Vitamin C Inhibits Endothelial Cell Apoptosis in Congestive Heart Failure

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289 · see citing works

Ascorbate is an outstanding antioxidant in human blood plasma

Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870 · see citing works

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

Dimmeler, S., Haendeler, J., Nehls, M. C., & Zeiher, A. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.601 · Cited by 806 · see citing works

Endothelium-dependent vasodilation is attenuated in patients with heart failure.

Kubo, S. H., Rector, T. S., Bank, A. J., Williams, R. E., & Heifetz, S. M. (1991) · Circulation · doi:10.1161/01.cir.84.4.1589 · Cited by 775 · see citing works

Oxidant Signaling in Vascular Cell Growth, Death, and Survival

Irani, K. (2000) · Circulation Research · doi:10.1161/01.res.87.3.179 · Cited by 748 · see citing works

Increased Oxidative Stress in Patients With Congestive Heart Failure 11This study was supported by a grant jointly sponsored by the Medical Research Council of Canada, Ottawa and Bayer Pharmaceuticals, Etobicoke, Ontario, Canada.

Keith, M. E., Geranmayegan, A., Sole, M. J., Kurian, R., Robinson, A., Omran, A., & Jeejeebhoy, K. N. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00101-6 · Cited by 556 · see citing works

Oxygen free radicals and congestive heart failure.

Belch, J. J. F., Bridges, A., Scott, N., & Chopra, M. (1991) · Heart · doi:10.1136/hrt.65.5.245 · Cited by 550 · see citing works

Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure

Katz, S. D., Biasucci, L. M., Sabbà, C., Strom, J. A., Jondeau, G., Galvao, M., Solomon, S. B., Nikolic, S. D., Forman, R. F., & LeJemtel, T. H. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90271-n · Cited by 395 · see citing works

Vitamin C Improves Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure

Hornig, B., Arakawa, N., Kohler, C., & Drexler, H. (1998) · Circulation · doi:10.1161/01.cir.97.4.363 · Cited by 389 · see citing works

Dephosphorylation Targets Bcl-2 for Ubiquitin-dependent Degradation: A Link between the Apoptosome and the Proteasome Pathway

Dimmeler, S., Breitschopf, K., Haendeler, J., & Zeiher, A. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1815 · Cited by 314 · see citing works

High Glucose–Induced Apoptosis in Human Endothelial Cells Is Mediated by Sequential Activations of c-Jun NH 2 -Terminal Kinase and Caspase-3

Ho, F. M., Liu, S., Liau, C. S., Huang, P. J., & Lin‐Shiau, S. Y. (2000) · Circulation · doi:10.1161/01.cir.101.22.2618 · Cited by 288 · see citing works

Evidence of oxidative stress in chronic heart failure in humans

McMurray, J. J. V., Chopra, M., ABDULLAH, I., Smith, W. E., & Dargie, H. J. (1993) · European Heart Journal · doi:10.1093/eurheartj/14.11.1493 · Cited by 279 · see citing works

The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection.

Aupeix, K., Hugel, B., Martin, T., Bischoff, P., Lill, H., Pasquali, J. ‐., & Freyssinet, J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119317 · Cited by 273 · see citing works

Serum From Patients With Severe Heart Failure Downregulates eNOS and Is Proapoptotic

Agnoletti, L., Curello, S., Bachetti, T., Malacarne, F., Gaia, G., Comini, L., Volterrani, M., Bonetti, P., Parrinello, G., Cadei, M., et al. (1999) · Circulation · doi:10.1161/01.cir.100.19.1983 · Cited by 233 · see citing works

l-Ascorbic Acid Potentiates Nitric Oxide Synthesis in Endothelial Cells

Heller, R., Münscher-Paulig, F., Gräbner, R., & Till, U. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8254 · Cited by 224 · see citing works

Increased malondialdehyde in peripheral blood of patients with congestive heart failure

Díaz-Vélez, C. R., García-Castiñeiras, S., Mendoza-Ramos, E., & Hernández-López, E. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90063-0 · Cited by 216 · see citing works

Shear Stress Inhibits H 2 O 2 -Induced Apoptosis of Human Endothelial Cells by Modulation of the Glutathione Redox Cycle and Nitric Oxide Synthase

