Mitochondria and reactive oxygen species

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207

The L-Arginine-Nitric Oxide Pathway

Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084

[1] Role of free radicals and catalytic metal ions in human disease: An overview

Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994

Cell Death

Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651

Superoxide radical and superoxide dismutases

Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185

Mitochondrial free radical generation, oxidative stress, and aging

Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484

Oxidative stress and autophagy: The clash between damage and metabolic needs

Filomeni, G., De Zio, D., & Cecconi, F. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.150 · Cited by 2,195

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655

Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

Nolfi-Donegan, D., Braganza, A., & Shiva, S. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101674 · Cited by 1,488

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Brand, M. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.001 · Cited by 1,063

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

Verdin, E., Hirschey, M. D., Finley, L. W. S., & Haigis, M. C. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.003 · Cited by 661

Functions of ROS in Macrophages and Antimicrobial Immunity

Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042357 · Cited by 545

Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise

Goncalves, R. L. S., Quinlan, C. L., Perevoshchikova, I. V., Hey-Mogensen, M., & Brand, M. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.619072 · Cited by 329

DAMPs as mediators of sterile inflammation in aging-related pathologies

Feldman, N., Rotter-Maskowitz, A., & Okun, E. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.003 · Cited by 283

T cells and reactive oxygen species

Belikov, A. V., Schraven, B., & Simeoni, L. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0194-3 · Cited by 264

Redox activation of Nrf2 & NF-κB: A double end sword?

Buelna-Chontal, M., & Zazueta, C. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.08.007 · Cited by 239

Differential effects of complex II on mitochondrial ROS production and their relation to cardioprotective pre- and postconditioning

Dröse, S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.01.004 · Cited by 201

Human nlrp3 inflammasome activation is nox1-4 independent

van Bruggen, R., Köker, M. Y., Jansen, M., van Houdt, M., Roos, D., Kuijpers, T. W., & van den Berg, T. K. (2010) · Blood · doi:10.1182/blood-2009-10-250803 · Cited by 202

Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: An experimental-computational study

Aon, M. A., Stanley, B. A., Sivakumaran, V., Kembro, J. M., O'Rourke, B., Paolocci, N., & Cortassa, S. (2012) · Journal of General Physiology · doi:10.1085/jgp.201210772 · Cited by 200

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

Gianni, D., Taulet, N., Zhang, H., DerMardirossian, C., Kister, J., Martinez, L., Roush, W. R., Brown, S. J., Bokoch, G. M., & Rosen, H. (2010) · ACS Chemical Biology · doi:10.1021/cb100219n · Cited by 192

Mitochondrial uncoupling and lifespan

Mookerjee, S. A., Divakaruni, A. S., Jastroch, M., & Brand, M. D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.010 · Cited by 169

Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease

Cordero, M. D., De Miguel, M., Moreno Fernández, A. M., Carmona López, I. M., Garrido Maraver, J., Cotán, D., Gómez Izquierdo, L., Bonal, P., Campa, F., Bullon, P., et al. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2918 · Cited by 165

The Link between Chronic Stress and Accelerated Aging

Yegorov, Y. E., Poznyak, A. V., Nikiforov, N. G., Sobenin, I. A., & Orekhov, A. N. (2020) · Biomedicines · doi:10.3390/biomedicines8070198 · Cited by 147

The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment

Giménez-Palomo, A., Dodd, S., Anmella, G., Carvalho, A. F., Scaini, G., Quevedo, J., Pacchiarotti, I., Vieta, E., & Berk, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.546801 · Cited by 140

Hypoxia Tolerance in Animals: Biology and Application

Gorr, T. A., Wichmann, D., Hu, J., Hermes‐Lima, M., Welker, A. F., Terwilliger, N., Wren, J. F., Viney, M., Morris, S., Nilsson, G. E., et al. (2010) · Physiological and Biochemical Zoology · doi:10.1086/648581 · Cited by 134

Inflammasomes: sensors of metabolic stresses for vascular inflammation

Yang, X.-F. (2013) · Frontiers in Bioscience · doi:10.2741/4127 · Cited by 134

Q-site inhibitor induced ROS production of mitochondrial complex II is attenuated by TCA cycle dicarboxylates

Siebels, I., & Dröse, S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.06.005 · Cited by 130

The Tumor Microenvironment: Characterization, Redox Considerations, and Novel Approaches for Reactive Oxygen Species-Targeted Gene Therapy

Policastro, L. L., Ibañez, I. L., Notcovich, C., Duran, H. A., & Podhajcer, O. L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4367 · Cited by 120

