The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
Open accessAbstract
Morphogens act during development to provide graded spatial information that controls patterning and cell lineage specification in the nervous system. The role of morphogen signaling in instructing the expression of downstream effector transcription factors has been well established. However, a key requirement for morphogen signaling is the existence of functional intracellular machinery able to mediate the appropriate response in target cells. Here we suggest that dynamic changes in the temporal responses to Shh in the developing ventral telencephalon occur through alterations in progenitor competence. We suggest these developmental changes in competence are mediated by a transcriptional mechanism that intrinsically integrates information from the distinct signaling pathways that act to pattern the telencephalic neuroepithelium.
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“consistent with a role in MGE fate repression41 and LGE neuron state regulation (Extended Data Fig. 9h,i).”
From Inferring and perturbing cell fate regulomes in human brain organoids (2023) · cites this paper as [41]
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Hedgehog signaling in animal development: paradigms and principlesPreprint
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Neuronal specification in the spinal cord: inductive signals and transcriptional codes
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Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
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Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches
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Inductive interactions direct early regionalization of the mouse forebrain
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Pedraza, M., Grampa, V., Scotto‐Lomassese, S., Puech, J., Muzerelle, A., Mohammad, A., Lebon, S., Renier, N., Métin, C., & Masson, J. (2025) · eLife · doi:10.7554/elife.100328.4
Pedraza, M., Grampa, V., Scotto‐Lomassese, S., Puech, J., Muzerelle, A., Mohammad, A., Lebon, S., Renier, N., Métin, C., & Masson, J. (2025) · eLife · doi:10.7554/elife.100328.2
Expression and function of microRNAs in olfactory bulb neurogenesis
Follert, P. (2012) · theses.fr (ABES) · doi:10.70675/454cf17fze5a2z4340z9c96zdaac7afeedd3
Metadata
- Authors
- Sousa, V. H., & Fishell, G.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Fishell, Gord
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 20
- Issue
- 4
- Pages
- 391-399
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC2991106
- OpenAlex
- W2022089796
- Cited by
- 106
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 14 · 2013: 10 · 2012: 14
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH068469, R01MH071679, R37MH071679)
- National Institute of Neurological Disorders and Stroke (R01NS032993, R01NS039007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Sonic hedgehog, morphogen signaling, temporal competence, ventral telencephalon, forebrain development, transcriptional regulation, signaling pathway integration, cell lineage specification
- MeSH terms
- Zinc Finger Protein GLI1, Thyroid Nuclear Factor 1, Animals, Cell Differentiation, Fibroblast Growth Factors, Nuclear Proteins, Telencephalon, Transcription Factors, Signal Transduction, Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Developmental, Body Patterning, Mice, Hedgehog Proteins
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