Hermann, C., Zeiher, A. M., & Dimmeler, S. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3588 · Cited by 195 · see citing works

Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys

Asai, K., Kudej, R. K., Shen, Y.-T., Yang, G.-P., Takagi, G., Kudej, A. B., Geng, Y., Sato, N., Nazareno, J. B., Vatner, D. E., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1493 · Cited by 189 · see citing works

Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of Bcl-2 and Bax

Haendeler, J., Zeiher, A. M., & Dimmeler, S. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00759-5 · Cited by 186 · see citing works

Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors

Dimmeler, S., & Zeiher, A. M. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00105-1 · Cited by 178 · see citing works

Apoptosis in the vascular wall and atherosclerosis

Rössig, L., Dimmeler, S., & Zeiher, A. M. (2001) · Basic Research in Cardiology · doi:10.1007/s003950170073 · Cited by 158 · see citing works

Cyclosporin A Inhibits Apoptosis of Human Endothelial Cells by Preventing Release of Cytochrome C From Mitochondria

Walter, D. H., Haendeler, J., Galle, J., Zeiher, A. M., & Dimmeler, S. (1998) · Circulation · doi:10.1161/01.cir.98.12.1153 · Cited by 157 · see citing works

Neutrophil superoxide anion–generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy

Ellis, G. R., Anderson, R. A., Lang, D., Blackman, D. J., Morris, R. H. K., Morris‐Thurgood, J., McDowell, I., Jackson, S. K., LEWIS, M. J., & Frenneaux, M. P. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00916-5 · Cited by 144 · see citing works

Congestive heart failure induces endothelial cell apoptosis: protective role of carvedilol

Rössig, L., Haendeler, J., Mallat, Z., Hugel, B., Freyssinet, J., Tedgui, A., Dimmeler, S., & Zeiher, A. M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01002-0 · Cited by 143 · see citing works

Nitric Oxide Down-regulates MKP-3 mRNA Levels

Rössig, L., Haendeler, J., Hermann, C., Malchow, P., Urbich, C., Zeiher, A. M., & Dimmeler, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002283200 · Cited by 122 · see citing works

Exposure to low concentrations of hydrogen peroxide causes delayed endothelial cell death and inhibits proliferation of surviving cells

BONO, D. P. D., & Yang, W. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05488-5 · Cited by 77 · see citing works

Mechanisms and implications of endothelial dysfunction in congestive heart failure

Katz, S. D. (1997) · Current Opinion in Cardiology · doi:10.1097/00001573-199705000-00007 · Cited by 75 · see citing works

Mechanisms of exercise intolerance in congestive heart failure

Harrington, D., & Coats, A. J. S. (1997) · Current Opinion in Cardiology · doi:10.1097/00001573-199705000-00003 · Cited by 54 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

Oxygen, oxidative stress, hypoxia, and heart failure

Giordano, F. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24408 · Cited by 1,494 · see citing works

Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication

Ratajczak, J., Wysoczynski, M., Hayek, F., Janowska-Wieczorek, A., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404296 · Cited by 1,340 · see citing works

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924 · see citing works

Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease

Fadeel, B., & Orrenius, S. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01570.x · Cited by 699 · see citing works

Microparticles in cardiovascular diseases

VANWIJK, M., VanBavel, E., Sturk, A., & Nieuwland, R. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00367-5 · Cited by 610 · see citing works

Antioxidants and human diseases

Rajendran, P., Nandakumar, N., Rengarajan, T., Palaniswami, R., Edwinoliver, N. G., Uppalapati, L., Gopas, J., & Nishigaki, I. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.06.004 · Cited by 530 · see citing works

Mitochondria and Endothelial Function

Kluge, M. A., Fetterman, J. L., & Vita, J. A. (2013) · Circulation Research · doi:10.1161/circresaha.111.300233 · Cited by 508 · see citing works

Procoagulant Microparticles

Morel, O., Toti, F., Hugel, B., Bakouboula, B., Camoin‐Jau, L., Dignat‐George, F., & Freyssinet, J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000246775.14471.26 · Cited by 461 · see citing works

