Cited by 332Cancer Cells and MetastasisTGF-β signaling in diseasesAngiogenesis and VEGF in Cancer

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Microenvironmental regulation of cancer development

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Hu, Min, Polyak, Kornelia·2008·Current Opinion in Genetics & Development

DOI 10.1016/j.gde.2007.12.006PMC PMC2467152

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Abstract

Numerous studies have demonstrated that the tumor microenvironment not only responds to and supports carcinogenesis, but also actively contributes to tumor initiation, progression, and metastasis. During tumor progression all cells composing the tumor undergo phenotypic and epigenetic changes. Paracrine signaling between epithelial and stromal cells is important for the regulation of the proliferation, invasive, angiogenic, and metastatic behavior of cancer cells. Better understanding the molecular mechanisms by which stromal cells exert these effects may open up new venues for cancer therapeutic and preventative interventions.

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Authors: Hu, M., & Polyak, K.
Affiliations: Dana-Farber Cancer Institute (US)
ORCID: Hu, Min
Venue: Current Opinion in Genetics & Development
Publisher: Elsevier BV
Published: 2008-02
Volume: 18
Issue: 1
Pages: 27-34
ISSN: 0959-437X (ISSN-L)
DOI: 10.1016/j.gde.2007.12.006
PMC: PMC2467152
OpenAlex: W2049391622
Cited by: 330
References: 73
Citations by year: 2026: 2 · 2025: 5 · 2024: 6 · 2023: 15 · 2022: 9 · 2021: 10 · 2020: 20 · 2019: 11 · 2018: 15 · 2017: 20 · 2016: 23 · 2015: 21 · 2014: 31 · 2013: 32 · 2012: 24
FWCI: 2.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Genetics & Development (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Avon Foundation for Women
Susan G. Komen for the Cure
Biogen
Novartis Foundation
Susan G. Komen
IC Design Education Center
National Cancer Institute (CA 89393, CA94074, CA116235, R01CA094074, P50CA089393, R01CA116235)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: tumor microenvironment, carcinogenesis, tumor initiation, tumor progression, metastasis, paracrine signaling, stromal cells, stromal-epithelial interactions, angiogenesis, tumor invasion, epigenetic modifications
MeSH terms: Carcinoma in Situ, Epithelial Cells, Humans, Neoplasms, Phenotype, Signal Transduction, Stromal Cells, Disease Progression, Epigenesis, Genetic

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Microenvironmental regulation of cancer development

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