Cited by 201Gut microbiota and healthInflammatory Bowel DiseaseAbdominal vascular conditions and treatments

Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis

Rowan, F E, Docherty, N G, Coffey, J C, O'Connell, P R·2009·British Journal of Surgery

Abstract

Background: The aetiology of ulcerative colitis is uncertain but may relate to environmental factors in genetically predisposed individuals. Sulphate-reducing bacteria (SRB) have been implicated through the harmful effects of hydrogen sulphide, a by-product of their respiration. Hydrogen sulphide is freely permeable to cell membranes and inhibits butyrate. This review examines the available evidence relating to SRB as a possible cause of ulcerative colitis. Methods: A literature search was conducted using the PubMed database and search terms ‘sulphate reducing bacteria’, ‘hydrogen sulphide’, ‘ulcerative colitis’, ‘mucous gel layer’ and ‘trans-sulphuration’. Results: Search results were scrutinized and 113 pertinent full-text articles were selected for review. Collected data related to hydrogen sulphide metabolism, SRB respiration, mucous gel layer composition and their association with ulcerative colitis. Conclusion: There is evidence to implicate SRB as an environmental factor in ulcerative colitis. More sophisticated mucosal dissection and molecular techniques using bacteria-directed probes are required to determine an association definitively.

Integrity signals

Registry

Crossref · 10.1002/bjs.6454

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In five male volunteers consuming high intakes of animal protein, fecal sulfide production is related to meat intake; hydrogen sulfide is associated with ulcerative colitis.

    “a study of five male volunteers consuming high intakes of animal protein showed that fecal sulfide production is related to meat intake [176]; notably, hydrogen sulfide is a compound associated with ulcerative colitis [177].”

    From The athletic gut microbiota (2020) · cites this paper as [177]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Rowan, F. E., Docherty, N. G., Coffey, J. C., & O'Connell, P. R.
Affiliations
  • University College Dublin (IE)
  • School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
Venue
British Journal of Surgery
Published
2009-01-21
Volume
96
Issue
2
Pages
151-158
ISSN
  • 0007-1323 (ISSN-L)
  • 1365-2168
OpenAlex
W1997624799
Cited by
201
References
53
Citations by year
2026: 6 · 2025: 11 · 2024: 13 · 2023: 19 · 2022: 13 · 2021: 12 · 2020: 12 · 2019: 17 · 2018: 12 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 15 · 2012: 10
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Locations
  • British journal of surgery (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Royal College of Surgeons in Ireland
  • Royal College of Surgeons of Edinburgh
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
Keywords
sulfate-reducing bacteria, hydrogen sulfide, ulcerative colitis, etiology, environmental risk factors, gut microbiota, bacterial respiration
MeSH terms
Amino Acids, Colitis, Ulcerative, Glutathione, Humans, Hydrogen Sulfide, Intestinal Mucosa, Thiosulfate Sulfurtransferase, Gram-Negative Bacterial Infections, Sulfur-Reducing Bacteria

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review