Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms
Abstract
Oxidants have critical functions inside healthy and unhealthy cells. Deregulated cell cycle and apoptosis, both regulated by oxidative stress, have been described as hallmarks of mitotic (cancer) and postmitotic (neuronal) cells. This review provides an updated revision of the oxidant effects of some environmental contaminants such as dioxins and the heavy metals cadmium, cobalt, and copper. Dioxins exert their toxic actions by acting on phase I and phase II enzymes, such as cytochromes P450, superoxide dismutase, and glutathione peroxidase, promoting cell proliferation, growth arrest, and apoptosis, affecting cancer homeostasis and neuronal function. Heavy metals manifest cytotoxic effects in various cells and tissues, and tight regulation of metals is essential to the health of organisms. Cadmium modulates gene expression and signal transduction and reduces activities of proteins involved in antioxidant defense, interfering with DNA repair and modifying cancer development and brain function. Cobalt provokes generation of reactive oxygen species and DNA damage in cancer cells and brain tissues, altering proliferation and differentiation and causing apoptosis. Copper is a key metal in cell division processes in both normal and tumor cells. Copper also has been shown to have an important role in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exposure to heavy metals can detrimentally impact many bodily functions, inducing neurological and behavioral impairment.
“Exposure to heavy metals can detrimentally impact many bodily functions, inducing neurological and behavioral impairment [191–195].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [194]
Cites
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680 · see citing works
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452 · see citing works
Oxidative mechanisms in the toxicity of metal ions
Stohs, S. J., & Bagchi, D. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00159-h · Cited by 4,219 · see citing works
Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378 · see citing works
Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology
Matés, J. M. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00306-1 · Cited by 1,510 · see citing works
Self-citationCadmium, Environmental Exposure, and Health Outcomes
Satarug, S., Garrett, S. H., Sens, M. A., & Sens, D. A. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901234 · Cited by 1,172 · see citing works
Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein
Uversky, V. N., Li, J., & Fink, A. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105343200 · Cited by 1,103 · see citing works
Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm.1868 · Cited by 935 · see citing works
Bertin, G., & Averbeck, D. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.001 · Cited by 934 · see citing works
Role of oxidative stress in cadmium toxicity and carcinogenesis
Liu, J., Qu, W., & Kadiiska, M. B. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.01.029 · Cited by 855 · see citing works
Signaling Functions of Reactive Oxygen Species
Forman, H. J., Maiorino, M., & Ursini, F. (2010) · Biochemistry · doi:10.1021/bi9020378 · Cited by 827 · see citing works
Copper in diseases and treatments, and copper‐based anticancer strategies
Tisato, F., Marzano, C., Porchia, M., Pellei, M., & Santini, C. (2009) · Medicinal Research Reviews · doi:10.1002/med.20174 · Cited by 801 · see citing works
Oxidative stress and apoptosis: Impact on cancer therapy
Ozben, T. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20874 · Cited by 751 · see citing works
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727 · see citing works
Copper in the brain and Alzheimer’s disease
Hung, Y. H., Bush, A. I., & Cherny, R. A. (2009) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-009-0600-y · Cited by 496 · see citing works
Matés, J. M., Segura, J. A., Alonso, F. J., & Márquez, J. (2008) · Archives of Toxicology · doi:10.1007/s00204-008-0304-z · Cited by 460 · see citing works
Self-citationMultitargeted therapy of cancer by silymarin
Ramasamy, K., & Agarwal, R. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.053 · Cited by 443 · see citing works
Wells, P. G., McCallum, G. P., Chen, C. S., Henderson, J. T., Lee, C. J. J., Perstin, J., Preston, T. J., Wiley, M. J., & Wong, A. W. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfn263 · Cited by 430 · see citing works
The stimulation of angiogenesis and collagen deposition by copper
Gérard, C., Bordeleau, L., Barralet, J. E., & Doillon, C. J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.009 · Cited by 420 · see citing works
López, E., Arce, C., Oset‐Gasque, M. J., Cañadas, S., & González, M. P. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.062 · Cited by 402 · see citing works
Environmental-induced oxidative stress in neurodegenerative disorders and aging
Migliore, L., & Coppedè, F. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.09.013 · Cited by 396 · see citing works
Metals and apoptosis: Recent developments
Rana, S. V. S. (2008) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2008.08.002 · Cited by 380 · see citing works
Reactive oxygen species: Destroyers or messengers?
Bartosz, G. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.009 · Cited by 379 · see citing works
Agarwal, A. K., Gupta, S., Sekhon, L. H., & Shah, R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1964 · Cited by 360 · see citing works
Théophanides, T., & Anastassopoulou, J. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(02)00007-0 · Cited by 354 · see citing works
Multifunctional Activities of Green Tea Catechins in Neuroprotection
Mandel, S. A., Avramovich‐Tirosh, Y., Reznichenko, L., Zheng, H., Weinreb, O., Amit, T., & Youdim, M. B. H. (2005) · Neurosignals · doi:10.1159/000085385 · Cited by 347 · see citing works
Matés, J. M., Pérez‐Gómez, C., de Castro, I. N., Asenjo, M., & Márquez, J. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00143-1 · Cited by 340 · see citing works
Self-citationCauses of oxidative stress in Alzheimer disease
Zhu, X., Su, B., Wang, X., Smith, M. A., & Perry, G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7218-4 · Cited by 336 · see citing works
COPPER AND ANGIOGENESIS: UNRAVELLING A RELATIONSHIP KEY TO CANCER PROGRESSION
Finney, L. A., Vogt, S., Fukai, T., & Glesne, D. A. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04969.x · Cited by 314 · see citing works
Oxidative Stress: Apoptosis in Neuronal Injury
Loh, K. P., Huang, S. H., de Silva, R., Tan, B., & Zhu, Y. Z. (2006) · Current Alzheimer Research · doi:10.2174/156720506778249515 · Cited by 298 · see citing works
Guilloreau, L., Combalbert, S., Sournia‐Saquet, A., Mazarguil, H., & Faller, P. (2007) · ChemBioChem · doi:10.1002/cbic.200700111 · Cited by 273 · see citing works
Kawanishi, S., Hiraku, Y., Murata, M., & Oikawa, S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00779-7 · Cited by 271 · see citing works
DNA repair in neurons: So if they don’t divide what's to repair?
