Regulation of mitochondrial function and energetics by reactive nitrogen oxides
Abstract
Endogenous nitric oxide (NO) generated from L-arginine by NO synthase regulates mitochondrial function by binding to cytochrome c oxidase in competition with oxygen. This interaction can elicit a variety of intracellular signaling events of both physiological and pathophysiological significance. Recent lines of research demonstrate that inorganic nitrate and nitrite, derived from oxidized NO or from the diet, are metabolized in vivo to form NO and other bioactive nitrogen oxides with intriguing effects on cellular energetics and cytoprotection. Here we discuss the latest advances in our understanding of the roles of nitrate, nitrite, and NO in the modulation of mitochondrial function, with a particular focus on dietary nitrate and exercise.
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In humans, boosting inorganic nitrite either from oxidation of endogenously produced NO or from dietary supplementation of nitrate enhances mitochondrial function and efficiency by improving oxidative phosphorylation.
“In humans, boosting inorganic nitrite either from oxidation of endogenously produced NO or from dietary supplementation of nitrate, enhances mitochondrial function and efficiency by improving oxidative phosphorylation (102, 103).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [103]
Cites
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,184 · see citing works
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works
Ischemia and reperfusion—from mechanism to translation
Eltzschig, H. K., & Eckle, T. D. L. G. (2011) · Nature Medicine · doi:10.1038/nm.2507 · Cited by 3,389 · see citing works
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · see citing works
Self-citationDweik, R. A., Boggs, P. B., Erzurum, S. C., Irvin, C. G., Leigh, M. W., Lundberg, J. O., Olin, A.-C., Plummer, A. L., & Taylor, D. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.9120-11st · Cited by 2,539 · see citing works
Self-citationAdaptations of skeletal muscle to endurance exercise and their metabolic consequences
Holloszy, J. O., & Coyle, E. F. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.4.831 · Cited by 1,985 · see citing works
Role of endothelium-derived nitric oxide in the regulation of blood pressure.
Rees, D. D., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3375 · Cited by 1,827 · see citing works
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.019 · Cited by 1,281 · see citing works
Cleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., & Schapira, A. H. V. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00424-2 · Cited by 1,241 · see citing works
Increased amount of nitric oxide in exhaled air of asthmatics
Alving, K., Weitzberg, E., & Lundberg, J. (1993) · European Respiratory Journal · doi:10.1183/09031936.93.06091368 · Cited by 1,232 · see citing works
Self-citationWebb, A. J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103523 · Cited by 1,078 · see citing works
Food sources of nitrates and nitrites: The physiologic context for potential health benefits
Hord, N. G., Tang, Y., & Bryan, N. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27131 · Cited by 1,069 · see citing works
Brown, G. C., & Cooper, C. E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01290-3 · Cited by 1,055 · see citing works
Workgroup Report: Drinking-Water Nitrate and Health—Recent Findings and Research Needs
Ward, M. H., de Kok, T. M. C. M., Levallois, P., Brender, J. D., Guliš, G., Nolan, B. T., & VanDerslice, J. A. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8043 · Cited by 892 · see citing works
Mitochondrial threshold effects
Rossignol, R., Faustin, B., Rocher, C., Malgat, M., Mazat, J., & Letellier, T. (2003) · Biochemical Journal · doi:10.1042/bj20021594 · Cited by 802 · see citing works
Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn
Roberts, J. D., Fineman, J. R., Morin, F. C., Shaul, P. W., Rimar, S., Schreiber, M. D., Polin, R. A., Zwass, M. S., Zayek, M. M., Gross, I., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702273360902 · Cited by 800 · see citing works
Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2009 · Cited by 759 · see citing works
Protein S-nitrosylation in health and disease: a current perspective
Foster, M. W., Hess, D. T., & Stamler, J. S. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.007 · Cited by 752 · see citing works
Nitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739 · see citing works
Self-citationDuncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M., & Benjamin, N. (1995) · Nature Medicine · doi:10.1038/nm0695-546 · Cited by 734 · see citing works
Poderoso, J. J., Carreras, M. C., Lisdero, C., Riobó, N., Schöpfer, F., & Boveris, A. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0146 · Cited by 726 · see citing works
Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans
Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689 · see citing works
Self-citationBenjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665 · see citing works
Intragastric nitric oxide production in humans: measurements in expelled air.
Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661 · see citing works
Self-citationInorganic nitrate is a possible source for systemic generation of nitric oxide
Lundberg, J. O., & Govoni, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.027 · Cited by 657 · see citing works
Self-citationEffects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · see citing works
Self-citationNitrate and nitrite in biology, nutrition and therapeutics
Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., Cabrales, P., Fago, A., Feelisch, M., Ford, P. C., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.260 · Cited by 617 · see citing works
Self-citationBailey, S. J., Fulford, J., Vanhatalo, A., Winyard, P. G., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Benjamin, N., & Jones, A. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00046.2010 · Cited by 607 · see citing works
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599 · see citing works
Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596 · see citing works
Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works
Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Pavey, T. G., Wilkerson, D. P., Benjamin, N., Winyard, P. G., & Jones, A. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00206.2010 · Cited by 529 · see citing works
Update on Mechanism and Catalytic Regulation in the NO Synthases
Stuehr, D. J., Santolini, J., Wang, Z., Wei, C., & Adak, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400017200 · Cited by 516 · see citing works
Castello, P. R., David, P. S., McClure, T., Crook, Z., & Poyton, R. O. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.011 · Cited by 495 · see citing works
Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507621200 · Cited by 464 · see citing works
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works
Self-citationNitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes
Bolaños, J. P., Peuchen, S., Heales, S., Land, J. M., & Clark, J. B. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63030910.x · Cited by 413 · see citing works
Nitric Oxide and the Vascular Endothelium
Moncada, S., & Higgs, E. A. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6_7 · Cited by 408 · see citing works
Lansley, K. E., Winyard, P. G., Fulford, J., Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Gilchrist, M., Benjamin, N., & Jones, A. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01070.2010 · Cited by 404 · see citing works
Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306706101 · Cited by 400 · see citing works
Fukuto, J. M., Carrington, S. J., Tantillo, D. J., Harrison, J. G., Ignarro, L. J., Freeman, B. A., Chen, A., & Wink, D. A. (2012) · Chemical Research in Toxicology · doi:10.1021/tx2005234 · Cited by 389 · see citing works
Acute Dietary Nitrate Supplementation Improves Cycling Time Trial Performance
LANSLEY, K. E., WINYARD, P. G., BAILEY, S. J., VANHATALO, A., WILKERSON, D. P., BLACKWELL, J. R., GILCHRIST, M., BENJAMIN, N., & JONES, A. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821597b4 · Cited by 388 · see citing works
Paradies, G., Petrosillo, G., Pistolese, M., & Ruggiero, F. M. (2002) · Gene · doi:10.1016/s0378-1119(01)00814-9 · Cited by 372 · see citing works
Sun, J., Morgan, M., Shen, R.-F., Steenbergen, C., & Murphy, E. (2007) · Circulation Research · doi:10.1161/circresaha.107.155879 · Cited by 367 · see citing works
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
Jansson, E. Å., Huang, L., Malkey, R., Govoni, M., Nihlén, C., Olsson, A., Stensdotter, M., Petersson, J., Holm, L., Weitzberg, E., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.92 · Cited by 356 · see citing works
Self-citationCytochrome c Nitration by Peroxynitrite
Cassina, A. M., Hodara, R., Souza, J. M., Thomson, L., Castro, L., Ischiropoulos, H., Freeman, B. A., & Radi, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909978199 · Cited by 354 · see citing works
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349 · see citing works
Health Implications of Exposure to Environmental Nitrogenous Compounds
Mensinga, T. T., Speijers, G. J. A., & Meulenbelt, J. (2003) · Toxicological Reviews · doi:10.2165/00139709-200322010-00005 · Cited by 347 · see citing works
Nitrite reductase activity is a novel function of mammalian mitochondria
Kozlov, A. V., Staniek, K., & Nohl, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00788-7 · Cited by 342 · see citing works
Nitric Oxide and Mitochondrial Signaling: From Physiology to Pathophysiology
Erusalimsky, J. D., & Moncada, S. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.151167 · Cited by 336 · see citing works
Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334 · see citing works
Nitrate Supplementation’s Improvement of 10-km Time-Trial Performance in Trained Cyclists
Cermak, N. M., Gibala, M. J., & van Loon, L. J. C. (2012) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.22.1.64 · Cited by 326 · see citing works
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.006 · Cited by 320 · see citing works
Self-citationRole of nitric oxide in the regulation of oxygen consumption in conscious dogs.
