Acute prooxidant effects of vitamin C in EDTA chelation therapy and long-term antioxidant benefits of therapy
Abstract
Chelation therapy is thought to not only remove contaminating metals but also to decrease free radical production. EDTA chelation therapy, containing high doses of vitamin C as an antioxidant, is often used in the treatment of diseases such as diabetes and cardiovascular diseases but the effectiveness of this treatment may be variable and its efficacy has not been demonstrated conclusively. The objective of this work was to determine if the vitamin C added to standard chelation therapy cocktails was prooxidant. We administered a standard EDTA cocktail solution with or without 5 g of sodium ascorbate. One hour following the standard chelation therapy, there were highly significant prooxidant effects on lipids, proteins, and DNA associated with decreased activities of RBC glutathione peroxidase and superoxide dismutase while in the absence of sodium ascorbate, there were no acute signs of oxidative damage. After 16 sessions of standard chelation therapy, the acute prooxidant effects of vitamin C remained, but, even in the absence of nutrient supplements, there were beneficial long-term antioxidant effects of chelation therapy and plasma peroxide levels decreased. In conclusion, multiple sessions of EDTA chelation therapy protect lipids against oxidative damage. However, standard high amounts of vitamin C added to EDTA chelation solutions also display short term prooxidant effects. The added benefits of lower levels of vitamin C in chelation therapy need to be documented.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A variety of antioxidants can act as pro-oxidants and promote the production of OH• radicals in the presence of inappropriately or inadequately liganded Fe(II).
“One interpretation for these disappointing results, that is consistent with the general theme of this review, involves the recognition that a variety of antioxidants can in fact act as pro-oxidants and thus actually promote the production of OH• radicals in the presence of inappropriately or inadequately liganded Fe(II) [130,528,1602,1604,1659,1660].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [1660]
Cites
A simple technique for quantitation of low levels of DNA damage in individual cells
Singh, N. P., McCoy, M. T., Tice, R. R., & Schneider, E. L. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90265-0 · Cited by 10,828 · see citing works
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382 · see citing works
Glutathione Metabolism and Its Implications for Health
Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842 · see citing works
Inflammation: the link between insulin resistance, obesity and diabetes
Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170 · see citing works
Akerboom, T. P. M., & Sies, H. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77050-2 · Cited by 1,580 · see citing works
Vitamin C pharmacokinetics: Implications for oral and intravenous use
Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992 · see citing works
Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid
Buettner, G. R., & Jurkiewicz, B. A. (1996) · Radiation Research · doi:10.2307/3579271 · Cited by 884 · see citing works
Vitamin C in Human Health and Disease Is Still a Mystery? An Overview
Naidu, K. A. (2003) · Nutrition Journal · doi:10.1186/1475-2891-2-7 · Cited by 810 · see citing works
Vitamin C exhibits pro-oxidant properties
Podmore, I. D., Griffiths, H. R., Herbert, K. E., Mistry, N., Mistry, P., & Lunec, J. (1998) · Nature · doi:10.1038/33308 · Cited by 800 · see citing works
Loft, S., Vistisen, K., Ewertz, M., Tjønneland, A., Overvad, K., & Poulsen, H. E. (1992) · Carcinogenesis · doi:10.1093/carcin/13.12.2241 · Cited by 643 · see citing works
Sohal, R. S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00856-0 · Cited by 477 · see citing works
An Improved Coupled Test Procedure for Glutathione Peroxidase (EC 1.11.1.9.) in Blood
Günzler, W. A., Kremers, H., & Flohé, L. (1974) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1974.12.10.444 · Cited by 369 · see citing works
Childs, A. C., Jacobs, C. A., Kaminski, T. W., Halliwell, B. B., & Leeuwenburgh, C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00640-2 · Cited by 335 · see citing works
Oxidative Stress Caused by Inactivation of Glutathione Peroxidase and Adaptive Responses
Miyamoto, Y., Koh, Y. H., Park, Y. S., Fujiwara, N., Sakiyama, H., Misonou, Y., Ookawara, T., Suzuki, K., Honke, K., & Taniguchi, N. (2003) · Biological Chemistry · doi:10.1515/bc.2003.064 · Cited by 212 · see citing works
