Depletion of cardiolipin and cytochrome c during ischemia increases hydrogen peroxide production from the electron transport chain
Abstract
Mitochondrial electron transport is a major source of reactive oxygen species (ROS) during cardiac ischemia and reperfusion. In the isolated rabbit heart, 30 and 45 min of ischemia decrease the contents of cardiolipin and cytochrome c in subsarcolemmal mitochondria (SSM) located beneath the plasma membrane. In contrast, interfibrillar mitochondria (IFM) in the interior of the myocyte do not sustain a decrease in cardiolipin. We proposed that the depletion of cardiolipin and the accompanying cytochrome c loss during ischemia were critical events that amplified ROS production by mitochondria. The total production of H2O2 was measured in submitochondrial particles (SMP) prepared from rabbit heart SSM and IFM after 0, 15, 30, and 45 min of ischemia. With NADH as substrate, total H2O2 production was increased only in SMP from SSM after 30 and 45 min ischemia, when ischemia decreased the content of cardiolipin and cytochrome c. In contrast, ischemia did not augment H2O2 generation in SMP from IFM with preserved cardiolipin and cytochrome c content. Thus, during the evolution of ischemic injury, H2O2 production from the electron transport chain increased after depletion of cardiolipin and the loss of cytochrome c.
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Blocking complex III with antimycin A and cyanide to block complex IV did not inhibit the HIF-1α in isolated cardiomyocytes in response to hypoxia.
“However, blocking complex III with antimycin A and cyanide to block complex IV did not inhibit the HIF-1α in isolated cardiomyocytes in response to hypoxia (79).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [79]
Cites
Principles and procedures of statistics.
Steel, R. G. D., & Torrie, J. H. (1960) · Cited by 24,135 · see citing works
Principles and Procedures of Statistics
Robinson, H. F. (1961) · Agronomy Journal · doi:10.2134/agronj1961.00021962005300050002x · Cited by 17,727 · see citing works
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084 · see citing works
Production of Reactive Oxygen Species by Mitochondria
Chen, Q., Vazquez, E. J., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304854200 · Cited by 1,616 · see citing works
Self-citationComplete Structure of the 11-Subunit Bovine Mitochondrial Cytochrome bc <sub>1</sub> Complex
Iwata, S., Lee, J. W., Okada, K., Lee, J. K., Iwata, M., Rasmussen, B., Link, T. A., Ramaswamy, S., & Jap, B. K. (1998) · Science · doi:10.1126/science.281.5373.64 · Cited by 1,253 · see citing works
Cytochrome c release from mitochondria proceeds by a two-step process
Ott, M., Robertson, J. D., Gogvadze, V. G., Zhivotovsky, B., & Orrenius, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241655498 · Cited by 955 · see citing works
Palmer, J. W., Tandler, B., & Hoppel, C. L. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75283-1 · Cited by 830 · see citing works
Han, D., Antunes, F., Canali, R., Rettori, D., & Cadenas, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210269200 · Cited by 711 · see citing works
Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure
Lesnefsky, E. J., Moghaddas, S., Tandler, B., Kerner, J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1378 · Cited by 709 · see citing works
Self-citationNew concepts in reactive oxygen species and cardiovascular reperfusion physiology
Becker, L. C. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.025 · Cited by 703 · see citing works
Kushnareva, Y., Murphy, A. N., & Andreyev, A. Y. (2002) · Biochemical Journal · doi:10.1042/bj20021121 · Cited by 677 · see citing works
Trumpower, B. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38410-8 · Cited by 596 · see citing works
Cardiolipins and biomembrane function
Hoch, F. L. (1992) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(92)90035-9 · Cited by 596 · see citing works
Ambrosio, G., Zweier, J. L., Duilio, C., Kuppusamy, P., Santoro, G., Elia, P. P., Tritto, I., Cirillo, P. L., Condorelli, M., & Chiariello, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46660-9 · Cited by 515 · see citing works
Ricci, J.-E., Gottlieb, R. A., & Green, D. R. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208089 · Cited by 504 · see citing works
Generation of superoxide in cardiomyocytes during ischemia before reperfusion
Becker, L. B., Hoek, T. L. V., Shao, Z., Li, C., & Schumacker, P. T. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.6.h2240 · Cited by 413 · see citing works
Fry, M., & Green, D. E. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69888-1 · Cited by 405 · see citing works
Kagan, V. E., Borisenko, G. G., Tyurina, Y. Y., Tyurin, V. A., Jiang, J., Potapovich, A. I., Kini, V., Amoscato, A. A., & Fujii, Y. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.016 · Cited by 342 · see citing works
Kevin, L. G., Camara, A. K. S., Riess, M. L., Novalija, E., & Stowe, D. F. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00711.2002 · Cited by 272 · see citing works
Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase
Kadenbach, B., Hüttemann, M., Arnold, S., Lee, I., & Bender, E. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00305-1 · Cited by 268 · see citing works
McMillin, J. B., & Dowhan, W. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00329-3 · Cited by 266 · see citing works
Evidence for two distinct acidic phospholipid-binding sites in cytochrome c.
