Evidence mounts that red cells and deoxyhemoglobin can reduce nitrite to bioactive NO to mediate intravascular endocrine NO signaling: commentary on “Anti-platelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex”
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Nitrite-dependent NO generation in vivo catalyzed by Hb and Mb is well documented.
“However, nitrite-dependent NO generation in vivo catalyzed by Hb and Mb is well documented (183, 185, 365, 862, 975); it is very likely that the measurement of this NO generation is due to the fact that the high concentrations of Hb and Mb (in the mM range) can overcome the low efficiency of the nitrite reduction reaction.”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [183]
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- Authors
- Corti, P., Tejero, J., & Gladwin, M. T.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Gladwin, Mark T.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 65
- Pages
- 1518-1520
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2043189456
- Cited by
- 13
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL098032)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Laser Applications in Dentistry and Medicine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- nitric oxide bioavailability, dietary nitrate, nitrite reduction, erythrocytes, deoxyhemoglobin, endothelial dysfunction, low-level laser therapy, near-infrared light, NIR-II window, cardiovascular disease, cyclic GMP
- MeSH terms
- Blood Platelets, Female, Humans, Male, Nitrates, Platelet Aggregation, Platelet Aggregation Inhibitors, Potassium Compounds
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