Cellular microparticles: a disseminated storage pool of bioactive vascular effectors

Morel, O., Toti, F., Hugel, B., & Freyssinet, J. (2004) · Current Opinion in Hematology · doi:10.1097/01.moh.0000131441.10020.87 · Cited by 454 · see citing works

Endothelial microparticles in diseases

Chironi, G. N., Boulanger, C. M., Simon, A., Dignat-George, F., Freyssinet, J.-M., & Tedgui, A. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0710-9 · Cited by 420 · see citing works

Immune-enhancing role of vitamin C and zinc and effect on clinical conditions

Wintergerst, E. S., Maggini, S., & Hornig, D. H. (2006) · Annals of Nutrition and Metabolism · doi:10.1159/000090495 · Cited by 418 · see citing works

Cellular microparticles: what are they bad or good for?

Freyssinet, J. M. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00309.x · Cited by 399 · see citing works

Circulating Microparticles

Boulanger, C. M., Amabile, N., & Tedgui, A. (2006) · Hypertension · doi:10.1161/01.hyp.0000231507.00962.b5 · Cited by 372 · see citing works

Cellular microparticles: new players in the field of vascular disease?

Diamant, M., Tushuizen, M. E., Sturk, A., & Nieuwland, R. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01355.x · Cited by 364 · see citing works

Role of Vitamin C in the Function of the Vascular Endothelium

May, J. M., & Harrison, F. E. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5205 · Cited by 358 · see citing works

Role of Heat Shock Proteins in Atherosclerosis

Xu, Q. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000029720.59649.50 · Cited by 354 · see citing works

Oxidative Stress and Preeclampsia

Raijmakers, M. T. M., Dechend, R., & Poston, L. (2004) · Hypertension · doi:10.1161/01.hyp.0000141085.98320.01 · Cited by 329 · see citing works

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Bjelaković, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. N. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176 · Cited by 307 · see citing works

The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure

Witte, K. K., Nikitin, N. P., Parker, A. C., von Haehling, S., Volk, H., Anker, S. D., Clark, A. L., & Cleland, J. G. F. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi442 · Cited by 298 · see citing works

Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors

Wysoczynski, M., & Ratajczak, M. Z. (2009) · International Journal of Cancer · doi:10.1002/ijc.24479 · Cited by 216 · see citing works

Nutritional and Anti-Inflammatory Interventions in Chronic Heart Failure

Kalantar‐Zadeh, K., Anker, S. D., Horwich, T. B., & Fonarow, G. C. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.03.007 · Cited by 195 · see citing works

Oxidative Stress and Antioxidant Treatments in Cardiovascular Diseases

Wang, W., & Kang, P. M. (2020) · Antioxidants · doi:10.3390/antiox9121292 · Cited by 192 · see citing works

The involvement of circulating microparticles in inflammation, coagulation and cardiovascular diseases

Puddu, P., Puddu, G. M., Cravero, E., Muscari, S., & Muscari, A. (2010) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(10)70371-8 · Cited by 179 · see citing works

Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endothelium

Wilson, J. X. (2009) · BioFactors · doi:10.1002/biof.7 · Cited by 176 · see citing works

Targeting inflammation to reduce cardiovascular disease risk: A realistic clinical prospect?

Welsh, P., Grassia, G., Botha, S., Sattar, N., & Maffia, P. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13818 · Cited by 164 · see citing works

Systemic Endothelial Dysfunction as an Early Predictor of Adverse Outcome in Heart Failure

Heitzer, T. A., Baldus, S. E., Kodolitsch, Y. V., Rudolph, V., & Meinertz, T. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166516.52477.81 · Cited by 157 · see citing works

Cell-derived vesicles for drug therapy and diagnostics: Opportunities and challenges

Fuhrmann, G., Herrmann, I. K., & Stevens, M. M. (2015) · Nano Today · doi:10.1016/j.nantod.2015.04.004 · Cited by 155 · see citing works

The role of endothelial cell apoptosis in inflammatory and immune diseases

Winn, R. K., & Harlan, J. M. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01378.x · Cited by 152 · see citing works