Fishel, M. L., Vasko, M. R., & Kelley, M. R. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.06.007 · Cited by 256 · see citing works
Park, J. Y., Shigenaga, M. K., & Ames, B. N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2322 · Cited by 255 · see citing works
A threshold concept for cancer therapy
Kong, Q., Beel, J. A., & Lillehei, K. O. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.0982 · Cited by 250 · see citing works
Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium
Acharya, U. R., Mishra, M., Patro, J., & Panda, M. K. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.10.004 · Cited by 228 · see citing works
Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis
Witkiewicz-Kucharczyk, A., & Bal, W. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.10.018 · Cited by 215 · see citing works
Salivary analysis in oral cancer patients
Bahar, G., Feinmesser, R., Shpitzer, T., Popovtzer, A., & Nagler, R. M. (2006) · Cancer · doi:10.1002/cncr.22386 · Cited by 191 · see citing works
Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity
Meloni, G., Sonois, V., Delaine, T., Guilloreau, L., Gillet, A., Teissié, J., Faller, P., & Vašák, M. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.89 · Cited by 190 · see citing works
Wang, J., Rahman, M. F., Duhart, H. M., Newport, G. D., Patterson, T. A., Murdock, R. C., Hussain, S. M., Schlager, J. J., & Ali, S. F. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.09.005 · Cited by 188 · see citing works
Zou, W., Yan, M., Xu, W., Huo, H., Sun, L., Zheng, Z., & Liu, X. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1118 · Cited by 185 · see citing works
Neurochemical Targets and Behavioral Effects of Organohalogen Compounds: An Update
Mariussen, E., & Fonnum, F. (2006) · Critical Reviews in Toxicology · doi:10.1080/10408440500534164 · Cited by 175 · see citing works
Mitochondrial DNA damage and a hypoxic response are induced by CoCl2 in rat neuronal PC12 cells
Wang, G. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.10.2135 · Cited by 173 · see citing works
Carcinogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in experimental models
Knerr, S., & Schrenk, D. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600006 · Cited by 169 · see citing works
Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines
Davison, K. L., Côté, S., Mader, S., & Miller, W. H. (2003) · Leukemia · doi:10.1038/sj.leu.2402876 · Cited by 165 · see citing works
Molecular mechanisms of cadmium induced mutagenicity
Filipič, M., Fatur, T., & Vudrag, M. (2006) · Human & Experimental Toxicology · doi:10.1191/0960327106ht590oa · Cited by 162 · see citing works
Ikediobi, C. O., Badisa, V. L. D., Ayuk‐Takem, L. T., Latinwo, L. M., & West, J. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.14.1.87 · Cited by 157 · see citing works
Activation of Nrf2 in Defense against Cadmium-Induced Oxidative Stress
He, X., Chen, M. G., & Ma, Q. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800019a · Cited by 157 · see citing works
Faria, M., Carrasco, L., Dı́ez, S., Riva, M. C., Bayona, J. M., & Barata, C. (2008) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.07.012 · Cited by 152 · see citing works
Liu, G., Men, P., Kudo, W., Perry, G., & Smith, M. A. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.064 · Cited by 148 · see citing works
Reactive oxygen species in melanoma and its therapeutic implications
Wittgen, H. G. M., & van Kempen, L. C. L. T. (2007) · Melanoma Research · doi:10.1097/cmr.0b013e3282f1d312 · Cited by 144 · see citing works
Bioimaging Probes for Reactive Oxygen Species and Reactive Nitrogen Species
Nagano, T. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.r09-66 · Cited by 143 · see citing works
Cell-density-dependent regulation of neural precursor cell function
Limoli, C. L., Rola, R., Giedzinski, E., Mantha, S., Huang, T., & Fike, J. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407065101 · Cited by 136 · see citing works
Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium
Rockwell, P. (2003) · Cellular Signalling · doi:10.1016/j.cellsig.2003.08.006 · Cited by 132 · see citing works
Cadmium-Induced Oxidative Cellular Damage in Human Fetal Lung Fibroblasts (MRC-5 Cells)
Yang, C., Shen, H., Shen, Y., Zhuang, Z. X., & Ong, C. N. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105712 · Cited by 127 · see citing works
Wen, S., Yang, F., Gong, Y. J., Zhang, X., Hui, Y., Li, J., Liu, A., Wu, Y., Lu, W.-Q., & Xu, Y. (2008) · Environmental Science & Technology · doi:10.1021/es800044m · Cited by 122 · see citing works
Roux, S., Breu, V., Giller, T., Neidhart, W. L., Ramuz, H., Coassolo, P., Clozel, J., & Clozel, M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37130-7 · Cited by 116 · see citing works
Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis.
Melnick, R. L., Kohn, M. C., & Portier, C. J. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s1123 · Cited by 113 · see citing works
Lavigne, J. A., Goodman, J. E., Fonong, T., Odwin, S.-A., He, P., Roberts, D. W., & Yager, J. D. (2001) · PubMed · Cited by 113 · see citing works
Huang, Y., Shih, C.-M., Huang, C., Lin, C., Chou, C., Tsai, M., Liu, T. P., Chiu, J., & Chen, C. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20772 · Cited by 112 · see citing works
Dikalov, S., Vitek, M. P., & Mason, R. P. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.004 · Cited by 109 · see citing works
Biomarkers of oxidative damage to DNA and repair
Loft, S. H., Danielsen, P. H., Mikkelsen, L., Risom, L., Forchhammer, L., & Möller, P. (2008) · Biochemical Society Transactions · doi:10.1042/bst0361071 · Cited by 109 · see citing works
Cole, G. M., & Frautschy, S. A. (2006) · Nutrition and Health · doi:10.1177/026010600601800307 · Cited by 109 · see citing works
Induction of oxidative damage by copper-based antineoplastic drugs (Casiopeínas®)
Alemón‐Medina, R., Breña-Valle, M., Muñoz-Sánchez, J. L., Gracia‐Mora, I., & Ruíz-Azuara, L. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-006-0364-9 · Cited by 107 · see citing works
Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells
Stolzing, A., & Grune, T. (2004) · The FASEB Journal · doi:10.1096/fj.03-0374fje · Cited by 107 · see citing works
Li, G., & Osborne, N. N. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.073 · Cited by 106 · see citing works
Safe, S. H. (1997) · Teratogenesis Carcinogenesis and Mutagenesis · doi:10.1002/(sici)1520-6866(1997)17:4/5 · Cited by 102 · see citing works
Cell Apoptosis Induced by Carcinogenic Metals
Chen, F., Vallyathan, V., Castranova, V., & Shi, X. (2001) · Springer eBooks · doi:10.1007/978-1-4615-0793-2_21 · Cited by 101 · see citing works
Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity
Murray, I. A., Morales, J. L., Flaveny, C. A., DiNatale, B. C., Chiaro, C. R., Gowda, K., Amin, S., & Perdew, G. H. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.061788 · Cited by 100 · see citing works
HIF and reactive oxygen species regulate oxidative phosphorylation in cancer
Hervouet, É., Vrbacká-Čížková, A., Demont, J., Pecinová, A., Pecina, P., Hal, N. L. W. F.-V., Keijer, J., Simonnet, H., Ivánek, R., Kmoch, S., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn125 · Cited by 99 · see citing works
Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease
Castellani, R. J., Honda, K., Zhu, X., Cash, A., Nunomura, A., Perry, G. L., & Smith, M. A. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.01.002 · Cited by 97 · see citing works
Cell apoptosis induced by carcinogenic metals
Chen, F., Vallyathan, V., Castranova, V., & Shi, X. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1017970330982 · Cited by 97 · see citing works
Delaying the Mitochondrial Decay of Aging
Ames, B. N. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.073 · Cited by 94 · see citing works
Nair, J., Sone, H., Nagao, M., Barbin, A., & Bartsch, H. (1996) · PubMed · Cited by 93 · see citing works
Frelon, S., Douki, T., Favier, A. E., & Cadet, J. (2003) · Chemical Research in Toxicology · doi:10.1021/tx025650q · Cited by 92 · see citing works
Orhan, G., Orhan, I., Subutay-Oztekin, N., Ak, F., & Sener, B. (2009) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488909787002582 · Cited by 90 · see citing works
Lin, P., LIN, C., Chuang, M.-C., CHUANG, M., & LIN, P. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.06.003 · Cited by 89 · see citing works
Perrone, L., Mothes-Martin, E., Vignes, M., Mockel, A., Figueroa, C. M., Miquel, M., Maddelein, M., & Faller, P. (2009) · ChemBioChem · doi:10.1002/cbic.200900474 · Cited by 89 · see citing works
Redox-Based Escape Mechanism from Death: The Cancer Lesson
Pani, G., Giannoni, E., Galeotti, T., & Chiarugi, P. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2739 · Cited by 89 · see citing works
Patel, R. D., Hollingshead, B. D., Omiecinski, C. J., & Perdew, G. H. (2007) · Hepatology · doi:10.1002/hep.21671 · Cited by 88 · see citing works
Modulation of Sirtuins: New Targets for Antiageing
Pallàs, M., Verdaguer, E., Tajes, M., Cuesta, J., & Camins, A. (2008) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488908783421492 · Cited by 88 · see citing works
Boeck, M. D. (1998) · Carcinogenesis · doi:10.1093/carcin/19.11.2021 · Cited by 88 · see citing works
Pharmacokinetics and Molecular Detoxication
Cashman, J. R., Perotti, B. Y. T., Berkman, C. E., & Lin, J. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s123 · Cited by 84 · see citing works
ERK and cell death: cadmium toxicity, sustained ERK activation and cell death
Martin, P., & Pognonec, P. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07369.x · Cited by 83 · see citing works
Yang, C., Tzou, B., Liu, Y., Tsai, M., Shyue, S., & Tzeng, S. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21452 · Cited by 81 · see citing works
Nair, J., Strand, S., Frank, N., Knauft, J., Wesch, H., Galle, P. R., & Bartsch, H. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi073 · Cited by 81 · see citing works
Wang, H., Cheng, E., Brooke, S. M., Chang, P. P., & Sapolsky, R. M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02123.x · Cited by 79 · see citing works
Lai, Y., Tsai, P.-S., & Huang, C.-J. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.07.010 · Cited by 77 · see citing works
Pathways from glutamine to apoptosis
Matés, J. M. (2006) · Frontiers in bioscience · doi:10.2741/2040 · Cited by 75 · see citing works
Self-citationTrumbull, K. A., & Beckman, J. S. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2574 · Cited by 75 · see citing works
Inhibition of B(a)P induced strand breaks in presence of curcumin
Polasa, K., Naidu, A., Ravindranath, I., & Krishnaswamy, K. (2003) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.10.016 · Cited by 75 · see citing works
The Aryl Hydrocarbon Receptor Directly Regulates Expression of the Potent Mitogen Epiregulin
Patel, R. D., Kim, D. J., Peters, J. M., & Perdew, G. H. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi344 · Cited by 74 · see citing works
Tritscher, A. M., Seacat, A. M., Yager, J. D., Groopman, J. D., Miller, B. D., Bell, D. A., Sutter, T. R., & Lucier, G. W. (1996) · Cancer Letters · doi:10.1016/s0304-3835(06)80035-2 · Cited by 72 · see citing works
Cobalt toxicity: Chemical and radiological combined effects on HaCaT keratinocyte cell line
Gault, N., Sandre, C., Poncy, J. L., Moulin, C., Lefaix, J.-L., & Bresson, C. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.08.027 · Cited by 69 · see citing works
Akan, I., Akan, S., Akça, H., Savaş, B., & Özben, T. (2005) · Cancer Cell International · doi:10.1186/1475-2867-5-22 · Cited by 68 · see citing works
Mutagenesis by metal-induced oxygen radicals.
Reid, T. M., Feig, D. I., & Loeb, L. A. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102s357 · Cited by 67 · see citing works
Thibodeau, P. A., & Paquette, B. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00183-5 · Cited by 67 · see citing works
Eybl, V., Kotyzová, D., Lešetický, L., Bludovská, M., & Koutensky, J. (2005) · Journal of Applied Toxicology · doi:10.1002/jat.1124 · Cited by 64 · see citing works
RX 821002 as a Tool for Physiological Investigation of α2‐Adrenoceptors
Clarke, R. W., & Harris, J. E. (2002) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2002.tb00222.x · Cited by 64 · see citing works
Sato, M., & Noble‐Haeusslein, L. J. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00817-8 · Cited by 61 · see citing works
Natural Antioxidants: Therapeutic Prospects for Cancer and Neurological Diseases
Matés, J. M., Segura, J., Alonso, F. J., & Márquez, J. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709789055180 · Cited by 59 · see citing works
Self-citationCooke, M. S., Loft, S. H., Oliński, R., Evans, M. D., Białkowski, K., Wagner, J. R., Dedon, P. C., Möller, P., Greenberg, M. M., & Cadet, J. (2010) · Chemical Research in Toxicology · doi:10.1021/tx1000706 · Cited by 58 · see citing works
Cai, X., Pan, N., & Zou, G. (2006) · BioMetals · doi:10.1007/s10534-006-9008-0 · Cited by 57 · see citing works
Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function
Garratt, J. C., Crespi, F., Mason, R. J., & Marsden, C. A. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90204-4 · Cited by 56 · see citing works
Metals and metal compounds in carcinogenesis.