Rytömaa, M., & Kinnunen, P. K. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42094-1 · Cited by 254 · see citing works
Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation
Shidoji, Y., Hayashi, K., KOMURA, S., Ohishi, N., & Yagi, K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1410 · Cited by 250 · see citing works
The cardiolipin–cytochrome c interaction and the mitochondrial regulation of apoptosis
Iverson, S. L., & Orrenius, S. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.002 · Cited by 235 · see citing works
Cardiolipin requirement by cytochrome oxidase and the catalytic role of phospholipid
Fry, M., & Green, D. E. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(80)90622-1 · Cited by 230 · see citing works
Lesnefsky, E. J., Tandler, B., Ye, J., Slabe, T. J., Turkaly, J. S., & Hoppel, C. L. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.3.h1544 · Cited by 229 · see citing works
Self-citationBlockade of Electron Transport during Ischemia Protects Cardiac Mitochondria
Lesnefsky, E. J., Chen, Q., Moghaddas, S., Hassan, M. O., Tandler, B., & Hoppel, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409720200 · Cited by 229 · see citing works
Self-citationBorutaite, V., Jekabsone, A., Morkūnienė, R., & Brown, G. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00005-1 · Cited by 206 · see citing works
Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria
Lesnefsky, E. J., Slabe, T. J., Stoll, M. S. K., Minkler, P. E., & Hoppel, C. L. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2770 · Cited by 194 · see citing works
Self-citationLesnefsky, E. J., Chen, Q., Slabe, T. J., Stoll, M. S. K., Minkler, P. E., Hassan, M. O., Tandler, B., & Hoppel, C. L. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00348.2003 · Cited by 135 · see citing works
Self-citationLipid requirements for cytochrome c oxidase activity
Vik, S. B., & Capaldi, R. (1977) · Biochemistry · doi:10.1021/bi00645a016 · Cited by 130 · see citing works
Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00166-8 · Cited by 120 · see citing works
Self-citationThe Ubiquinol/bc1 Redox Couple Regulates Mitochondrial Oxygen Radical Formation
Gille, L., & Nohl, H. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2257 · Cited by 106 · see citing works
Role of Oxalacetate in the Regulation of Mammalian Succinate Dehydrogenase
Ackrell, B. A. C., Kearney, E. B., & Mayr, M. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42790-7 · Cited by 102 · see citing works
Trumpower, B. L. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(02)00273-6 · Cited by 98 · see citing works
Borutaitė, V., Jekabsone, A., Morkūnienė, R., & Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00062-x · Cited by 97 · see citing works
The role of cytochrome c diffusion in mitochondrial electron transport.
Gupte, S. S., & Hackenbrock, C. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60707-0 · Cited by 88 · see citing works
Activation of beef-heart cytochrome c oxidase by cardiolipin and analogues of cardiolipin
Abramovitch, D. A., Marsh, D., & Powell, G. L. (1990) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(90)90090-q · Cited by 77 · see citing works
Powell, G. L., Knowles, P. F., & Marsh, D. (1987) · Biochemistry · doi:10.1021/bi00399a018 · Cited by 76 · see citing works
A Possible Role of Slips in Cytochrome C Oxidase in the Antioxygen Defense System of the Cell
Papa, S., GUERRIERI, F., & Capitanio, N. (1997) · Bioscience Reports · doi:10.1023/a:1027331116866 · Cited by 49 · see citing works
Effect of membrane environment on succinate dehydrogenase activity.