Vitamin C Inhibits Endothelial Cell Apoptosis in Congestive Heart Failure
Rössig, L., Hoffmann, J., Hugel, B., Mallat, Z., Haase, A., Freyssinet, J.-M., Tedgui, A., Aicher, A., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation · doi:10.1161/hc4301.098284 · Cited by 182 · see citing works
Novel repair action of vitamin C upon in vivo oxidative DNA damage
Cooke, M. S., Evans, M. D., Podmore, I. D., Herbert, K. E., Mistry, N., Mistry, P., Hickenbotham, P. T., Hussieni, A., Griffiths, H. R., & Lunec, J. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01403-3 · Cited by 160 · see citing works
Richard, M., Guiraud, P., Meo, J., & Favier, A. E. (1992) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(92)80593-f · Cited by 139 · see citing works
Oxidative status and malondialdehyde in β‐thalassaemia patients
Cighetti, G., Duca, L., Bortone, L., Sala, S., Nava, I., Fiorelli, G., & Cappellini, M. D. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.0320s1055.x · Cited by 136 · see citing works
Ascorbic acid and oxidative inactivation of proteins
Stadtman, E. R. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1125s · Cited by 126 · see citing works
Increased Lipid Peroxidation in Pregnant Women after Iron and Vitamin C Supplementation
Lachili, B., Hininger, I., Faure, H., Arnaud, J., Richard, M.-J., Favier, A., & Roussel, A.-M. (2001) · Biological Trace Element Research · doi:10.1385/bter:83:2:103 · Cited by 116 · see citing works
Self-citationThe reaction of ascorbic acid with different heme iron redox states of myoglobin
Giulivi, C., & Cadenas, E. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80651-a · Cited by 115 · see citing works
Hininger‐Favier, I., Chollat-Namy, A., Sauvaigo, S., Osman, M., Faure, H., Cadet, J., Favier, A. E., & Roussel, A. (2004) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.11.004 · Cited by 112 · see citing works
Self-citationWaters, R. S., Bryden, N. A., Patterson, K. Y., Veillon, C., & Anderson, R. A. (2001) · Biological Trace Element Research · doi:10.1385/bter:83:3:207 · Cited by 98 · see citing works
Self-citationThiols are Main Determinants of Total Antioxidant Capacity of Cellular Homogenates
Balcerczyk, A., & Bartosz, G. (2003) · Free Radical Research · doi:10.1080/1071576031000083189 · Cited by 84 · see citing works
Pennathur, S. (2004) · Frontiers in bioscience · doi:10.2741/1257 · Cited by 74 · see citing works
Vega‐López, S., Devaraj, S., & Jialal, I. (2004) · Journal of Investigative Medicine · doi:10.1136/jim-52-01-23 · Cited by 65 · see citing works
Diet modification affects DNA oxidative damage in healthy humans
Chen, L., Bowen, P. E., Berzy, D., Aryee, F., Stacewicz‐Sapuntzakis, M., & Riley, R. E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00254-8 · Cited by 55 · see citing works
Hamabe, A., Takase, B., Uehata, A., Kurita, A., Ohsuzu, F., & Tamai, S. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01485-0 · Cited by 46 · see citing works
Ershov, A. V., & Bazan, N. G. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991015)58:2 · Cited by 44 · see citing works
Anderson, T. J., Hubacek, J., Wyse, D. G., & Knudtson, M. L. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02770-5 · Cited by 38 · see citing works
Clinical evaluation of chelation therapy: Is there any wheat amidst the chaff?
Lamas, G. A., & Ackermann, A. (2000) · American Heart Journal · doi:10.1067/mhj.2000.107549 · Cited by 37 · see citing works
Chen, W.-T., Lin, Y., Yu, F.-C., Kao, W., Huang, W.-H., & Yan, H.-C. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00419-0 · Cited by 35 · see citing works
Koh, Y. H., Suzuki, K., Che, W., Park, Y. S., Miyamoto, Y., Higashiyama, S., & Taniguchi, N. (2001) · The FASEB Journal · doi:10.1096/fj.00-0572fje · Cited by 33 · see citing works
Richartz, B. M., Werner, G. S., Ferrari, M. W., & Figulla, H. R. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01977-4 · Cited by 31 · see citing works
Kapsokefalou, M., & Miller, D. D. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001319 · Cited by 24 · see citing works
Cooke, M. S., Mistry, N., Ahmad, J., Waller, H. L., Langford, L., Bevan, R. J., Evans, M. D., Jones, G. D. D., Herbert, K. E., Griffiths, H. R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01240-6 · Cited by 22 · see citing works
EDTA Chelation Therapy in the Treatment of Vascular Disease
Chappell, L. T., & Janson, M. (1996) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-199604000-00008 · Cited by 21 · see citing works
Rozema, T. C. (1997) · Journal of Advancement in Medicine · doi:10.1023/b:jame.0000008701.26923.ab · Cited by 19 · see citing works
Reduced-Carbohydrate Diets: No Roll in Weight Management?
