Pharmahuasca and DMT rescue ROS production and differentially expressed genes observed after predator and psychosocial stress: Relevance to human PTSD
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R compared to 5-HT. DMT and pharmahuasca reduced ROS production in the PFC and HC, while harmaline had mixed effects. Treatments normalized 9, 12, and 14 overlapping DEGs, and pathway analysis implicated that genes were involved in ROS production, inflammation, growth factor signaling, neurotransmission, and neuroplasticity.
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Harmine, tetrahydroharmine, harmaline, and dimethyltryptamine stimulate adult neurogenesis and neuroplasticity similarly to other serotoninergic psychedelic substances.
“in vitro, animal and human studies have demonstrated how harmine, tetrahydroharmine, harmaline (all three present in B. caapi) and dimethyltryptamine (present in P. viridis) stimulate adult neurogenesis and neuroplasticity, similarly to other serotoninergic psychedelic substances (40–43).”
From Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol (2025) · cites this paper as [41]
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Towards an understanding of psychedelic-induced neuroplasticity
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- Authors
- Kelley, D. P., Venable, K., Destouni, A., Billac, G., Ebenezer, P., Stadler, K., Nichols, C., Barker, S., & Francis, J.
- Affiliations
- Louisiana State University (US)
- Louisiana State University Health Sciences Center New Orleans (US)
- Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, United States
- Corresponding author
- Kelley, D. Parker
- Francis, Joseph
- ORCID
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-01-06
- Volume
- 13
- Issue
- 2
- Pages
- 257-274
- ISSN
- 1948-7193 (ISSN-L)
- OpenAlex
- W4205158881
- Cited by
- 42
- References
- 115
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 5 · 2023: 7 · 2022: 5
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- ACS Chemical Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Civil War Book Review (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- DMT, harmaline, reactive oxygen species, predator stress, psychosocial stress, post-traumatic stress disorder, differentially expressed genes, prefrontal cortex, hippocampus, inflammation, neuroplasticity, neurotransmission, growth factor signaling
- MeSH terms
- Dorsolateral Prefrontal Cortex, Animals, N,N-Dimethyltryptamine, Humans, Stress Disorders, Post-Traumatic, Stress, Psychological, Reactive Oxygen Species, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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