Ackrell, B. A. C., Kearney, E. B., & Singer, T. P. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40590-4 · Cited by 23 · see citing works
Studies on the nucleotide specificity of mitochondrial inner membrane particles
Hoppel, C. L., & Cooper, C. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90529-3 · Cited by 21 · see citing works
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Reactive oxygen species, cellular redox systems, and apoptosis
Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340 · see citing works
ROS signalling in the biology of cancer
Moloney, J. N., & Cotter, T. G. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.05.023 · Cited by 1,983 · see citing works
Mechanisms of Cell Death in Oxidative Stress
Ryter, S. W., Kim, H. P., Hoetzel, A., Park, J. W., Nakahira, K., Wang, X., & Choi, A. M. K. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.49 · Cited by 1,262 · see citing works
Abramov, A. Y., Scorziello, A., & Duchen, M. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4468-06.2007 · Cited by 686 · see citing works
Oxidative Stress in Cancer Cell Metabolism
Arfin, S., Jha, N. K., Jha, S. K., Kesari, K. K., Ruokolainen, J., Roychoudhury, S., Rathi, B., & Kumar, D. (2021) · Antioxidants · doi:10.3390/antiox10050642 · Cited by 691 · see citing works
Apoptosis and Oxidative Stress in Neurodegenerative Diseases
Radi, E., Formichi, P., Battisti, C., & Federico, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132738 · Cited by 632 · see citing works
Radak, Z. O., Zhao, Z., Koltai, E., Ohno, H., & Atalay, M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4498 · Cited by 616 · see citing works
Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works
Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works
Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies
Lesnefsky, E. J., Chen, Q., Tandler, B., & Hoppel, C. L. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103335 · Cited by 443 · see citing works
Self-citationden Hengst, W. A., Gielis, J. F., Lin, J. Y., Schil, P. E. V., Windt, L. J. D., & Moens, A. L. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00251.2010 · Cited by 401 · see citing works
Raedschelders, K., Ansley, D. M., & Chen, D. D. Y. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.11.004 · Cited by 387 · see citing works
Cytochrome c oxidase dysfunction in oxidative stress
Srinivasan, S., & Avadhani, N. G. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.021 · Cited by 371 · see citing works
Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System
Branca, J. J. V., Fiorillo, C., Carrino, D., Paternostro, F., Taddei, N., Gulisano, M., Pacini, A., & Becatti, M. (2020) · Antioxidants · doi:10.3390/antiox9060492 · Cited by 319 · see citing works
Chen, Q., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00211.2007 · Cited by 299 · see citing works
Self-citationMitochondria-Targeted Cytoprotective Peptides for Ischemia–Reperfusion Injury
Szeto, H. H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1892 · Cited by 269 · see citing works
Chen, Q., Camara, A. K. S., Stowe, D. F., Hoppel, C. L., & Lesnefsky, E. J. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00270.2006 · Cited by 271 · see citing works
Self-citationRole of Oxidative Stress in Pancreatic Inflammation
Leung, P. S., & Chan, Y. C. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2109 · Cited by 264 · see citing works
Mariappan, N., Elks, C. M., Sriramula, S., Guggilam, A., Liu, Z., Borkhsenious, O. N., & Francis, J. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp305 · Cited by 240 · see citing works
Chen, Q., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.110262 · Cited by 215 · see citing works
Self-citationPotential Therapeutic Benefits of Strategies Directed to Mitochondria
Camara, A. K. S., Lesnefsky, E. J., & Stowe, D. F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2788 · Cited by 195 · see citing works
Self-citationOxidative phosphorylation and aging
Lesnefsky, E. J., & Hoppel, C. L. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.04.001 · Cited by 190 · see citing works
Self-citationFormation and Regulation of Mitochondrial Membranes
Schenkel, L. C., & Bakovic, M. (2014) · International Journal of Cell Biology · doi:10.1155/2014/709828 · Cited by 180 · see citing works
Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria
Boengler, K., Stahlhofen, S., van de Sand, A., Gres, P., Ruiz‐Meana, M., David Garcia-dorado, A., Heusch, G., & Schulz, R. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0007-5 · Cited by 172 · see citing works
Yang, L., Zhao, K., Calingasan, N. Y., Luo, G., Szeto, H. H., & Beal, M. F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2445 · Cited by 169 · see citing works
Hollander, J. M., Thapa, D., & Shepherd, D. L. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00747.2013 · Cited by 171 · see citing works
Gao, W. Z., Xu, K., Ji, L., & Tang, B. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.05.1018 · Cited by 136 · see citing works
Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology?