Willett, W. C. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-10-200405180-00016 · Cited by 19 · see citing works
Reversal of endothelial dysfunction in humans
Hornig, B., & Drexler, H. (2001) · Coronary Artery Disease · doi:10.1097/00019501-200109000-00005 · Cited by 18 · see citing works
Vogel, U. B., Daneshvar, B., Risom, L., Weimann, A., Poulsen, H. E., Møller, P., Autrup, H. N., Loft, S. H., Wallin, H., & Dragsted, L. O. (2003) · Free Radical Research · doi:10.1080/1071576031000150779 · Cited by 17 · see citing works
Vega‐López, S., Devaraj, S., & Jialal, I. (2004) · Journal of Investigative Medicine · doi:10.2310/6650.2004.11932 · Cited by 16 · see citing works
EDTA chelation therapy does not selectively increase chromium losses
Anderson, R. A., Bryden, N. A., & Waters, R. (1999) · Biological Trace Element Research · doi:10.1007/bf02783835 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
1 of the 45 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works
Cao, H., Polansky, M. M., & Anderson, R. A. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.12.034 · Cited by 275 · see citing works
Self-citationThe neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases
Dušek, P., Roos, P. M., Litwin, T., Schneider, S. A., Flaten, T. P., & Aaseth, J. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.05.007 · Cited by 253 · see citing works
Rui, L., Xie, M., Hu, B., Zhou, L., Saeeduddin, M., & Zeng, X. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.04.076 · Cited by 207 · see citing works
Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone
Timoshnikov, V. A., Kobzeva, T. V., Polyakov, N. E., & Kontoghiorghes, G. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113967 · Cited by 181 · see citing works
Reversible reduction of nitroxides to hydroxylamines: Roles for ascorbate and glutathione
Bobko, A. A., Kirilyuk, I. A., Григорьев, И. А., Zweier, J. L., & Khramtsov, V. V. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.007 · Cited by 150 · see citing works
Kontoghiorghes, G. J., Kolnagou, A., Kontoghiorghe, C., Mourouzidis, L., Timoshnikov, V. A., & Polyakov, N. E. (2020) · Medicines · doi:10.3390/medicines7080045 · Cited by 112 · see citing works
Timoshnikov, V. A., Selyutina, O. Y., Polyakov, N. E., Didichenko, V., & Kontoghiorghes, G. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031247 · Cited by 97 · see citing works
Harvey, B. H., Joubert, C., du Preez, J. L., & Berk, M. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9466-y · Cited by 81 · see citing works
Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals
Ferrero, M. E. (2016) · BioMed Research International · doi:10.1155/2016/8274504 · Cited by 77 · see citing works
Kell, D. B., & Pretorius, E. (2022) · Biochemical Journal · doi:10.1042/bcj20220154 · Cited by 68 · see citing works
Oxalic acid excretion after intravenous ascorbic acid administration
Robitaille, L., Mamer, O. A., Miller, W. H., Levine, M., Assouline, S., Melnychuk, D., Rousseau, C., & Hoffer, L. J. (2009) · Metabolism · doi:10.1016/j.metabol.2008.09.023 · Cited by 67 · see citing works
Dragsted, L. O. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-2003-1 · Cited by 57 · see citing works
Winterbone, M. S., Sampson, M., Saha, S., Hughes, J. C., & Hughes, D. A. (2007) · Cardiovascular Diabetology · doi:10.1186/1475-2840-6-8 · Cited by 55 · see citing works
Born, T., Kontoghiorghe, C., Spyrou, A., Kolnagou, A., & Kontoghiorghes, G. J. (2012) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2012.730562 · Cited by 47 · see citing works
de Graft‐Johnson, J., & Nowak, D. (2016) · Molecules · doi:10.3390/molecules22010059 · Cited by 39 · see citing works
Chen, K., Lin, J., Lin‐Tan, D., Hsu, H., Hsu, C., Hsu, K., & Yen, T. (2012) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.04.028 · Cited by 35 · see citing works
Protective effect of EDTA preadministration on renal ischemia
