Oxidative stress and diabetic cardiovascular complications

Jay, Desmond; Hitomi, Hirofumi; Griendling, Kathy K.

doi:10.1016/j.freeradbiomed.2005.06.018

Cited by 464Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressAdvanced Glycation End Products research

Oxidative stress and diabetic cardiovascular complications

Jay, Desmond, Hitomi, Hirofumi, Griendling, Kathy K.·2006·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2005.06.018

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Abstract

Diabetes diagnoses are increasing at an alarming rate worldwide. The majority of diabetes-related deaths arise from cardiovascular complications such as myocardial infarction, stroke, and peripheral vascular disease. Oxidative stress has been demonstrated to be present in animal models as well as in patients with diabetes and has been suggested as a possible contributor to the accelerated atherosclerosis seen in diabetics. The generation of reactive oxygen species in diabetes occurs via several mechanisms and is initiated not only by glucose, but also by other substances that are found at elevated levels in diabetic patients. The resulting oxidative stress leads to a number of proatherogenic events. The elucidation of the mechanisms of oxidative stress in diabetes and their relationship with atherosclerosis could potentially identify molecular targets of therapy for this condition and its cardiovascular consequences.

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Damage from oxidative stress due to chronic mitochondrial overproduction of reactive oxygen species (ROS) plays a crucial role in inflammation and results in irreversible fibrosis and cardiomyocyte death.
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From Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population (2016) · cites this paper as [15]
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From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [680]

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Author index
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Letter to the editor
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Authors: Jay, D., Hitomi, H., & Griendling, K. K.
Affiliations: Emory University (US)
Corresponding author: Griendling, Kathy K.
ORCID: Hitomi, Hirofumi
Griendling, Kathy K.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2006-01
Volume: 40
Issue: 2
Pages: 183-192
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2005.06.018
OpenAlex: W2012627116
Cited by: 464
References: 126
Citations by year: 2026: 3 · 2025: 5 · 2024: 4 · 2023: 11 · 2022: 17 · 2021: 23 · 2020: 19 · 2019: 16 · 2018: 20 · 2017: 21 · 2016: 17 · 2015: 34 · 2014: 40 · 2013: 34 · 2012: 27
FWCI: 3.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords: oxidative stress, diabetes mellitus, cardiovascular complications of diabetes, atherosclerosis, reactive oxygen species, myocardial infarction, stroke, peripheral vascular disease, glucose metabolism, therapeutic target
MeSH terms: Animals, Antioxidants, Cardiovascular Diseases, Free Radicals, Humans, Models, Biological, Reactive Oxygen Species, Oxidative Stress, Diabetes Complications, Atherosclerosis

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