Shen, W., Xu, X., Ochoa, M., Zhao, G., Wolin, M. S., & Hintze, T. H. (1994) · Circulation Research · doi:10.1161/01.res.75.6.1086 · Cited by 317 · see citing works
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease
Kenjale, A. A., Ham, K. L., Stabler, T., Robbins, J. L., Johnson, J. L., VanBruggen, M., Privette, G., Yim, E., Kraus, W. E., & Allen, J. D. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00071.2011 · Cited by 316 · see citing works
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
Protein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria
Costa, A. D. T., Garlid, K. D., West, I. C., Lincoln, T. M., Downey, J. M., Cohen, M. V., & Critz, S. D. (2005) · Circulation Research · doi:10.1161/01.res.0000178451.08719.5b · Cited by 307 · see citing works
Thomas, D. D., Espey, M. G., Ridnour, L. A., Hofseth, L. J., Mancardi, D., Harris, C. C., & Wink, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400453101 · Cited by 289 · see citing works
Nitric Oxide Production from Nitrite Occurs Primarily in Tissues Not in the Blood
Li, H., Cui, H., Kundu, T. K., Alzawahra, W., & Zweier, J. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801785200 · Cited by 269 · see citing works
Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase
Kadenbach, B., Hüttemann, M., Arnold, S., Lee, I., & Bender, E. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00305-1 · Cited by 268 · see citing works
Live high:train low increases muscle buffer capacity and submaximal cycling efficiency
Gore, C. J., Hahn, A., Aughey, R. J., Martin, D. T., Ashenden, M., Clark, S. A., GARNHAM, A. P., Roberts, A. D., Slater, G., & McKenna, M. J. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00906.x · Cited by 267 · see citing works
Carlström, M., Persson, A. E. G., Larsson, E., Hezel, M., Scheffer, P. G., Teerlink, T., Weitzberg, E., & Lundberg, J. O. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq366 · Cited by 261 · see citing works
Self-citationDietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia
Vanhatalo, A., Fulford, J., Bailey, S. J., Blackwell, J. R., Winyard, P. G., & Jones, A. M. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.216341 · Cited by 233 · see citing works
Lang, J. D., Teng, X., Chumley, P., Crawford, J. H., Isbell, T. S., Chacko, B. K., Liu, Y., Jhala, N., Crowe, D. R., Smith, A. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31892 · Cited by 224 · see citing works
Nitrite reductase activity of cytochrome c
Basu, S., Azarova, N. A., Font, M. D., King, S. B., Hogg, N., Gladwin, M. T., Shiva, S., & Kim-Shapiro, D. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806934200 · Cited by 214 · see citing works
Aamand, R., Dalsgaard, T., Jensen, F. B., Simonsen, U., Roepstorff, A., & Fago, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00525.2009 · Cited by 213 · see citing works
Powers, K. A., Szászi, K., Khadaroo, R. G., Tawadros, P. S., Marshall, J. C., Kapùs, A., & Rotstein, O. D. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060943 · Cited by 203 · see citing works
Webb, A. J., Milsom, A. B., Rathod, K. S., Chu, W. L., Qureshi, S., Lovell, M. J., Lecomte, F. M. J., Perrett, D., Raimondo, C., Khoshbin, E., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.175810 · Cited by 203 · see citing works
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.001 · Cited by 198 · see citing works
Borutaitė, V., Jekabsone, A., & Brown, G. C. (2000) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00178-x · Cited by 197 · see citing works
Ishibashi, Y., Duncker, D. J., Zhang, J. J., & Bache, R. J. (1998) · Circulation Research · doi:10.1161/01.res.82.3.346 · Cited by 197 · see citing works
Carlsson, S., Wiklund, N. P., Engstrand, L., Weitzberg, E., & Lundberg, J. O. N. (2001) · Nitric Oxide · doi:10.1006/niox.2001.0371 · Cited by 189 · see citing works
Self-citationOn the mechanism and biology of cytochrome oxidase inhibition by nitric oxide
Antunes, F., Boveris, A., & Cadenas, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405368101 · Cited by 189 · see citing works
Red wine-dependent reduction of nitrite to nitric oxide in the stomach
Gago, B., Lundberg, J. O., Barbosa, R. M., & Laranjinha, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.007 · Cited by 186 · see citing works
Self-citationTherapeutic Uses of Inorganic Nitrite and Nitrate: From the Past to the Future
Butler, A. R., & Feelisch, M. (2008) · Circulation · doi:10.1161/circulationaha.107.753814 · Cited by 184 · see citing works
High Efficiency of Type I Muscle Fibers Improves Performance
Horowitz, J. D., Sidossis, L. S., & Coyle, E. F. (1994) · International Journal of Sports Medicine · doi:10.1055/s-2007-1021038 · Cited by 183 · see citing works
Pesta, D. H., Hoppel, F., Macek, C., Messner, H., Faulhaber, M., Kobel, C., Parson, W., Burtscher, M., Schocke, M. F. H., & Gnaiger, E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00285.2011 · Cited by 181 · see citing works
Early changes in intramitochondrial cardiolipin distribution during apoptosis.