Koopman, W. J. H., Verkaart, S., Visch, H.-J., Vries, S. E. V. E., Nijtmans, L. G. J., Smeitink, J. A. M., & Willems, P. H. G. M. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00194.2006 · Cited by 132 · see citing works
Pasdois, P., Parker, J. E., Griffiths, E. J., & Halestrap, A. P. (2011) · Biochemical Journal · doi:10.1042/bj20101957 · Cited by 127 · see citing works
Szczepanek, K., Chen, Q., Larner, A. C., & Lesnefsky, E. J. (2012) · Mitochondrion · doi:10.1016/j.mito.2011.08.011 · Cited by 117 · see citing works
Self-citationSahlin, K., Shabalina, I. G., Mattsson, C. M., Bakkman, L., Fernström, M., Rozhdestvenskaya, Z., Enqvist, J. K., Nedergaard, J., Ekblom, B. T., & Tonkonogi, M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00966.2009 · Cited by 109 · see citing works
Lee, W.-J., Hsiao, M., Chang, J.-L., Yang, S., Tseng, T., Cheng, C., Chow, J., Lin, K.-H., Lin, Y.-W., Liu, C.-C., et al. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1300-0 · Cited by 106 · see citing works
Mitochondrial Respiratory Dysfunction in Familiar Parkinsonism Associated with PINK1 Mutation
Piccoli, C., Sardanelli, A. M., Scrima, R., Ripoli, M. C., Quarato, G., D’Aprile, A., Bellomo, F., Scacco, S., Michele, G. D., Filla, A., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9729-2 · Cited by 105 · see citing works
Development of Mitochondria‐targeted Aromatic‐cationic Peptides for Neurodegenerative Diseases
Szeto, H. H. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.013 · Cited by 100 · see citing works
Monteiro, J. P., Oliveira, P. J., & Jurado, A. S. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.06.002 · Cited by 98 · see citing works
Exercise Protects Cardiac Mitochondria against Ischemia–Reperfusion Injury
Lee, Y., Min, K., Talbert, E. E., Kavazis, A. N., Smuder, A. J., Willis, W. T., & Powers, S. K. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318231c037 · Cited by 98 · see citing works
Hickey, A. J., Renshaw, G. M. C., Speers‐Roesch, B., Richards, J. G., Wang, Y., Farrell, A. P., & Brauner, C. J. (2011) · Journal of Comparative Physiology B · doi:10.1007/s00360-011-0599-6 · Cited by 90 · see citing works
Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia
Birk, A. V., Chao, W. M., Liu, S., Soong, Y., & Szeto, H. H. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.06.006 · Cited by 63 · see citing works
Chen, Q., & Lesnefsky, E. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.029 · Cited by 64 · see citing works
Self-citationCritical role of complex III in the early metabolic changes following myocardial infarction
Heather, L. C., Carr, C. A., Stuckey, D. J., Pope, S. A. S., Morten, K., Carter, E. E., Edwards, L. M., & Clarke, K. J. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp276 · Cited by 61 · see citing works
Kolli, V. K., Natarajan, K., Isaac, B. T. J., Selvakumar, D., & Abraham, P. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113515503 · Cited by 57 · see citing works
Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1
Jian, B., Yang, S., Chaudry, I. H., & Raju, R. P. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00365 · Cited by 57 · see citing works
Mitigation of NADH: Ubiquinone oxidoreductase deficiency by chronic Trolox treatment
Koopman, W. J. H., Verkaart, S., Vries, S. E. V. E., Grefte, S., Smeitink, J. A. M., Nijtmans, L. G. J., & Willems, P. H. G. M. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.028 · Cited by 56 · see citing works
Li, X., Arslan, F., Ren, Y., Adav, S. S., Poh, K. K., Sorokin, V. A., Lee, C. N., de Kleijn, D. P. V., Lim, S. K., & Sze, S. K. (2012) · Journal of Proteome Research · doi:10.1021/pr201025m · Cited by 56 · see citing works
Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer
Han, C., Wang, Z., Xu, Y., Chen, S., Han, Y., Li, L., Wang, M., & Xun-bo, J. (2020) · BioMed Research International · doi:10.1155/2020/1269624 · Cited by 55 · see citing works
Botta, A. M., Laher, I., Beam, J., DeCoffe, D., Brown, K., Halder, S., Devlin, A. M., Gibson, D. L., & Ghosh, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070248 · Cited by 56 · see citing works
Brown, D. A., Sabbah, H. N., & Shaikh, S. R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.005 · Cited by 50 · see citing works
Look into brain energy crisis and membrane pathophysiology in ischemia and reperfusion
Chomová, M., & Žitňanová, I. (2016) · Stress · doi:10.1080/10253890.2016.1174848 · Cited by 51 · see citing works
Chen, M., Wang, M., Yang, Q., Wang, M., Wang, Z., Zhu, Y., Zhang, Y., Wang, C., Jia, Y., Li, Y., et al. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2571 · Cited by 49 · see citing works
Sepuri, N. B. V., Angireddy, R., Srinivasan, S., Guha, M., Spear, J. F., Lü, B., Anandatheerthavarada, H. K., Suzuki, C. K., & Avadhani, N. G. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.04.003 · Cited by 49 · see citing works
Matsuyama, D., & Kawahara, K. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0178-8 · Cited by 46 · see citing works
Kennedy, R. K., Veena, V., Naik, P. R., Lakshmi, P., Krishna, R., Sudharani, S., & Sakthivel, N. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1118-0 · Cited by 46 · see citing works
Goswami, S. K., Maulik, N., & Das, D. K. (2007) · Annals of Medicine · doi:10.1080/07853890701374677 · Cited by 47 · see citing works
Postconditioning Modulates Ischemia-damaged Mitochondria During Reperfusion
Chen, Q., Paillard, M., Gomez, L., Li, H., Hu, Y., & Lesnefsky, E. J. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31823827cc · Cited by 46 · see citing works
Self-citationRoss, T., Szczepanek, K., Bowler, E., Hu, Y., Larner, A. C., Lesnefsky, E. J., & Chen, Q. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.035 · Cited by 45 · see citing works
Self-citationYang, T., Mao, Y., Liu, S., Hou, J., Cai, Z.-Y., Hu, J., Ni, X., Deng, X., & Zhu, X. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.12.025 · Cited by 43 · see citing works
Vessey, D. A., Li, L., Jin, Z.-Q., Kelley, M., Honbo, N. Y., Zhang, J., & Karliner, J. S. (2011) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2011/961059 · Cited by 44 · see citing works
Zhang, H., Chen, Y., Chen, Y., Jia, P., Ji, S., Xu, J., Li, Y., & Wang, T. Z. (2020) · Food & Function · doi:10.1039/d0fo00732c · Cited by 44 · see citing works
Petrosillo, G., Venosa, N. D., Moro, N., Colantuono, G., Paradies, V., Tiravanti, E., Federici, A., Ruggiero, F. M., & Paradies, G. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.030 · Cited by 42 · see citing works
Oxidative injury induces selective rather than global inhibition of proteasomal activity
Gurusamy, N., Goswami, S. K., Malik, G., & Das, D. K. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.10.005 · Cited by 40 · see citing works
Jian, B., Yang, S., Chaudry, I. H., & Raju, R. P. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00077 · Cited by 38 · see citing works
HYPOXIA-INDUCED ALTERATION OF MITOCHONDRIAL GENES IN CARDIOMYOCYTES
Jian, B., Wang, D., Chen, D., Voss, J. G., Chaudry, I. H., & Raju, R. P. (2010) · Shock · doi:10.1097/shk.0b013e3181cffe7d · Cited by 38 · see citing works
Mulligan, C. M., Le, C. H., deMooy, A. B., Nelson, C. B., & Chicco, A. J. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt209 · Cited by 37 · see citing works
Matsuzaki, S., Szweda, P. A., Szweda, L. I., & Humphries, K. M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.008 · Cited by 35 · see citing works
Chen, Q., Yin, G., Stewart, S., Hu, Y., & Lesnefsky, E. J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.137 · Cited by 34 · see citing works
