Function of alternative splicing

AUGUSTUS: ab initio prediction of alternative transcripts

Stanke, M., Keller, O., Gunduz, I., Hayes, A., Waack, S., & Morgenstern, B. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl200 · Cited by 2,829

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820

The Spliceosome: Design Principles of a Dynamic RNP Machine

Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

Tripathi, V., Ellis, J. D., Shen, Z., Song, D. Y., Pan, Q., Watt, A. T., Freier, S. M., Bennett, C. F., Sharma, A., Bubulya, P. A., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.011 · Cited by 2,291

Spliced segments at the 5′ terminus of adenovirus 2 late mRNA

Berget, S. M., Moore, C. L., & Sharp, P. A. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3171 · Cited by 1,483

Function of alternative splicing

Stamm, S., Ben‐Ari, S., Rafalska, I., Tang, Y., Zhang, Z., Toiber, D., Thanaraj, T. A., & Soreq, H. (2004) · Gene · doi:10.1016/j.gene.2004.10.022 · Cited by 1,398

The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing

Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

Licatalosi, D. D., Mele, A., Fak, J. J., Ule, J., Kayikci, M., Chi, S. W., Clark, T. A., Schweitzer, A. C., Blume, J. E., Wang, X., et al. (2008) · Nature · doi:10.1038/nature07488 · Cited by 1,352

Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources

Stanke, M., Schöffmann, O., Morgenstern, B., & Waack, S. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-62 · Cited by 1,304

Understanding alternative splicing: towards a cellular code

Matlin, A. J., Clark, F., & Smith, C. W. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1645 · Cited by 1,299

A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

Sultan, M., Schulz, M. H., Richard, H., Magen, A., Klingenhoff, A., Scherf, M., Seifert, M., Borodina, T., Soldatov, A., Parkhomchuk, D., et al. (2008) · Science · doi:10.1126/science.1160342 · Cited by 1,293

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284

An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA

Chow, L. T., Gelinas, R. E., Broker, T. R., & Roberts, R. J. (1977) · Cell · doi:10.1016/0092-8674(77)90180-5 · Cited by 1,234

RNA and Disease

Cooper, T. A., Wan, L., & Dreyfuss, G. (2009) · Cell · doi:10.1016/j.cell.2009.02.011 · Cited by 1,198

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

König, J., Zarnack, K., Rot, G., Curk, T., Kayikci, M., Zupan, B., Turner, D. J., Luscombe, N. M., & Ule, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1838 · Cited by 1,126

CLIP Identifies Nova-Regulated RNA Networks in the Brain

Ule, J., Jensen, K. B., Ruggiu, M., Mele, A., Ule, A., & Darnell, R. B. (2003) · Science · doi:10.1126/science.1090095 · Cited by 1,120

Regulation of Alternative Splicing by Histone Modifications

Luco, R. F., Pan, Q., Tominaga, K., Blencowe, B. J., Pereira‐Smith, O. M., & Misteli, T. (2010) · Science · doi:10.1126/science.1184208 · Cited by 1,099

Exon Recognition in Vertebrate Splicing

Berget, S. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2411 · Cited by 1,090

Alternative splicing and evolution: diversification, exon definition and function

Keren, H., Lev-Maor, G., & Ast, G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2776 · Cited by 1,082

Splicing in disease: disruption of the splicing code and the decoding machinery

Wang, G., & Cooper, T. A. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2164 · Cited by 1,077

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., & Vigneri, R. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0047 · Cited by 1,058

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhingedPreprint

David, C. J., & Manley, J. L. (2010) · Genes & Development · doi:10.1101/gad.1973010 · Cited by 848

Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance

Dehm, S. M., Schmidt, L. J., Heemers, H. V., Vessella, R. L., & Tindall, D. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0594 · Cited by 834

Structure and evolution of transcriptional regulatory networks

Babu, M. M., Luscombe, N. M., Aravind, L., Gerstein, M., & Teichmann, S. A. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.05.004 · Cited by 780

Acid-Mediated Tumor Invasion: a Multidisciplinary Study

Gatenby, R. A., Gawlinski, E. T., Gmitro, A. F., Kaylor, B., & Gillies, R. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4193 · Cited by 771

The Honey Bee Epigenomes: Differential Methylation of Brain DNA in Queens and Workers

Lyko, F., Foret, S., Kucharski, R., Wolf, S., Falckenhayn, C., & Maleszka, R. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000506 · Cited by 727

The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator

Feng, J., Bi, C., Clark, B. S., Mady, R., Shah, P., & Kohtz, J. D. (2006) · Genes & Development · doi:10.1101/gad.1416106 · Cited by 712

Differential chromatin marking of introns and expressed exons by H3K36me3

Kolasinska-Zwierz, P., Down, T. A., Latorre, I. J., Liu, T., Liu, X. S., & Ahringer, J. (2009) · Nature Genetics · doi:10.1038/ng.322 · Cited by 699

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

Frías, M. A., Thoreen, C. C., Jaffe, J. D., Schroder, W. A., Sculley, T. B., Carr, S. A., & Sabatini, D. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.001 · Cited by 690

Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets

Denis, M. M., Tolley, N. D., Bunting, M., Schwertz, H., Jiang, H., Lindemann, S., Yost, C. C., Rubner, F. J., Albertine, K. H., Swoboda, K. J., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.015 · Cited by 663

AceView: a comprehensive cDNA-supported gene and transcripts annotation

Thierry-Mieg, D., & Thierry-Mieg, J. (2006) · Genome Biology · doi:10.1186/gb-2006-7-s1-s12 · Cited by 629

Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis

Johnson, M. B., Kawasawa, Y. I., Mason, C. E., Krsnik, Ž., Coppola, G., Bogdanović, D., Geschwind, D. H., Mane, S. M., State, M. W., & Šestan, N. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.027 · Cited by 603

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

Yeo, G. W., Coufal, N. G., Liang, T. Y., Peng, G. E., Fu, X.-D., & Gage, F. H. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1545 · Cited by 572

Different levels of alternative splicing among eukaryotes

Kim, E., Magen, A., & Ast, G. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl924 · Cited by 569

Alternative splicing and disease

Tazi, J., Bakkour, N., & Stamm, S. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.017 · Cited by 569

Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms

Romero, P. R., Zaidi, S., Fang, Y. Y., Uversky, V. N., Radivojac, P., Oldfield, C. J., Cortese, M. S., Sickmeier, M., LeGall, T., Obradovic, Z., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507916103 · Cited by 480

Nucleosome positioning as a determinant of exon recognition

Tilgner, H., Nikolaou, C., Althammer, S., Sammeth, M., Beato, M., Valcárcel, J., & Guigó, R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1658 · Cited by 479

RNA-MEDIATED NEUROMUSCULAR DISORDERS

Ranum, L. P. W., & Cooper, T. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113014 · Cited by 472

Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

Xue, Y., Zhou, Y., Wu, T., Zhu, T., Ji, X., Kwon, Y.-S., Zhang, C., Yeo, G., Black, D. L., Sun, H., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.003 · Cited by 469

The pathobiology of splicing

Ward, A. J., & Cooper, T. A. (2009) · The Journal of Pathology · doi:10.1002/path.2649 · Cited by 436

The Birth of an Alternatively Spliced Exon: 3' Splice-Site Selection in Alu Exons

Lev-Maor, G., Sorek, R., Shomron, N., & Ast, G. (2003) · Science · doi:10.1126/science.1082588 · Cited by 435

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Cheah, M. T., Wachter, A., Sudarsan, N., & Breaker, R. R. (2007) · Nature · doi:10.1038/nature05769 · Cited by 430

Influence of RNA Secondary Structure on the Pre-mRNA Splicing Process

Buratti, E., & Baralle, F. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10505-10514.2004 · Cited by 424

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

Clower, C. V., Chatterjee, D., Wang, Z., Cantley, L. C., Vander Heiden, M. G., & Krainer, A. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914845107 · Cited by 424

Intron—exon structures of eukaryotic model organisms

Long, M., & Deutsch, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.15.3219 · Cited by 417

Cell Motility Is Controlled by SF2/ASF through Alternative Splicing of the Ron Protooncogene

Ghigna, C., Giordano, S., Shen, H., Benvenuto, F., Castiglioni, F., Comoglio, P. M., Green, M. R., Riva, S., & Biamonti, G. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.026 · Cited by 387

An ESRP‐regulated splicing programme is abrogated during the epithelial–mesenchymal transition

Warzecha, C. C., Jiang, P., Amirikian, K., Dittmar, K. A., Lu, H., Shen, S., Guo, W., Xing, Y., & Carstens, R. P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.195 · Cited by 383

LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation

Ko, J., Fuccillo, M. V., Malenka, R. C., & Südhof, T. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.12.012 · Cited by 380

ASTALAVISTA: dynamic and flexible analysis of alternative splicing events in custom gene datasets

Foissac, S., & Sammeth, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm311 · Cited by 377

Neuronal regulation of alternative pre-mRNA splicing

Li, Q., Lee, J.-A., & Black, D. L. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2237 · Cited by 376

Polypyrimidine Tract Binding Protein Antagonizes Exon Definition

Wagner, E. J., & García-Blanco, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3281-3288.2001 · Cited by 376

Splign: algorithms for computing spliced alignments with identification of paralogs

Kapustin, Y., Souvorov, A. E., Tatusova, T. A., & Lipman, D. J. (2008) · Biology Direct · doi:10.1186/1745-6150-3-20 · Cited by 365

Regulation of Fas Alternative Splicing by Antagonistic Effects of TIA-1 and PTB on Exon Definition

Izquierdo, J. M., Oró, N. M., Bonnal, S., Martínez, C., Castelo, R., Guigó, R., Bilbao, D., & Valcárcel, J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.06.015 · Cited by 364

Cancer-associated regulation of alternative splicing

Venables, J. P., Klinck, R., Koh, C., Gervais-Bird, J., Bramard, A., Inkel, L., Durand, M., Couture, S., Froehlich, U., Lapointe, E., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1608 · Cited by 355