Garcia‐Fernandez, M. I., Troiano, L., Moretti, L., Nasi, M., Pinti, M., Salvioli, S., Dobrucki, J. W., & Cossarizza, A. (2002) · PubMed · Cited by 181 · see citing works
Metabolic and work efficiencies during exercise in Andean natives
Hochachka, P. W., Stanley, C., Matheson, G. O., McKenzie, D. C., Allen, P. S., & Parkhouse, W. S. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.4.1720 · Cited by 178 · see citing works
Richardson, R. S., Leigh, J. S., Wagner, P. D., & Noyszewski, E. A. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.325 · Cited by 164 · see citing works
Tonkonogi, M., Walsh, B. J., Svensson, M., & Sahlin, K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00379.x · Cited by 161 · see citing works
Myoglobin desaturation with exercise intensity in human gastrocnemius muscle
Mole, P. A., Chung, Y., Tran, T. K., Sailasuta, N., Hurd, R. E., & Jue, T. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.1.r173 · Cited by 160 · see citing works
Acclimatization of skeletal muscle mitochondria to high‐altitude hypoxia during an ascent of Everest
Levett, D. Z. H., Radford, E. J., Menassa, D. A., Graber, E. F., Morash, A. J., Hoppeler, H. H., Clarke, K., Martín, D., Ferguson‐Smith, A. C., Montgomery, H., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-197772 · Cited by 155 · see citing works
Regulation of Mitochondrial Respiration by Oxygen and Nitric Oxide
BOVERIS, A., Costa, L. E., Poderoso, J. J., Carreras, M. C., & Cadenas, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06181.x · Cited by 148 · see citing works
Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions
Petersen, M. G., Dewilde, S., & Fago, A. (2008) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2008.05.008 · Cited by 144 · see citing works
Acute Administration of Inorganic Nitrate Reduces V˙O2peak in Endurance Athletes
BESCÓS, R., RODRÍGUEZ, F. A., IGLESIAS, X., FERRER, M. D., IBORRA, E., & PONS, A. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318217d439 · Cited by 137 · see citing works
Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria
Toime, L. J., & Brand, M. D. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.05.010 · Cited by 135 · see citing works
No Differences in Cycling Efficiency Between World-Class and Recreational Cyclists
Moseley, L., Achten, J., Martin, J. C., & Jeukendrup, A. E. (2004) · International Journal of Sports Medicine · doi:10.1055/s-2004-815848 · Cited by 127 · see citing works
Nitric oxide increases oxidative phosphorylation efficiency
Clerc, P., Rigoulet, M., Leverve, X. M., & Fontaine, E. M. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9074-1 · Cited by 122 · see citing works
Grover, G. J., Atwal, K. S., Sleph, P. G., Wang, F., Monshizadegan, H., Monticello, T. M., & Green, D. W. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01019.2003 · Cited by 121 · see citing works
Befroy, D. E., Petersen, K. F., Dufour, S., Mason, G. F., Rothman, D. L., & Shulman, G. I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808889105 · Cited by 120 · see citing works
NO-synthase and nitrite-reductase components of nitric oxide cycle.
Reutov, V. P., & Sorokina, E. G. (1998) · PubMed · Cited by 118 · see citing works
Arnold, S. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.05.003 · Cited by 117 · see citing works
Liu, B., Tewari, A. K., Zhang, L., Green‐Church, K. B., Zweier, J. L., Chen, Y., & He, G. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2008.12.008 · Cited by 116 · see citing works
Heinonen, I., Saltin, B., Kemppainen, J., Sipilä, H. T., Oikonen, V., Nuutila, P., Knuuti, J. M., Kalliokoski, K. K., & Hellsten, Y. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00996.2010 · Cited by 109 · see citing works
Nitric Oxide Modulates Mitochondrial Respiration in Failing Human Heart
Loke, K. E., Laycock, S. K., Mital, S. R., Wolin, M. S., Bernstein, R. D., Oz, M. C., Addonizio, L. J., Kaley, G., & Hintze, T. H. (1999) · Circulation · doi:10.1161/01.cir.100.12.1291 · Cited by 107 · see citing works
Vlasova, I. I., Tyurin, V. A., Kapralov, A. A., Kurnikov, I. V., Osipov, A. N., Potapovich, M. V., Stoyanovsky, D. A., & Kagan, V. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509507200 · Cited by 98 · see citing works
Jädert, C., Petersson, J., Massena, S., Ahl, D., Grapensparr, L., Holm, L., Lundberg, J. O., & Phillipson, M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.018 · Cited by 97 · see citing works
Self-citationZhu, S.-G., Kukreja, R. C., Das, A., Chen, Q., Lesnefsky, E. J., & Xi, L. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.024 · Cited by 96 · see citing works
Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration
Castro, L., Eiserich, J. P., Sweeney, S., Radi, R., & Freeman, B. A. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.033 · Cited by 84 · see citing works
Mitochondrial oxygen affinity predicts basal metabolic rate in humans
Larsen, F. J., Schiffer, T. A., Sahlin, K., Ekblom, B. T., Weitzberg, E., & Lundberg, J. O. (2011) · The FASEB Journal · doi:10.1096/fj.11-182139 · Cited by 81 · see citing works
Self-citationImpact of Energy Intake and Exercise on Resting Metabolic Rate
Mole, P. A. (1990) · Sports Medicine · doi:10.2165/00007256-199010020-00002 · Cited by 79 · see citing works
