The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Microbial regulation of host hydrogen sulfide bioavailability and metabolism
Open accessAbstract
Hydrogen sulfide (H2S), generated through various endogenous enzymatic and non-enzymatic pathways, is emerging as a regulator of physiological and pathological events throughout the body. Bacteria in the gastrointestinal tract also produce significant amounts of H2S that regulates microflora growth and virulence responses. However, the impact of the microbiota on host global H2S bioavailability and metabolism remain unknown. To address this question, we examined H2S bioavailability in its various forms (free, acid labile or bound sulfane sulfur), cystathionine gamma lyase (CSE) activity and cysteine levels in tissues from germ free versus conventionally housed mice. Free H2S levels were significantly reduced in plasma and gastrointestinal tissues of germ free mice. Bound sulfane sulfur levels were decreased by 50–80% in germ free mouse plasma, adipose and lung tissues. Tissue CSE activity was significantly reduced in many organs from germ free mice, whereas tissue cysteine levels were significantly elevated compared to conventional mice. These data reveal that the microbiota profoundly regulates systemic bioavailability and metabolism of H2S.
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Cites
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
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Tlaskalová-Hogenová, H., Štěpánková, R., Kozáková, H., Hudcovic, T., Vannucci, L., Tučková, L., Rossmann, P., Hrnčíř, T., Kverka, M., Zákostelská, Z., et al. (2011) · Cellular & Molecular Immunology · doi:10.1038/cmi.2010.67 · Cited by 693
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
Jansson, E. Å., Huang, L., Malkey, R., Govoni, M., Nihlén, C., Olsson, A., Stensdotter, M., Petersson, J., Holm, L., Weitzberg, E., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.92 · Cited by 356
Self-citationAnalytical measurement of discrete hydrogen sulfide pools in biological specimens
Shen, X., Peter, E. A., Bir, S., Wang, R., & Kevil, C. G. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.007 · Cited by 214
Self-citationSulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis
Rowan, F. E., Docherty, N. G., Coffey, J. C., & O'Connell, P. R. (2009) · British Journal of Surgery · doi:10.1002/bjs.6454 · Cited by 201
Levitt, M. D., Abdel-Rehim, M. S., & Furne, J. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3525 · Cited by 177
Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept
Oldstone, M. B. A. (2005) · Current Topics in Microbiology and Immunology · doi:10.1007/3-540-30791-5_1 · Cited by 146
Cited by
Gut microbiota functions: metabolism of nutrients and other food components
Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878
“Recycling of hydrogen via dissimilatory sulphate reduction generates hydrogen sulphide, which is a cell signalling molecule of emerging physiological importance [38], but also is highly toxic to colonic cells and is potentially implicated in inflammatory bowel disease, since sufferers of ulcerative colitis have a univ…”
BackgroundPhysiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Cirino, G., Szabo, C., & Papapetropoulos, A. (2023) · Physiological Reviews · doi:10.1152/physrev.00028.2021 · Cited by 553
Hydrogen sulfide chemical biology: pathophysiological roles and detection
Kolluru, G. K., Shen, X., Bir, S. C., & Kevil, C. G. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.002 · Cited by 480
Self-citationSzabo, C., Ransy, C., Módis, K., Andriamihaja, M., Murghes, B., Coletta, C., Olah, G., Yanagi, K., & Bouillaud, F. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12369 · Cited by 440
The gut-bone axis: How bacterial metabolites bridge the distance
Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128521 · Cited by 403
Metadata
- Authors
- Shen, X., Carlström, M., Borniquel, S., Jädert, C., Kevil, C. G., & Lundberg, J. O.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 60
- Pages
- 195-200
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1986012170
- Cited by
- 194
- References
- 8
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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