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Emerging roles for Polycomb proteins in cancer

Pasini, Diego, Di Croce, Luciano·2016·Current Opinion in Genetics & Development
DOI 10.1016/j.gde.2016.03.013
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Abstract

The activities of the heterogeneous Polycomb (PcG) group of proteins ensure that the developmental processes of proliferation and cellular identity establishment are carried out correctly. PcG proteins assemble stable multiprotein complexes that, together with additional factors, maintain their target genes in a transcriptionally repressive state. The biochemical and functional features of PcG proteins have been extensively investigated over the years. Here we analyse the biochemical and mechanistic proprieties of PcG proteins with respect to recent advances that link the genetic alterations of PcG activity to cancer development.

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Metadata

Authors
Pasini, D., & Di Croce, L.
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2016-02
Volume
36
Pages
50-58
ISSN
0959-437X
DOI
10.1016/j.gde.2016.03.013
Cited by
133
References
10
Language
en
Licence
Funders
  • Ministerio de Educación y Ciencia (SAF2013-48926-P)
  • AGAUR
  • La Marato TV3
  • Fundación Vencer El Cáncer (VEC)
  • Spanish Ministry of Economy and Competitiveness
  • Italian Association for Cancer Research
  • Italian Ministry of Health (GR-2011-02348313)
  • Umberto Veronesi Foundation

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