The DOI matches its Crossref record; 72 of the 73 references it cites were found in a registry or an index.
Microenvironmental regulation of cancer development
Open accessAbstract
Numerous studies have demonstrated that the tumor microenvironment not only responds to and supports carcinogenesis, but also actively contributes to tumor initiation, progression, and metastasis. During tumor progression all cells composing the tumor undergo phenotypic and epigenetic changes. Paracrine signaling between epithelial and stromal cells is important for the regulation of the proliferation, invasive, angiogenic, and metastatic behavior of cancer cells. Better understanding the molecular mechanisms by which stromal cells exert these effects may open up new venues for cancer therapeutic and preventative interventions.
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“While stroma in normal tissues may possess anti-tumor properties, tumor-associated stroma—comprising cancer-associated fibroblasts, ECM, endothelial cells, and immune cells—actively facilitates tumor initiation, invasion, and therapeutic resistance [139,140,141,142].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [141]
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Metadata
- Authors
- Hu, M., & Polyak, K.
- Affiliations
- Dana-Farber Cancer Institute (US)
- ORCID
- Hu, Min
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 18
- Issue
- 1
- Pages
- 27-34
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC2467152
- OpenAlex
- W2049391622
- Cited by
- 330
- References
- 73
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 15 · 2022: 9 · 2021: 10 · 2020: 20 · 2019: 11 · 2018: 15 · 2017: 20 · 2016: 23 · 2015: 21 · 2014: 31 · 2013: 32 · 2012: 24
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Avon Foundation for Women
- Susan G. Komen for the Cure
- Biogen
- Novartis Foundation
- Susan G. Komen
- IC Design Education Center
- National Cancer Institute (CA 89393, CA94074, CA116235, R01CA094074, P50CA089393, R01CA116235)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- tumor microenvironment, carcinogenesis, tumor initiation, tumor progression, metastasis, paracrine signaling, stromal cells, stromal-epithelial interactions, angiogenesis, tumor invasion, epigenetic modifications
- MeSH terms
- Carcinoma in Situ, Epithelial Cells, Humans, Neoplasms, Phenotype, Signal Transduction, Stromal Cells, Disease Progression, Epigenesis, Genetic
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