Cited by 770Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

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Reactive oxygen species in cardiovascular disease

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Sugamura, Koichi, Keaney,, John F.·2011·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2011.05.004PMC PMC3156326

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Abstract

Based on the "free radical theory" of disease, researchers have been trying to elucidate the role of oxidative stress from free radicals in cardiovascular disease. Considerable data indicate that reactive oxygen species and oxidative stress are important features of cardiovascular diseases including atherosclerosis, hypertension, and congestive heart failure. However, blanket strategies with antioxidants to ameliorate cardiovascular disease have not generally yielded favorable results. However, our understanding of reactive oxygen species has evolved to the point at which we now realize these species have important roles in physiology as well as pathophysiology. Thus, it is overly simplistic to assume a general antioxidant strategy will yield specific effects on cardiovascular disease. Indeed, there are several sources of reactive oxygen species that are known to be active in the cardiovascular system. This review addresses our understanding of reactive oxygen species sources in cardiovascular disease and both animal and human data defining how reactive oxygen species contribute to physiology and pathology.

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Items 201–302 of 302

Xanthine Oxidoreductase Inhibition Causes Reverse Remodeling in Rats With Dilated Cardiomyopathy
Minhas, K. M., Saraiva, R. M., Schuleri, K. H., Lehrke, S., Zheng, M., SALIARIS, A. P., Berry, C. E., Vandegaer, K., Li, D., & Hare, J. M. (2005) · Circulation Research · doi:10.1161/01.res.0000200181.59551.71 · Cited by 170
Expression of Human Myeloperoxidase by Macrophages Promotes Atherosclerosis in Mice
McMillen, T. S., Heinecke, J. W., & LeBoeuf, R. C. (2005) · Circulation · doi:10.1161/circulationaha.104.516278 · Cited by 168
In vivo action of 15-lipoxygenase in early stages of human atherogenesis.
Kühn, H., Heydeck, D., Hugou, I., & Gniwotta, C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119253 · Cited by 168
Treatment With 5-Lipoxygenase Inhibitor VIA-2291 (Atreleuton) in Patients With Recent Acute Coronary Syndrome
Tardif, J., L’Allier, P. L., Ibrahim, R., Grégoire, J. C., Nozza, A., Cossette, M., Kouz, S., Lavoie, M.-A., Paquin, J., Brotz, T. M., et al. (2010) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.110.937169 · Cited by 161
Antioxidant changes in hypertrophied and failing guinea pig hearts
Dhalla, A. K., & Singal, P. K. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.4.h1280 · Cited by 161
Effect of Supersaturated Oxygen Delivery on Infarct Size After Percutaneous Coronary Intervention in Acute Myocardial Infarction
Stone, G. W., Martin, J. L., de Boer, M., Margheri, M., Bramucci, E., Blankenship, J. C., Metzger, D. C., Gibbons, R. J., Lindsay, B., Weiner, B. H., et al. (2009) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.108.840066 · Cited by 160
Inducible Nitric Oxide Synthase Deficiency Protects the Heart From Systolic Overload–Induced Ventricular Hypertrophy and Congestive Heart Failure
Zhang, P., Xu, X., Hu, X., van Deel, E. D., Zhu, G., & Chen, Y. (2007) · Circulation Research · doi:10.1161/01.res.0000264081.78659.45 · Cited by 152
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Antoniades, C. A., Shirodaria, C. C., Leeson, P., Baarholm, O., Van-Assche, T., Cunnington, C., Pillai, R. G., Ratnatunga, C., Tousoulis, D., Stefanadis, C., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.808675 · Cited by 151
12/15-Lipoxygenase Activity Mediates Inflammatory Monocyte/Endothelial Interactions and Atherosclerosis in Vivo
Reilly, K. B., Srinivasan, S. R., Hatley, M. E., Patricia, M. K., Lannigan, J. A., Bolick, D. T., Vandenhoff, G. E., Pei, H., Natarajan, R. D., Nadler, J. L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m303857200 · Cited by 147
nNOS Gene Deletion Exacerbates Pathological Left Ventricular Remodeling and Functional Deterioration After Myocardial Infarction
Dawson, D. K., Lygate, C. A., Zhang, M.-H., Hulbert, K., Neubauer, S., & Casadei, B. (2005) · Circulation · doi:10.1161/circulationaha.105.539437 · Cited by 146
Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure
Tsutsui, T., Tsutamoto, T., Wada, A., Maeda, K., Mabuchi, N., Hayashi, M., Ohnishi, M., & Kinoshita, M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01721-7 · Cited by 142
Mechanisms of Inducible Nitric Oxide Synthase–Mediated Vascular Dysfunction
Gunnett, C. A., Lund, D. D., McDowell, A. K., Faraci, F. M., & Heistad, D. D. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000172626.00296.ba · Cited by 141
