonde, M., Ruas‐Madiedo, P., & Margollés, A. (2012) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2012.02.002 · Cited by 67 · see citing works
Towards a bacterial treatment for armpit malodour
Callewaert, C., Lambert, J., & de Wiele, T. V. (2016) · Experimental Dermatology · doi:10.1111/exd.13259 · Cited by 64 · see citing works
Oral Administration of Recombinant Lactococcus lactis Expressing HSP65 and Tandemly Repeated P277 Reduces the Incidence of Type I Diabetes in Non-Obese Diabetic Mice
Ma, Y., Liu, J., Hou, J., Dong, Y., Lu, Y., Jin, L., Cao, R., Li, T., & Wu, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105701 · Cited by 63 · see citing works
Identification and Characterization of Lactobacillus brevis P68 with Antifungal, Antioxidant and Probiotic Functional Properties
Arasu, M. V., Al-Dhabi, N. A., Rejiniemon, T. S., Lee, K. D., Huxley, V. A. J., Kim, D., Duraipandiyan, V., Karuppiah, P., & Choi, K. C. (2014) · Indian Journal of Microbiology · doi:10.1007/s12088-014-0495-3 · Cited by 60 · see citing works
Effect of LTA isolated from bifidobacteria on d-galactose-induced aging
Yi, Z., Fu, Y., Li, M., Gao, K.-S., & Zhang, X. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.08.011 · Cited by 59 · see citing works
Recombinant Lactococcus lactis NZ9000 secretes a bioactive kisspeptin that inhibits proliferation and migration of human colon carcinoma HT-29 cells
Zhang, B., Li, A., Zuo, F., Yu, R., Zeng, Z., Ma, H., & Chen, S. (2016) · Microbial Cell Factories · doi:10.1186/s12934-016-0506-7 · Cited by 58 · see citing works
In vitro Antioxidative Properties of Lactobacilli
Kim, H. S., Chae, H. S., Jeong, S.-H., et al. (2005) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2006.262 · Cited by 56 · see citing works
Purification and Characterization of an Antihypertensive Compound fromLactohacillus casei
Sawada, H., Furushiro, M., Hirai, K., Motoike, M., Watanabe, T., & Yokokura, T. (1990) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1990.10870492 · Cited by 55 · see citing works
Probiotical Cell Fragments (PCFs) as “Novel Nutraceutical Ingredients”
Shigwedha, N., Sichel, L. S., Jia, L., & Zhang, L. (2014) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2014.23007 · Cited by 55 · see citing works
Saccharomyces boulardii Improves Intestinal Cell Restitution through Activation of the α2β1 Integrin Collagen Receptor
Canonici, A., Siret, C., Pellegrino, E., Pontier-Bres, R., Pouyet, L., Montero, M.-P., Colin, C., Czerucka, D., Rigot, V., & André, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018427 · Cited by 51 · see citing works
Bioengineered microbes in disease therapy
Paton, A. W., Morona, R., & Paton, J. C. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.05.006 · Cited by 50 · see citing works
Anionic metabolic profiling of urine from antibiotic-treated rats by capillary electrophoresis–mass spectrometry
Kok, M. G. M., Ruijken, M., Swann, J. R., Wilson, I. D., Somsen, G. W., & de Jong, G. J. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6701-4 · Cited by 42 · see citing works
Proteomics as a Quality Control Tool of Pharmaceutical Probiotic Bacterial Lysate Products
Klein, G., Schanstra, J. P., Hoffmann, J., Mischak, H., Siwy, J., & Zimmermann, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066682 · Cited by 38 · see citing works
Preclinical Testing in the Development of Probiotics: A Regulatory Perspective withBacillusStrains as an Example
Sorokulova, I. (2008) · Clinical Infectious Diseases · doi:10.1086/523334 · Cited by 38 · see citing works
Probiotics and Bioactive Carbohydrates in Colon Cancer Management
Raman, M., Ambalam, P. S., & Doble, M. (2015) · Springer eBooks · doi:10.1007/978-81-322-2586-7 · Cited by 38 · see citing works
Purification and characterization of an antihypertensive compound from Lactobacillus casei.