Desoize, B. (2004) · PubMed · Cited by 55 · see citing works
Kasprzak, K. S., Zastawny, T. H., North, S. L., Riggs, C. W., Diwan, B. A., Rice, J. M., & Dizdaroğlu, M. (1994) · Chemical Research in Toxicology · doi:10.1021/tx00039a009 · Cited by 54 · see citing works
Metal inhibition of human N-methylpurine-DNA glycosylase activity in base excision repair
Wang, P., Guliaev, A. B., & Hang, B. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.06.647 · Cited by 53 · see citing works
Can Nutrition Affect Chemical Toxicity
Fürst, A. (2002) · International Journal of Toxicology · doi:10.1080/10915810290096649 · Cited by 52 · see citing works
The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage
Kaindl, U., Eyberg, I., Rohr‐Udilova, N., Heinzle, C. F., & Marian, B. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.002 · Cited by 52 · see citing works
Verma, R., Ramnath, J., Clemens, F., Kaspin, L. C., & Landolph, J. R. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000007276.94488.3d · Cited by 50 · see citing works
Wyde, M. E., Wong, V. A., Kim, A. H., Lucier, G. W., & Walker, N. J. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000266j · Cited by 50 · see citing works
Fenoglio, I., Corazzari, I., Francia, C., Bodoardo, S., & Fubini, B. (2008) · Free Radical Research · doi:10.1080/10715760802350904 · Cited by 50 · see citing works
Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease
Marlatt, M. W., Lee, H., Perry, G. L., Smith, M. A., & Zhu, X. (2004) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2004-1493 · Cited by 50 · see citing works
Matsumura, F. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.3.695s · Cited by 49 · see citing works
Inflammation, but not hypoxia, mediated HIF-1α activation depends on COX-2
Stasinopoulos, I. A., O’Brien, D. R., & Bhujwalla, Z. M. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.1.7079 · Cited by 49 · see citing works
Inhibition of antimutagenic enzymes, 8-oxo-dGTPases, by carcinogenic metals. Recent developments
Kasprzak, K. S., & Białkowski, K. (2000) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(99)00240-8 · Cited by 46 · see citing works
Yang, S., Misner, B., Chiu, R. J., & Meyskens, F. L. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm128 · Cited by 46 · see citing works
Forti, E., Bulgheroni, A., Çetin, Y., Härtung, T., Jennings, P., Pfaller, W., & Prieto, P. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000272060 · Cited by 45 · see citing works
Measurement of oxidatively generated base damage in cellular DNA and urine
Cadet, J., & Poulsen, H. E. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.004 · Cited by 44 · see citing works
Akahoshi, E., Yoshimura, S., Uruno, S., & Ishihara‐Sugano, M. (2009) · Environmental Health · doi:10.1186/1476-069x-8-24 · Cited by 44 · see citing works
Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells
Qian, Y., Zheng, Y., Abraham, L., Ramos, K. S., & Tiffany‐Castiglioni, E. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.11.004 · Cited by 43 · see citing works
Porter, D. W. (1997) · Carcinogenesis · doi:10.1093/carcin/18.9.1785 · Cited by 43 · see citing works
Biological oxidants and antioxidants
Packer, L., Cadenas, E., & Jo, D. (1995) · Transplant International · doi:10.1007/bf00336549 · Cited by 43 · see citing works
Vondráček, J., Krčmář, P., Procházková, J., Trilecová, L., Gavelová, M., Skálová, L., Szotáková, B., Bunček, M., Radilová, H., Kozubı́k, A., et al. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.03.011 · Cited by 42 · see citing works
Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline
Soh, Y. (2003) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.06.023 · Cited by 42 · see citing works
Environmental contaminants in pathogenesis of breast cancer.
Mukherjee, S., Koner, B. C., Ray, S., & Ray, A. (2006) · PubMed · Cited by 42 · see citing works
Kim, H.-J., Soh, Y., Jang, J. H., Lee, J. S., Oh, Y. J., & Surh, Y. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12605-3 · Cited by 40 · see citing works
Popp, J. A., Crouch, E. A. C., & McConnell, E. E. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj016 · Cited by 39 · see citing works
Sanada, N., Gotoh, Y., Shimazawa, R., Klinge, C. M., & Kizu, R. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08328fp · Cited by 38 · see citing works
Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line
Mikami, Y., Hisatsune, A., Tashiro, T., Isohama, Y., & Katsuki, H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.002 · Cited by 37 · see citing works
Molecular Carcinogenesis and the Molecular Biology of Human Cancer
(2005) · CRC Press eBooks · doi:10.1201/9780203503430 · Cited by 36 · see citing works
Landolph, J. R., Verma, A., Ramnath, J., & Clemens, F. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s5845 · Cited by 36 · see citing works
Kotake‐Nara, E., Takizawa, S., Quan, J., Wang, H., & Saida, K. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20568 · Cited by 35 · see citing works
Lin, P.-H., Pan, W., Kang, Y.-W., Chen, Y.-L., Lin, C.-H., Lee, M.-C., Chou, Y.-H., & Nakamura, J. (2005) · Chemical Research in Toxicology · doi:10.1021/tx050018t · Cited by 34 · see citing works
Eckers, A., Reimann, K., & Klotz, L. (2008) · BioMetals · doi:10.1007/s10534-008-9167-2 · Cited by 34 · see citing works
Spisni, E., Valerii, M. C., Manerba, M., Strillacci, A., Polazzi, E., Toni, M., Griffoni, C., & Tomasi, V. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.03.005 · Cited by 33 · see citing works
Kamiya, H. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.06.003 · Cited by 32 · see citing works
Copper related toxic effects on cellular protein metabolism in human astrocytes
Merker, K., Hapke, D., Reckzeh, K., Schmidt, H., Lochs, H. H., & Grune, T. (2005) · BioFactors · doi:10.1002/biof.5520240130 · Cited by 32 · see citing works
Interaction of carcinogenic metal compounds with deoxyribonucleic acid repair processes.
Hartwig, A., Schlepegrell, R., Dally, H., & Hartmann, M. (1996) · PubMed · Cited by 32 · see citing works
Wimalasena, D. S., Wiese, T. J., & Wimalasena, K. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04362.x · Cited by 29 · see citing works
Kotake‐Nara, E., & Saida, K. (2006) · The Scientific World JOURNAL · doi:10.1100/tsw.2006.37 · Cited by 29 · see citing works
Oxidativer Stress, altersabhängige Zellschädigungen und antioxidative Mechanismen
Gosslau, A., & Rensing, L. (2002) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s003910200018 · Cited by 28 · see citing works
Heavy Metals Modulate Glutamatergic System in Human Platelets
Borges, V. C., Cibin, F. W. S., da Rocha, J. B. T., & Nogueira, C. W. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9231-7 · Cited by 28 · see citing works
Kotake‐Nara, E., & Saida, K. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.06.026 · Cited by 27 · see citing works
