The DOI matches its Crossref record; 235 of the 235 references it cites were found in a registry or an index.
Mitochondria and reactive oxygen species
Open accessAbstract
Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the majority of cell types. Here we review the sources and metabolism of ROS in this organelle, including the conditions that regulate the production of these species, such as mild uncoupling, oxygen tension, respiratory inhibition, Ca2+ and K+ transport, and mitochondrial content and morphology. We discuss substrate-, tissue-, and organism-specific characteristics of mitochondrial oxidant generation. Several aspects of the physiological and pathological roles of mitochondrial ROS production are also addressed.
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“In the presence of these inhibitors, the highly reduced state of components of the electron transport system causes a rise in the production of superoxide at these sites [47,48], which would be a challenge to cell survival.”
From Proliferating Astrocytes in Primary Culture Do Not Depend upon Mitochondrial Respiratory Complex I Activity or Oxidative Phosphorylation (2023) · cites this paper as [48]
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“Thus, mitochondrial deficiencies that decrease matrix NADH or mitochondrial membrane potential will theoretically decrease mitochondrial NADPH regeneration, contributing to oxidative stress (226).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [226]
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Cites
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Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
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Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
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Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484
Oxidative stress and autophagy: The clash between damage and metabolic needs
Filomeni, G., De Zio, D., & Cecconi, F. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.150 · Cited by 2,195
Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655
Nolfi-Donegan, D., Braganza, A., & Shiva, S. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101674 · Cited by 1,488
Brand, M. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.001 · Cited by 1,063
Metadata
- Authors
- Kowaltowski, A. J., de Souza-Pinto, N. C., Castilho, R. F., & Vercesi, A. E.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 47
- Issue
- 4
- Pages
- 333-343
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2016693012
- Cited by
- 1,162
- References
- 235
- Citations by year
- 2026: 39 · 2025: 48 · 2024: 52 · 2023: 72 · 2022: 51 · 2021: 77 · 2020: 76 · 2019: 52 · 2018: 70 · 2017: 68 · 2016: 70 · 2015: 76 · 2014: 91 · 2013: 98 · 2012: 82
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondria, reactive oxygen species, mitochondrial ROS production, mitochondrial uncoupling, oxygen partial pressure, respiratory inhibition, calcium transport, potassium transport, mitochondrial morphology, mitochondrial content
- MeSH terms
- Aging, Animals, Calcium, Electron Transport, Humans, Mitochondria, Potassium, Respiration, Signal Transduction, Reactive Oxygen Species, Proton Pumps, Oxidative Stress, Feedback, Physiological
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