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Ahmed, M. I., Gladden, J. D., Litovsky, S. H., Lloyd, S. G., Gupta, H., Inusah, S., Denney, T. S., Powell, P. C., McGiffin, D. C., & Dell’Italia, L. J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.08.074 · Cited by 141
Cardiac-Specific Overexpression of Inducible Nitric Oxide Synthase Does Not Result in Severe Cardiac Dysfunction
Heger, J., Gödecke, A., Flögel, U., Merx, M. W., Molojavyi, A., Kühn‐Velten, W. N., & Schrader, J. (2002) · Circulation Research · doi:10.1161/hh0102.102757 · Cited by 141
Acute Myocardial Infarction With Hyperoxemic Therapy (AMIHOT)
O’Neill, W. W., Martin, J. L., Dixon, S. R., Bartorelli, A. L., Trabattoni, D., Oemrawsingh, P. V., Atsma, D. E., Chang, M., Marquardt, W., Oh, J. K., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.099 · Cited by 134
Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina
Kugiyama, K., Motoyama, T., Hirashima, O., Ohgushi, M., Soejima, H., Misumi, K., Kawano, H., Miyao, Y., Yoshimura, M., Ogawa, H., et al. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00185-5 · Cited by 126
Hyperuricemia and Incident Heart Failure
Krishnan, E. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.797662 · Cited by 125
Usefulness of Baseline Plasma Myeloperoxidase Levels as an Independent Predictor of Myocardial Infarction at Two Years in Patients Presenting With Acute Coronary Syndrome
Çavuşoğlu, E., Ruwende, C., Eng, C., Chopra, V., Yanamadala, S., Clark, L. T., Pinsky, D. J., & Marmur, J. D. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.060 · Cited by 125
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Nakamura, R., Egashira, K., Machida, Y., Hayashidani, S., Takeya, M., Utsumi, H., Tsutsui, H., & Takeshita, A. (2002) · Circulation · doi:10.1161/01.cir.0000021430.04195.51 · Cited by 122
Cardiac Myocyte–Specific Expression of Inducible Nitric Oxide Synthase Protects Against Ischemia/Reperfusion Injury by Preventing Mitochondrial Permeability Transition
West, M. B., Rokosh, G., Obal, D., Velayutham, M., Xuan, Y.-T., Hill, B. G., Keith, R. J., Schrader, J., Guo, Y., Conklin, D. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.791533 · Cited by 121
F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases
Praticò, D., Rokach, J., Lawson, J., & FitzGerald, G. A. (2004) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2003.09.012 · Cited by 120
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Keith, M. E., Jeejeebhoy, K. N., Langer, A., Kurian, R., Barr, A., O'Kelly, B. F., & Sole, M. J. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.219 · Cited by 119
12/15-Lipoxygenase Regulates Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Endothelium Through Activation of RhoA and Nuclear Factor-κB
Bolick, D. T., Orr, A. W., Whetzel, A. M., Srinivasan, S. R., Hatley, M. E., Schwartz, M. A., & Hedrick, C. C. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000186181.19909.a6 · Cited by 118
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Redout, E. M., van der Toorn, A., Zuidwijk, M. J., van de Kolk, C. W. A., van Echteld, C. J. A., Musters, R. J. P., van Hardeveld, C., Paulus, W. J., & Simonides, W. S. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00097.2009 · Cited by 117
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Vassalle, C., Botto, N., Andreassi, M. G., Berti, S. L., & Biagini, A. (2003) · Coronary Artery Disease · doi:10.1097/01.mca.0000063504.13456.c3 · Cited by 117
Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance
PARASKEVAIDIS, I. A., Iliodromitis, E. K., Vlahakos, D., Tsiapras, D. P., Nikolaidis, A., Marathias, A., Michalis, A., & Kremastinos, D. T. (2004) · European Heart Journal · doi:10.1093/eurheartj/ehi028 · Cited by 116
Mechanisms, management and future directions for reperfusion injury after acute myocardial infarction
Cannon, R. O. I. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0096 · Cited by 114
Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency
Ichinose, F., Bloch, K. D., Wu, J. C., Hataishi, R., Aretz, H. T., Picard, M. H., & Scherrer‐Crosbie, M. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00940.2003 · Cited by 114
Effects of edaravone on reperfusion injury in patients with acute myocardial infarction
Tsujita, K., Shimomura, H., Kawano, H., Hokamaki, J., Fukuda, M., Yamashita, T., Hida, S., Nakamura, Y., Nagayoshi, Y., Sakamoto, T., et al. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.05.007 · Cited by 113
ESR measurement of free radicals in whole mice
Utsumi, H., Muto, E., Masuda, S., & Hamada, A. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91597-l · Cited by 112
Serum bilirubin distribution and its relation to cardiovascular risk in children and young adults
Madhavan, M. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)06088-7 · Cited by 109