SR Proteins Function in Coupling RNAP II Transcription to Pre-mRNA Splicing

Das, R., Yu, J., Zhang, Z., Gygi, M. P., Krainer, A. R., Gygi, S. P., & Reed, R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.036 · Cited by 346

AUGUSTUS at EGASP: using EST, protein and genomic alignments for improved gene prediction in the human genome

Stanke, M., Tzvetkova, A., & Morgenstern, B. (2006) · Genome biology · doi:10.1186/gb-2006-7-s1-s11 · Cited by 330

Nucleosomes are well positioned in exons and carry characteristic histone modifications

Andersson, R., Enroth, S., Rada-Iglesias, A., Wadelius, C., & Komorowski, J. (2009) · Genome Research · doi:10.1101/gr.092353.109 · Cited by 325

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

Moore, M. J., Wang, Q., Kennedy, C. J., & Silver, P. A. (2010) · Cell · doi:10.1016/j.cell.2010.07.019 · Cited by 323

Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcriptsPreprint

Sanford, J. R., Wang, X., Mort, M. E., VanDuyn, N., Cooper, D. N., Mooney, S. D., Edenberg, H. J., & Liu, Y. (2008) · Genome Research · doi:10.1101/gr.082503.108 · Cited by 320

UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs

Grillo, G., Turi, A., Licciulli, F., Mignone, F., Liuni, S., Banfi, S., Gennarino, V. A., Horner, D. S., Pavesi, G., Picardi, E., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp902 · Cited by 307

Splicing regulates NAD metabolite binding to histone macroH2A

Kustatscher, G., Hothorn, M., Pugieux, C., Scheffzek, K., & Ladurner, A. G. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb956 · Cited by 300

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

Chalaris, A., Garbers, C., Rabe, B., Rose‐John, S., & Scheller, J. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.10.007 · Cited by 298

Mutually Exclusive Splicing of the Insect Dscam Pre-mRNA Directed by Competing Intronic RNA Secondary Structures

Graveley, B. R. (2005) · Cell · doi:10.1016/j.cell.2005.07.028 · Cited by 295

The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing

Kishore, S., Khanna, A., Zhang, Z., Hui, J., Balwierz, P. J., Stefan, M., Beach, C. M., Nicholls, R. D., Zavolan, M., & Stamm, S. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddp585 · Cited by 293

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.

Yan, M., Kanbe, E., Peterson, L. F., Boyapati, A., Miao, Y., Wang, Y., Chen, I.-M., Chen, Z., Rowley, J. D., Willman, C. L., et al. (2006) · Nature Medicine · doi:10.1038/nm1443 · Cited by 279

G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca2+Channels Is Dependent on a Shank-Binding Domain

Olson, P. A., Tkatch, T., Hernández‐López, S., Ulrich, S., Ilijić, E., Mugnaini, E., Zhang, H., Борисович, Б. И., & Surmeier, D. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3327-04.2005 · Cited by 270

Female-specific insect lethality engineered using alternative splicing

Fu, G., Condon, K. C., Epton, M. J., Gong, P., Jin, L., Condon, G. C., Morrison, N. I., Dafa’alla, T., & Alphey, L. (2007) · Nature Biotechnology · doi:10.1038/nbt1283 · Cited by 267

Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

Llorian, M., Schwartz, S., Clark, T. A., Hollander, D., Tan, L.-Y., Spellman, R., Gordon, A., Schweitzer, A. C., de la Grange, P., Ast, G., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1881 · Cited by 263

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

Bluemlein, K., Grüning, N., Feichtinger, R. G., Lehrach, H., Kofler, B., & Ralser, M. (2011) · Oncotarget · doi:10.18632/oncotarget.278 · Cited by 255

Alternative Splicing of the Robo3 Axon Guidance Receptor Governs the Midline Switch from Attraction to Repulsion

Chen, Z., Gore, B. B., Long, H., Ma, L., & Tessier‐Lavigne, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.016 · Cited by 251

Regulation of Alternative Splicing by Reversible Protein Phosphorylation

Stamm, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700034200 · Cited by 250

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

Varani, L., Hasegawa, M., Spillantini, M. G., Smith, M. J., Murrell, J. R., Ghetti, B. F., Klug, A., Goedert, M., & Varani, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8229 · Cited by 248

iCLIP Predicts the Dual Splicing Effects of TIA-RNA Interactions

Wang, Z., Kayikci, M., Briese, M., Zarnack, K., Luscombe, N. M., Rot, G., Zupan, B., Curk, T., & Ule, J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000530 · Cited by 242

Conservation of an RNA regulatory map between Drosophila and mammalsPreprint

Brooks, A. N., Yang, L. C., Duff, M. O., Hansen, K. D., Park, J. W., Dudoit, S., Brenner, S. E., & Graveley, B. R. (2010) · Genome Research · doi:10.1101/gr.108662.110 · Cited by 240

RegRNA: an integrated web server for identifying regulatory RNA motifs and elements

Huang, H.-L., Chien, C.-H., Jen, K.-H., & Huang, H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl333 · Cited by 235