Rocha, B. S., Gago, B., Barbosa, R. M., Lundberg, J. O., Radi, R., & Laranjinha, J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.011 · Cited by 74 · see citing works
Self-citationNitric oxide controls cardiac substrate utilization in the conscious dog
Recchia, F. A. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00245-x · Cited by 73 · see citing works
Bell, R. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00675-2 · Cited by 73 · see citing works
Variable stoichiometry of proton pumping by the mitochondrial respiratory chain
Murphy, M. P., & Brand, M. D. (1987) · Nature · doi:10.1038/329170a0 · Cited by 71 · see citing works
Mitochondrial respiration in the low oxygen environment of the cell effect of ADP on oxygen kinetics
Gnaiger, E., Lassnig, B., Kuznetsov, A. V., & Margreiter, R. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00076-0 · Cited by 71 · see citing works
Mitochondrial function in human skeletal muscle is not impaired by high intensity exercise
Tonkonogi, M., Walsh, B. J., Tiivel, T., Saks, V. A., & Sahlin, K. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050818 · Cited by 70 · see citing works
Capitanio, N., Capitanio, G., Nitto, E. D., Villani, G., & Papa, S. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81029-8 · Cited by 63 · see citing works
Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis
Little, J. P., Safdar, A., Benton, C. R., & Wright, D. C. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-076 · Cited by 62 · see citing works
Gouspillou, G., Bourdel-Marchasson, I., Rouland, R., Calmettes, G., Franconi, J.-M., Deschodt-Arsac, V., & Diolez, P. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.09.004 · Cited by 62 · see citing works
Nitrite as a mediator of ischemic preconditioning and cytoprotection
Murillo, D., Kamga, C., Mo, L., & Shiva, S. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.01.003 · Cited by 57 · see citing works
The reduction of nitrite by skeletal-muscle mitochondria
Walters, C. L., & Taylor, A. M. (1965) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(65)90570-8 · Cited by 55 · see citing works
Weerateerangkul, P., Chattipakorn, S. C., & Chattipakorn, N. (2011) · Medical Science Monitor · doi:10.12659/msm.881385 · Cited by 53 · see citing works
Shen, W., Tian, R., Saupe, K. W., Spindler, M., & Ingwall, J. S. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.2.h838 · Cited by 49 · see citing works
Economy of locomotion in high‐altitude Tibetan migrants exposed to normoxia
Marconi, C., Marzorati, M., Sciuto, D., Ferri, A., & Cerretelli, P. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.094979 · Cited by 47 · see citing works
Lacerda, A. C. R., Marubayashi, U., Balthazar, C. H., & Coimbra, C. C. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.076 · Cited by 44 · see citing works
Wang, L., Frizzell, S. A., Zhao, X., & Gladwin, M. T. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.002 · Cited by 22 · see citing works
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Drinking Water Nitrate and Human Health: An Updated Review
Ward, M., Jones, R., Brender, J., De Kok, T., Weyer, P., Nolan, B., Villanueva, C., & Van Breda, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15071557 · Cited by 1,576 · see citing works
The immune system’s role in sepsis progression, resolution, and long-term outcome
Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880 · see citing works
The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
Singer, M. (2013) · Virulence · doi:10.4161/viru.26907 · Cited by 624 · see citing works
Strategies to increase nitric oxide signalling in cardiovascular disease
Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576 · see citing works
Self-citationSepsis—Pathophysiology and Therapeutic Concepts
Jarczak, D., Kluge, S., & Nierhaus, A. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.628302 · Cited by 491 · see citing works
Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
Wyngene, L. V., Vandewalle, J., & Libert, C. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708712 · Cited by 264 · see citing works
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
Habermeyer, M., Roth, A., Guth, S., Diel, P. R., Engel, K., Epe, B., Fürst, P., Heinz, V., Humpf, H., Joost, H., et al. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400286 · Cited by 244 · see citing works
Metabolic Alterations in Sepsis
Wasyluk, W., & Zwolak, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112412 · Cited by 202 · see citing works
The oral microbiome and nitric oxide homoeostasis
Hezel, M., & Weitzberg, E. (2015) · Oral Diseases · doi:10.1111/odi.12157 · Cited by 201 · see citing works
Self-citationHomocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems
Kaplán, P., Tatarková, Z., Sivoňová, M. K., Račay, P., & Lehotský, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207698 · Cited by 195 · see citing works
Regulation of Mitochondrial Biogenesis and Its Intersection with Inflammatory Responses
Cherry, A. D., & Piantadosi, C. A. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6200 · Cited by 188 · see citing works
