Cited by 42Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorPosttraumatic Stress Disorder Research

Pharmahuasca and DMT rescue ROS production and differentially expressed genes observed after predator and psychosocial stress: Relevance to human PTSD

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Kelley, D. Parker, Venable, Katy, Destouni, Aspasia, Billac, Gerald, Ebenezer, Philip, Stadler, Krisztian, Nichols, Charles, Barker, Steven +1 more·2022·ACS Chemical Neuroscience

Abstract

R compared to 5-HT. DMT and pharmahuasca reduced ROS production in the PFC and HC, while harmaline had mixed effects. Treatments normalized 9, 12, and 14 overlapping DEGs, and pathway analysis implicated that genes were involved in ROS production, inflammation, growth factor signaling, neurotransmission, and neuroplasticity.

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Crossref · 10.1021/acschemneuro.1c00660

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115 of 115 references verified0 citation errors · 0 not checkable

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  • Harmine, tetrahydroharmine, harmaline, and dimethyltryptamine stimulate adult neurogenesis and neuroplasticity similarly to other serotoninergic psychedelic substances.

    “in vitro, animal and human studies have demonstrated how harmine, tetrahydroharmine, harmaline (all three present in B. caapi) and dimethyltryptamine (present in P. viridis) stimulate adult neurogenesis and neuroplasticity, similarly to other serotoninergic psychedelic substances (40–43).”

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Authors
Kelley, D. P., Venable, K., Destouni, A., Billac, G., Ebenezer, P., Stadler, K., Nichols, C., Barker, S., & Francis, J.
Affiliations
  • Louisiana State University (US)
  • Louisiana State University Health Sciences Center New Orleans (US)
  • Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, United States
Corresponding author
  • Kelley, D. Parker
  • Francis, Joseph
Venue
ACS Chemical Neuroscience
Published
2022-01-06
Volume
13
Issue
2
Pages
257-274
ISSN
1948-7193 (ISSN-L)
OpenAlex
W4205158881
Cited by
42
References
115
Citations by year
2026: 9 · 2025: 16 · 2024: 5 · 2023: 7 · 2022: 5
FWCI
7.52
Type
journal article
Language
en
Open access
Locations
  • ACS Chemical Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Civil War Book Review (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords
DMT, harmaline, reactive oxygen species, predator stress, psychosocial stress, post-traumatic stress disorder, differentially expressed genes, prefrontal cortex, hippocampus, inflammation, neuroplasticity, neurotransmission, growth factor signaling
MeSH terms
Dorsolateral Prefrontal Cortex, Animals, N,N-Dimethyltryptamine, Humans, Stress Disorders, Post-Traumatic, Stress, Psychological, Reactive Oxygen Species, Rats

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