Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis
Abstract
Background: The aetiology of ulcerative colitis is uncertain but may relate to environmental factors in genetically predisposed individuals. Sulphate-reducing bacteria (SRB) have been implicated through the harmful effects of hydrogen sulphide, a by-product of their respiration. Hydrogen sulphide is freely permeable to cell membranes and inhibits butyrate. This review examines the available evidence relating to SRB as a possible cause of ulcerative colitis. Methods: A literature search was conducted using the PubMed database and search terms ‘sulphate reducing bacteria’, ‘hydrogen sulphide’, ‘ulcerative colitis’, ‘mucous gel layer’ and ‘trans-sulphuration’. Results: Search results were scrutinized and 113 pertinent full-text articles were selected for review. Collected data related to hydrogen sulphide metabolism, SRB respiration, mucous gel layer composition and their association with ulcerative colitis. Conclusion: There is evidence to implicate SRB as an environmental factor in ulcerative colitis. More sophisticated mucosal dissection and molecular techniques using bacteria-directed probes are required to determine an association definitively.
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In five male volunteers consuming high intakes of animal protein, fecal sulfide production is related to meat intake; hydrogen sulfide is associated with ulcerative colitis.
“a study of five male volunteers consuming high intakes of animal protein showed that fecal sulfide production is related to meat intake [176]; notably, hydrogen sulfide is a compound associated with ulcerative colitis [177].”
From The athletic gut microbiota (2020) · cites this paper as [177]
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- Authors
- Rowan, F. E., Docherty, N. G., Coffey, J. C., & O'Connell, P. R.
- Affiliations
- University College Dublin (IE)
- School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01-21
- Volume
- 96
- Issue
- 2
- Pages
- 151-158
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W1997624799
- Cited by
- 201
- References
- 53
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 13 · 2023: 19 · 2022: 13 · 2021: 12 · 2020: 12 · 2019: 17 · 2018: 12 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 15 · 2012: 10
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- British journal of surgery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal College of Surgeons in Ireland
- Royal College of Surgeons of Edinburgh
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- sulfate-reducing bacteria, hydrogen sulfide, ulcerative colitis, etiology, environmental risk factors, gut microbiota, bacterial respiration
- MeSH terms
- Amino Acids, Colitis, Ulcerative, Glutathione, Humans, Hydrogen Sulfide, Intestinal Mucosa, Thiosulfate Sulfurtransferase, Gram-Negative Bacterial Infections, Sulfur-Reducing Bacteria
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