Polyphenolic Flavonoids Differ in Their Antiapoptotic Efficacy in Hydrogen Peroxide–Treated Human Vascular Endothelial Cells

Choi, Y. J., Park, J. H. Y., Lee, Y., Choi, J.-S., Kang, Y., & Kang, J.-S. (2003) · Journal of Nutrition · doi:10.1093/jn/133.4.985 · Cited by 146 · see citing works

Microparticles: Key Protagonists in Cardiovascular Disorders

Amabile, N., Rautou, P., Tedgui, A., & Boulanger, C. M. (2010) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0030-1267044 · Cited by 136 · see citing works

Inflammation in the vascular bed: Importance of vitamin C

Aguirre, R., & May, J. M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.05.002 · Cited by 141 · see citing works

Intercellular Vesicular Transfer by Exosomes, Microparticles and Oncosomes - Implications for Cancer Biology and Treatments

Jaiswal, R., & Sedger, L. M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00125 · Cited by 131 · see citing works

Rationale and impact of vitamin C in clinical nutrition

McGregor, G. P., & Biesalski, H. K. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000247478.79779.8f · Cited by 115 · see citing works

LOX-1 and ROS, inseparable factors in the process of endothelial damage

Lubrano, V., & Balzan, S. (2014) · Free Radical Research · doi:10.3109/10715762.2014.929122 · Cited by 110 · see citing works

Vitamins and cardiovascular disease

Honarbakhsh, S., & Schachter, M. (2008) · British Journal Of Nutrition · doi:10.1017/s000711450809123x · Cited by 111 · see citing works

Protective effects of icariin on human umbilical vein endothelial cell injury induced by H2O2 in vitro

Wang, Y., & Huang, Z. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.02.023 · Cited by 109 · see citing works

Antioxidant Vitamins and Their Use in Preventing Cardiovascular Disease

Farbstein, D., Kozak-Blickstein, A., & Levy, A. P. (2010) · Molecules · doi:10.3390/molecules15118098 · Cited by 106 · see citing works

Microparticles in Health and Disease

Herring, J. M., McMichael, M. A., & Smith, S. A. (2013) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12128 · Cited by 105 · see citing works

(-)Epigallocatechin Gallate and Quercetin Enhance Survival Signaling in Response to Oxidant-Induced Human Endothelial Apoptosis

Choi, Y. J., Jeong, Y.-J., Lee, Y., Kwon, H., & Kang, Y. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.707 · Cited by 91 · see citing works

Antioxidant therapy in critical care—Is the microcirculation the primary target?

Biesalski, H. K., & McGregor, G. P. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000278598.95294.c5 · Cited by 85 · see citing works

Naringenin more effectively inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in macrophages than in microglia

Chao, C., Weng, C.-S., Chang, N., Lin, J.-S., Kao, S.-T., & Ho, F. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.10.011 · Cited by 85 · see citing works

Sustained elevated amounts of circulating procoagulant membrane microparticles and soluble GPV after acute myocardial infarction in diabetes mellitus

Morel, O., Hugel, B., Jesel, L., Lanza, F., Douchet, M.-P., Zupan, M., Chauvin, M., Cazenave, J., Freyssinet, J., & Toti, F. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-05-0294 · Cited by 84 · see citing works

Differential suppression of intracellular reactive oxygen species-mediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids

Yi, L., Chen, C.-Y., Jin, X., Zhang, T., Zhou, Y. G., Zhang, Q., Zhu, J., & Mi, M. (2012) · Biochimie · doi:10.1016/j.biochi.2012.05.027 · Cited by 78 · see citing works

Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure

Tousoulis, D., Charakida, M., & Stefanadis, C. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.05.030 · Cited by 78 · see citing works

The antioxidant effects of quercetin metabolites on the prevention of high glucose-induced apoptosis of human umbilical vein endothelial cells

Chao, C., Hou, Y., Chao, P.-D. L., Weng, C.-S., & Ho, F. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508073637 · Cited by 75 · see citing works

Extracellular vesicles as new pharmacological targets to treat atherosclerosis

Yin, M., Loyer, X., & Boulanger, C. M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.06.047 · Cited by 75 · see citing works

Apoptosis and the cardiac action of insulin-like growth factor I.