Sawada, H., Furushiro, M., HIRAI, K., Motoike, M., Watanabe, T., & Yokokura, T. (1990) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.54.3211 · Cited by 38 · see citing works
Intrinsic and inducible resistance to hydrogen peroxide in Bifidobacterium species
Oberg, T. S., Steele, J. L., Ingham, S. C., Smeianov, V. V., Briczinski, E. P., Abdalla, A. K., & Broadbent, J. R. (2011) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-011-0983-y · Cited by 37 · see citing works
Advances in Probiotic Technology
(2015) · CRC Press eBooks · doi:10.1201/b18807 · Cited by 36 · see citing works
Phytate-degrading activity in lactic acid bacteria.
Haros, C. M., Bielecka, M., Honke, J., et al. (2008) · Polish Journal of Food and Nutrition Sciences · Cited by 35 · see citing works
Effects of different levels of metabolite combination produced byLactobacillus plantarumon growth performance, diarrhoea, gut environment and digestibility of postweaning piglets
Loh, T. C., Thu, T. V., Foo, H. L., & Bejo, M. H. (2013) · Journal of Applied Animal Research · doi:10.1080/09712119.2012.741046 · Cited by 34 · see citing works
Inhibitory activity of metabolites produced by strains of Lactobacillus plantarum isolated from Malaysian fermented food.
Thành, N. T., Loh, T. C., Foo, H. L., et al. (2010) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · Cited by 34 · see citing works
Identification of Plasmalogens in the Cytoplasmic Membrane of Bifidobacterium animalis subsp. lactis
Oberg, T. S., Ward, R. E., Steele, J. L., & Broadbent, J. R. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06968-11 · Cited by 32 · see citing works
Amelioration of Murine Colitis by Feeding a Solution of LysedEscherichia coli
Konrad, A., Mähler, M., Flogerzi, B., Kalousek, M. B., de Lange, J. M., Varga, L., & Seibold, F. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310000663 · Cited by 30 · see citing works
Gut Microbiota
Chaluvadi, S., Hotchkiss, A. T., & Yam, K. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802189-7.00036-8 · Cited by 30 · see citing works
Quantitative Proteogenomics and the Reconstruction of the Metabolic Pathway in Lactobacillus mucosae LM1
Pajarillo, E. A. B., Kim, S. H., Lee, J.-Y., Valeriano, V. D., & Kang, D. (2015) · Korean Journal for Food Science of Animal Resources · doi:10.5851/kosfa.2015.35.5.692 · Cited by 30 · see citing works
Cytoskeleton Reorganization and Cytokine Production of Macrophages by Bifidobacterial Cells and Cell-Free Extracts
Lee, M. J., Zang, Z. L., Choi, E. Y., Shin, H. K., & Ji, G. E. (2002) · Journal of Microbiology and Biotechnology · Cited by 30 · see citing works
Antioxidative effects of intracellular extracts of yogurt bacteria on lipid peroxidation and intestine 407 cells
Ou, C., Ko, J., & Lin, M. (2020) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.2474 · Cited by 29 · see citing works
In vitroinhibition activity of different bacteriocin-producingEscherichia coliagainstSalmonellastrains isolated from clinical cases
Zihler, A., Blay, G. L., de Wouters, T., et al. (2009) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2009.02614.x · Cited by 28 · see citing works
Novel bioactive from Lactobacillus brevis DSM17250 to stimulate the growth of Staphylococcus epidermidis: a pilot study
Holz, C., Benning, J., Schaudt, M., Heilmann, A., Schultchen, J., Goelling, D., & Lang, C. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0073 · Cited by 28 · see citing works
Probiotics in personal care products
Huang, M. J., & Tang, J. (2015) · Microbiology Discovery · doi:10.7243/2052-6180-3-5 · Cited by 27 · see citing works
Occurrence of Glutathione Sulphydryl (GSH) and Antioxidant Activities in Probiotic Lactobacillus spp.