Disease-related Modifications in Tau Affect the Interaction between Fyn and Tau

Bhaskar, K., Yen, S.-H. C., & Lee, G. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505895200 · Cited by 228

Composition and three‐dimensional EM structure of double affinity‐purified, human prespliceosomal A complexes

Behzadnia, N., Golas, M. M., Hartmuth, K., Sander, B. O., Kastner, B., Deckert, J., Dube, P., Will, C. L., Urlaub, H., Stark, H., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601631 · Cited by 218

Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients

Sadakata, T., Washida, M., Iwayama, Y., Shoji, S., Sato, Y., Ohkura, T., Katoh-Semba, R., Nakajima, M., Sekine, Y., Tanaka, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29031 · Cited by 218

Alternatively Spliced Lipin Isoforms Exhibit Distinct Expression Pattern, Subcellular Localization, and Role in Adipogenesis

Péterfy, M., Phan, J., & Reue, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503885200 · Cited by 215

Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function

Günzel, D., Stuiver, M., Kausalya, P. J., Haisch, L., Krug, S. M., Rosenthal, R., Meij, I. C., Hunziker, W., Fromm, M., & Müller, D. (2009) · Journal of Cell Science · doi:10.1242/jcs.040113 · Cited by 214

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

Ferrera, L., Caputo, A., Ubby, I., Bussani, E., Zegarra‐Moran, O., Ravazzolo, R., Pagani, F., & Galietta, L. J. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046607 · Cited by 212

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control

Sun, S., Zhang, Z., Sinha, R., Karni, R., & Krainer, A. R. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1750 · Cited by 204

Survivin splice variants regulate the balance between proliferation and cell death

Caldas, H., Jiang, Y., Holloway, M. P., Fangusaro, J., Mahotka, C., Conway, E. M., & Altura, R. A. (2005) · Oncogene · doi:10.1038/sj.onc.1208350 · Cited by 200

Pre-mRNA Secondary Structures Influence Exon Recognition

Hiller, M., Zhang, Z., Backofen, R., & Stamm, S. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030204 · Cited by 199

Hybrid Receptors Formed by Insulin Receptor (IR) and Insulin-like Growth Factor I Receptor (IGF-IR) Have Low Insulin and High IGF-1 Affinity Irrespective of the IR Splice Variant

Slaaby, R., Schäffer, L., Lautrup-Larsen, I., Andersen, A. S., Shaw, A. C., Mathiasen, I. S., & Brandt, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605189200 · Cited by 198

Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays

Sugnet, C. W., Srinivasan, K., Clark, T. A., O’Brien, G. S., Cline, M., Wang, H., Williams, A., Kulp, D., Blume, J. E., Haussler, D. H., et al. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020004 · Cited by 197

A catalog of SCN1A variants

Lossin, C. (2008) · Brain and Development · doi:10.1016/j.braindev.2008.07.011 · Cited by 195

POU5F1 Isoforms Show Different Expression Patterns in Human Embryonic Stem Cells and Preimplantation Embryos

Cauffman, G., Liebaers, I., Steirteghem, A. V., & de Velde, H. V. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0611 · Cited by 185

Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells

Adato, A., Lefevre, G. M., Delprat, B., Michel, V., Michalski, N., Chardenoux, S., Weil, D., El-Amraoui, A., & Petit, C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi416 · Cited by 185

Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences

Xu, Q. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg786 · Cited by 183

Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

Keats, J. J., Maxwell, C. A., Taylor, B. J., Hendzel, M. J., Chesi, M., Bergsagel, P. L., Larratt, L. M., Mant, M. J., Reiman, T., Belch, A. R., et al. (2005) · Blood · doi:10.1182/blood-2004-09-3704 · Cited by 183

Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA

Stoilov, P. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh051 · Cited by 180

fruitless regulates aggression and dominance in Drosophila

Vrontou, E., Nilsen, S. P., Demir, E., Kravitz, E. A., & Dickson, B. J. (2006) · Nature Neuroscience · doi:10.1038/nn1809 · Cited by 179

A Splicing Variant of the RON Transcript Induces Constitutive Tyrosine Kinase Activity and an Invasive Phenotype

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Genome-wide analysis of alternative splicing in Caenorhabditis elegansPreprint

Ramani, A. K., Calarco, J. A., Pan, Q., Mavandadi, S., Wang, Y., Nelson, A. C., Lee, L. J., Morris, Q., Blencowe, B. J., Zhen, M., et al. (2010) · Genome Research · doi:10.1101/gr.114645.110 · Cited by 176

Chromatin, transcript elongation and alternative splicing

Kornblihtt, A. R. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb0106-5 · Cited by 173

Angiomotin Regulates Endothelial Cell-Cell Junctions and Cell Motility

Bratt, A., Birot, O., Sinha, I., Veitonmäki, N., Aase, K., Ernkvist, M., & Holmgren, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503915200 · Cited by 173

Lipins: Multifunctional Lipid Metabolism Proteins

Csaki, L. S., & Reue, K. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104729 · Cited by 173

The Roles of Versican V1 and V2 Isoforms in Cell Proliferation and Apoptosis

Wang, S., Wang, G., Wang, Y., Liang, J., Wen, J., Zheng, P.-S., Wu, Y., Lee, V., Slingerland, J. M., Dumont, D. J., et al. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0295 · Cited by 169