Aldehyde dehydrogenase 2 has cardioprotective effects on myocardial ischaemia/reperfusion injury via suppressing mitophagy

Ji, W., Wei, S., Hao, P., Xing, J., Yuan, Q., Wang, J., Xu, F., & Chen, Y. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00101 · Cited by 106

2,4 Dinitrophenol as Medicine

Geisler, J. G. (2019) · Cells · doi:10.3390/cells8030280 · Cited by 104

Antifungal activity of 1-methylcyclopropene (1-MCP) against anthracnose (Colletotrichum gloeosporioides) in postharvest mango fruit and its possible mechanisms of action

Xu, X., Lei, H., Ma, X., Lai, T., Song, H., Shi, X., & Li, J. (2017) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.10.002 · Cited by 80

The impact of base excision DNA repair in age-related neurodegenerative diseases

Leandro, G. S., Sykora, P., & Bohr, V. A. (2015) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2014.12.011 · Cited by 72

Influence of aging on membrane permeability transition in brain mitochondria

Toman, J., & Fiskum, G. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9337-8 · Cited by 69

Mitochondrial peptidase IMMP2L mutation causes early onset of age‐associated disorders and impairs adult stem cell self‐renewal

George, S. K., Jiao, Y., Bishop, C. E., & Lu, B. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00686.x · Cited by 66

Changes in Oxidative Damage, Inflammation and [NAD(H)] with Age in Cerebrospinal Fluid

Guest, J., Grant, R., Mori, T. A., & Croft, K. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085335 · Cited by 66

A role for human mitochondrial complex II in the production of reactive oxygen species in human skin

Anderson, A., Bowman, A., Boulton, S. J., Manning, P., & Birch-Machin, M. A. (2014) · Redox Biology · doi:10.1016/j.redox.2014.08.005 · Cited by 65

A common mechanism links differently acting complex II inhibitors to cardioprotection: modulation of mitochondrial reactive oxygen species production

Dröse, S., Bleier, L., & Brandt, U. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.070342 · Cited by 64

Redox Characterization of Functioning Skeletal Muscle

Zuo, L., & Pannell, B. K. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00338 · Cited by 60

Actions of 17β-estradiol and testosterone in the mitochondria and their implications in aging

Vasconsuelo, A., Milanesi, L., & Boland, R. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.001 · Cited by 55

Energy demand of synaptic transmission at the hippocampal Schaffer-collateral synapse

Liotta, A., Rösner, J., Huchzermeyer, C., Wojtowicz, A., Kann, O., Schmitz, D., Heinemann, U., & Kovács, R. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.116 · Cited by 48

Amitriptyline induces coenzyme Q deficiency and oxidative damage in mouse lung and liver

Bautista-Ferrufino, M. R., Cordero, M. D., Sánchez-Alcázar, J. A., Illanes, M., Fernández-Rodríguez, A., Navas, P., & de Miguel, M. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.03.033 · Cited by 22

Bacopa monnieri supplements offset paraquat-induced behavioral phenotype and brain oxidative pathways in mice

Krishna, G., Hosamani, R., & Muralidhara (2019) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524919666190115125900 · Cited by 16

Proliferating Astrocytes in Primary Culture Do Not Depend upon Mitochondrial Respiratory Complex I Activity or Oxidative Phosphorylation

Silva, E. A., Dalla Costa, A. P., Ruas, J. S., Siqueira-Santos, E. S., Francisco, A., & Castilho, R. F. (2023) · Cells · doi:10.3390/cells12050683 · Cited by 5

Mitochondrial metabolism of reactive oxygen species

Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336

Reactive Oxygen Species and Oxidative Stress in Obesity—Recent Findings and Empirical Approaches

McMurray, F., Patten, D. A., & Harper, M. (2016) · Obesity · doi:10.1002/oby.21654 · Cited by 253

The role of mitochondria in reactive oxygen species metabolism and signaling

Starkov, A. A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.015 · Cited by 846

Gold-induced reactive oxygen species (ROS) do not mediate suppression of monocytic mitochondrial or secretory function

Omata, Y., Lewis, J. B., Lockwood, P. E., Tseng, W., Messer, R. L. W., Bouillaguet, S., & Wataha, J. C. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.11.001 · Cited by 14

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

Rouschop, K. M. A., Ramaekers, C. H. M. A., Schaaf, M. B. E., Keulers, T. G., Savelkouls, K. G. M., Lambin, P., Koritzinsky, M., & Wouters, B. G. (2009) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2009.06.029 · Cited by 145