Takahasi, H., Yanagi, K., Ueda, M., Nakade, K., & Fukuyama, Y. (2003) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.51.1377 · Cited by 27 · see citing works
Schreck, I., Chudziak, D., Schneider, S., Seidel, A., Platt, K. L., Oesch, F., & Weiß, C. (2009) · Toxicology · doi:10.1016/j.tox.2009.02.006 · Cited by 26 · see citing works
Catechol-estrogen modified DNA: A better antigen for cancer autoantibody
Khan, W. A., Alam, K., & Moinuddin, M. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.06.006 · Cited by 26 · see citing works
Effect of psoralens on Fenton‐like reaction generating reactive oxygen species
Aboul-Enein, H. Y., Kładna, A., Kruk, I., Lichszteld, K., & Michalska, T. (2002) · Biopolymers · doi:10.1002/bip.10285 · Cited by 25 · see citing works
Adamis, P. D. B., Mannarino, S. C., & Eleuthério, E. C. A. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.03.066 · Cited by 24 · see citing works
MacDonald, C. J., Cheng, R. Y. S., Roberts, D. D., Wink, D. A., & Yeh, G. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021063 · Cited by 24 · see citing works
Role of Free Radicals in Metal-Induced Carcinogenesis
Landolph, J. R. (2018) · Routledge eBooks · doi:10.1201/9780203747605-14 · Cited by 23 · see citing works
Mechanism of Cd2+ on DNA cleavage and Ca2+ on DNA repair in liver of silver crucian carp
Wu, C., Wang, L., Liu, C., Gao, F., Su, M., Wu, X. Y., & Hong, F. (2007) · Fish Physiology and Biochemistry · doi:10.1007/s10695-007-9144-7 · Cited by 22 · see citing works
Koenig, M. L., & Meyerhoff, J. L. (2003) · Neurotoxicity Research · doi:10.1007/bf03033384 · Cited by 21 · see citing works
Zhu, X., Zhou, W., Cui, Y., Zhu, L., Li, J., Xia, Z., Shao, B., Wang, H., & Chen, H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.04.080 · Cited by 21 · see citing works
Alcaraz-Zubeldia, M., Boll, M., Montes-López, S., Pérez‐Severiano, F., Martínez‐Lazcano, J. C., Dı́az-Ruiz, A., & Rı́os, C. (2009) · PubMed · Cited by 21 · see citing works
Lee, Y. S., Jin, D., Park, S. H., Han, S. Y., Kim, H. S., Jeong, T. C., Huh, K. Y., & Kim, J. W. (2002) · Free Radical Research · doi:10.1080/1071576021000016517 · Cited by 20 · see citing works
Oxidation and Glycolytic Cleavage of Etheno and Propano DNA Base Adducts
Knutson, C. G., Rubinson, E. H., Akingbade, D., Anderson, C. S., Stec, D. F., Petrova, K. V., Kozekov, I. D., Guengerich, F. P., Rizzo, C. J., & Marnett, L. J. (2009) · Biochemistry · doi:10.1021/bi801654j · Cited by 19 · see citing works
Lee, Y. (2009) · Oncology Reports · doi:10.3892/or_00000337 · Cited by 19 · see citing works
Metallothionein expression in HaCaT and C6 cell lines exposed to cadmium
Nzengue, Y., Lefèbvre, E., Cadet, J., Favier, A. E., Rachidi, W., Steiman, R. L., & Guiraud, P. (2009) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2009.05.005 · Cited by 18 · see citing works
Legare, M. E., Hanneman, W. H., Barhoumi, R., & Tiffany‐Castiglioni, E. (1997) · PubMed · Cited by 18 · see citing works
Gene therapy in the nervous system with superoxide dismutase
Zemlyak, I., Nimon, V., Brooke, S. M., Moore, T., McLaughlin, J. R., & Sapolsky, R. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.109 · Cited by 17 · see citing works
A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats
McCoy, J. G., Strawbridge, C., McMurtrey, K. D., Kane, V. B., & Ward, C. P. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00018-2 · Cited by 16 · see citing works
Copper(II) as an efficient scavenger of singlet molecular oxygen.
Joshi, P. C. (1998) · PubMed · Cited by 15 · see citing works
Keller, J. M., Zelditch, M. L., Huet, Y. M., & Leamy, L. J. (2008) · Toxicologic Pathology · doi:10.1177/0192623308327409 · Cited by 13 · see citing works
Apinan, R., Satarug, S., Ruengweerayut, R., Tassaneeyakul, W., & Na‐Bangchang, K. (2009) · PubMed · Cited by 11 · see citing works
Pavan, M., Todeschini, R., & Orlandi, M. E. (2006) · Annali di Chimica · doi:10.1002/adic.200690004 · Cited by 11 · see citing works
Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase.
Alonso, F. J., Segura, J. A., Lora, J., Lobo, C., Fernandez-Molina, B., Márquez, J., & Matés, J. M. (2005) · PubMed · Cited by 11 · see citing works
Self-citation4-Methoxyestradiol-induced oxidative injuries in human lung epithelial cells
Cheng, Y.-H., Chang, L. W., Cheng, L., Tsai, M., & Lin, P. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.01.024 · Cited by 10 · see citing works
Nelli, S., Craig, J., & Martin, W. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.033 · Cited by 9 · see citing works
In vitro assessment of the effects of cadmium and zinc on mammalian nerve fibres
Moschou, M., Papaefthimiou, C., Kagiava, A., Antonopoulou, E., & Theophilidis, G. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.01.070 · Cited by 9 · see citing works
Zhang, Z., & Buffle, J. (2009) · Environmental Science & Technology · doi:10.1021/es9003526 · Cited by 8 · see citing works
Generation of Antioxidant Adenovirus Gene Transfer Vectors Encoding CuZnSOD, MnSOD, and Catalase
Duffy, A. M., O’Brien, T., & McMahon, J. M. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-411-1_27 · Cited by 6 · see citing works
Budhram, R., & Lau‐Cam, C. A. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.02.017 · Cited by 4 · see citing works
Chemically Induced Morphological and Neoplastic Transformation in C3H/10T1/2 Cl 8 Mouse Embryo Cells
Landolph, J. R. (2005) · CRC Press eBooks · doi:10.1201/9780203503430.ch9 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis
Sinha, K., Das, J., Pal, P. B., & Sil, P. C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1034-4 · Cited by 1,622 · see citing works
The contribution of environmental exposure to the etiology of autism spectrum disorder
Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509 · see citing works
Potential Biotechnological Strategies for the Cleanup of Heavy Metals and Metalloids
Mosa, K. A., Saadoun, I. M. K., Kumar, K., Helmy, M., & Dhankher, O. P. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00303 · Cited by 448 · see citing works
Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin
Barchitta, M., Maugeri, A., Favara, G., Lio, R. M. S., Evola, G., Agodi, A., & Basile, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051119 · Cited by 342 · see citing works
Oxidative stress in apoptosis and cancer: an update
Matés, J. M., Segura, J. A., Alonso, F. J., & Márquez, J. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0906-3 · Cited by 341 · see citing works
Self-citationTraumatic Brain Injury: Oxidative Stress and Neuroprotection
Cornelius, C., Crupi, R., Calabrese, V., Graziano, A., Milone, P., Pennisi, G., Radak, Z. O., Calabrese, E. J., & Cuzzocrea, S. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4981 · Cited by 343 · see citing works
Cadmium-Induced Pathologies: Where Is the Oxidative Balance Lost (or Not)?