Coupling Transcription and Alternative Splicing

Kornblihtt, A. R. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77374-2_11 · Cited by 168

Structures of APRIL-Receptor Complexes

Hymowitz, S. G., Patel, D. R., Wallweber, H. J. A., Runyon, S., Yan, M., Yin, J., Shriver, S. K., Gordon, N. C., Pan, B., Skelton, N. J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411714200 · Cited by 167

Functional genetic analysis of mutations implicated in a human speech and language disorder

Vernes, S. C., Nicod, J., Elahi, F. M., Coventry, J. A., Kenny, N., Coupe, A.-M., Bird, L. E., Davies, K. E., & Fisher, S. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl392 · Cited by 167

Targeted Inhibition of the KLF6 Splice Variant, KLF6 SV1, Suppresses Prostate Cancer Cell Growth and Spread

Narla, G., DiFeo, A. V., Yao, S., Banno, A., Hod, E. A., Reeves, H. L., Qiao, R., Camacho‐Vanegas, O., Levine, A. C., Kirschenbaum, A. M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0217 · Cited by 166

Identification of Common Genetic Variation That Modulates Alternative Splicing

Hull, J., Campino, S. G., Rowlands, K., Chan, M., Copley, R. R., Taylor, M. S., Rockett, K. A., Elvidge, G. P., Keating, B. J., Knight, J. C., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030099 · Cited by 165

Polypyrimidine Tract Binding Protein Blocks the 5′ Splice Site-Dependent Assembly of U2AF and the Prespliceosomal E Complex

Sharma, S., Falick, A. M., & Black, D. L. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.014 · Cited by 165

Insights into the connection between cancer and alternative splicing

Kim, E., Goren, A., & Ast, G. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.10.001 · Cited by 162

A Truncated P2X7 Receptor Variant (P2X7-j) Endogenously Expressed in Cervical Cancer Cells Antagonizes the Full-length P2X7 Receptor through Hetero-oligomerization

Feng, Y., Li, X., Wang, L., Zhou, L., & Gorodeski, G. I. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602999200 · Cited by 162

Global Profiling and Molecular Characterization of Alternative Splicing Events Misregulated in Lung Cancer

Misquitta-Ali, C. M., Cheng, E., O’Hanlon, D., Liu, G., McGlade, C. J., Tsao, M., & Blencowe, B. J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00709-10 · Cited by 162

Discovery and Analysis of Evolutionarily Conserved Intronic Splicing Regulatory Elements

Yeo, G. W.-M., Nostrand, E. L. V., & Liang, T. Y. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030085 · Cited by 162

An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exonsPreprint

Lee, J.-A., Tang, Z., & Black, D. L. (2009) · Genes & Development · doi:10.1101/gad.1837009 · Cited by 162

Ras-induced Modulation of CXCL10 and Its Receptor Splice Variant CXCR3-B in MDA-MB-435 and MCF-7 Cells: Relevance for the Development of Human Breast Cancer

Datta, D. B., Flaxenburg, J. A., Laxmanan, S., Geehan, C. S., Grimm, M. R., Waaga-Gasser, A. M., Briscoe, D. M., & Pal, S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4345 · Cited by 162

Characterization of the Human LPIN1-encoded Phosphatidate Phosphatase Isoforms

Han, G., & Carman, G. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.117747 · Cited by 161

Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis

Pihlajamäki, J., Lerín, C., Itkonen, P., Boes, T., Floß, T., Schroeder, J., Dearie, F., Crunkhorn, S., Burak, M. F., Jiménez‐Chillarón, J. C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.007 · Cited by 160

Differential Role of N-Type Calcium Channel Splice Isoforms in Pain

Altier, C., Dale, C. S., Kisilevsky, A. E., Chapman, K., Castiglioni, A. J., Matthews, E. A., Evans, R. M., Dickenson, A. H., Lipscombe, D., Vergnolle, N., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0307-07.2007 · Cited by 159

Global regulation of alternative splicing during myogenic differentiation

Bland, C. S., Wang, E. T., Vu, A. Q., David, M. P., Castle, J. C., Johnson, J. M., Burge, C. B., & Cooper, T. A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq614 · Cited by 155

Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes

Wang, J. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki810 · Cited by 153

A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion

Lo, H., Zhu, H., Cao, X., Aldrich, A. J., & Ali‐Osman, F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0886 · Cited by 153

Alternative mRNA Splicing Produces a Novel Biologically Active Short Isoform of PGC-1α

Zhang, Y., Huypens, P., Adamson, A. W., Chang, J. S., Henagan, T. M., Boudreau, A., Lenard, N. R., Burk, D. H., Klein, J. C., Perwitz, N., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.037556 · Cited by 152

Selective Knockdown of the Long Variant of Cellular FLICE Inhibitory Protein Augments Death Receptor-mediated Caspase-8 Activation and Apoptosis

Sharp, D. A., Lawrence, D. A., & Ashkenazi, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413962200 · Cited by 152