Suleiman, M., Singh, R., & Stewart, C. (2007) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2007.03.001 · Cited by 82 · see citing works

Discovery of new therapeutic redox targets for cardioprotection against ischemia/reperfusion injury and heart failure

Daiber, A., Andreadou, I., Oelze, M. W., Davidson, S. M., & Hausenloy, D. J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.026 · Cited by 73 · see citing works

Potential use of antioxidants for the treatment of chronic inflammatory diseases

Blagov, A. V., Summerhill, V. I., Sukhorukov, V. N., Zhigmitova, E. B., Postnov, A. Y., & Orekhov, A. N. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1378335 · Cited by 72 · see citing works

Protective effects of vitamin C on endothelium damage and platelet activation during myocardial infarction in patients with sustained generation of circulating microparticles

Morel, O., Jesel, L., Hugel, B., Douchet, M., Zupan, M., Chauvin, M., Freyssinet, J.-M., & Toti, F. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00010.x · Cited by 71 · see citing works

Xanthine oxidase inhibition ameliorates cardiovascular dysfunction in dogs with pacing-induced heart failure

Amado, L. C., SALIARIS, A. P., Raju, S., Lehrke, S., John, M. S., XIE, J., Stewart, G. C., Fitton, T. P., Minhas, K. M., & BRAWN, J. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.04.008 · Cited by 71 · see citing works

Plasmodium falciparumMalaria: Reduction of Endothelial Cell Apoptosis In Vitro

Hemmer, C. J., Lehr, H. A., Westphal, K., Unverricht, M., Kratzius, M., & Reisinger, E. C. (2005) · Infection and Immunity · doi:10.1128/iai.73.3.1764-1770.2005 · Cited by 67 · see citing works

Enhanced survival effect of pyruvate correlates MAPK and NF-κB activation in hydrogen peroxide-treated human endothelial cells

Lee, Y., Kang, I., Bünger, R., & Kang, Y. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00797.2003 · Cited by 65 · see citing works

Dietary Flavonoids Differentially Reduce Oxidized LDL-Induced Apoptosis in Human Endothelial Cells: Role of MAPK- and JAK/STAT-Signaling

Choi, J.-S., Choi, Y. J., Shin, S.-Y., Li, J., Kang, S., Bae, J., Kim, D. S., Ji, G. E., Kang, J.-S., & Kang, Y. (2008) · Journal of Nutrition · doi:10.1093/jn/138.6.983 · Cited by 64 · see citing works

Curculigoside attenuates human umbilical vein endothelial cell injury induced by H2O2

Wang, Y. K., Hong, Y. J., Wei, M., Wu, Y., Huang, Z. Q., Chen, R. Z., & Chen, H. Z. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.08.008 · Cited by 63 · see citing works

The role of endothelial dysfunction and oxidative stress in cerebrovascular diseases

Scicchitano, P., Cortese, F., Gesualdo, M., Palo, M. D., Massari, F., Giordano, P., & Ciccone, M. M. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1620939 · Cited by 59 · see citing works

Vitamins C and E attenuate apoptosis, β-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction

Qin, F., Chen, Y., Patel, R., Liu, W., & Dong, E. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.019 · Cited by 59 · see citing works

Mechanisms of pyruvate inhibition of oxidant-induced apoptosis in human endothelial cells

Lee, Y., Kang, I., Bünger, R., & Kang, Y. (2003) · Microvascular Research · doi:10.1016/s0026-2862(03)00052-9 · Cited by 56 · see citing works

Acute prooxidant effects of vitamin C in EDTA chelation therapy and long-term antioxidant benefits of therapy

Hininger, I., Waters, R., Osman, M., Garrel, C., Fernholz, K., Roussel, A. M., & Anderson, R. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.016 · Cited by 53 · see citing works

Vitamin C supplementation for diabetes management: A comprehensive narrative review

Mason, S. A., Parker, L., van der Pligt, P., & Wadley, G. D. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.003 · Cited by 53 · see citing works