Nair, A., DeGheselle, O., Smeets, K., Kerkhove, E. V., & Cuypers, A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036116 · Cited by 333 · see citing works
β-Galactosidase-Based Colorimetric Paper Sensor for Determination of Heavy Metals
Hossain, S. M. Z., & Brennan, J. D. (2011) · Analytical Chemistry · doi:10.1021/ac202290d · Cited by 297 · see citing works
Tajik, S., Beitollahi, H., Nejad, F. G., Dourandish, Z., Khalilzadeh, M. A., Jang, H. W., Venditti, R. A., Varma, R. S., & Shokouhimehr, M. (2021) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.0c04952 · Cited by 298 · see citing works
Perfluoroalkylated substances (PFAS) affect oxidative stress biomarkers in vitro
Wielsøe, M., Long, M., Ghisari, M., & Bonefeld‐Jørgensen, E. C. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.10.014 · Cited by 286 · see citing works
Kruk, J., Aboul-Enein, H. Y., Kładna, A., & Bowser, J. E. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1612059 · Cited by 292 · see citing works
Impacts of environmental toxicants on male reproductive dysfunction
Wong, E. W. P., & Cheng, C. Y. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.01.001 · Cited by 284 · see citing works
Oxidative stress and metal carcinogenesis
Lee, J., Son, Y., Pratheeshkumar, P., & Shi, X. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.002 · Cited by 277 · see citing works
Role of Environmental Contaminants in the Etiology of Alzheimer’s Disease: A Review
Yegambaram, M., Manivannan, B., Beach, T. G., & Halden, R. U. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150204121719 · Cited by 277 · see citing works
Food security and food self‐sufficiency in China: from past to 2050
Bishwajit, G. (2014) · Food and Energy Security · doi:10.1002/fes3.48 · Cited by 262 · see citing works
PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field
Bonato, M., Corrà, F., Bellio, M., Guidolin, L., Tallandini, L., Irato, P., & Santovito, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218020 · Cited by 243 · see citing works
Potential of Curcumin in Skin Disorders
Vollono, L., Falconi, M., Gaziano, R., Iacovelli, F., Dika, E., Terracciano, C., Bianchi, L., & Campione, E. (2019) · Nutrients · doi:10.3390/nu11092169 · Cited by 245 · see citing works
Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA
Radak, Z. O., Zhao, Z., Goto, S., & Koltai, E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.010 · Cited by 226 · see citing works
Kippler, M. J., Tofail, F., Hamadani, J. D., Gardner, R. M., Grantham‐McGregor, S., Bottai, M., & Vahter, M. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104431 · Cited by 223 · see citing works
Branco, V., Canário, J., Lu, J., Holmgren, A., & Carvalho, C. M. L. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.002 · Cited by 186 · see citing works
Sun, J., Fang, R., Wang, H., Xu, D., Yang, J., Huang, X., Cozzolino, D., Fang, M., & Huang, Y. (2021) · Environment International · doi:10.1016/j.envint.2021.106941 · Cited by 184 · see citing works
Ex-Situ Remediation Technologies for Environmental Pollutants: A Critical Perspective
Kuppusamy, S., Thavamani, P., Megharaj, M., Venkateswarlu, K., & Naidu, R. (2015) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-3-319-20013-2_2 · Cited by 172 · see citing works
Oxidative stress and Parkinson’s disease: conflict of oxidant-antioxidant systems
Hemmati-Dinarvand, M., Saedi, S., Valilo, M., Kalantary‐Charvadeh, A., Sani, M. A., Kargar, R., Safari, H., & Samadi, N. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134296 · Cited by 156 · see citing works
Saghazadeh, A., & Rezaei, N. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.011 · Cited by 146 · see citing works
Wang, H., Li, Y., Wei, J., Ji-run, X., Wang, Y., & Zheng, G. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-7715-x · Cited by 125 · see citing works
Ruszkiewicz, J. A., & Albrecht, J. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2014.12.012 · Cited by 122 · see citing works
on behalf of the PUFAH group, Hanson, S., Thorpe, G., Winstanley, L. E., Abdelhamid, A. S., & Hooper, L. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0761-6 · Cited by 115 · see citing works
Chen, S., Ren, Q., Zhang, J., Ye, Y., Zhang, Z., Xu, Y., Guo, M., Ji, H., Xu, C., Gu, C., et al. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12103 · Cited by 113 · see citing works
Cellular Basis of Organotin(IV) Derivatives as Anticancer Metallodrugs: A Review
Annuar, S. N. S., Kamaludin, N. F., Awang, N., & Chan, K. M. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.657599 · Cited by 113 · see citing works
Husain, N., & Mahmood, R. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-05345-1 · Cited by 111 · see citing works
Li, X., Wang, S., Liu, Y., Jiang, L., Song, B., Li, M., Zeng, G., Tan, X., Cai, X., & Ding, Y. (2016) · Journal of Chemical & Engineering Data · doi:10.1021/acs.jced.6b00746 · Cited by 107 · see citing works
Naranmandura, H., Xu, S., Sawata, T., Hao, W. H., Liu, H., Bu, N., Ogra, Y., Lou, Y. J., & Suzuki, N. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200156k · Cited by 103 · see citing works
Shaw, P., Mondal, P., Bandyopadhyay, A., & Chattopadhyay, A. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135622 · Cited by 94 · see citing works
Wu, D., Liu, B., Yin, J., Xu, T., Zhao, S., Xu, Q., Chen, X., & Wang, H. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.08.033 · Cited by 93 · see citing works
Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity
Andréau, K., Leroux, M., & Bouharrour, A. (2012) · Biochemistry Research International · doi:10.1155/2012/493894 · Cited by 94 · see citing works
High doses of cobalt induce optic and auditory neuropathy
Apostoli, P., Catalani, S., Zaghini, A., Mariotti, A., Poliani, P. L., Vielmi, V., Semeraro, F., Duse, S., Porzionato, A., Macchi, V., et al. (2012) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2012.09.006 · Cited by 88 · see citing works
Shahid, M., Farooqi, Z. H., Begum, R., Arif, M., Irfan, A., & Azam, M. (2020) · Chemical Physics Letters · doi:10.1016/j.cplett.2020.137645 · Cited by 87 · see citing works
Modeling the dioxin emission of a municipal solid waste incinerator using neural networks
Bunsan, S., Chen, W., Chen, H., Chuang, Y.-H., & Grisdanurak, N. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.01.083 · Cited by 84 · see citing works
Multielemental Analysis of Bee Pollen, Propolis, and Royal Jelly Collected in West-Central Poland
Matuszewska, E., Klupczyńska-Gabryszak, A., Maciołek, K., Kokot, Z. J., & Matysiak, J. (2021) · Molecules · doi:10.3390/molecules26092415 · Cited by 86 · see citing works
Zeliger, H. I. (2013) · Interdisciplinary Toxicology · doi:10.2478/intox-2013-0018 · Cited by 79 · see citing works