Alternatively spliced tissue factor induces angiogenesis through integrin ligation

van den Berg, Y. W., van den Hengel, L. G., Myers, H. R., Ayachi, O., Jordanova, E. S., Ruf, W., Spek, C. A., Reitsma, P. H., Bogdanov, V. Y., & Versteeg, H. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905325106 · Cited by 150

Alternative splicing of conserved exons is frequently species-specific in human and mouse

Pan, Q., Bakowski, M. A., Morris, Q., Zhang, W., Frey, B. J., Hughes, T. R., & Blencowe, B. J. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.12.004 · Cited by 149

A class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zones

Gooding, C., Clark, F., Wollerton, M., Grellscheid, S., Groom, H. C. T., & Smith, C. W. J. (2006) · Genome biology · doi:10.1186/gb-2006-7-1-r1 · Cited by 149

Alternative splicing: global insights

Hallegger, M., Llorian, M., & Smith, C. W. J. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07521.x · Cited by 147

Multiple Alternative Splicing Markers for Ovarian Cancer

Klinck, R., Bramard, A., Inkel, L., Dufresne‐Martin, G., Gervais-Bird, J., Madden, R., Paquet, É. R., Koh, C., Venables, J. P., Prinos, P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2580 · Cited by 147

Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin

Lüke, Y., Zaim, H., Karakesisoglou, I., Jaeger, V. M., Sellin, L. K., Lu, W., Schneider, M., Neumann, S., Beijer, Å., Munck, M., et al. (2008) · Journal of Cell Science · doi:10.1242/jcs.019075 · Cited by 146

QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation

Novikov, L., Park, J. W., Chen, H., Klerman, H., Jalloh, A. S., & Gamble, M. J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05244-11 · Cited by 146

Useful ‘junk’: Alu RNAs in the human transcriptome

Häsler, J., Samuelsson, T., & Strub, K. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7084-0 · Cited by 142

Isoform and Splice-Variant Specific Functions of Dynamin-2 Revealed by Analysis of Conditional Knock-Out Cells

Liu, Y., Surka, M. C., Schroeter, T., Lukiyanchuk, V., & Schmid, S. L. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-08-0890 · Cited by 141

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

Weise, A., Bruser, K., Elfert, S., Wallmen, B., Wittel, Y., Wöhrle, S., & Hecht, A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1197 · Cited by 139

Positive and Negative Regulation of Nuclear Factor-κB-mediated Transcription by IκB-ζ, an Inducible Nuclear Protein

Motoyama, M., Yamazaki, S., Eto-Kimura, A., Takeshige, K., & Muta, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412738200 · Cited by 138

Reciprocal intronic and exonic histone modification regions in humans

Huff, J. T., Plocik, A. M., Guthrie, C., & Yamamoto, K. R. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1924 · Cited by 138

Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies

Dhir, A., & Buratti, E. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07520.x · Cited by 135

RNA Helicase p68 (DDX5) Regulates tau Exon 10 Splicing by Modulating a Stem-Loop Structure at the 5′ Splice Site

Kar, A. N., Fushimi, K., Zhou, X., Ray, P., Chen, S., Chen, X., Liu, Z., Chen, S., & Wu, J. Y. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01149-10 · Cited by 132

An intronic element contributes to splicing repression in spinal muscular atrophy

Kashima, T., Rao, N., & Manley, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700343104 · Cited by 130

Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5′ Splice Site Competition

Yu, Y., Maroney, P. A., Denker, J. A., Zhang, X. H.-F., Dybkov, O., Lührmann, R., Jankowsky, E., Chasin, L. A., & Nilsen, T. W. (2008) · Cell · doi:10.1016/j.cell.2008.10.046 · Cited by 129

A Structure-based Model of the c-Myc/Bin1 Protein Interaction Shows Alternative Splicing of Bin1 and c-Myc Phosphorylation are Key Binding Determinants

Pineda‐Lucena, A., Ho, C. S. W., Mao, D. Y. L., Sheng, Y., Laister, R. C., Muhandiram, R., Lü, Y., Seet, B. T., Katz, S., Szyperski, T., et al. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.05.046 · Cited by 129

MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development

Kalsotra, A., Wang, K., Li, P.-F., & Cooper, T. A. (2010) · Genes & Development · doi:10.1101/gad.1894310 · Cited by 129

Alternative Splicing of Vitamin D-24-Hydroxylase

Ren, S., Nguyen, L., Wu, S., Encinas, C., Adams, J. S., & Hewison, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414522200 · Cited by 126

FGF8 spliceforms mediate early mesoderm and posterior neural tissue formation in Xenopus

Fletcher, R. B., Baker, J. C., & Harland, R. M. (2006) · Development · doi:10.1242/dev.02342 · Cited by 126

Sam68 Regulates a Set of Alternatively Spliced Exons during Neurogenesis

Chawla, G., Lin, C.-H., Han, A., Shiue, L., Ares, M., & Black, D. L. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01349-08 · Cited by 126

A Smooth Muscle Cav1.2 Calcium Channel Splice Variant Underlies Hyperpolarized Window Current and Enhanced State-dependent Inhibition by Nifedipine