Lin, Y., Lin, Y., Lin, H., Chen, Y., Wang, H., & Shi, J. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.07.118 · Cited by 161 · see citing works
Sepsis-induced cardiac dysfunction: a review of pathophysiology
Habimana, R., Choi, I., Cho, H. J., Kim, D., Lee, K., & Jeong, I. S. (2020) · Acute and Critical Care · doi:10.4266/acc.2020.00248 · Cited by 153 · see citing works
Mrakic‐Sposta, S., Gussoni, M., Moretti, S., Pratali, L., Giardini, G., Tacchini, P., Dellanoce, C., Tonacci, A., Mastorci, F., Borghini, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141780 · Cited by 136 · see citing works
Diabetes and Sepsis: Risk, Recurrence, and Ruination
Frydrych, L. M., Fattahi, F., He, K., Ward, P. A., & Delano, M. J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00271 · Cited by 133 · see citing works
Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health
Kapil, V., Weitzberg, E., Lundberg, J. O., & Ahluwalia, A. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.03.162 · Cited by 126 · see citing works
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Zhang, H., Feng, Y., & Yao, Y.-M. (2018) · Military Medical Research · doi:10.1186/s40779-018-0187-0 · Cited by 110 · see citing works
Recent advances in pathophysiology and biomarkers of sepsis-induced acute kidney injury
Umbro, I., Gentile, G., Tinti, F., Muiesan, P., & Mitterhofer, A. P. (2015) · Journal of Infection · doi:10.1016/j.jinf.2015.11.008 · Cited by 95 · see citing works
Xin, Y., Tian, M., Deng, S., Li, J., Yang, M., Gao, J., Pei, X., Wang, Y., Tan, J., Zhao, F., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03148-z · Cited by 99 · see citing works
Ahluwalia, A., Gladwin, M., Coleman, G. D., Hord, N., Howard, G., Kim‐Shapiro, D. B., Lajous, M., Larsen, F. J., Lefer, D. J., McClure, L. A., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003402 · Cited by 92 · see citing works
Self-citationÜremiş, N., & Üremi̇ş, M. M. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70133 · Cited by 98 · see citing works
Coletta, C., Módis, K., Oláh, G., Brunyánszki, A., Herzig, D. S., Sherwood, E. R., Ungvari, Z. I., & Szabó, C. (2014) · Critical Care · doi:10.1186/s13054-014-0511-3 · Cited by 88 · see citing works
Beyer, A., Zinkevich, N. S., Miller, B., Liu, Y., Wittenburg, A. L., Mitchell, M., Galdieri, R. J., Sorokin, A., & Gutterman, D. D. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0594-x · Cited by 88 · see citing works
Advances and Challenges in Sepsis Management: Modern Tools and Future Directions
Santacroce, E., D’Angerio, M., Ciobanu, A. L., Masini, L., Tartaro, D. L., Coloretti, I., Busani, S., Rubio, I., Meschiari, M., Franceschini, E., et al. (2024) · Cells · doi:10.3390/cells13050439 · Cited by 93 · see citing works
Mechanisms underlying blood pressure reduction by dietary inorganic nitrate
Carlström, M., Lundberg, J. O., & Weitzberg, E. (2018) · Acta Physiologica · doi:10.1111/apha.13080 · Cited by 86 · see citing works
Self-citationDyakova, E. Y., Капилевич, Л. В., Shylko, V. G., Popov, S. V., & Anfinogenova, Y. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00019 · Cited by 85 · see citing works
Sepsis-Associated AKI: Epithelial Cell Dysfunction
Emlet, D. R., Shaw, A., & Kellum, J. A. (2015) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2015.01.009 · Cited by 80 · see citing works
The role of nitric oxide in melanoma
Yarlagadda, K., Hassani, J., Foote, I. P., & Markowitz, J. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.09.005 · Cited by 75 · see citing works
Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis
Park, D. W., & Zmijewski, J. W. (2017) · Infection and Chemotherapy · doi:10.3947/ic.2017.49.1.10 · Cited by 69 · see citing works
Ferguson, S. K., Hirai, D. M., Copp, S. W., Holdsworth, C. T., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C. (2013) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2013.04.001 · Cited by 69 · see citing works
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works
Comparison between 'Fuyan' and 'Dongbi' longans in aril breakdown and respiration metabolism
Lin, L., Lin, Y., Lin, H., Lin, M., Ritenour, M. A., Chen, Y., Wang, H., Hung, Y., & Lin, Y. (2019) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2019.04.008 · Cited by 65 · see citing works
Ciarlone, G. E., Hinojo, C. M., Stavitzski, N. M., & Dean, J. B. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101159 · Cited by 64 · see citing works
Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis
Little, J. P., Safdar, A., Benton, C. R., & Wright, D. C. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-076 · Cited by 62 · see citing works
Ashmore, T., Fernandez, B. O., Branco‐Price, C., West, J. A., Cowburn, A. S., Heather, L. C., Griffin, J. L., Johnson, R. S., Feelisch, M., & Murray, A. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.275263 · Cited by 58 · see citing works
Peleli, M., Ferreira, D. M. S., Tarnawski, L., Haworth, S. M., Xuechen, L., Zhuge, Z., Newton, P. T., Massart, J., Chagin, A. S., Olofsson, P. S., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101387 · Cited by 58 · see citing works
Self-citationSundqvist, M. L., Lundberg, J. O., & Weitzberg, E. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.10.003 · Cited by 46 · see citing works