Role of environmental pollutants in Alzheimer’s disease: a review
Mir, R. H., Sawhney, G., Pottoo, F. H., Mohi-ud-din, R., Madishetti, S., Jachak, S. M., Ahmed, Z., & Masoodi, M. H. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-09964-x · Cited by 78 · see citing works
Biological Hallmarks of Cancer in Alzheimer’s Disease
Nudelman, K. N. H., McDonald, B. C., Lahiri, D. K., & Saykin, A. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1591-5 · Cited by 72 · see citing works
Öztürk, P., Kurutaş, E. B., & Ataseven, A. (2013) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2013.04.002 · Cited by 72 · see citing works
Performance IQ in children is associated with blood cadmium concentration in early pregnancy
Jeong, K. S., Park, H., Ha, E., Hong, Y., Ha, M., Park, H., Kim, B.-N., Lee, B.-E., Lee, S.-J., Lee, K. Y., et al. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.11.007 · Cited by 71 · see citing works
The Wisdom of Honeybee Defenses Against Environmental Stresses
Li, G., Zhao, H., Liu, Z., Wang, H., Xu, B., & Guo, X. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00722 · Cited by 71 · see citing works
Jin, Y., Liu, L., Zhang, S., He, R., Wu, Y., Chen, G., & Fu, Z. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.08.084 · Cited by 70 · see citing works
Wan, C., Liu, J., Nie, X., Zhao, J., Zhou, S., Duan, Z., Tang, C., Liang, L., & Xu, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089811 · Cited by 70 · see citing works
RetractedXu, C., Wang, X., Zhu, Y., Dong, X., Liu, C., Zhang, H., Liu, L., Huang, S., & Chen, L. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.01.030 · Cited by 69 · see citing works
Harmful Interactions of Non-Essential Heavy Metals with Cells of the Innate Immune System
GR, T. A. T. (2011) · Journal of Clinical Toxicology · doi:10.4172/2161-0495.s3-005 · Cited by 66 · see citing works
Anticancer Antioxidant Regulatory Functions of Phytochemicals
Matés, J. M., Segura, J. A., Alonso, F. J., & Márquez, J. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711795656036 · Cited by 65 · see citing works
Self-citationYang, Y., Liang, S., Geng, H., Xiong, M., Li, M., Su, Q., Jia, F., Zhao, Y., Wang, K., Jiang, J., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.023 · Cited by 65 · see citing works
Khalaf, E. M., Jabbar, H. S., Romero‐Parra, R. M., Al‐Awsi, G. R. L., Budi, H. S., Altamimi, A. S. A., Gatea, M. A., Falih, K. T., Singh, K., & Alkhuzai, K. A. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.108692 · Cited by 65 · see citing works
Naranmandura, H., Xu, S., Koike, S., Pan, L. Q., Chen, B., Wang, Y. W., Rehman, K., Wu, B., Chen, Z., & Suzuki, N. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.02.017 · Cited by 65 · see citing works
Gong, P., Chen, F., Wang, L., Wang, J., Jin, S., & Ma, Y. (2014) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2014.03.017 · Cited by 63 · see citing works
Breast milk lead and cadmium levels from suburban areas of Ankara
Örün, E., Yalçın, S. S., Aykut, O., Orhan, G., Morgil, G. K., Yurdakök, K., & Uzun, R. (2011) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2011.02.035 · Cited by 62 · see citing works
Nejadshafiee, V., & Islami, M. R. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06732-4 · Cited by 60 · see citing works
Chen, C., Chen, S.-J., Su, C., Yen, C., Tseng, T.-J., Jinn, T., Tang, F., Chen, K., Su, Y., Lee, K.-I., et al. (2012) · Toxicology · doi:10.1016/j.tox.2012.10.008 · Cited by 59 · see citing works
Association Studies of MMP-9 in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
He, X., Zhang, L., Yao, X., Hu, J., Yu, L., Jia, H., An, R., Liu, Z., & Xu, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073777 · Cited by 59 · see citing works
Bartha, S., Tăut, I., Goji, G., Vlad, I. A., & Dinulică, F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051507 · Cited by 59 · see citing works
Zhang, S., Shi, Q., Christodoulatos, C., & Meng, X. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.05.190 · Cited by 56 · see citing works
García-Sevillano, M. Á., Rodríguez‐Moro, G., García‐Barrera, T., Navarro, F., & Gómez‐Ariza, J. L. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.02.001 · Cited by 56 · see citing works
ROS regulation in gliomas: implications for treatment strategies
Yang, Y.-C., Zhu, Y., Sun, S.-J., Zhao, C.-J., Bai, Y., Wang, J., & Ma, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1259797 · Cited by 56 · see citing works
Paola, D. D., Capparucci, F., Lanteri, G., Cordaro, M., Crupi, R., Siracusa, R., D’Amico, R., Fusco, R., Impellizzeri, D., Cuzzocrea, S., et al. (2021) · Toxics · doi:10.3390/toxics9120344 · Cited by 54 · see citing works
RetractedHuang, P., Wang, M., Wang, J., Sun, H., Han, S., Feng, S., Shi, L. D., Meng, P., Li, J., & Sun, Z. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s103489 · Cited by 54 · see citing works
Fu, S. X., Jiang, W., & Zheng, W. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00022 · Cited by 53 · see citing works
Li, Y., Chen, G., Zhao, J., Nie, X., Wan, C., Liu, J., Duan, Z., & Xu, G. (2013) · Toxicology · doi:10.1016/j.tox.2013.08.008 · Cited by 53 · see citing works
The preventive and carcinogenic effect of metals on cancer: a systematic review
Khoshakhlagh, A. H., Mohammadzadeh, M., & Gruszecka‐Kosowska, A. (2024) · BMC Public Health · doi:10.1186/s12889-024-19585-5 · Cited by 50 · see citing works
Tang, J., Su, Q., Guo, Z., Zhou, J., Zheng, F., Yu, G., Shao, W., Hu, H., Wu, S., & Li, H. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118749 · Cited by 50 · see citing works
Bambaeero, A., & Lari, R. B. (2020) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2020.07.066 · Cited by 48 · see citing works
Zhang, R., Zhang, N., Zhang, H., Liu, C., Dong, X., Wang, X., Zhu, Y., Xu, C., Liu, L., Yang, S., et al. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13655 · Cited by 48 · see citing works
Chi, T., Sang, T., Wang, Y., & Ye, Z. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00476 · Cited by 47 · see citing works
The reaction of HOCl and cyanocobalamin: Corrin destruction and the liberation of cyanogen chloride
Abu‐Soud, H. M., Maitra, D., Byun, J., Souza, C. E. A., Banerjee, J., Saed, G. M., Diamond, M. P., Andreana, P. R., & Pennathur, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.496 · Cited by 47 · see citing works
Ultrasonic vibration seeds showed improved resistance to cadmium and lead in wheat seedling
Chen, Y., Liu, Q., Yue, X.-Z., Meng, Z.-W., & Liang, J. L. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-012-1411-1 · Cited by 45 · see citing works
Microalgal motility measurement microfluidic chip for toxicity assessment of heavy metals
Zheng, G., Wang, Y., & Qin, J. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6408-6 · Cited by 44 · see citing works