Foglieni, C., Fulgenzi, A., Ticozzi, P., Pellegatta, F., Sciorati, C., Belloni, D., Ferrero, E., & Ferrero, M. E. (2006) · BMC Nephrology · doi:10.1186/1471-2369-7-5 · Cited by 33 · see citing works
Zhao, Y., Zhao, J., Zhang, Y., & Gao, J. (2016) · Aquaculture Research · doi:10.1111/are.13231 · Cited by 31 · see citing works
Zhang, G., Wang, S., Chen, C., Ma, Y., Xie, D., Wang, Y., Sun, L., You, C., & Li, Y. (2019) · Aquaculture Research · doi:10.1111/are.14239 · Cited by 29 · see citing works
Roussel, A., Hininger‐Favier, I., Waters, R. S., Osman, M., Fernholz, K., & Anderson, R. A. (2009) · PubMed · Cited by 26 · see citing works
Self-citationKuo, D. J., Bruckner, A. L., & Jeng, M. (2006) · Pediatric Dermatology · doi:10.1111/j.1525-1470.2006.00314.x · Cited by 25 · see citing works
Banihani, S. A., & Alawneh, R. F. (2019) · Biomolecules · doi:10.3390/biom9030111 · Cited by 22 · see citing works
Therapeutic Effect of EDTA in Experimental Model of Multiple Sclerosis
Mosayebi, G., Haghmorad, D., Namaki, S., Ghazavi, A., Ekhtiari, P., & Mirshafiey, A. (2010) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923970903338367 · Cited by 20 · see citing works
Filipović, N. R., Marković, I., Mitić, D. M., Polović, N., Milčić, M. K., Dulović, M., Jovanović, M., Savić, M., Nikšić, M., Anđelković, K., et al. (2013) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21541 · Cited by 18 · see citing works
Pirković, A., Dekanski, D., Živković, L., Milanović-Čabarkapa, M., Bajić, V., Topalović, D., Giampieri, F., Gasparrini, M., Battino, M. A., & Spremo‐Potparević, B. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.12.023 · Cited by 16 · see citing works
González-Cuevas, J., Navarro‐Partida, J., Márquez-Aguirre, A. L., Bueno‐Topete, M. R., Beas‐Zárate, C., & Armendáriz‐Borunda, J. (2011) · Redox Report · doi:10.1179/174329211x13002357050851 · Cited by 14 · see citing works
CaNa2EDTA chelation attenuates cell damage in workers exposed to lead-a pilot study
Čabarkapa, A., Borozan, S. Z., Živković, L., Stojanović, S. Đ., Milanović-Čabarkapa, M., Bajić, V., & Spremo‐Potparević, B. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.10.002 · Cited by 12 · see citing works
Mastrangelo, D., Massai, L., Fioritoni, G., & Lo‐Coco, F. (2017) · InTech eBooks · doi:10.5772/intechopen.68746 · Cited by 11 · see citing works
Propiedades prooxidantes del camu camu (Myrciaria dubia)
Guerra, H. G., Troncoso, L., & Guija, E. (2013) · Anales de la Facultad de Medicina · doi:10.15381/anales.v66i4.1320 · Cited by 11 · see citing works
Effect of the consumption on buriti oil on the metabolism of rats induced by iron overload
Aquino, J. D. S., Tavares, R. L., Medeiros, L. D. B., Martins, C. C. D. L., Pessoa, D. C. N. D. P., & Stamford, T. L. M. (2015) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000105 · Cited by 10 · see citing works
Kontoghiorghes, G. J. (2025) · Antioxidants · doi:10.3390/antiox14080982 · Cited by 11 · see citing works
Ihedioha, J. I., Ochiogu, I. S., & Ihedioha, T. E. (2007) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2007.01.003 · Cited by 9 · see citing works
Tripathi, R. P., Gupta, S. K., Rai, S., & Mittal, P. C. (2011) · PubMed · Cited by 9 · see citing works
Kontoghiorghes, G. J. (2025) · Nutrients · doi:10.3390/nu17203270 · Cited by 9 · see citing works
Rapid determination of trace EDTA in wines and beers by LC-MS/MS
Wei, X., Zhuang, L., Wu, C., Chen, W., Li, Z., & Xu, B. (2016) · LWT · doi:10.1016/j.lwt.2016.05.019 · Cited by 8 · see citing works
Modulatory role of chelating agents in diet-induced hypercholesterolemia in rats
Mahmoud, H. M., Zaki, H. F., Sherbiny, G. A. E., & El‐Latif, H. A. A. (2014) · Bulletin of Faculty of Pharmacy Cairo University · doi:10.1016/j.bfopcu.2013.11.002 · Cited by 5 · see citing works
Medulloblastoma: need for targeted treatment
Luttjeboer, M., & Kaspers, G. J. L. (2006) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.6.5.649 · Cited by 5 · see citing works
Citric acid as a decalcifying agent for the excised calcified human heart valves.
