Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPβ

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262 · see citing works

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189 · see citing works

NITRIC OXIDE AND MACROPHAGE FUNCTION

MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,184 · see citing works

Nitric oxide and the immune response

Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447 · see citing works

Arginine metabolism: nitric oxide and beyond

WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811 · see citing works

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

Andrews, N. C., & Faller, D. V. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.9.2499 · Cited by 2,337 · see citing works

Essential role of Stat6 in IL-4 signalling

Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996) · Nature · doi:10.1038/380627a0 · Cited by 1,557 · see citing works

Nitric oxide : biology and pathobiology

Ignarro, L. J. (2000) · Cited by 1,306 · see citing works

Luciferase reporter gene vectors for analysis of promoters and enhancers.

Nordeen, S. K. (1988) · PubMed · Cited by 994 · see citing works

Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l -Arginine Metabolism

Hesse, M., Modolell, M., Flamme, A. C. L., Schito, M. L., Fuentes, J. M., Cheever, A. W., Pearce, E. J., & Wynn, T. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6533 · Cited by 706 · see citing works

Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4+ T Cells Correlates with Th1/Th2 Phenotype

Munder, M., Eichmann, K., & Modolell, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5347 · Cited by 647 · see citing works

Comparative properties of arginases

Jenkinson, C. P., Grody, W. W., & Cederbaum, S. D. (1996) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/0305-0491(95)02138-8 · Cited by 610 · see citing works

Th1/Th2-Regulated Expression of Arginase Isoforms in Murine Macrophages and Dendritic Cells

Munder, M., Eichmann, K., Morán, J. M., Centeno, F., Soler, G., & Modolell, M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3771 · Cited by 561 · see citing works

Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

Zimmermann, N., King, N. E., Laporte, J. D., Yang, M., Mishra, A., Pope, S. M., Muntel, E. E., Witte, D. P., Pegg, A. A., Foster, P. S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17912 · Cited by 488 · see citing works

Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: A strategy for bacterial survival

Gobert, A. P., McGee, D. J., Akhtar, M., Mendz, G. L., Newton, J. C., Cheng, Y., Mobley, H. L. T., & Wilson, K. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241443798 · Cited by 380 · see citing works

DNA Binding Specificity of Different STAT Proteins

Ehret, G. B., Reichenbach, P., Schindler, U., Horvath, C. M., Fritz, S., Nabholz, M., & Bucher, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001748200 · Cited by 369 · see citing works

Regulation of Nitric Oxide Production by Arginine Metabolic Enzymes

Mori, M., & Gotoh, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3169 · Cited by 346 · see citing works

Interaction and functional collaboration of p300 and C/EBPβ

Mink, S., Haenig, B., & Klempnauer, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6609 · Cited by 344 · see citing works

Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production

Rutschman, R. L., Lang, R., Hesse, M., Ihle, J. N., Wynn, T. A., & Murray, P. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2173 · Cited by 324 · see citing works

Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization

Boucher, J., Moali, C., & Tenu, J. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050352 · Cited by 316 · see citing works

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

Plevy, S. E., Gemberling, J. H. M., Hsu, S., Dorner, A. J., & Smale, S. T. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4572 · Cited by 302 · see citing works

DNA Binding Specificity of the CCAAT/Enhancer-binding Protein Transcription Factor Family

Osada, S., Yamamoto, H., Nishihara, T., & Imagawa, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3891 · Cited by 295 · see citing works

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

Mikita, T., Campbell, D., Wu, P., Williamson, K., & Schindler, U. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5811 · Cited by 271 · see citing works

Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells

Morris, S. M., Kepka‐Lenhart, D., & Chen, L.-C. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e740 · Cited by 254 · see citing works

Components of a stat recognition code: Evidence for two layers of molecular selectivity

Schindler, U., Wu, P., Rothe, M., Brasseur, M., & McKnight, S. L. (1995) · Immunity · doi:10.1016/1074-7613(95)90013-6 · Cited by 246 · see citing works

Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression

Pauleau, A., Rutschman, R. L., Lang, R., Pernis, A. B., Watowich, S. S., & Murray, P. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7565 · Cited by 243 · see citing works

Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

Zimmermann, N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317912 · Cited by 218 · see citing works

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

Delphin, S. A., & Stavnezer, J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.181 · Cited by 201 · see citing works

Arginine metabolism in wounds

Albina, J. E., Mills, C. D., Barbul, A., Thirkill, C. E., Henry, W. L., Mastrofrancesco, B., & Caldwell, M. D. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.4.e459 · Cited by 196 · see citing works

Arginase I induction in macrophages, triggered by Th2‐type cytokines, supports the growth of intracellular Leishmania parasites

Iniesta, V., Gómez-Nieto, L. C., Molano, I., Mohedano‐Moriano, A., Carcelén, J., Mirón, C., Alonso‐Moreno, C., & Corraliza, I. (2002) · Parasite Immunology · doi:10.1046/j.1365-3024.2002.00444.x · Cited by 163 · see citing works

IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells

Liu, W., Jacobs, A. T., Morris, S. M., & Ignarro, L. J. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.1.c248 · Cited by 157 · see citing works

Increased arginase activity underlies allergen‐induced deficiency of cNOS‐derived nitric oxide and airway hyperresponsiveness

Meurs, H., McKay, S., Maarsingh, H., Hamer, M. A. M., Macic, L., Molendijk, N., & Zaagsma, J. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704725 · Cited by 146 · see citing works

