The Role of Oxidative Stress in Diabetic Vascular and Neural Disease

Yorek, Mark A.

doi:10.1080/1071576031000083161

Cited by 219Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressAdvanced Glycation End Products research

The Role of Oxidative Stress in Diabetic Vascular and Neural Disease

Yorek, Mark A.·2003·Free Radical Research

DOI 10.1080/1071576031000083161

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Abstract

This review will focus on the impact of hyperglycemia-induced oxidative stress in the development of diabetes-induced vascular and neural dysfunction. Oxidative stress occurs when the balance between the production of oxidation products and the ability of antioxidant mechanisms to neutralize these products is tilted in the favor of the former. The production of reactive oxygen species has been shown to be increased in patients with diabetes. The possible sources for the overproduction of reactive oxygen species is widespread and include enzymatic pathways, autoxidation of glucose and the mitochondria. Increase in oxidative stress has clearly been shown to contribute to the pathology of vascular disease not only in diabetes but also in hypertension, stroke and ischemia. Since the etiology of diabetic neuropathy is considered to have a large vascular component, prevention of oxidative stress in diabetes is considered by many investigators to be a primary defense against the development of diabetic vascular disease. Potential therapies for preventing increased oxidative stress in diabetes and the neural vasculature will be discussed.

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Therapeutic use of CoQ10 and other antioxidants in vivo, particularly in human studies directed at vascular events, has been disappointing.
“However, the therapeutic use of CoQ10 and other antioxidants in vivo, particularly in human studies directed at vascular events, has been disappointing (341, 345).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [341]

