Cited by 286Heavy Metal Exposure and ToxicityCancer and biochemical researchToxic Organic Pollutants Impact

Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

Matés, José M., Segura, Juan A., Alonso, Francisco J., Márquez, Javier·2010·Free Radical Biology and Medicine

Abstract

Oxidants have critical functions inside healthy and unhealthy cells. Deregulated cell cycle and apoptosis, both regulated by oxidative stress, have been described as hallmarks of mitotic (cancer) and postmitotic (neuronal) cells. This review provides an updated revision of the oxidant effects of some environmental contaminants such as dioxins and the heavy metals cadmium, cobalt, and copper. Dioxins exert their toxic actions by acting on phase I and phase II enzymes, such as cytochromes P450, superoxide dismutase, and glutathione peroxidase, promoting cell proliferation, growth arrest, and apoptosis, affecting cancer homeostasis and neuronal function. Heavy metals manifest cytotoxic effects in various cells and tissues, and tight regulation of metals is essential to the health of organisms. Cadmium modulates gene expression and signal transduction and reduces activities of proteins involved in antioxidant defense, interfering with DNA repair and modifying cancer development and brain function. Cobalt provokes generation of reactive oxygen species and DNA damage in cancer cells and brain tissues, altering proliferation and differentiation and causing apoptosis. Copper is a key metal in cell division processes in both normal and tumor cells. Copper also has been shown to have an important role in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis.

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2010.07.028

Cites

174 of 174 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Matés, J. M., Segura, J. A., Alonso, F. J., & Márquez, J.
Affiliations
Universidad de Málaga (ES)
Corresponding author
Matés, José M.
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2010-11
Volume
49
Issue
9
Pages
1328-1341
ISSN
0891-5849 (ISSN-L)
OpenAlex
W2059124139
Cited by
286
References
174
Citations by year
2026: 7 · 2025: 16 · 2024: 14 · 2023: 23 · 2022: 13 · 2021: 18 · 2020: 20 · 2019: 20 · 2018: 11 · 2017: 12 · 2016: 19 · 2015: 21 · 2014: 23 · 2013: 25 · 2012: 25
FWCI
2.26
Type
journal article
Language
en
Open access
closed
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
dioxins, heavy metals, cadmium, cobalt, copper, reactive oxygen species, oxidative stress, cancer, neurodegenerative diseases, apoptosis, cell cycle, cytochrome P450, superoxide dismutase, glutathione peroxidase, DNA damage, DNA repair, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, environmental pollutants
MeSH terms
Animals, Cell Differentiation, Cell Transformation, Neoplastic, Dioxins, Environmental Pollutants, Humans, Neoplasms, Nervous System Diseases, Reactive Oxygen Species, Oxidative Stress, Metals, Heavy, Cell Proliferation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review