Yoon, Y. H., & Byun, J. R. (2004) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2004.1582 · Cited by 26 · see citing works
Newer Developments in HPLC Impacting Pharmaceutical Analysis : A Brief Review
Guillarme, D., & Dong, M. W. (2013) · Archive ouverte UNIGE (University of Geneva) · Cited by 24 · see citing works
Genetically ModifiedLactococcus lactisfor Delivery of Human Interleukin-10 to Dendritic Cells
Huibregtse, I. L., Zaat, S. A., Kapsenberg, M. L., da Silva, M. A. S., Peppelenbosch, M. P., van Deventer, S. J. H., & Braat, H. (2011) · Gastroenterology Research and Practice · doi:10.1155/2012/639291 · Cited by 24 · see citing works
Probiotics as prevention of radiation-induced diarrhoea
Timko, J. (2010) · Journal of Radiotherapy in Practice · doi:10.1017/s1460396910000087 · Cited by 24 · see citing works
Optimisation of medium composition for probiotic biomass production using response surface methodology
Anvari, M., Khayati, G., & Rostami, S. (2013) · Journal of Dairy Research · doi:10.1017/s0022029913000733 · Cited by 19 · see citing works
Preventive effect of an E. coli-filtrate (ColibiogenR) in polymorphous light eruption
Przybilla, B., Heppeler, M., & Ruzicka, T. (1989) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1989.tb01803.x · Cited by 19 · see citing works
Proteomic analysis of an engineered isolate of Lactobacillus plantarum with enhanced raffinose metabolic capacity
Wang, J., Hui, W., Cao, C., Jin, R., Ren, C., Zhang, H., & Zhang, W. (2016) · Scientific Reports · doi:10.1038/srep31403 · Cited by 19 · see citing works
[The chronic gastritis, the dysbacteriosis and the use of Hylak forte at the treatment].
Омаров, Т. Р., Omarova, L. A., Омарова, В. А., & Сарсенова, С. В. (2014) · PubMed · Cited by 18 · see citing works
Foreword
Venema, K. (2013) · Beneficial Microbes · doi:10.3920/bm2013.x001 · Cited by 12 · see citing works
The Potential of Probiotics and Prebiotics for Skin Health
Ouwehand, A. C., Lahtinen, S. J., & Tiihonen, K. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_77-2 · Cited by 10 · see citing works
Probiotics and Colorectal Cancer
Raman, M., Ambalam, P. S., & Doble, M. (2015) · Springer eBooks · doi:10.1007/978-81-322-2586-7_2 · Cited by 10 · see citing works
Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells
Huibregtse, I. L., Zaat, S. A. J., Kapsenberg, M. L., da Silva, M. A. S., Peppelenbosch, M. P., van Deventer, S. J. H., & Braat, H. (2012) · Leiden Repository (Leiden University) · Cited by 4 · see citing works
Pharmacy as a patient-centered practice: Reflections from center stage
Gouveia, W. A. (2009) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp090017 · Cited by 2 · see citing works

Flagged first, then by citations

Sorted by citations

The International Scientific Association of Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Postbiotics
Salminen, S., Collado, M. C., Endo, A., Hill, C., Lebeer, S., Quigley, E. M. M., Sanders, M. E., Shamir, R., Swann, J. R., Szajewska, H., et al. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00440-6 · Cited by 2,488 · see citing works
The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics
Swanson, K. S., Gibson, G. R., Hutkins, R., Reimer, R. A., Reid, G., Verbeke, K., Scott, K. P., Holscher, H. D., Azad, M. B., Delzenne, N. M., et al. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0344-2 · Cited by 2,196 · see citing works
Postbiotics-Parabiotics: The New Horizons in Microbial Biotherapy and Functional Foods
Nataraj, B. H., Ali, S. A., Behare, P. V., & Yadav, H. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-01426-w · Cited by 737 · see citing works
The effects of vegetarian and vegan diets on gut microbiota
Tomova, A., Bukovsky, I., Rembert, E., Yonas, W., Alwarith, J., Barnard, N. D., & Kahleova, H. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00047 · Cited by 713 · see citing works