Liver dysfunction and its nutritional implications in heart failure

Valentová, M., von Haehling, S., Doehner, W., Murín, J., Anker, S. D., & Sandek, A. (2012) · Nutrition · doi:10.1016/j.nut.2012.06.002 · Cited by 53 · see citing works

Osteogenic differentiation of intact human amniotic membrane

Lindenmair, A., Wolbank, S., Stadler, G., Meinl, A., Peterbauer-Scherb, A., Eibl, J., Polin, H., Gabriel, C., van Griensven, M., & Redl, H. R. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.090 · Cited by 53 · see citing works

Aging and the endothelium

d’Alessio, P. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.025 · Cited by 52 · see citing works

Vasoplegia in septic shock: Do we really fight the right enemy?

Sharawy, N. (2013) · Journal of Critical Care · doi:10.1016/j.jcrc.2013.08.021 · Cited by 51 · see citing works

Supplementation of maturation medium with CoQ10 enhances developmental competence of ovine oocytes through improvement of mitochondrial function

Heydarnejad, A., Ostadhosseini, S., Varnosfaderani, S. R., Jafarpour, F., Moghimi, A., & Nasr‐Esfahani, M. H. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23159 · Cited by 49 · see citing works

Protective Effect of Nano-Vitamin C on Infertility due to Oxidative Stress Induced by Lead and Arsenic in Male Rats

Raeeszadeh, M., Karimfar, B., Amiri, A. A., & Akbari, A. (2021) · Journal of Chemistry · doi:10.1155/2021/9589345 · Cited by 49 · see citing works

Influence of Vitamin C on Baroreflex Sensitivity in Chronic Heart Failure

Piccirillo, G., Nocco, M., Moisè, A., Lionetti, M., Naso, C., Carlo, S. D., & Marigliano, V. (2003) · Hypertension · doi:10.1161/01.hyp.0000073581.74107.22 · Cited by 48 · see citing works

Blockade of Oxidized LDL-Triggered Endothelial Apoptosis by Quercetin and Rutin through Differential Signaling Pathways Involving JAK2

Choi, J.-S., Kang, S., Li, J., Kim, J. L., Bae, J., Kim, D. S., Shin, S.-Y., Jun, J., Wang, M., & Kang, Y. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803390m · Cited by 48 · see citing works

Periconceptional vitamin use and leukemia risk in children with Down syndrome

Ross, J. A., Blair, C. K., Olshan, A. F., Robison, L. L., Smith, F. O., Heerema, N. A., & Roesler, M. A. (2005) · Cancer · doi:10.1002/cncr.21171 · Cited by 48 · see citing works

l-Arginine and antioxidant vitamins E and C improve the cardiovascular performance of broiler chickens grown under chronic hypobaric hypoxia

Bautista-Ortega, J., & Ruiz-Feria, C. A. (2010) · Poultry Science · doi:10.3382/ps.2010-00764 · Cited by 44 · see citing works

Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients

Lavillegrand, J., Raia, L., Urbina, T., Hariri, G., Gabarre, P., Bonny, V., Bigé, N., Baudel, J.-L., Bruneel, A., Dupré, T., et al. (2022) · Critical Care · doi:10.1186/s13054-022-03891-8 · Cited by 43 · see citing works

Micronutrients and their supplementation in chronic cardiac failure. An update beyond theoretical perspectives

Witte, K. K., & Clark, A. L. (2006) · Heart Failure Reviews · doi:10.1007/s10741-006-9194-4 · Cited by 42 · see citing works

Infections, heat shock proteins, and atherosclerosis

Xu, Q. (2003) · Current Opinion in Cardiology · doi:10.1097/00001573-200307000-00001 · Cited by 42 · see citing works

Ascorbic Acid Blocks the Growth Inhibitory Effect of Tumor Necrosis Factor-α on Endothelial Cells

Saeed, R. W., Peng, T., & Metz, C. N. (2003) · Experimental Biology and Medicine · doi:10.1177/15353702-0322807-12 · Cited by 41 · see citing works

Nutrition in pediatric cardiomyopathy

Miller, T. L., Neri, D. A., Extein, J., Somarriba, G. A., & Strickman-Stein, N. (2007) · Progress in Pediatric Cardiology · doi:10.1016/j.ppedcard.2007.08.007 · Cited by 40 · see citing works

Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease

Zhou, L., Sun, J., Gu, L., Wang, S., Yang, T., Wei, T., Shan, T., Wang, H., & Wang, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.794879 · Cited by 37 · see citing works

Vitamin C Protects Against UV Irradiation-Induced Apoptosis Through Reactivating Silenced Tumor Suppressor Genes p21 and p16 in a Tet-Dependent DNA Demethylation Manner in Human Skin Cancer Cells

Lin, J.-R., Qin, H.-H., Wu, W.-Y., He, S.-J., & Xu, J.-H. (2014) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2014.1647 · Cited by 37 · see citing works

Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-α, and ROS production in Gulo(−/−) mice

Kim, H.-M., Bae, S., Kim, Y., Cho, C., Kim, S. J., Kim, Y.-J., Lee, S., Kim, H., Hwang, Y., Kang, J. S., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.023 · Cited by 37 · see citing works

Protective effects of silybin on human umbilical vein endothelial cell injury induced by H2O2 in vitro

Wang, Y., Hong, Y.-J., & Huang, Z. (2005) · Vascular Pharmacology · doi:10.1016/j.vph.2005.06.002 · Cited by 36 · see citing works

Cardioprotective Actions of Ascorbic Acid during Isoproterenol-Induced Acute Myocardial Infarction in Rats

Buttros, J. B., Bergamaschi, C. T., Ribeiro, D. A., Fracalossi, A. C. C., & Campos, R. R. (2009) · Pharmacology · doi:10.1159/000222245 · Cited by 36 · see citing works

Antioxidant effect of estrogen on bovine aortic endothelial cells

Song, J., Kim, M., Jo, H.-H., Hwang, S.-J., Chae, B., Chung, J., Kwon, D.-J., Lew, Y.-O., Lim, Y.-T., Kim, J.-H., et al. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.07.006 · Cited by 34 · see citing works

Ascorbic Acid Promotes Detoxification and Elimination of 4-Hydroxy-2(E)-nonenal in Human Monocytic THP-1 Cells

Miranda, C. L., Reed, R. L., Kuiper, H. C., Alber, S. A., & Stevens, J. F. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900042u · Cited by 33 · see citing works

Les microparticules circulantes : rôles physiologiques et implications dans les maladies inflammatoires et thrombotiques

Morel, O., Morel, N., Hugel, B., Jesel, L., Vinzio, S., Goichot, B., Bakouboula, B., Grunebaum, L., Freyssinet, J., & Toti, F. (2005) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2005.03.015 · Cited by 33 · see citing works

Design, synthesis and antioxidant activity evaluation of novel β-elemene derivatives

Chen, J., Duan, W.-L., Bai, R., Yao, H., Shang, J., & Xu, J. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.05.078 · Cited by 31 · see citing works

Prenatal Vitamin C Status is Associated with Placental Apoptosis in Normal-term Human Pregnancies

Ahn, Y. M., Kim, Y. J., Park, H., Park, B., & Lee, H. (2006) · Placenta · doi:10.1016/j.placenta.2006.01.018 · Cited by 29 · see citing works

Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness

Weitzel, L.-R. B., Mayles, W. J., Sandoval, P. A., & Wischmeyer, P. E. (2009) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e328328d32f · Cited by 28 · see citing works

Benefits of multiple micronutrient supplementation in heart failure: A comprehensive review

Dragan, S. R., Buleu, F. N., Christodorescu, R., Cobzariu, F., Iurciuc, S., Velimirovici, D. E., Xiao, J., & Luca, C. T. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1540398 · Cited by 28 · see citing works

Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

Ichim, T. E., Minev, B., Braciak, T. A., Luna, B., Hunninghake, R., Mikirova, N. A., Jackson, J. A., González, M. J., Miranda-Massari, J. R., Alexandrescu, D. T., et al. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-25 · Cited by 26 · see citing works

Homocysteine, brain natriuretic peptide and chronic heart failure: a critical review

Herrmann, W., Herrmann, M., Joseph, J., & Tyagi, S. C. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.360 · Cited by 27 · see citing works

