Cited by 120Antioxidant Activity and Oxidative StressFatty Acid Research and HealthRedox biology and oxidative stress

F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases

Praticò, Domenico, Rokach, Joshua, Lawson, John, FitzGerald, Garret A.·2004·Chemistry and Physics of Lipids

Abstract

Isoprostanes are a new class of lipids, isomers of conventional enzymatically derived prostaglandins, which are produced in vivo primarily by a free radical-catalyzed peroxidation of polyunsaturated fatty acids. F2-isoprostanes, isomers of the enzyme-derived prostaglandin F2alpha, are the most studied species. Because of their mechanisms of formation, specific structural features that distinguish them from other free radical-generated products and chemical stability, they provide a reliable index of the oxidative component of several diseases in vivo. Consistent data suggest that formation of F2-isoprostanes is indeed altered in a variety of clinical settings associated with inflammation and oxidant stress. Moreover, measurement of F2-isoprostanes might provide a sensitive biochemical basis of dose-selection in studies of natural and synthetic antioxidants.

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Crossref · 10.1016/j.chemphyslip.2003.09.012

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Authors
Praticò, D., Rokach, J., Lawson, J., & FitzGerald, G. A.
Affiliations
  • University of Pennsylvania (US)
  • Florida Institute of Technology (US)
Corresponding author
FitzGerald, Garret A.
Venue
Chemistry and Physics of Lipids
Publisher
Elsevier BV
Published
2004-03
Volume
128
Issue
1-2
Pages
165-171
ISSN
0009-3084 (ISSN-L)
OpenAlex
W1983796684
Cited by
120
References
76
Citations by year
2026: 1 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 6
FWCI
0.99
Type
journal article
Language
en
Open access
closed
Locations
  • Chemistry and Physics of Lipids (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health (5r01hl061364-03, 5r03es011475-02)
  • National Heart, Lung, and Blood Institute (HL 61364, HL54500, P50HL054500, HL-69835, HL62250, R01HL069835, P01HL062250)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 44730, R01DK044730)
  • National Institute of Environmental Health Sciences (ES-11475)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
F2-isoprostanes, lipid peroxidation, inflammation, oxidative stress, free radical peroxidation, polyunsaturated fatty acids, prostaglandins, oxidative stress biomarkers, antioxidants, dose selection
MeSH terms
Alzheimer Disease, Animals, Arteriosclerosis, Disease Models, Animal, Humans, Inflammation, Risk Factors, Lipid Peroxidation, Isoprostanes

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