The Th2 Cell Cytokines IL-4 and IL-13 Regulate Found in Inflammatory Zone 1/Resistin-Like Molecule α Gene Expression by a STAT6 and CCAAT/Enhancer-Binding Protein-Dependent Mechanism

Stütz, A. M., Pickart, L. A., Trifilieff, A., Baumruker, T., Prieschl, E. E., & Woisetschläger, M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.1789 · Cited by 129 · see citing works

p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6

Gingras, S., Simard, J., Groner, B., & Pfitzner, E. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.13.2722 · Cited by 129 · see citing works

The Glucocorticoid-responsive Gene Cascade

Gotoh, T., Chowdhury, S., Takiguchi, M., & Mori, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3694 · Cited by 106 · see citing works

Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophages

Louis, C. A., Mody, V. C., Henry, W. L., Reichner, J. S., & Albina, J. E. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.1.r237 · Cited by 94 · see citing works

The C/EBP bZIP Domain Can Mediate Lipopolysaccharide Induction of the Proinflammatory Cytokines Interleukin-6 and Monocyte Chemoattractant Protein-1

Hu, H.-M., Tian, Q., Baer, M., Spooner, C. J., Williams, S. C., Johnson, P. F., & Schwartz, R. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910269199 · Cited by 92 · see citing works

Cooperation of the Transcriptional Coactivators CBP and p300 with Stat6

McDonald, C., & Reich, N. C. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313550 · Cited by 74 · see citing works

Regulation of Arginine Availability and Its Impact on NO Synthesis

Morris, S. M. (2000) · Nitric Oxide · doi:10.1016/b978-012370420-7/50012-5 · Cited by 74 · see citing works

Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta.

Mikita, T., Kurama, M., & Schindler, U. (1998) · PubMed · Cited by 62 · see citing works

Synergistic Activation of the Germline ε Promoter Mediated by Stat6 and C/EBPβ

Mikita, T., Kurama, M., & Schindler, U. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.4.1822 · Cited by 58 · see citing works

IFN-γ induces a p91/Stat1 α-related transcription factor with distinct activation and binding properties

Guyer, N. B., Severns, C. W., Wong, P., Feghali, C. A., & Wright, T. M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.7.3472 · Cited by 55 · see citing works

Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site.

Lundgren, M., Larsson, C., Femino, A. M., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.7.2983 · Cited by 40 · see citing works

Arginase activity is modulated by IL-4 and HOArg in nephritic glomeruli and mesangial cells

Waddington, S. N., Tam, F. W. K., Cook, H. T., & Cattell, V. (1998) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1998.274.3.f473 · Cited by 38 · see citing works

CCAAT/enhancer‐binding protein β is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary‐cultured hepatocytes

Kimura, T., Chowdhury, S., Tanaka, T., Shimizu-Yabe, A., Iwase, K., Oyadomari, S., Gotoh, T., Matsuzaki, H., Mori, M., Akira, S., et al. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02320-1 · Cited by 27 · see citing works

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

El Kasmi, K. C., Qualls, J. E., Pesce, J. T., Smith, A. M., Thompson, R. W., Henao-Tamayo, M., Basaraba, R. J., König, T., Schleicher, U., Koo, M.-S., et al. (2008) · Nature Immunology · doi:10.1038/ni.1671 · Cited by 646 · see citing works

Regulation of Inflammation by Adenosine

Haskó, G., & Cronstein, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00085 · Cited by 367 · see citing works

Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disorders

Yang, Z., & Ming, X.-F. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00533 · Cited by 290 · see citing works

<i>Trem2</i> promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Liu, W., Taso, O., Wang, R., Bayram, S., Graham, A. C., Garcia-Reitboeck, P., Mallach, A., Andrews, W. D., Piers, T. M., Botia, J. A., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa209 · Cited by 214 · see citing works

Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness

Yang, M., Rangasamy, D., MATTHAEI, K. I., Frew, A. J., Zimmmermann, N., Mahalingam, S., Webb, D. C., Tremethick, D. J., Thompson, P. J., Hogan, S. P., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5595 · Cited by 91 · see citing works

STAT6: its role in interleukin 4-mediated biological functions

Takeda, K., Kishimoto, T., & Akira, S. (1997) · Journal of molecular medicine · doi:10.1007/s001090050117 · Cited by 145 · see citing works

Shaping the Murine Macrophage Phenotype: IL-4 and Cyclic AMP Synergistically Activate the Arginase I Promoter

Sheldon, K. E., Shandilya, H. K., Kepka‐Lenhart, D., Poljakovic, M., Ghosh, A., & Morris, S. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202102 · Cited by 65 · see citing works

Unexpected Phenotype of STAT6 Heterozygous Mice Implies Distinct STAT6 Dosage Requirements for Different IL-4 Functions

Bürgis, S., & Gessner, A. (2007) · International Archives of Allergy and Immunology · doi:10.1159/000100571 · Cited by 12 · see citing works

1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) Modulates Th2 Immunity through Attenuation of IL-4 Expression

Yoon, S. Y., Kang, H. B., Ko, Y., Shin, S.-H., Kim, Y.-J., Sohn, K., Han, Y., Chong, S., & Kim, J. W. (2015) · Immune Network · doi:10.4110/in.2015.15.2.100 · Cited by 19 · see citing works