Self-citationArazi, H., & Eghbali, E. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.660150 · Cited by 46 · see citing works
No effect of dietary nitrate supplementation on endurance training in hypoxia
Puype, J., Ramaekers, M., Van Thienen, R., Deldicque, L., & Hespel, P. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12199 · Cited by 39 · see citing works
Gorman, S., Lucas, R. M., Aidan, A.-H., Fleury, N., & Feelisch, M. (2016) · Photochemical & Photobiological Sciences · doi:10.1039/c6pp00274a · Cited by 41 · see citing works
Siervo, M., Oggioni, C., Jakovljevic, D. G., Trenell, M., Mathers, J. C., Houghton, D., Celis-Morales, C., Ashor, A. W., Ruddock, A., Ranchordas, M., et al. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.11.004 · Cited by 37 · see citing works
Nitric oxide, interorganelle communication, and energy flow: a novel route to slow aging
Valerio, A., & Nisoli, E. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00006 · Cited by 37 · see citing works
Mogen, A. B., Carroll, R. K., James, K. L., Lima, G., Silva, D., Culver, J. A., Petucci, C. J., Shaw, L. N., & Rice, K. C. (2017) · Molecular Microbiology · doi:10.1111/mmi.13693 · Cited by 37 · see citing works
Singh, S., Zhuo, M., Gorgun, F. M., & Englander, E. W. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.03.008 · Cited by 35 · see citing works
Construction of effective disposable biosensors for point of care testing of nitrite
Monteiro, T., Rodrigues, P. D. S., Gonçalves, A. L., Moura, J. J. G., Jubete, E., Añorga, L., Piknova, B., Schechter, A. N., Silveira, C. M., & Almeida, M. G. (2015) · Talanta · doi:10.1016/j.talanta.2015.04.057 · Cited by 35 · see citing works
Hu, Z., Xu, D., Meng, H., Liu, W., Zheng, Q., & Wang, J. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115992 · Cited by 33 · see citing works
Nitric oxide in exercise physiology: past and present perspectives
Mueller, B. J., Roberts, M. D., Mobley, C. B., Judd, R. L., & Kavazis, A. N. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2024.1504978 · Cited by 32 · see citing works
Ferguson, S. K., Hirai, D. M., Copp, S. W., Holdsworth, C. T., Allen, J. D., JONES, A. M., Musch, T. I., & Poole, D. C. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.04.007 · Cited by 28 · see citing works
Liubertas, T., Kairaitis, R., Stasiulė, L., Čapkauskienė, S., Stasiulis, A., Viškelis, P., Viškelis, J., & Urbonavičienė, D. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00366-5 · Cited by 26 · see citing works
Prospects of Photocatalysis in the Management of Nitrate Contamination in Potable Water
Ajmal, Z., Naciri, Y., Hsini, A., Bresolin, B.-M., Qadeer, A., Nauman, M., Arif, M. Z., Irshad, M. S., Khan, K. A., Djellabi, R., et al. (2021) · Environmental contamination remediation and management · doi:10.1007/978-3-030-70757-6_7 · Cited by 24 · see citing works
Portella, R. D. L., Bickta, J., & Shiva, S. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6260 · Cited by 21 · see citing works
Nitrate supplementation and human exercise performance
POORTMANS, J. R., Gualano, B., & Carpentier, A. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000222 · Cited by 19 · see citing works
Pang, D., Bashir, D. A., Carcillo, J. A., Nguyen, T. C., Aneja, R. K., & Alcamo, A. M. (2018) · Journal of Pediatric Intensive Care · doi:10.1055/s-0038-1675639 · Cited by 18 · see citing works
Christensen, P. M., Petersen, N., Friis, S. N., Weitzberg, E., & Nybo, L. (2017) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12848 · Cited by 16 · see citing works
Self-citationShen, X., Han, G., Li, S., Song, Y., Shen, H., Zhai, Y., Wang, Y., Zhang, F., Dong, N., Li, T., et al. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13746 · Cited by 15 · see citing works
Tyrosine nitration of mitochondrial proteins during myocardial ischemia and reperfusion
Tatarková, Z., Kovalská, M., Sivoňová, M. K., Račay, P., Lehotský, J., & Kaplán, P. (2019) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00683-7 · Cited by 15 · see citing works
Corti, P., Tejero, J., & Gladwin, M. T. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.020 · Cited by 13 · see citing works
Macrophage activation syndrome in Sepsis: from pathogenesis to clinical management
Chen, S., Zhang, C., Luo, J., Lin, Z., Chang, T., Dong, L., Chen, D., & Tang, Z. (2024) · Inflammation Research · doi:10.1007/s00011-024-01957-7 · Cited by 12 · see citing works
Montero‐Bullón, J., Melo, T., Domingues, M. R., & Domingues, P. M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.009 · Cited by 11 · see citing works
Bahar, O., & Eraslan, G. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26105-2 · Cited by 10 · see citing works
The Effects of Dietary Nitrate (Beetroot Juice) Supplementation on Exercise Performance: A Review
Zafeiridis, A. (2014) · American Journal of Sports Science · doi:10.11648/j.ajss.20140204.15 · Cited by 10 · see citing works
The Role of the Innate Immune System in Sepsis
Censoplano, N. M., Epting, C. L., & Coates, B. M. (2014) · Clinical Pediatric Emergency Medicine · doi:10.1016/j.cpem.2014.04.007 · Cited by 9 · see citing works
Progress of Research in Neonatal Sepsis
