The DOI matches its Crossref record; 223 of the 223 references it cites were found in a registry or an index.
Microalgae as a Sustainable Source of Edible Proteins and Bioactive Peptides—Current Trends and Future Prospects
Abstract
The global demand for protein ingredients is continuously increasing owing to the growing population, rising incomes, increased urbanization, and aging population. Conventionally, animal-derived products (dairy, egg, and meat) satisfy the major dietary protein requirements of humans. With the global population set to reach 9.6 billion by 2050, there would be a huge deficit in meeting dietary protein requirements. Therefore, it is necessary to identify sustainable alternative protein sources that could complement high-quality animal proteins. In recent years, microalgae have been advocated as a potential industrial source of edible proteins owing to their wide and excellent ecological adaptation. Microalgae can grow in marginal areas utilizing non-potable wastewaters with high photosynthetic efficiency. Previously microalgae species such as Arthospira, and Chlorella have been used as single-cell proteins (SCP) with limited application in pharmaceutical industries. In recent years, the demand for innovative and sustainable functional ingredients for food applications has renewed the interest worldwide in microalgae proteins. The present review aims to provide a holistic view of various aspects related to the production and processing of edible proteins from microalgae biomass. A critical review of available literature on the nutritional quality, techno-functional properties, applications in food and feed sectors, and biological activities is presented. Further, challenges associated with each stage of processing are discussed. From the literature review, it can be summarized that microalgae proteins are comparable to reference proteins both in terms of amino acid (AA) quality and techno-functional properties. However recalcitrant cell wall poses a challenge in digestibility and effective utilization of the microalgae proteins. Further, poor sensory scores and palatability of microalgae biomass limit its applications in the food and feed sector. Novel applications of microalgae proteins include meat analogues, emulsifying agents, and bioactive peptides. Development of low-cost cultivation strategies, wet biomass-based downstream processing along with the bio-refinery approach of complete biomass volarization would enhance the sustainability quotient for human food applications.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Microalgae are a rich source of carbohydrates, proteins, fatty acids, enzymes, and dietary fibre [75].”
From Multi-Sensing Monitoring of the Microalgae Biomass Cultivation Systems for Biofuels and Added Value Products Synthesis—Challenges and Opportunities (2025) · cites this paper as [75]
Citations
Cites
1 retracted
Items 201–223 of 223
Medina, C., Rubilar, M., Shene, C., Torres, S., & Verdugo, M. (2015) · Journal of Biobased Materials and Bioenergy · doi:10.1166/jbmb.2015.1534 · Cited by 42
Influence of a powdered Spirulina platensis biomass on acid production of lactococci in milk
Molnar, N., Gyenis, B., & Varga, L. (2005) · Milk science international/Milchwissenschaft · Cited by 38
Hlaing, S. A. A., Sadiq, M. B., & Anal, A. K. (2019) · Journal of Food Science and Technology · doi:10.1007/s13197-019-04144-3 · Cited by 37
Larrosa, A. P. Q., Comitre, A. A., Vaz, L. B., & Pinto, L. A. A. (2017) · Journal of Food Process Engineering · doi:10.1111/jfpe.12359 · Cited by 32
Microalgae Biomass as a Novel Functional Ingredient in Mixed Gel Systems
Batista, A. P., Gouveia, L., Nunes, M. C., Franco, J. M., & Raymundo, A. (2008) · Royal Society of Chemistry eBooks · doi:10.1039/9781847558312-00487 · Cited by 32
Digestibility of Schizochytrium sp. whole cell biomass by Atlantic salmon (Salmo salar)
Hart, B., Schurr, R., Narendranath, N. V., Kuehnle, A., & Colombo, S. M. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.736156 · Cited by 31
Potential Health Effects of Enzymatic Protein Hydrolysates from Chlorella vulgaris
Sedighi, M., Jalili, H., Siadat, S. O. R., & Amrane, A. (2016) · Applied food biotechnology · doi:10.22037/afb.v3i3.11306 · Cited by 29
Dietary microalgae on poultry meat and eggs: explained versus unexplained effects
Kalia, S., & Lei, X. G. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102689 · Cited by 29
Spirulina platensis meal inclusion effects on broilers fed a reduced protein diet
Mullenix, G. J., Maynard, C. J., Owens, C. M., Rochell, S. J., Bottje, W. G., Brister, R. D., & Kidd, M. T. (2021) · The Journal of Applied Poultry Research · doi:10.1016/j.japr.2021.100199 · Cited by 28
Šefcová, M. A., Santacruz, F., Larrea-Álvarez, C. M., Vinueza-Burgos, C., Ortega-Paredes, D., Molina-Cuasapaz, G., Rodríguez, J., Calero‐Cáceres, W., Révajová, V., Fernández-Moreira, E., et al. (2021) · Animals · doi:10.3390/ani11123601 · Cited by 28
Tibbetts, S. M., & Patelakis, S. J. J. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737236 · Cited by 26
Selective cytotoxicity of microcystins LR, LW and LF in rat astrocytes
Rozman, K. B., Jurič, D. M., & Šuput, D. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.11.008 · Cited by 25
