Cited by 87Nitric Oxide and Endothelin EffectsMitochondrial Function and PathologyExercise and Physiological Responses

Regulation of mitochondrial function and energetics by reactive nitrogen oxides

Larsen, Filip J, Schiffer, Tomas A, Weitzberg, Eddie, Lundberg, Jon O·2012·Free Radical Biology and Medicine

Abstract

Endogenous nitric oxide (NO) generated from L-arginine by NO synthase regulates mitochondrial function by binding to cytochrome c oxidase in competition with oxygen. This interaction can elicit a variety of intracellular signaling events of both physiological and pathophysiological significance. Recent lines of research demonstrate that inorganic nitrate and nitrite, derived from oxidized NO or from the diet, are metabolized in vivo to form NO and other bioactive nitrogen oxides with intriguing effects on cellular energetics and cytoprotection. Here we discuss the latest advances in our understanding of the roles of nitrate, nitrite, and NO in the modulation of mitochondrial function, with a particular focus on dietary nitrate and exercise.

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Crossref · 10.1016/j.freeradbiomed.2012.08.580

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  • In humans, boosting inorganic nitrite either from oxidation of endogenously produced NO or from dietary supplementation of nitrate enhances mitochondrial function and efficiency by improving oxidative phosphorylation.

    “In humans, boosting inorganic nitrite either from oxidation of endogenously produced NO or from dietary supplementation of nitrate, enhances mitochondrial function and efficiency by improving oxidative phosphorylation (102, 103).”

    From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [103]

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Authors
Larsen, F. J., Schiffer, T. A., Weitzberg, E., & Lundberg, J. O.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Larsen, Filip J
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2012-11
Volume
53
Issue
10
Pages
1919-1928
ISSN
0891-5849 (ISSN-L)
OpenAlex
W2084630350
Cited by
87
References
120
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 12 · 2013: 6
FWCI
1.00
Type
journal article
Language
en
Open access
closed
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Hjärt-Lungfonden
  • Karolinska Institutet
  • Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
nitric oxide, nitrate, nitrite, mitochondrial function, cellular energetics, cytochrome c oxidase, nitric oxide synthase, L-arginine, reactive nitrogen oxides, dietary nitrate, physical activity, cytoprotection, intracellular signaling
MeSH terms
Animals, Electron Transport Complex IV, Humans, Mitochondria, Nitric Oxide, Oxidation-Reduction, Oxygen, Signal Transduction, Exercise, Nitric Oxide Synthase, Reactive Nitrogen Species

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