Chen, S., & Shi, Y. (2019) · Springer eBooks · doi:10.1007/978-981-13-3353-8_16 · Cited by 9 · see citing works
Kolb, L., Orbegozo, D., Créteur, J., Preiser, J., Vincent, J., & Backer, D. D. (2017) · Journal of Vascular Research · doi:10.1159/000468541 · Cited by 9 · see citing works
Ye, L., Wang, L., Kuang, G., Zhang, Z., Peng, Q., He, M., & Fan, J. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156881 · Cited by 9 · see citing works
The O2-sensitive brain stem, hyperoxic hyperventilation, and CNS oxygen toxicity
Dean, J. B., & Stavitzski, N. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.921470 · Cited by 8 · see citing works
Roemmelt, A. T., Franckenberg, S., Steuer, A. E., & Kræmer, T. (2014) · Forensic Science International · doi:10.1016/j.forsciint.2014.03.016 · Cited by 6 · see citing works
Mitochondrial gene mutations in pediatric septic shock
Park, J. S., Kang, E., Kang, S., Kim, D., Kim, D., Park, S. J., & Jhang, W. K. (2021) · Pediatric Research · doi:10.1038/s41390-020-01358-6 · Cited by 5 · see citing works
Association Between Myocardial Dysfunction and Septic Shock
Pădureanu, V., Caragea, D. C., Pîrșcoveanu, D. F. V., Dop, D., Munteanu, A. C., Rădulescu, D., Popa, D. G., Forțofoiu, D., Drăgoescu, A. N., & Pădureanu, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062552 · Cited by 3 · see citing works
Factors impacting the regulation of nos gene expression in Staphylococcus aureus
Brandwein, J. N., Sculthorpe, T. S., Ridder, M. J., Bose, J. L., & Rice, K. C. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01688-23 · Cited by 3 · see citing works
Cai, C., Huang, P., Cheng, X., & Zhou, J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1844096 · Cited by 2 · see citing works
The Mitochondrion: A Physiological Target of Nitrite
Guimarães, D. A., Reyes, C., & Shiva, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_5 · Cited by 2 · see citing works
Beetroot Juice - Legal Doping for Athletes?
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Kanmani, P., & Hu, G. (2024) · Methods in cell biology · doi:10.1016/bs.mcb.2024.01.006 · Cited by 1 · see citing works
An, W., Reyes, C., Espinosa‐Díez, C., Patel, P., Guimaraes, D., Villareal, F., Jessup, M., Croix, C. S., Gomez, D. A., Rao, K., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104169 · Cited by 1 · see citing works
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Algallie, H. M., Banerjee, S., Kumar, A., Rubab, U. I., Agarwal, A. K., Nahid, S., Shaikh, N., & Rahman, M. A. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1007151 · Cited by 1 · see citing works
Liubertas, T., Kairaitis, R., Stasiulė, L., Čapkauskienė, S., Stasiulis, A., Viškelis, P., Viškelis, J., & Urbonavičienė, D. (2019) · Preprints.org · doi:10.20944/preprints201911.0336.v1 · Cited by 1 · see citing works
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Perez, S. D. L. F. (2014) · doi:10.35376/10324/4528
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Melo, M. E., Uchimura, M. H., Silva, E. P., & Carvalho, B. B. (2018)
Some features of the influence of nitrogen oxide on humans at rest, physical activity and pathology
Котко, Д., Goncharuk, N., Levon, M., & Shevtsov, S. (2021) · Scientific Journal of National Pedagogical Dragomanov University Series 15 Scientific and pedagogical problems of physical culture (physical culture and sports) · doi:10.31392/npu-nc.series15.2021.12(144).16
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Weng, J., Wang, X., Shang, X., Xiao, J., Ye, Y., Yu, R., & Shang, J. (2024) · Research Square · doi:10.21203/rs.3.rs-3802999/v1
Stelmashook, E. V., Alexandrova, O. P., Генрихс, Е. Е., Verma, Y., Salmina, A. B., & Исаев, Н. К. (2024) · Annals of Clinical and Experimental Neurology · doi:10.54101/acen.2023.4.6
Martins, D. (2014) · Spectrum Research Repository (Concordia University)
Role of PGC-1β and TIF2 co-regulators in mouse skeletal muscle function
Ramamoorthy, T. G. (2013) · theses.fr (ABES) · doi:10.70675/e05002c4z4806z4363z90b1z0e406b6c0e4c
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Fleurance, R. (2021) · theses.fr (ABES) · doi:10.70675/0a82ed6ez6595z4366z832fz70cbe839c7ff
Ferguson, S. K. (2015) · K-State Research Exchange (Kansas State University)
- Authors
- Larsen, F. J., Schiffer, T. A., Weitzberg, E., & Lundberg, J. O.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Larsen, Filip J
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 53
- Issue
- 10
- Pages
- 1919-1928
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2084630350
- Cited by
- 87
- References
- 120
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 12 · 2013: 6
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hjärt-Lungfonden
- Karolinska Institutet
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- nitric oxide, nitrate, nitrite, mitochondrial function, cellular energetics, cytochrome c oxidase, nitric oxide synthase, L-arginine, reactive nitrogen oxides, dietary nitrate, physical activity, cytoprotection, intracellular signaling
- MeSH terms
- Animals, Electron Transport Complex IV, Humans, Mitochondria, Nitric Oxide, Oxidation-Reduction, Oxygen, Signal Transduction, Exercise, Nitric Oxide Synthase, Reactive Nitrogen Species
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