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Result
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“Diabetic nephropathy is one of the major microvascular complications of diabetes and one of the leading causes of end-stage renal failure and death in diabetic patients (Evans et al., 2002; Yorek, 2003).”
BackgroundInfluential
Increased methionine sulfoxide content of apoA-I in type 1 diabetes
Brock, J. W. C., Jenkins, A. J., Lyons, T. J., Klein, R. L., Yim, E., Lopes-Virella, M. F., Carter, R. E., Thorpe, S. R., & Baynes, J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800015-jlr200 · Cited by 49 · see citing works
“Despite the evidence for increased oxidative stress in diabetes (2–4, 50), in the present study diabetic patients with nephropathy, which is thought to increase oxidative stress and CVD risk (50–52), did not show a statistically significant increase in Met oxidation.”
Influential
Enhanced hydrogen peroxide sensing based on Prussian Blue modified macroporous microelectrodes
Mokrushina, A. V., Heim, M., Karyakina, E. E., et al. (2013) · Electrochemistry Communications · doi:10.1016/j.elecom.2013.01.004 · Cited by 48 · see citing works
Impact of antioxidants on seminal vesicles function and fertilizing potential in diabetic rats
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“OS also contributes to the development and progression of vascular and neural dysfunction in diabetic patients (Yorek, 2003).”
Background
Pt-MWCNT modified carbon electrode strip for rapid and quantitative detection of H 2 O 2 in food
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Synthesis, Molecular Docking, and Bioactivity Study of Novel Hybrid Benzimidazole Urea Derivatives: A Promising α-Amylase and α-Glucosidase Inhibitor Candidate with Antioxidant Activity
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“Furthermore, free radical scavengers and chelators have been reported for their potential role in diabetes management, such as reducing the vascular relaxation and neurovascular impairments associated with hyperalgesia, improving endoneurial blood flow, and overall reducing the production of OH- and the initiation of…”
Background
Insulin Promotes Survival of Amyloid-Beta Oligomers Neuroblastoma Damaged Cells via Caspase 9 Inhibition and Hsp70 Upregulation
Carlo, M. D., Picone, P., Carrotta, R., Giacomazza, D., & Biagio, P. L. S. (2010) · BioMed Research International · doi:10.1155/2010/147835 · Cited by 43 · see citing works
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Increased Susceptibility to Amyloid-β Toxicity in Rat Brain Microvascular Endothelial Cells under Hyperglycemic Conditions
Carvalho, C., Katz, P. S., Dutta, S., Katakam, P. V. G., Moreira, P. I., & Busija, D. W. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130464 · Cited by 42 · see citing works
“…severaldeleteriouspathwaysculminatinginseveral ahyperglycemicstate,highlevelsofreactiveoxygen species(ROS )areproducedactivatingseveraldeleteri-ouspathways factornuclearfactor κ B (NF κ B) enhancing monocytes adhesion to the vessel walls, which may initiate an atherosclerotic state [6].”
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“carcinogenesis and many other inflammatory and degenerative conditions [1,2].”
Background
Neuroprotection by α-Lipoic Acid in Streptozotocin-Induced Diabetes
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“, lipids, proteins and nucleic acids ultimately contributing to ischemic damage (Yorek 2003).”
Nanoparticle tethered antioxidant response element as a biosensor for oxygen induced toxicity in retinal endothelial cells.
Prow, T. W., Grebe, R. R., Merges, C. A., Smith, J. N., McLeod, D. S., Leary, J. F., & Lutty, G. A. (2006) · PubMed · Cited by 41 · see citing works
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Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders
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“Various vitamins and chemical compounds with antioxidant properties have been developed, including coenzymeQ [120], vitamin E [121], a-lipoic acid [122], N-acetylcysteine (NAC) [123], vitamin C, and inducers of heme oxygenase [124], which are able to reduce ROS production.”
Background
Retracted
Nanostructured ZnO thin film for hydrogen peroxide sensing
Sivalingam, D., Jeyaprakash, B. G., Krishnan, U. M., et al. (2011) · Physica E Low-dimensional Systems and Nanostructures · doi:10.1016/j.physe.2011.06.015 · Cited by 35 · see citing works
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“H2O2 is cytotoxic to cellular life and acts as an indicator of oxidative stress (Lases et al., 2000; Yorek, 2003); it is the product of several biological, enzymecatalysed reactions (Clark, 1970; Ruiz et al., 1993; Yang et al., 1995, 2006; Thomé-Duret et al., 1996; Niwa et al., 1998; Armstrong &…”
Background
Method development and validation for monitoring in vivo oxidative stress: Evaluation of lipid peroxidation and fat-soluble vitamin status by HPLC in rat plasma
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Background
Synthesis of silver and silver@zero valent iron nanoparticles using Chromolaena odorata phenolic extract for antibacterial activity and hydrogen peroxide detection
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Background
Bridging advanced glycation end product, receptor for advanced glycation end product and nitric oxide with hormonal replacement/estrogen therapy in healthy versus diabetic postmenopausal women: A perspective
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“[90] M.”
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Authors: Yorek, M. A.
Affiliations: University of Iowa (US)
Corresponding author: Yorek, Mark A.
ORCID: Yorek, Mark A.
Venue: Free Radical Research
Publisher: Informa UK Limited
Published: 2003-01
Volume: 37
Issue: 5
Pages: 471-480
ISSN: 1029-2470 (ISSN-L)
1071-5762
DOI: 10.1080/1071576031000083161
OpenAlex: W2086273061
Cited by: 219
References: 0
Citations by year: 2025: 5 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 5 · 2018: 2 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 16 · 2013: 12 · 2012: 13
FWCI: 8.62
Type: journal article
Language: en
Open access: closed
Locations: Free Radical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords: oxidative stress, hyperglycemia, diabetes mellitus, diabetic vascular disease, diabetic neuropathy, reactive oxygen species, antioxidant defense, mitochondrial oxidative stress, hypertension, stroke, ischemia, neurovascular dysfunction, antioxidant therapy
MeSH terms: Animals, Diabetes Mellitus, Diabetic Angiopathies, Diabetic Neuropathies, Endothelium, Vascular, Free Radicals, Humans, Models, Biological, Neural Conduction, Reactive Oxygen Species, Oxidative Stress, Diabetes Complications

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The Role of Oxidative Stress in Diabetic Vascular and Neural Disease

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