Borrelli, A., Schiattarella, A., Bonelli, P., Tuccillo, F. M., Buonaguro, F. M., & Mancini, A. (2014) · BioMed Research International · doi:10.1155/2014/476789 · Cited by 44 · see citing works
Tang, Y., Kang, H., Qin, Z., Zhang, K., Zhong, Y., Li, H., & Mo, L. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135867 · Cited by 43 · see citing works
Aldalbahi, A. K., El‐Naggar, M. E., Khattab, T. A., Abdelrahman, M. S., Rahaman, M., Alrehaili, A., & El-Newehy, M. H. (2020) · Polymers · doi:10.3390/polym12112501 · Cited by 42 · see citing works
Brown, C., Lacharme‐Lora, L., Mukonoweshuro, B., Sood, A., Newson, R. B., Fisher, J., Case, C., & Ingham, E. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.073 · Cited by 42 · see citing works
Morales‐Hernández, A., Sánchez-Martín, F. J., Hortigon-Vinagre, M. P., Henao, F., & Merino, J. M. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0760-z · Cited by 42 · see citing works
Gaman, L. E., Rădoi, M. P., Delia, C., Luzardo, O. P., Zumbado, M. L., Rodríguez-Hernández, Á., Stoian, I. A.-M., Gîlcă, M., Boada, L. D., & Henríquez‐Hernández, L. A. (2019) · International Journal of Environmental Health Research · doi:10.1080/09603123.2019.1685079 · Cited by 42 · see citing works
Kim, J., Choi, W. I., Kim, Y. H., & Tae, G. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.07.017 · Cited by 42 · see citing works
Assessment of cadmium-induced nephrotoxicity using a kidney-on-a-chip device
Li, Z., Jiang, L., Tao, T., Su, W., Guo, Y., Yu, H., & Qin, J. (2017) · Toxicology Research · doi:10.1039/c6tx00417b · Cited by 41 · see citing works
Genetic engineering of plants to tolerate toxic metals and metalloids
Raza, A., Habib, M., Charagh, S., & Kakavand, S. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819382-2.00026-0 · Cited by 41 · see citing works
Abdel-Halim, K. Y., & Osman, S. R. (2020) · Journal of Toxicology · doi:10.1155/2020/4364650 · Cited by 41 · see citing works
Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species
Kovacic, P., & Somanathan, R. (2012) · Current Neuropharmacology · doi:10.2174/157015912804499429 · Cited by 41 · see citing works
Chen, H., Chen, J., Guo, Y., Wen, Y., Liu, J., & Liu, W. (2012) · Aquatic Toxicology · doi:10.1016/j.aquatox.2012.04.011 · Cited by 41 · see citing works
The effect of dibenzo-p-dioxin- and dibenzofuran-contaminated soil on the earthworm Eisenia andrei
Roubalová, R., Dvořák, J., Procházková, P., Elhottová, D., Rossmann, P., Škanta, F., & Bilej, M. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2014.05.026 · Cited by 40 · see citing works
Morcillo, P., Chaves-Pozo, E., Meseguer, J., Esteban, M. Á., & Cuesta, A. (2016) · Toxicology in Vitro · doi:10.1016/j.tiv.2016.10.005 · Cited by 40 · see citing works
Recent Progress of Surface Modified Nanomaterials for Scavenging Reactive Oxygen Species in Organism
Liu, J., Ma, L., Zhang, G., Chen, Y., & Wang, Z. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00402 · Cited by 39 · see citing works
Superoxide dismutase: a key target for the neuroprotective effects of curcumin
Khayatan, D., Razavi, S. M., Arab, Z. N., Hosseini, Y., Niknejad, A., Momtaz, S., Abdolghaffari, A. H., Sathyapalan, T., Jamialahmadi, T., Kesharwani, P., et al. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04757-5 · Cited by 39 · see citing works
Ultrasonic seed treatment improved physiological and yield traits of rice under lead toxicity
Rao, G., Ashraf, U., Huang, S., Cheng, S., Abrar, M., Mo, Z., Pan, S., & Tang, X. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3303-5 · Cited by 39 · see citing works
Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices
Wen, W., Wang, C., Wu, D., Chen, S., Hung, C., & Kuo, C. (2020) · Nutrients · doi:10.3390/nu12092666 · Cited by 39 · see citing works
Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species
Kovacic, P., & Somanathan, R. (2012) · Current Neuropharmacology · doi:10.2174/157015912804143487 · Cited by 38 · see citing works
Determination of heavy metals in the roasted and ground coffee beans and brew
Sabrina, A. D. S., Fabrícia, Q. M., dos Reis, M. R., Passos, F. R., Andre, M. X. D. C., Katia, R. D. O. R., & Frederico, G. P. (2017) · African Journal of Agricultural Research · doi:10.5897/ajar2016.11832 · Cited by 38 · see citing works
Mu, Y. P., Hu, X., Yang, P., Sun, L., Gu, W., & Zhang, M. (2021) · Toxicology · doi:10.1016/j.tox.2021.152931 · Cited by 38 · see citing works
Emerging energy and environmental application of graphene and their composites: a review
Fadlalla, M. I., Kumar, P., Selvam, V., & Babu, S. G. (2020) · Journal of Materials Science · doi:10.1007/s10853-020-04474-0 · Cited by 37 · see citing works
Recent progress in macrocyclic chemosensors for lead, cadmium and mercury heavy metal ions
Zhang, H., Song, J., Wang, S., Song, Q., Guo, H., & Li, Z. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111380 · Cited by 36 · see citing works
Recent progress in fluorescent probes for Cu2+ based on small organic molecules
Yan, L., Bao, K., Xu, X., Li, L., & Wu, X. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.139100 · Cited by 36 · see citing works
Parent, M., Turner, M. C., Lavoué, J., Richard, H., Figuerola, J., Kincl, L. D., Richardson, L., Benke, G., Blettner, M., Fleming, S., et al. (2017) · Environmental Health · doi:10.1186/s12940-017-0300-y · Cited by 35 · see citing works
Mishra, A., Mishra, S., Arshi, A., Agarwal, A., & Dwivedi, S. K. (2019) · Springer eBooks · doi:10.1007/978-981-13-3426-9_17 · Cited by 35 · see citing works
- Authors
- Matés, J. M., Segura, J. A., Alonso, F. J., & Márquez, J.
- Affiliations
- Universidad de Málaga (ES)
- Corresponding author
- Matés, José M.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 49
- Issue
- 9
- Pages
- 1328-1341
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2059124139
- Cited by
- 286
- References
- 174
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 14 · 2023: 23 · 2022: 13 · 2021: 18 · 2020: 20 · 2019: 20 · 2018: 11 · 2017: 12 · 2016: 19 · 2015: 21 · 2014: 23 · 2013: 25 · 2012: 25
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- dioxins, heavy metals, cadmium, cobalt, copper, reactive oxygen species, oxidative stress, cancer, neurodegenerative diseases, apoptosis, cell cycle, cytochrome P450, superoxide dismutase, glutathione peroxidase, DNA damage, DNA repair, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, environmental pollutants
- MeSH terms
- Animals, Cell Differentiation, Cell Transformation, Neoplastic, Dioxins, Environmental Pollutants, Humans, Neoplasms, Nervous System Diseases, Reactive Oxygen Species, Oxidative Stress, Metals, Heavy, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review