Liao, P. H., Yu, D., Li, G., Yong, T. F., Soon, J.-L., Chua, Y. L., & Soong, T. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705478200 · Cited by 125

Functional coupling of RNAP II transcription to spliceosome assemblyPreprint

Das, R., Dufu, K., Romney, B., Feldt, M. C., Elenko, M. P., & Reed, R. (2006) · Genes & Development · doi:10.1101/gad.1397406 · Cited by 125

Global analysis of positive and negative pre-mRNA splicing regulators in DrosophilaPreprint

Blanchette, M., Green, R. E., Brenner, S. E., & Rio, D. C. (2005) · Genes & Development · doi:10.1101/gad.1314205 · Cited by 124

The discovery of split genes and RNA splicing

Sharp, P. A. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.04.002 · Cited by 122

Autoregulation of Fox protein expression to produce dominant negative splicing factors

Damianov, A., & Black, D. L. (2010) · RNA · doi:10.1261/rna.1838210 · Cited by 120

In Vivo and In Vitro Studies Support That a New Splicing Isoform of OLR1 Gene Is Protective Against Acute Myocardial Infarction

Mango, R., Biocca, S., Vecchio, F. D., Clementi, F., Sangiuolo, F. C., Amati, F., Filareto, A., Grelli, S., Spitalieri, P., Filesi, I., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000174563.62625.8e · Cited by 119

Genomic features defining exonic variants that modulate splicing

Woolfe, A., Mullikin, J. C., & Elnitski, L. L. (2010) · Genome biology · doi:10.1186/gb-2010-11-2-r20 · Cited by 119

UMD (Universal Mutation Database): 2005 update

Béroud, C., Hamroun, D., Collod‐Béroud, G., Boileau, C., Soussi, T., & Claustres, M. (2005) · Human Mutation · doi:10.1002/humu.20210 · Cited by 118

The Novel CXCL12γ Isoform Encodes an Unstructured Cationic Domain Which Regulates Bioactivity and Interaction with Both Glycosaminoglycans and CXCR4

Laguri, C., Sadir, R., Rueda, P., Baleux, F., Gans, P., Arenzana‐Seisdedos, F., & Lortat‐Jacob, H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001110 · Cited by 117

The ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species

Kim, N., Alekseyenko, A. V., Roy, M., & Lee, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl884 · Cited by 117

Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways

Gonçalves, V., Matos, P., & Jordan, P. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp317 · Cited by 116

Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

Bao, J., Lu, Z., Joseph, J. J., Carabenciov, D., Dimond, C. C., Pang, L., Samsel, L., McCoy, J. P., Leclerc, J., Nguyen, P., et al. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22531 · Cited by 116

ΔBAFF, a Splice Isoform of BAFF, Opposes Full-Length BAFF Activity In Vivo in Transgenic Mouse Models

Gavin, A. L., Duong, B. H., Skog, P. D., Aït‐Azzouzene, D., Greaves, D. R., Scott, M. L., & Nemazee, D. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.319 · Cited by 115

Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothoraxPreprint

Noro, B., Culí, J., McKay, D. J., Zhang, W., & Mann, R. S. (2006) · Genes & Development · doi:10.1101/gad.1412606 · Cited by 114

Rescuing Z + agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing

Ruggiu, M., Herbst, R., Kim, N., Jevsek, M., Fak, J. J., Mann, M. A., Fischbach, G., Burden, S. J., & Darnell, R. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813112106 · Cited by 113

Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions

Pan, Y., Xu, J., Xu, M., Rossi, G. C., Matulonis, J. E., & Pasternak, G. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811586106 · Cited by 112

Alternative trans ‐splicing: a novel mode of pre‐mRNA processing

Horiuchi, T., & Aigaki, T. (2006) · Biology of the Cell · doi:10.1042/bc20050002 · Cited by 111

Enzyme-inhibitor-like tuning of Ca2+ channel connectivity with calmodulin

Liu, X., Yang, P. S., Yang, W., & Yue, D. T. (2010) · Nature · doi:10.1038/nature08766 · Cited by 111

MicroRNAs-10a and -10b Contribute to Retinoic Acid-induced Differentiation of Neuroblastoma Cells and Target the Alternative Splicing Regulatory Factor SFRS1 (SF2/ASF)

Meseguer, S., Mudduluru, G., Escamilla, J. M., Allgayer, H., & Barettino, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.167817 · Cited by 107

Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertilePreprint

Dunn, N. R., Koonce, C. H., Anderson, D. C., Islam, A., Bikoff, E. K., & Robertson, E. J. (2005) · Genes & Development · doi:10.1101/gad.1243205 · Cited by 107

Intronic polyadenylation signal sequences and alternate splicing generate human soluble Fltl variants and regulate the abundance of soluble Flt1 in the placenta

Thomas, C. P., Andrews, J. I., & Liu, K. Z. (2007) · The FASEB Journal · doi:10.1096/fj.07-8809com · Cited by 106

A Splice Variant of CD99 Increases Motility and MMP-9 Expression of Human Breast Cancer Cells through the AKT-, ERK-, and JNK-dependent AP-1 Activation Signaling Pathways

Byun, H.-J., Hong, I., Kim, E., Jin, Y., Jeoung, D., Hahn, J.-H., Kim, Y.-M., Park, S. H., & Lee, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605483200 · Cited by 105

Coactivator-associated Arginine Methyltransferase 1, CARM1, Affects Pre-mRNA Splicing in an Isoform-specific Manner*♦

Ohkura, N., Takahashi, M., Yaguchi, H., Nagamura, Y., & Tsukada, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502173200 · Cited by 105

Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms

Sundvall, M., Korhonen, A., Paatero, I., Gaudio, E., Melino, G., Croce, C. M., Aqeilan, R. I., & Elenius, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708333105 · Cited by 104

New isoforms of rat Aquaporin-4

Moe, S. E., Sorbo, J. G., Sogaard, R., Zeuthen, T., Ottersen, O. P., & Holen, T. (2008) · Genomics · doi:10.1016/j.ygeno.2007.12.003 · Cited by 103

Steroid Receptor Coactivator-1 Splice Variants Differentially Affect Corticosteroid Receptor Signaling

Meijer, O. C., Kalkhoven, E., van der Laan, S., Steenbergen, P. J., Houtman, S., Dijkmans, T. F., Pearce, D., & de Kloet, E. R. (2004) · Endocrinology · doi:10.1210/en.2004-0411 · Cited by 103

A Novel Splice Variant of Interleukin-1 Receptor (IL-1R)-Associated Kinase 1 Plays a Negative Regulatory Role in Toll/IL-1R-Induced Inflammatory Signaling

Rao, N. L., Nguyen, S. M., Ngo, K., & Fung‐Leung, W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6521-6532.2005 · Cited by 103

A Novel DNMT3B Splice Variant Expressed in Tumor and Pluripotent Cells Modulates Genomic DNA Methylation Patterns and Displays Altered DNA Binding

Gopalakrishnan, S., Emburgh, B. O. V., Shan, J., Su, Z. Z., Fields, C. R., Vieweg, J., Hamazaki, T., Schwartz, P. H., Terada, N., & Robertson, K. D. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0018 · Cited by 103

Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc

López, V., & Kelleher, S. L. (2009) · Biochemical Journal · doi:10.1042/bj20081189 · Cited by 102

SFmap: a web server for motif analysis and prediction of splicing factor binding sites

Paz, I., Akerman, M., Dror, I., Kosti, I., & Mandel-Gutfreund, Y. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq444 · Cited by 102

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD

Hövelmeyer, N., Wunderlich, F. T., Massoumi, R., Jakobsen, C. G., Song, J., Wörns, M., Merkwirth, C., Kovalenko, A., Aumailley, M., Strand, D. J., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070318 · Cited by 102

Three- and Four-repeat Tau Regulate the Dynamic Instability of Two Distinct Microtubule Subpopulations in Qualitatively Different Manners

Levy, S. F., LeBoeuf, A. C., Massie, M. R., Jordan, M. A., Wilson, L., & Feinstein, S. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413490200 · Cited by 102

Characterization of GPRA, a Novel G Protein–Coupled Receptor Related to Asthma

Vendelin, J., Pulkkinen, V., Rehn, M., Pirskanen, A., Räisänen-Sokolowski, A. K., Laitinen, A., Laitinen, L. A., Kere, J., & Laitinen, T. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0405oc · Cited by 102

Developments in RNA Splicing and Disease

Poulos, M. G., Batra, R., Charizanis, K., & Swanson, M. S. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000778 · Cited by 98

Fox-3 and PSF interact to activate neural cell-specific alternative splicing

Kim, K. K., Kim, Y. C., Adelstein, R. S., & Kawamoto, S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1221 · Cited by 97

A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies

Zhong, X., Liu, J. R., Kyle, J. W., Hanck, D. A., & Agnew, W. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl068 · Cited by 97

Novel Splice Variants of ING4 and Their Possible Roles in the Regulation of Cell Growth and Motility

Unoki, M., Shen, J., Zheng, Z., & Harris, C. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606296200 · Cited by 97

Alternative Pre-mRNA Splicing Governs Expression of a Conserved Acidic Transactivation Domain in Myocyte Enhancer Factor 2 Factors of Striated Muscle and Brain

Zhu, B., Ramachandran, B., & Gulick, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502491200 · Cited by 96

Human–mouse comparative analysis reveals that branch-site plasticity contributes to splicing regulation

Kol, G., Lev-Maor, G., & Ast, G. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi164 · Cited by 95

A soluble mouse brain splice variant of type 2α corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity

Chen, A., Perrin, M. H., DiGruccio, M. R., Vaughan, J. M., Brar, B. K., Arias, C. M., Lewis, K. A., Rivier, J., Sawchenko, P. E., & Vale, W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409583102 · Cited by 94

Alternative splicing: regulation of HIV‐1 multiplication as a target for therapeutic action

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The Drosophila Class B Scavenger Receptor NinaD-I Is a Cell Surface Receptor Mediating Carotenoid Transport for Visual Chromophore Synthesis

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