Self-citationJian, B., Yang, S., Chen, D., Zou, L., Chatham, J. C., Chaudry, I. H., & Raju, R. P. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00195 · Cited by 33 · see citing works
Impaired mitochondrial function in chronically ischemic human heart
Stride, N. O., Larsen, S., Hey‐Mogensen, M., HANSEN, C. N., Prats, C., Steinbrüchel, D. A., Køber, L., & Dela, F. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00991.2012 · Cited by 30 · see citing works
Thompson, J., Maceyka, M. W., & Chen, Q. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111380 · Cited by 30 · see citing works
Self-citationRohrbach, S., Aslam, M., Niemann, B., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12650 · Cited by 30 · see citing works
Wang, B., & Xu, A. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.12.004 · Cited by 30 · see citing works
Nguyen, T. T. M., Ogbi, M., & Johnson, J. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801642200 · Cited by 29 · see citing works
Reactive Oxygen Species and Apoptosis
Azad, N., & Iyer, A. K. V. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_15 · Cited by 27 · see citing works
Hu, H., Doll, D. N., Sun, J., Lewis, S. E., Wimsatt, J., Kessler, M. J., Simpkins, J. W., & Ren, X. S. (2016) · Aging and Disease · doi:10.14336/ad.2015.0906 · Cited by 24 · see citing works
Zhang, D., Chen, C., Wang, H., Niu, E., Zhao, P., Fang, S., Zhu, G., Shang, X., & Guo, W. (2020) · Genetics · doi:10.1093/genetics/iyaa017 · Cited by 24 · see citing works
Chess, D. J., Billings, E. M., Covián, R., Glancy, B. C., French, S. A., Taylor, J. F., Bari, H. D., Murphy, E., & Balaban, R. S. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.04.017 · Cited by 24 · see citing works
Oxidative complexity: The role of ROS in the tumor environment and therapeutic implications
Shen, T., Wang, Y., Cheng, L., Bode, A. M., Gao, Y., Zhang, S., Chen, X., & Luo, X. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118241 · Cited by 23 · see citing works
Duffy, B. M., & Staples, J. F. (2022) · Physiological and Biochemical Zoology · doi:10.1086/719931 · Cited by 23 · see citing works
Grayson, C., & Mailloux, R. J. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.08.015 · Cited by 22 · see citing works
Metabolic Alterations at the Crossroad of Aging and Oncogenesis
Raffaghello, L., & Longo, V. D. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.01.003 · Cited by 18 · see citing works
Mitochondria as a target of cardioprotection in models of preconditioning
Jasova, M., Kancirová, I., Waczulı́ková, I., & Ferko, M. (2017) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-017-9720-1 · Cited by 17 · see citing works
Pennington, E. R., Sullivan, E. M., Fix, A., Dadoo, S., Zeczycki, T. N., DeSantis, A., Schlattner, U., Coleman, R., Chicco, A. J., Brown, D. A., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004948 · Cited by 16 · see citing works
Dave, A. R., Shukla, F., Wala, H., & Pillai, P. P. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1197-9 · Cited by 17 · see citing works
A Pathophysiological Role of Cytochrome P450 Involved in Production of Reactive Oxygen Species
Shimamoto, N. (2013) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.12-00263 · Cited by 15 · see citing works
Monolysocardiolipin: improved preparation with high yield
Kim, J. H., & Hoppel, C. L. (2010) · Journal of Lipid Research · doi:10.1194/jlr.d010587 · Cited by 14 · see citing works
Zhang, X., Zhao, Y.-Q., Yan, H., Liu, H., & Huang, G. (2016) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-016-9688-2 · Cited by 12 · see citing works
Chomová, M., Balážová, M., & Muchová, J. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3061-6 · Cited by 12 · see citing works