Myeloperoxidase level in patients with stable coronary artery disease and acute coronary syndromes
Ndrepepa, G., Braun, S., Mehilli, J., von Beckerath, N., Schömig, A., & Kastrati, A. (2008) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01908.x · Cited by 108
The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis
LOTZER, K., FUNK, C., & HABENICHT, A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.07.001 · Cited by 108
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Houard, X., Ollivier, V., Louedec, L., Michel, J., & Bäck, M. (2009) · The FASEB Journal · doi:10.1096/fj.08-116202 · Cited by 108
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Kono, Y., Nakamura, K., Kimura, H., Nishii, N., Watanabe, A., Banba, K., Miura, A., Nagase, S., Sakuragi, S., KUSANO, K. F., et al. (2006) · Circulation Journal · doi:10.1253/circj.70.1001 · Cited by 107
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Chen, K., Craige, S. M., & Keaney, J. F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2594 · Cited by 106
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Recent Advances in Platelet-Polymorphonuclear Leukocyte Interaction
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Zhao, L., Cuff, C. A., Moss, E., Wille, U., Cyrus, T., Klein, E. A., Praticò, D., Rader, D. J., Hunter, C. A., Puré, E., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205738200 · Cited by 102
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Nauseef, W. (1986) · Blood · doi:10.1182/blood.v67.4.865.865 · Cited by 101
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Antioxidants attenuate myocyte apoptosis and improve cardiac function in CHF: association with changes in MAPK pathways
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Flögel, U., Decking, U. K. M., Gödecke, A., & Schrader, J. (1999) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1998.0921 · Cited by 96
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Bell, R. M., Cave, A. C., Johar, S., Hearse, D. J., Shah, A. M., & Shattock, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2774fje · Cited by 95
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Apple, F. S., Pearce, L. A., Chung, A., Ler, R., & Murakami, M. M. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.080192 · Cited by 95
Differential response to myocardial reperfusion injury in eNOS-deficient mice
Sharp, B. R., Jones, S. P., Rimmer, D. M., & Lefer, D. J. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00855.2001 · Cited by 95
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Traber, M. G., Frei, B. B., & Beckman, J. S. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f2dab6 · Cited by 93
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Thom, S. R., & Elbüken, M. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90050-d · Cited by 91
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Sorescu, D. (2001) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00097-4 · Cited by 91
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Maytin, M., Siwik, D. A., 伊藤, 正., Xiao, L., Sawyer, D. B., Liao, R., & Colucci, W. S. (2004) · Circulation · doi:10.1161/01.cir.0000117229.60628.2f · Cited by 86
Myoglobin Protects the Heart from Inducible Nitric-oxide Synthase (iNOS)-mediated Nitrosative Stress
Gödecke, A., Molojavyi, A., Heger, J., Flögel, U., Ding, Z., Jacoby, C., & Schrader, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302573200 · Cited by 86
Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet
Schröder, K., Vecchione, C., Jung, O., Schreiber, J. G., Shiri‐Sverdlov, R., van Gorp, P. J., Busse, R., & Brandes, R. P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.026 · Cited by 86
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Stocker, R., Huang, A., Jeranian, E., Hou, J. Y., Wu, T. T., Thomas, S. R., & Keaney, J. F. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000143388.20994.fa · Cited by 84
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Vita, J. A., Keaney, J. F., Raby, K. E., Morrow, J. D., Freedman, J. E., Lynch, S. M., Koulouris, S. N., Hankin, B., & Frei, B. B. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00059-x · Cited by 82
Cardiomyocyte Overexpression of Neuronal Nitric Oxide Synthase Delays Transition Toward Heart Failure in Response to Pressure Overload by Preserving Calcium Cycling
Loyer, X., Gomez, A. M., Milliez, P., Fernández‐Velasco, M., Vangheluwe, P., Vinet, L., Charue, D., Vaudin, E., Zhang, W., Sainte–Marie, Y., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.741702 · Cited by 82
Improved post-myocardial infarction survival with probucol in rats: Effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression
Sia, Y. T., Parker, T. G., Liu, P. X., Tsoporis, J. N., Adam, A. A., & Rouleau, J. L. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01709-0 · Cited by 82
Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease
Asselbergs, F. W., Reynolds, W. F., Tervaert, J. W. C., Jessurun, G. A. J., & Tio, R. A. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.10.025 · Cited by 78
Analysis of the peptide subunits of human neutrophil myeloperoxidase
Nauseef, W., & Malech, H. L. (1986) · Blood · doi:10.1182/blood.v67.5.1504.1504 · Cited by 77
Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury
Chen, Z., Keaney, J. F., Schulz, E., Levison, B. S., Shan, L., Sakuma, M., Zhang, X., Shi, C., Hazen, S. L., & Simon, D. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405389101 · Cited by 77
Effects of Afterload-Reducing Drugs on Pathogenesis of Antioxidant Changes and Congestive Heart Failure in Rats
Khaper, N., & Singal, P. K. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00574-8 · Cited by 76
Long-Term Efficacy of Edaravone in Patients With Acute Myocardial Infarction
Tsujita, K., Shimomura, H., Kaikita, K., Kawano, H., Hokamaki, J., Nagayoshi, Y., Yamashita, T., Fukuda, M., Nakamura, Y., Sakamoto, T., et al. (2006) · Circulation Journal · doi:10.1253/circj.70.832 · Cited by 76
Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice
Miyoshi, T., Li, Y., Shih, D. M., Wang, X., Laubach, V. E., Matsumoto, A. H., Helm, G. A., Lusis, A. J., & Shi, W. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.01.043 · Cited by 74
Effects of α tocopherol and β carotene supplements on symptoms, progression, and prognosis of angina pectoris
Rapola, J., Virtamo, J. R. K., Ripatti, S., Haukka, J. K., Huttunen, J. K., Albanes, D., Taylor, P. R., & Heinonen, O. P. (1998) · Heart · doi:10.1136/hrt.79.5.454 · Cited by 74
Noninvasive Mapping of Reactive Oxygen Species by in Vivo Electron Spin Resonance Spectroscopy in Indomethacin-Induced Gastric Ulcers in Rats
Utsumi, H., Yasukawa, K., Soeda, T., Yamada, K., Shigemi, R., Yao, T., & Tsuneyoshi, M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.095166 · Cited by 74
Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice
Barouch, L. A. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00079-8 · Cited by 73
Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload
Buys, E. S., Raher, M. J., Blake, S. L., Neilan, T. G., Graveline, A. R., Passeri, J. J., Llano, M., Pérez-Sanz, T. M., Ichinose, F., Janssens, S. P., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01236.2006 · Cited by 72
Effect of Collection Tube Type and Preanalytical Handling on Myeloperoxidase Concentrations
Shih, J., Datwyler, S. A., Hsu, S. C., Matias, M. S., Pacenti, D. P., Lueders, C., Mueller, C., Danne, O., & Möckel, M. M. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.101568 · Cited by 72
ISOPROSTANES—RROSTAGLANDIN-LIKE COMPOUNDS FORMED IN VIVO INDEPENDENTLY OF CYCLOOXYGENASE
Awad, J. A., Roberts, L. J., Burk, R. F., & Morrow, J. D. (1996) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70255-7 · Cited by 71
The Effect of Hyperbaric Oxygen on Reperfusion of Ischemic Axial Skin Flaps: A Laser Doppler Analysis
Zamboni, W. A., Roth, A. C., Russell, R. C., & Smoot, E. C. (1992) · Annals of Plastic Surgery · doi:10.1097/00000637-199204000-00008 · Cited by 70
Myeloperoxidase aids prognostication together with N-terminal pro-B-type natriuretic peptide in high-risk patients with acute ST elevation myocardial infarction
Khan, S. Q., Kelly, D., Quinn, P. A., Davies, J. E., & Ng, L. L. (2006) · Heart · doi:10.1136/hrt.2006.091041 · Cited by 69
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Properties of the xanthine oxidase from human liver
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Authors: Sugamura, K., & Keaney
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: Keaney,, John F.
ORCID: Sugamura, Koichi
Keaney,, John F.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2011-09
Volume: 51
Issue: 5
Pages: 978-992
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2011.05.004
PMC: PMC3156326
OpenAlex: W2037586146
Cited by: 769
References: 304
Citations by year: 2026: 12 · 2025: 31 · 2024: 40 · 2023: 48 · 2022: 56 · 2021: 48 · 2020: 51 · 2019: 56 · 2018: 58 · 2017: 67 · 2016: 45 · 2015: 69 · 2014: 72 · 2013: 49 · 2012: 58
FWCI: 6.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Uehara Memorial Foundation
Japan Heart Foundation
National Institutes of Health
Bayer Yakuhin
National Heart, Lung, and Blood Institute (HL081587, R01HL098407, P01HL081587, HL098407, HL092122, R01HL092122)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 32520, P30DK032520)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: reactive oxygen species, oxidative stress, free radicals, cardiovascular disease, atherosclerosis, hypertension, congestive heart failure, antioxidants, antioxidant therapy, redox signaling
MeSH terms: Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Heart, Humans, Biomarkers, Reactive Oxygen Species, Oxidative Stress, Molecular Targeted Therapy

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