Shaping the Future of Probiotics and Prebiotics
Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637 · see citing works
Postbiotics and paraprobiotics: From concepts to applications
Cuevas-González, P. F., Liceaga, A. M., & Aguilar-Toalá, J. E. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109502 · Cited by 431 · see citing works
Self-citation
Paraprobiotics and postbiotics: Concepts and potential applications in dairy products
Barros, C. P., Guimarães, J. T., Esmerino, E. A., Duarte, M. C. K., Silva, M. C., Silva, R., Ferreira, B. M., Sant’Ana, A. S., Freitas, M. Q., & Cruz, A. G. (2020) · Current Opinion in Food Science · doi:10.1016/j.cofs.2019.12.003 · Cited by 345 · see citing works
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health
De Filippis, F., Pasolli, E., & Ercolini, D. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa015 · Cited by 303 · see citing works
International Society of Sports Nutrition Position Stand: Probiotics
Jäger, R., Mohr, A. E., Carpenter, K. C., Kerksick, C. M., Purpura, M., Moussa, A., Townsend, J. R., Lamprecht, M., West, N. P., Black, K., et al. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0329-0 · Cited by 277 · see citing works
Probiotics in the dairy industry—Advances and opportunities
Gao, J., Li, X., Zhang, G., Sadiq, F. A., Simal‐Gandara, J., Xiao, J., & Sang, Y. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12755 · Cited by 195 · see citing works
Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility
Calcaterra, V., Verduci, E., Cena, H., Magenes, V. C., Todisco, C. F., Tenuta, E., Gregorio, C., De Giuseppe, R., Bosetti, A., Di Profio, E., et al. (2021) · Nutrients · doi:10.3390/nu13061848 · Cited by 183 · see citing works
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
Potential Pharmaceutical and Food Applications of Postbiotics: A Review
Rad, A. H., Abbasi, A., Kafil, H. S., & Ganbarov, K. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666200516154833 · Cited by 113 · see citing works
Biological and Cosmetical Importance of Fermented Raw Materials: An Overview
Majchrzak, W., Motyl, I., & Śmigielski, K. (2022) · doi:10.20944/preprints202207.0245.v1 · Cited by 71 · see citing works
Optimizing postbiotic production through solid-state fermentation with Bacillus amyloliquefaciens J and Lactiplantibacillus plantarum SN4 enhances antibacterial, antioxidant, and anti-inflammatory activities
Tong, Y., Guo, H., Abbas, Z., Zhang, J., Wang, J., Cheng, Q., Peng, S., Yang, T., Bai, T., Zhou, Y., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1229952 · Cited by 70 · see citing works
Investigation of antimicrobial and antioxidant properties of postbiotics produced by lactobacillus rhamnosus and limosilactobacillus reuteri and their potential application in surface decontamination of red meat
Jalali, S., Mojgani, N., Haghighat, S., Sanjabi, M. R., & Sarem-Nezhad, S. (2024) · LWT · doi:10.1016/j.lwt.2024.116758 · Cited by 59 · see citing works
Recent advances in understanding of multifaceted changes in the vaginal microenvironment: implications in vaginal health and therapeutics
Das, S., Bhattacharjee, M. J., Mukherjee, A. K., & Khan, M. R. (2023) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2049696 · Cited by 51 · see citing works
Analysis of Chemical Structure and Antibiofilm Properties of Exopolysaccharides from Lactiplantibacillus plantarum EIR/IF-1 Postbiotics
Karaca, B., Haliscelik, O., Gursoy, M., Kiran, F., Loimaranta, V., Söderling, E., & Gursoy, U. K. (2022) · Microorganisms · doi:10.3390/microorganisms10112200 · Cited by 26 · see citing works
“Postbiotics are metabolic byproducts released by living bacteria or by bacterial lysis that can have beneficial effects on the host [6].”
