The DOI matches its Crossref record; 554 of the 559 references it cites were found in a registry or an index.
Function of alternative splicing
Abstract
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative splicing events that have been experimentally determined. The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has profound functional effects. Experimental analysis of these protein isoforms showed that alternative splicing regulates binding between proteins, between proteins and nucleic acids as well as between proteins and membranes. Alternative splicing regulates the localization of proteins, their enzymatic properties and their interaction with ligands. In most cases, changes caused by individual splicing isoforms are small. However, cells typically coordinate numerous changes in 'splicing programs', which can have strong effects on cell proliferation, cell survival and properties of the nervous system. Due to its widespread usage and molecular versatility, alternative splicing emerges as a central element in gene regulation that interferes with almost every biological function analyzed.
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“RNA-seq can also distinguish between the expression of different splice variants [46, 47], which can have distinct interaction partners [48] and biological functions [49].”
From Gene co-expression analysis for functional classification and gene–disease predictions (2017) · cites this paper as [49]
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Cites
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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
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The Spliceosome: Design Principles of a Dynamic RNP Machine
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Function of alternative splicing
Stamm, S., Ben‐Ari, S., Rafalska, I., Tang, Y., Zhang, Z., Toiber, D., Thanaraj, T. A., & Soreq, H. (2004) · Gene · doi:10.1016/j.gene.2004.10.022 · Cited by 1,398
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HITS-CLIP yields genome-wide insights into brain alternative RNA processing
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Understanding alternative splicing: towards a cellular code
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5 of the 559 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Zmijewski, 2009, Modulation of corticotropin releasing factor (CRF) signaling through receptor splicing in mouse pituitary cell line AtT-20—emerging role of soluble isoforms, J. Physiol. Pharmacol., 60, 39
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Mechanisms and Regulation of Alternative Pre-mRNA Splicing
Lee, Y., & Rio, D. C. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034316 · Cited by 1,291
Gene co-expression analysis for functional classification and gene–disease predictions
van Dam, S., Võsa, U., van der Graaf, A., Franke, L., & de Magalhães, J. P. (2017) · Briefings in Bioinformatics · doi:10.1093/bib/bbw139 · Cited by 995
Molecular mechanisms of ROS production and oxidative stress in diabetes
Newsholme, P., Cruzat, V. F., Keane, K. N., Carlessi, R., & de Bittencourt, P. I. H. (2016) · Biochemical Journal · doi:10.1042/bcj20160503c · Cited by 878
Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution
Ule, J., & Blencowe, B. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.017 · Cited by 780
Introducing Protein Intrinsic Disorder
Habchi, J., Tompa, P., Longhi, S., & Uversky, V. N. (2014) · Chemical Reviews · doi:10.1021/cr400514h · Cited by 767
Metadata
- Authors
- Kelemen, O., Convertini, P., Zhang, Z., Wen, Y., Shen, M., Falaleeva, M., & Stamm, S.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Stamm, Stefan
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 514
- Issue
- 1
- Pages
- 1-30
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W3042475334
- Cited by
- 743
- References
- 559
- Citations by year
- 2026: 29 · 2025: 49 · 2024: 57 · 2023: 55 · 2022: 73 · 2021: 82 · 2020: 77 · 2019: 64 · 2018: 52 · 2017: 56 · 2016: 46 · 2015: 38 · 2014: 40 · 2013: 25
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM083187)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- alternative splicing, protein isoforms, protein-protein interaction, protein-nucleic acid interactions, protein-membrane binding, protein localization, ligand binding, gene expression regulation, cell proliferation, cell survival, nervous system
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