Chandralekha, A., Prashanth, H. S., Tavanandi, H. A., & Raghavarao, K. S. M. S. (2020) · Journal of Food Science and Technology · doi:10.1007/s13197-020-04684-z · Cited by 24
Ko, S., Heo, S., Choi, S., Qian, Z., Heo, S., Kang, D.-H., Kim, N., & Jung, W. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1443-0 · Cited by 20
Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities
Yücetepe, A., & Özçelik, B. (2016) · DergiPark (Istanbul University) · Cited by 17
Großmann, L., Wörner, V., Hinrichs, J., & Weiß, J. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10082 · Cited by 15
The thermal stability of Quorntm pieces
Knight, N., Roberts, G., & Shelton, D. (2001) · International Journal of Food Science & Technology · doi:10.1046/j.1365-2621.2001.00424.x · Cited by 15
Microbial ribonucleases (RNases): production and application potential
Hameş, E. E., & Demir, T. (2015) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-015-1945-8 · Cited by 11
Zhang, D., Liu, S., Zhang, J., Zhang, J. K., Hu, C., & Liu, Y. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.06.024 · Cited by 10
Yu, Z., Liu, L., Chen, J., Wang, X., & Wei, D. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1551-x · Cited by 10
Editorial foreword for "environment, development and sustainability" journal
Kell, S. L. (2022) · Environment Development and Sustainability · doi:10.1007/s10668-021-02070-z · Cited by 10
Microalgae-Derived Toxic Compounds
Qian, Z., Kang, K., & Ryu, B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800776-1.00035-2 · Cited by 8
Singla, R., Parmar, P., Anand, S. G., & Srivatsan, V. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839162473-00325 · Cited by 5
Self-citation
Research works printed but not linked: 10
- Aguero, 2017, Membrane processes for whey proteins separation and purification, A review. Current Organic Chemistry, 21, 1740
- Cho, 2004, Keeping quality and sensory properties of drinkable yoghurt with added Chlorella extract, Korean Journal of Food Nutrition, 17, 128
- European Food Safety Authority, Union List of Novel Food in Accordance with Regulation (EU) 2015/2283 (COMMISSION IMPLEMENTING REGULATION (EU) 2017/2470), Official Journal of European Union. https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32017R2470&qid=1638194717330&from=EN, accessed on November 2021.
- https://www.grandviewresearch.com/press-release/global-algae-protein-market.
- Jassby, A. in Algae and Human Affairs, ed(s). C.A. Lembi and J.R. Waaland, Phycological Society of America, Cambridge University Press, Cambridge, 1988, ch. 8, 181-204.
- Kulpys, 2009, Influence of cyanobacteria Arthrospira (Spirulina) platensis biomass additive towards the body condition of lactation cows and biochemical milk indexes, Agronomy Research, 7, 823
- Odum, E. P., & Barrett, G. W. (1971). Fundamentals of ecology (Vol. 3, p. 5). Philadelphia: Saunders.
- Saleh, 1987, Blue-green algae in bread manufacture. Blaugruene Algen bei der Brotherstellung), Getreide Mehl und Brot, 41, 19
- Sarker, 2020, Towards sustainable and ocean-friendly aquafeeds: Evaluating a fish-free feed for rainbow trout (Oncorhynchus mykiss) using three marine microalgae species, Elementa: Science of the Anthropocene, 8
- Vúkari, 1977, Reduction of nucleic acid content of SCP, Process biochemistry., 16, 17
Cited by
Sorted by citations
Parmar, P., Kumar, R., Neha, Y., & Srivatsan, V. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1073546 · Cited by 279
Self-citationPerez-Vazquez, A., Carpena, M., Barciela, P., Cassani, L., Simal‐Gándara, J., & Prieto, M. A. (2023) · Antioxidants · doi:10.3390/antiox12030612 · Cited by 134
Algae as a potential source of protein meat alternatives
Espinosa‐Ramírez, J., Mondragón, A. D. C., Rodríguez, J. A., Lorenzo, J. M., & Santos, E. M. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1254300 · Cited by 129
Hu, J., Meng, W., Su, Y., Qian, C., & Fu, W. (2023) · Frontiers in Marine Science · doi:10.3389/fmars.2023.1260709 · Cited by 124
Microalgae: potential novel protein for sustainable human nutrition
Williamson, E., Ross, I. L., Wall, B. T., & Hankamer, B. D. (2023) · Trends in Plant Science · doi:10.1016/j.tplants.2023.08.006 · Cited by 122
Metadata
- Authors
- Kumar, R., Hegde, A. S., Sharma, K., Parmar, P., & Srivatsan, V.
- Affiliations
- Institute of Himalayan Bioresource Technology (IN)
- Corresponding author
- Srivatsan, Vidyashankar
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 157
- Pages
- 111338
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W4280632959
- Cited by
- 209
- References
- 223
- Citations by year
- 2026: 53 · 2025: 63 · 2024: 54 · 2023: 34 · 2022: 5
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India (33/FTT/FTC/ANB/2020-TMD-IND_INT)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- microalgal proteins, edible protein, bioactive peptides, microbial protein, alternative protein sources, Arthrospira, Chlorella, techno-functional properties, cell wall recalcitrance, digestibility, meat substitutes, emulsifiers, food and feed applications, biorefinery, downstream processing, sustainable protein production
- MeSH terms
- Animals, Chlorella, Dietary Proteins, Peptides, Biomass, Microalgae
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review