Köse, N., Aytaçoğlu, B. N., Yılmaz, N., Döndaş, H. A., Tamer, L., Yılmaz, B. C., Vezir, Ö., Sucu, N., & Dikmengil, M. (2008) · PubMed · Cited by 4 · see citing works
Olive leaf, DNA damage and chelation therapy
Pirković, A., Živković, L., Dekanski, D., Topalović, D., & Spremo‐Potparević, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819528-4.00021-3 · Cited by 4 · see citing works
Meszaros, A., & Fekete, J. (2014) · Food Analytical Methods · doi:10.1007/s12161-014-9946-z · Cited by 4 · see citing works
Muhoberac, B. B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1006203 · Cited by 3 · see citing works
Padron, D. A., & Klausmeyer, K. K. (2013) · Inorganica Chimica Acta · doi:10.1016/j.ica.2013.03.037 · Cited by 3 · see citing works
Kulprachakarn, K., & Pangjit, K. (2013) · Vitamins & Minerals · doi:10.4172/vms.1000115 · Cited by 3 · see citing works
Liver mitochondrial function in ZDF rats during the early stages of diabetes disease
Vial, G., Guen, M. L., Lamarche, F., Détaille, D., Cottet‐Rousselle, C., Demaison, L., Hininger‐Favier, I., Theurey, P., Crouzier, D., Debouzy, J. C., et al. (2016) · Physiological Reports · doi:10.14814/phy2.12686 · Cited by 2 · see citing works
Inhibitory Effects of Type IV Collagenase by Disulfiram
Sin, D.-I. (2006) · Journal of Life Science · doi:10.5352/jls.2006.16.6.964 · Cited by 1 · see citing works
Davila, R. A. (2010) · Cybertesis (National University of San Marcos) · Cited by 1 · see citing works
Protective Effects of Processing Condition and Antioxidant on Vitamin A in Chicken Liver Sausage
Liu, A. J., Guo, J., Chen, Y., Wang, Z., & Teng, A. G. (2013) · Advanced materials research · doi:10.4028/www.scientific.net/amr.864-867.541
Reactive nitrogen and oxygen species in anticoagulated blood of healthy sheep
Nwose, E. U., Bwititi, P., & Chalada, M. J. (2013) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2013.808187
Sorption of Arsenic Species using Chitosan Based Biopolymer Sorbent Materials
Pratt, D. Y. (2011) · University Library - University of Saskatchewan (University of Saskatchewan)
Vitamin C, a Key Factor in Post-extraction Healings A Preliminary Study
Miron, M. I., Ciora, E. D., Baitar, L., Tudor, A., Ogodescu, E., Bojoga, D. E., Rosu, S. N., Popovici, R. A., & Todea, C. D. (2020) · Revista de Chimie · doi:10.37358/rc.20.6.8193
Barakat, A. I., & Radwan, E. (2020) · Journal of Zoological Research · doi:10.14302/issn.2694-2275.jzr-20-3435
- Authors
- Hininger, I., Waters, R., Osman, M., Garrel, C., Fernholz, K., Roussel, A. M., & Anderson, R. A.
- Affiliations
- Université Joseph Fourier (FR)
- Agricultural Research Service (US)
- Corresponding author
- Anderson, Richard A.
- ORCID
- Anderson, Richard A.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 38
- Issue
- 12
- Pages
- 1565-1570
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2072919516
- Cited by
- 53
- References
- 45
- Citations by year
- 2025: 2 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 2 · 2017: 2 · 2016: 6 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 2
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- EDTA chelation therapy, vitamin C, sodium ascorbate, pro-oxidant activity, oxidative stress, lipid peroxidation, protein oxidation, DNA oxidation, glutathione peroxidase, superoxide dismutase, antioxidant activity, free radical scavenging
- MeSH terms
- Adult, Aged, Antioxidants, Ascorbic Acid, Chelating Agents, DNA Damage, Drug Therapy, Combination, Edetic Acid, Female, Humans, Male, Malondialdehyde, Middle Aged, Time Factors, Lipid Peroxidation, Chelation Therapy, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