Reversing Heart Failure–Associated Pathophysiology with Exercise

Adams, V., & Niebauer, J. (2014) · Heart Failure Clinics · doi:10.1016/j.hfc.2014.08.001 · Cited by 26 · see citing works

The Release of Nitric Oxide from S-Nitrosothiols Promotes Angiogenesis

Al‐Ani, B., Hewett, P. W., Ahmed, S., Cudmore, M., Fujisawa, T., Ahmad, S., & Ahmed, A. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000025 · Cited by 26 · see citing works

Microparticules circulantes au cours des traumatismes graves et des sepsis : un élément du couplage inflammation–thrombose

Morel, N., Morel, O., Delabranche, X., Jesel, L., Sztark, F., Dabadie, P., Freyssinet, J., & Toti, F. (2006) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2006.04.013 · Cited by 26 · see citing works

Microvesicles at the Crossroads Between Infection and Cardiovascular Diseases

Xiong, J., Miller, V. M., Li, Y., & Jayachandran, M. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31820c6254 · Cited by 25 · see citing works

Dose-dependent modulation of the T cell proteome by ascorbic acid

Grant, M. M., Mistry, N., Lunec, J., & Griffiths, H. R. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507197592 · Cited by 25 · see citing works

Antioxidant treatment for heart failure: friend or foe?

Thomson, M. J., Frenneaux, M. P., & Kaski, J. C. (2008) · QJM · doi:10.1093/qjmed/hcn160 · Cited by 24 · see citing works

A comparative study of the effects of vitamin C, sirolimus, and paclitaxel on the growth of endothelial and smooth muscle cells for cardiovascular medical device applications

MANI, M., & Kakade, S. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s45162 · Cited by 23 · see citing works

The methanolic extract of Moringa oleifera attenuates CCl4 induced hepatonephro toxicity in the male rat.

Elbakry, M., Rabey, H. A. E., Elremaly, W., Sakran, M. I., & Almutairi, F. M. (2019) · Biomedical Research · doi:10.35841/biomedicalresearch.30-18-1056 · Cited by 22 · see citing works

Vitamin C Prevents Cigarette Smoke Induced Atherosclerosis in Guinea Pig Model

Ray, T., Maity, P. C., Banerjee, S., Deb, S., Dasgupta, A. K., Sarkar, S., & Sil, A. K. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.2881 · Cited by 21 · see citing works

Grape seed extract ameliorates tumor necrosis factor-α-induced inflammatory status of human umbilical vein endothelial cells

Chao, C., Chang, N., Weng, C.-S., Lee, K., Kao, S.-T., Hsu, J.-C., & Ho, F. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0151-6 · Cited by 21 · see citing works

Congestive heart failure induces endothelial cell apoptosis: protective role of carvedilol

Rössig, L., Haendeler, J., Mallat, Z., Hugel, B., Freyssinet, J., Tedgui, A., Dimmeler, S., & Zeiher, A. M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01002-0 · Cited by 143 · see citing works

Vitamin C Improves Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure

Hornig, B., Arakawa, N., Kohler, C., & Drexler, H. (1998) · Circulation · doi:10.1161/01.cir.97.4.363 · Cited by 389 · see citing works

Endothelial Dysfunction in Congestive Heart Failure: Effects of Carvedilol

Ferrari, R., Agnoletti, L., Ceconi, C., Curello, S., Delling, F. N., & Manfredini, R. (1999) · Heart Failure Reviews · doi:10.1023/a:1009855801777 · Cited by 2 · see citing works

The changes of Endothelin-1 and tumor necrosis factor-α in the congestive heart failure and the intervention role of vitamin E and vitamin C

王矩伟, 邹秋萍, 陈春波, 张金英, 党波, & 赵云 (2001) · 中国综合临床 · doi:10.3760/cma.j.issn.1008-6315.2001.10.009

Neutrophil superoxide anion–generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy

Ellis, G. R., Anderson, R. A., Lang, D., Blackman, D. J., Morris, R. H. K., Morris‐Thurgood, J., McDowell, I., Jackson, S. K., LEWIS, M. J., & Frenneaux, M. P. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00916-5 · Cited by 144 · see citing works