Chen, Q., Qi, S. S., Stone, L. H., Lesnefsky, E. J., Kelly, R. F., & McFalls, E. O. (2021) · Antioxidants · doi:10.3390/antiox10020276 · Cited by 11 · see citing works
Self-citationXu, Y., Sun, D., Song, C., Wang, R., & Dong, X. (2018) · The Journal of Toxicological Sciences · doi:10.2131/jts.43.545 · Cited by 11 · see citing works
Salimi, A., Bahreini, F., Jamali, Z., & Pourahmad, J. (2020) · International Journal of Toxicology · doi:10.1177/1091581820918163 · Cited by 10 · see citing works
Ischemic preconditioning does not protect via blockade of electron transport
Tanaka‐Esposito, C., Chen, Q., Moghaddas, S., & Lesnefsky, E. J. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00943.2006 · Cited by 10 · see citing works
Self-citationIschemia In Vivo Induces Cardiolipin Oxidation in Rat Kidney Mitochondria
Strazdauskas, A., Trumbeckaitė, S., Jakštas, V., Kamarauskaitė, J., Іванаускас, Л., & Banienė, R. (2022) · Biology · doi:10.3390/biology11040541 · Cited by 10 · see citing works
Deciphering the Blood-Brain Barrier Damage in Stroke: Mitochondrial Mechanism
Ren, X. S., & Simpkins, J. W. (2015) · Journal of Neuroinfectious Diseases · doi:10.4172/2314-7326.s2-e002 · Cited by 7 · see citing works
Castillo, S. R., Rickeard, B. W., DiPasquale, M., Nguyen, M. H. L., Lewis-Laurent, A., Doktorova, M., Kav, B., Miettinen, M. S., Nagao, M., Kelley, E. G., et al. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00926 · Cited by 8 · see citing works
Brandão, S. R., Ferreira, R. M., & Rocha, H. (2019) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1628065 · Cited by 6 · see citing works
Novitasari, D., Nakamae, I., Jenie, R. I., Yoneda‐Kato, N., Kato, J., & Meiyanto, E. (2023) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2023.101892 · Cited by 6 · see citing works
Reid, C., & Finnerty, N. J. (2017) · Sensors · doi:10.3390/s17071596 · Cited by 6 · see citing works
Dong, L., Zhou, Y., Wang, L., Mao, X., Wang, J., Du, Z., Che, X., & Li, Y. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70043 · Cited by 5 · see citing works
Isei, M. O., Chinnappareddy, N., Stevens, D., & Kamunde, C. (2021) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2021.109111 · Cited by 5 · see citing works
Dewilde, A. H., Wang, G., Zhang, J., Marx, K. A., Therrien, J. M., & Braunhut, S. J. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.04.002 · Cited by 4 · see citing works
Musatov, A. (2013) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-013-1019-z · Cited by 3 · see citing works
- Authors
- Chen, Q., & Lesnefsky, E. J.
- Affiliations
- Xuzhou Medical College (CN)
- Louis Stokes Cleveland VA Medical Center (US)
- Corresponding author
- Lesnefsky, Edward J.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 40
- Issue
- 6
- Pages
- 976-982
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2092718544
- Cited by
- 119
- References
- 42
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 9 · 2013: 11 · 2012: 6
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- American Heart Association
- Office of Research and Development
- National Institutes of Health
- National Institute on Aging (1PO1 AG-15885, P01AG015885)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- cytochrome c, hydrogen peroxide production, mitochondrial electron transport chain, myocardial ischemia, reperfusion, reactive oxygen species, subsarcolemmal mitochondria, interfibrillar mitochondria, submitochondrial particles, NADH oxidation, rabbit heart
- MeSH terms
- Animals, Antimycin A, Cardiolipins, Electron Transport Complex IV, Electron Transport, Hydrogen Peroxide, Mitochondria, Heart, Rabbits, Rotenone, Myocardial Reperfusion Injury, Myocardial Ischemia, Sodium Azide, Cytochromes c
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