Background
Effects of Fermented Oils on Alpha-Biodiversity and Relative Abundance of Cheek Resident Skin Microbiota
Ciardiello, T., Pinto, D., Marotta, L., Giuliani, G., & Rinaldi, F. (2020) · Cosmetics · doi:10.3390/cosmetics7020034 · Cited by 23 · see citing works
Endocrine, Genetic, and Microbiome Nexus of Obesity and Potential Role of Postbiotics: A Narrative Review
Wu, W., Chen, Z., Han, J., Qian, L., Wang, W., Lei, J., & Wang, H. (2023) · Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity · doi:10.1007/s40519-023-01593-w · Cited by 18 · see citing works
Probiotics: mechanism of action and gastrointestinal health: gut guardians: unlocking the power of probiotics
Rana, A., & Smriti (2026) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70275 · Cited by 7 · see citing works

Immunobiological Activity of Cell Wall Antigens of Staphylococcus aureus
Kowalski, J. J., & Berman, D. T. (1971) · Infection and Immunity · doi:10.1128/iai.4.3.205-211.1971 · Cited by 27 · see citing works
Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus
Atilano, M. L., Pereira, P. M., Yates, J. R., Reed, P., Veiga, H., Pinho, M. G., & Filipe, S. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004304107 · Cited by 266 · see citing works
Production and release of peptidoglycan and wall teichoic acid polymers in pneumococci treated with beta-lactam antibiotics
Fischer, H., & Tomasz, A. (1984) · Journal of Bacteriology · doi:10.1128/jb.157.2.507-513.1984 · Cited by 52 · see citing works
Hidden Mode of Action of Glycopeptide Antibiotics: Inhibition of Wall Teichoic Acid Biosynthesis
Singh, M., Chang, J. D., Coffman, L., et al. (2017) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.7b00324 · Cited by 21 · see citing works
Determinants of Murein Hydrolase Targeting to Cross-wall of Staphylococcus aureus Peptidoglycan
Frankel, M. B., & Schneewind, O. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336404 · Cited by 89 · see citing works

Authors: Aguilar-Toalá, J. E., Garcia-Varela, R., Garcia, H. S., Mata-Haro, V., González-Córdova, A. F., Vallejo-Cordoba, B., & Hernández-Mendoza, A.
Affiliations: Centro de Investigación en Alimentación y Desarrollo (MX)
Instituto Tecnológico de Veracruz (MX)
ORCID: Aguilar-Toalá, J.E.
Garcia, H.S.
González-Córdova, A.F.
Venue: Trends in Food Science & Technology
Publisher: Elsevier BV
Published: 2018-05
Volume: 75
Pages: 105-114
ISSN: 0924-2244 (ISSN-L)
DOI: 10.1016/j.tifs.2018.03.009
OpenAlex: W2793397992
Cited by: 1,078
References: 129
Citations by year: 2026: 184 · 2025: 187 · 2024: 134 · 2023: 136 · 2022: 138 · 2021: 122 · 2020: 114 · 2019: 56 · 2018: 6
FWCI: 69.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Food Science & Technology (publishedVersion)
Funders: CONACYT (230338)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: postbiotics, paraprobiotics, bacterial cell lysate, bacterial metabolites, health benefits, anti-inflammatory activity, immunomodulation, anti-obesogenic effects, antihypertensive effect, cholesterol-lowering effect, antioxidant activity, signaling pathways, functional foods, pharmaceutical applications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Postbiotics: An Evolving Term within the Functional Foods Field

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks