The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine
Abstract
Ergothioneine (EGT) is a histidine betaine derivative that exhibits antioxidant action in humans. EGT is primarily synthesized by fungal species and a number of bacterial species. A five-gene cluster (egtA, egtB, egtC, egtD &egtE) responsible for EGT production in Mycobacteria smegmatis has recently been identified. The first fungal biosynthetic EGT gene (NcEgt-1) has also been identified in Neurospora crassa. NcEgt-1 contains domains similar to those found in M. smegmatis egtB and egtD. EGT is biomembrane impermeable. Here we inferred the evolutionary history of the EGT cluster in prokaryotes as well as examining the phyletic distribution of Egt-1 in the fungal kingdom. A genomic survey of 2509 prokaryotes showed that the five-gene EGT cluster is only found in the Actinobacteria. Our survey identified more than 400 diverse prokaryotes that contain genetically linked orthologs of egtB and egtD. Phylogenetic analyses of Egt proteins show a complex evolutionary history and multiple incidences of horizontal gene transfer. Our analysis also identified two independent incidences of a fusion event of egtB and egtD in bacterial species. A genomic survey of over 100 fungal genomes shows that Egt-1 is found in all fungal phyla, except species that belong to the Saccharomycotina subphylum. This analysis provides a comprehensive analysis of the distribution of the key genes involved in the synthesis of EGT in prokaryotes and fungi. Our phylogenetic inferences illuminate the complex evolutionary history of the genes involved in EGT synthesis in prokaryotes. The potential to synthesize EGT is a fungal trait except for species belonging to the Saccharomycotina subphylum.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ERG is synthesised by a variety of microbes, especially fungi and actinobacteria.
“The chief organisms capable of its synthesis are fungi and certain yeasts(59,60), though actinobacteria and certain other micro-organisms(60–66), including the slime mould Physarum polycephalum (65), cyanobacteria(67–71) and methylotrophs(72) are also naturally capable of its production.”
From The biology of ergothioneine, an antioxidant nutraceutical (2020) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works
MUSCLE: multiple sequence alignment with high accuracy and high throughput
Edgar, R. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh340 · Cited by 44,662 · see citing works
A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood
Guindon, S., & Gascuel, O. (2003) · Systematic Biology · doi:10.1080/10635150390235520 · Cited by 16,698 · see citing works
ProtTest 3: fast selection of best-fit models of protein evolution
Darriba, D., Taboada, G. L., Doallo, R., & Posada, D. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr088 · Cited by 2,677 · see citing works
Genes required for mycobacterial growth defined by high density mutagenesis
Sassetti, C. M., Boyd, D. H., & Rubin, E. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03425.x · Cited by 2,544 · see citing works
Detecting Protein Function and Protein-Protein Interactions from Genome Sequences
Marcotte, E. M., Pellegrini, M., Ng, H.-L., Rice, D. W., Yeates, T. O., & Eisenberg, D. (1999) · Science · doi:10.1126/science.285.5428.751 · Cited by 1,670 · see citing works
Griffin, J. E., Gawronski, J. D., DeJesus, M. A., Ioerger, T. R., Akerley, B. J., & Sassetti, C. M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002251 · Cited by 1,048 · see citing works
Functional variants of OCTN cation transporter genes are associated with Crohn disease
Peltekova, V. D., Wintle, R. F., Rubin, L. A., Amos, C. I., Huang, Q., Gu, X., Newman, W. G., Oene, M. V., Cescon, D. W., Greenberg, G. R., et al. (2004) · Nature Genetics · doi:10.1038/ng1339 · Cited by 837 · see citing works
Discovery of the ergothioneine transporter
Gründemann, D., Harlfinger, S., Gölz, S., Geerts, A., Lazar, A., Berkels, R., Jung, N., RUBBERT, A., & Schömig, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408624102 · Cited by 613 · see citing works
Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes
Newton, G. L., Arnold, K., Price, M. S., Sherrill, C., Delcardayre, S. B., Aharonowitz, Y., Cohen, G., Davies, J., Fahey, R. C., & Davis, C. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.7.1990-1995.1996 · Cited by 523 · see citing works
Ergothioneine; antioxidant potential, physiological function and role in disease
Cheah, I. K., & Halliwell, B. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.017 · Cited by 514 · see citing works
DUBOST, N., OU, B., & BEELMAN, R. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.01.030 · Cited by 365 · see citing works
Rooting the Eukaryote Tree by Using a Derived Gene Fusion
Stechmann, A., & Cavalier‐Smith, T. (2002) · Science · doi:10.1126/science.1071196 · Cited by 335 · see citing works
In Vitro Reconstitution of Mycobacterial Ergothioneine Biosynthesis
Seebeck, F. P. (2010) · Journal of the American Chemical Society · doi:10.1021/ja101721e · Cited by 293 · see citing works
Relative rates of gene fusion and fission in multi-domain proteins
Kummerfeld, S., & Teichmann, S. A. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.11.007 · Cited by 208 · see citing works
[32] Ergothioneine as antioxidant
Hartman, P. E. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86124-e · Cited by 197 · see citing works
Snel, ., Bork, P., & Huynen, M. A. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01924-1 · Cited by 183 · see citing works
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis
Vilchèze, C., Av‐Gay, Y., Attarian, R., Liu, Z., Hazbón, M. H., Colangeli, R., Chen, B., Liu, W., Alland, D., Sacchettini, J. C., et al. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06365.x · Cited by 166 · see citing works
Cyanobacteria produce high levels of ergothioneine
Pfeiffer, C., Bauer, T., Surek, B., Schömig, E., & Gründemann, D. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.06.047 · Cited by 153 · see citing works
Bello, M. H., Barrera-Perez, V., Morin, D., & Epstein, L. (2012) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2011.12.007 · Cited by 126 · see citing works
Rahman, I., Gilmour, P. S., Jimenez, L. A., Biswas, S. K., Antonicelli, F. D., & Aruoma, O. I. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00224-9 · Cited by 125 · see citing works
Newton, G. L., Bewley, C. A., Dwyer, T. J., Horn, R., Aharonowitz, Y., Cohen, G., DAVIES, J. E., Faulkner, D. J., & Fahey, R. C. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0821h.x · Cited by 122 · see citing works
TB database 2010: Overview and update
Galagan, J. E., Sisk, P., Stolte, C., Weiner, B., Koehrsen, M., Wymore, F., Reddy, T. B. K., Zucker, J., Engels, R., Gellesch, M., et al. (2010) · Tuberculosis · doi:10.1016/j.tube.2010.03.010 · Cited by 114 · see citing works
Biosynthesis of Ergothioneine and Hercynine by Fungi and <i>Actinomycetales</i>
Genghof, D. S. (1970) · Journal of Bacteriology · doi:10.1128/jb.103.2.475-478.1970 · Cited by 113 · see citing works
ERGOTHIONEINE IN MICROORGANISMS
Melville, D. B., Genghof, D. S., Inamine, E., & Kovalenko, V. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65113-0 · Cited by 95 · see citing works
BIOSYNTHESIS OF ERGOTHIONEINE AND HERCYNINE BY MYCOBACTERIA
Genghof, D. S., & Damme, O. V. (1964) · Journal of Bacteriology · doi:10.1128/jb.87.4.852-862.1964 · Cited by 90 · see citing works
Ergothioneine Is a Secreted Antioxidant in Mycobacterium smegmatis
Sao Emani, C., Williams, M. J., Wiid, I. J., Hiten, N. F., Viljoen, A. J., Pietersen, R.-D. D., van Helden, P. D., & Baker, B. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02572-12 · Cited by 81 · see citing works
Ta, P., Buchmeier, N. A., Newton, G. L., Rawat, M., & Fahey, R. C. (2011) · Journal of Bacteriology · doi:10.1128/jb.01402-10 · Cited by 78 · see citing works
THE BIOSYNTHESIS OF ERGOTHIONEINE
Melville, D. B., Eich, S., & Ludwig, M. L. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64979-8 · Cited by 56 · see citing works
Leung, E. Y., Hong, J., Fraser, A. G., Merriman, T. R., Vishnu, P., & Krissansen, G. W. (2006) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2006.01423.x · Cited by 51 · see citing works
Fisher, S. A., Hampe, J., Onnie, C. M., Daly, M. J., Curley, C., Purcell, S., Sanderson, J. D., Mansfield, J. C., Annese, V., Forbes, A., et al. (2006) · Human Mutation · doi:10.1002/humu.20358 · Cited by 48 · see citing works
Santiago, J. L., Martínez, A., de la Calle, H., Fernández‐Arquero, M., Figueredo, M. A., de la Concha, E. G., & Urcelay, E. (2006) · BMC Medical Genetics · doi:10.1186/1471-2350-7-54 · Cited by 44 · see citing works
Medina, E. M., Jones, G. W., & Fitzpatrick, D. A. (2011) · Journal of Molecular Evolution · doi:10.1007/s00239-011-9461-4 · Cited by 44 · see citing works
Self-citationRecurring cluster and operon assembly for Phenylacetate degradation genes
Martin, F. J., & McInerney, J. O. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-36 · Cited by 30 · see citing works
Ergothioneine accumulation in a medicinal plant Gastrodia elata.
Park, E., Lee, W. Y., Kim, S. T., Ahn, J. K., & Bae, E. K. (2010) · Journal of Medicinal Plants Research · doi:10.5897/jmpr10.184 · Cited by 30 · see citing works
Zhu, B., Mao, L., & Frei, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.10.596 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Enzymatic Carbon–Sulfur Bond Formation in Natural Product Biosynthesis
Dunbar, K. L., Scharf, D. H., Litomska, A., & Hertweck, C. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00697 · Cited by 619 · see citing works
The biology of ergothioneine, an antioxidant nutraceutical
Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, S. A., & Kell, D. B. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422419000301 · Cited by 296 · see citing works
“An excellent phylogenetic analysis is given by Jones et al. (60) .”
BackgroundMethodRole of Ergothioneine in Microbial Physiology and Pathogenesis
Cumming, B. M., Chinta, K. C., Reddy, V. P., & Steyn, A. J. C. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7300 · Cited by 139 · see citing works
Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis
Halliwell, B., Cheah, I. K., & Drum, C. L. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.124 · Cited by 123 · see citing works
Production of ergothioneine by Methylobacterium species
Alamgir, K. M., Masuda, S., Fujitani, Y., Fukuda, F., & Tani, A. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01185 · Cited by 100 · see citing works
Ergothioneine: an underrecognised dietary micronutrient required for healthy ageing?
Tian, X., Thorne, J. L., & Moore, J. B. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114522003592 · Cited by 90 · see citing works
Heterologous and High Production of Ergothioneine in Escherichia coli
Osawa, R., Kamide, T., Satoh, Y., Kawano, Y., Ohtsu, I., & Dairi, T. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04924 · Cited by 82 · see citing works
Ergothioneine Antioxidant Function: From Chemistry to Cardiovascular Therapeutic Potential
Servillo, L., D'Onofrio, N., & Balestrieri, M. L. (2017) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000464 · Cited by 81 · see citing works
Tanaka, N., Kawano, Y., Satoh, Y., Dairi, T., & Ohtsu, I. (2019) · Scientific Reports · doi:10.1038/s41598-018-38382-w · Cited by 81 · see citing works
Naowarojna, N., Cheng, R., Chen, L., Quill, M., Xu, M., Zhao, C., & Liu, P. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00239 · Cited by 76 · see citing works
The Role of Organosulfur Compounds as Nrf2 Activators and Their Antioxidant Effects
Egbujor, M. C., Petrosino, M., Zuhra, K., & Saso, L. (2022) · Antioxidants · doi:10.3390/antiox11071255 · Cited by 76 · see citing works
Sheridan, K. J., Lechner, B. E., Keeffe, G. O., Keller, M. A., Werner, E. R., Lindner, H., Jones, G. W., Haas, H., & Doyle, S. (2016) · Scientific Reports · doi:10.1038/srep35306 · Cited by 73 · see citing works
Self-citationVit, A., Misson, L., Blankenfeldt, W., & Seebeck, F. P. (2014) · ChemBioChem · doi:10.1002/cbic.201402522 · Cited by 71 · see citing works
Hanafi, K. E., Pedrero, Z., Ouerdane, L., Marchán-Moreno, C., Queipo-Abad, S., Bueno, M., Pannier, F., Corns, W. T., Cherel, Y., Paco Bustamante, A., et al. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.1c04966 · Cited by 59 · see citing works
Convergent Evolution of Ergothioneine Biosynthesis in Cyanobacteria
Liao, C., & Seebeck, F. P. (2017) · ChemBioChem · doi:10.1002/cbic.201700354 · Cited by 58 · see citing works
Recent Strategies for the Biosynthesis of Ergothioneine
Qiu, Y., Chen, Z., Su, E., Wang, L., Sun, L., Lei, P., Xu, H. L., & Li, S. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05280 · Cited by 57 · see citing works
Selenoneine is a major selenium species in beluga skin and red blood cells of Inuit from Nunavik
Achouba, A., Dumas, P., Ouellet, N., Little, M., Lemire, M., & Ayotte, P. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.04.191 · Cited by 56 · see citing works
Ergothioneine production using Methylobacterium species, yeast, and fungi
Fujitani, Y., Alamgir, K. M., & Tani, A. (2018) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2018.05.021 · Cited by 53 · see citing works
Toward more efficient ergothioneine production using the fungal ergothioneine biosynthetic pathway
Chen, Z., He, Y., Wu, X., Wang, L., Dong, Z., & Chen, X. (2022) · Microbial Cell Factories · doi:10.1186/s12934-022-01807-3 · Cited by 53 · see citing works
Traynor, A. M., Sheridan, K. J., Jones, G. W., Calera, J. A., & Doyle, S. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02859 · Cited by 53 · see citing works
Self-citationAbby, S. S., Kerou, M., & Schleper, C. (2020) · mBio · doi:10.1128/mbio.02371-20 · Cited by 49 · see citing works
Structure of the Ergothioneine‐Biosynthesis Amidohydrolase EgtC
Vit, A., Mashabela, G. T., Blankenfeldt, W., & Seebeck, F. P. (2015) · ChemBioChem · doi:10.1002/cbic.201500168 · Cited by 48 · see citing works
Kamide, T., Takusagawa, S., Tanaka, N., Ogasawara, Y., Kawano, Y., Ohtsu, I., Satoh, Y., & Dairi, T. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01846 · Cited by 45 · see citing works
Yadan, J. (2021) · FEBS Letters · doi:10.1002/1873-3468.14264 · Cited by 40 · see citing works
Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtD
Misson, L., Burn, R., Vit, A., Hildesheim, J., Beliaeva, M. A., Blankenfeldt, W., & Seebeck, F. P. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00127 · Cited by 37 · see citing works
Endogenous cross-talk of fungal metabolites
Sheridan, K. J., Dolan, S. K., & Doyle, S. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00732 · Cited by 34 · see citing works
Self-citationFungi's treasure in cosmeceuticals-a comprehensive chemical approach
Mukherjee, A., Das, S., Chakraborty, D., Pal, N., & Das, N. (2024) · South African Journal of Botany · doi:10.1016/j.sajb.2024.01.036 · Cited by 32 · see citing works
Gamage, A. M., Liao, C., Cheah, I. K.-M., Chen, Y., Lim, D. R. X., Ku, J. W. K., Chee, R. S., Gengenbacher, M., Seebeck, F. P., Halliwell, B. B., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800716 · Cited by 32 · see citing works
Rawat, M., & Maupin-furlow, J. A. (2020) · Antioxidants · doi:10.3390/antiox9050381 · Cited by 32 · see citing works
In Vitro Reconstitution of a Five-Step Pathway for Bacterial Ergothioneine Catabolism
Beliaeva, M. A., Leisinger, F., & Seebeck, F. P. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.0c00968 · Cited by 31 · see citing works
Cordell, G. A., & Lamahewage, S. N. S. (2022) · Molecules · doi:10.3390/molecules27092673 · Cited by 31 · see citing works
Iterative l ‐Tryptophan Methylation in Psilocybe Evolved by Subdomain Duplication
Blei, F., Fricke, J., Wick, J., Slot, J. C., & Hoffmeister, D. (2018) · ChemBioChem · doi:10.1002/cbic.201800336 · Cited by 30 · see citing works
The role of low molecular weight thiols in Mycobacterium tuberculosis
Emani, C. S., Gallant, J., Wiid, I. J. F., & Baker, B. (2019) · Tuberculosis · doi:10.1016/j.tube.2019.04.003 · Cited by 27 · see citing works
Engineering non-conventional yeast Rhodotorula toruloides for ergothioneine production
Liu, K., Xiang, G., Li, L., Liu, T., Ke, J., Xiong, L., Wei, D., & Wang, F. (2024) · Biotechnology for Biofuels and Bioproducts · doi:10.1186/s13068-024-02516-2 · Cited by 26 · see citing works
Pahila, J., Ishikawa, Y., & Ohshima, T. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00485 · Cited by 24 · see citing works
Beliaeva, M. A., & Seebeck, F. P. (2022) · JACS Au · doi:10.1021/jacsau.2c00365 · Cited by 22 · see citing works
Daunay, S., Lebel, R., Farescour, L., Yadan, J., & Erdelmeier, I. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob01870j · Cited by 21 · see citing works
Yan, J., Chen, Y., Ma, Y., Yang, X., Yao, Y., Zhao, G., & Zhang, Y. (2025) · Trends in biotechnology · doi:10.1016/j.tibtech.2025.09.014 · Cited by 20 · see citing works
Syahputra, R. A., Ahmed, A., Asriadi, Sitorus, A. G. B., Putri, S. K., Tan, M.-S., Chandra, Q. M., Brathennovic, Angiosaki, Y., Lu, F. C., et al. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110006 · Cited by 19 · see citing works
Gao, H., Sun, J., Zhang, X., Rao, Z., & Xu, M. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108744 · Cited by 18 · see citing works
Lei, Z., Wang, Z., Zhang, H., Jia, Y., Zhang, D., Shi, R., Wang, C., & Chen, W. (2025) · Food & Function · doi:10.1039/d5fo02337h · Cited by 18 · see citing works
Quantitative determination of the sulfur-containing antioxidant ergothioneine by HPLC/ICP-QQQ-MS
Kroepfl, N., Marschall, T. A., Francesconi, K. A., Schwerdtle, T., & Kuehnelt, D. (2017) · Journal of Analytical Atomic Spectrometry · doi:10.1039/c7ja00030h · Cited by 16 · see citing works
Doyle, S., Cuskelly, D. D., Conlon, N., Fitzpatrick, D. A., Gilmartin, C. B., Dix, S. H., & Jones, G. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810832 · Cited by 14 · see citing works
Self-citationProteomic analysis of Aspergillus fumigatus – clinical implications
Moloney, N. M., Owens, R. A., & Doyle, S. (2016) · Expert Review of Proteomics · doi:10.1080/14789450.2016.1203783 · Cited by 12 · see citing works
Self-citationLittle, M., Winters, N., Achouba, A., Magesky, A., Ayotte, P., Palliser, T., Naylor, A. W., Jararuse, W., & Lemire, M. (2023) · Arctic Science · doi:10.1139/as-2022-0039 · Cited by 12 · see citing works
Little, M., Achouba, A., Ayotte, P., & Lemire, M. (2024) · Nutrition Research Reviews · doi:10.1017/s0954422424000039 · Cited by 12 · see citing works
Ganoderma Fusions with High Yield of Ergothioneine and Comparative Analysis of Its Genomics
Xie, J., Yu, Y., You, J., Ye, Z., Zhou, F., Wang, N., Zhong, J., Guo, L., & Lin, J. (2023) · Journal of Fungi · doi:10.3390/jof9111072 · Cited by 9 · see citing works
Engineering Saccharomyces boulardii for Probiotic Supplementation of l ‐Ergothioneine
Tang, C., Zhang, L., Wang, J., Zou, C., Zhang, Y., & Yuan, J. (2024) · Biotechnology Journal · doi:10.1002/biot.202400527 · Cited by 9 · see citing works
Convergent Evolution of Fungal Cysteine Dioxygenases
Flückger, S., Igareta, N. V., & Seebeck, F. P. (2020) · ChemBioChem · doi:10.1002/cbic.202000317 · Cited by 9 · see citing works
de Dios, R., Rivas‐Marín, E., Santero, E., & Reyes, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-62101-z · Cited by 9 · see citing works
Li, Y., Rao, J., Jiang, Z., Zhang, X., Zhu, Q., Zhu, C., Yu, W., Dong, X. W., Gao, S., Zhang, W., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147266 · Cited by 7 · see citing works
Serum ergothioneine and risk of dementia in a general older Japanese population: the Hisayama Study
Meng, X., Ohara, T., Nishioka, K., Shibata, M., Katsube, M., Tateishi, N., Nakamura, Y., Oishi, E., Sakata, S., Furuta, Y., et al. (2025) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13893 · Cited by 7 · see citing works
Suzuki, K., Kaneda, Y., Izumo, T., Nakao, Y., Iidaka, T., Horii, C., Muraki, S., Oka, H., Kawaguchi, H., Akune, T., et al. (2025) · Nutrients · doi:10.3390/nu17030517 · Cited by 5 · see citing works
Kim, M., Jung, J., Kim, W., Park, Y., Jeon, C. O., & Park, W. (2024) · The Journal of Microbiology · doi:10.1007/s12275-024-00172-7 · Cited by 5 · see citing works
Revalorization of brewer’s spent grain through solid-state fermentation with Pleurotus ostreatus
Pascual, M. M., Painefilú, J. C., Ranalli, N., Santos, M. V., Langenheim, M., Campos, M., Jurski, V., & Luquet, C. M. (2025) · Food and Humanity · doi:10.1016/j.foohum.2025.100984 · Cited by 3 · see citing works
Li, Z., Ding, J., Huang, W., Bian, Y., Feng, X., & Liu, Y. (2024) · Molecules · doi:10.3390/molecules29246005 · Cited by 3 · see citing works
Wei, X., Liu, L., Dong, S., Wu, P., Zhang, X., Yang, M., Zheng, R., & Zhang, H. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.146618 · Cited by 2 · see citing works
Maurer, A., & Seebeck, F. P. (2020) · ChemBioChem · doi:10.1002/cbic.202000232 · Cited by 2 · see citing works
Wang, K., Liu, Y., Cui, X., Chen, T., Liu, G., Zhang, W., Han, Z., & Zhang, G. (2024) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.006546 · Cited by 2 · see citing works
Seminara, A. B., & Hatzios, S. K. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.02.004 · Cited by 2 · see citing works
Li-Yang, Y. A. N. G., Gong, Q., Guo, J., & Li, G. (2021) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(21)60058-4 · Cited by 2 · see citing works
(2016) · The Korean Journal of Mycology · doi:10.4489/kjm.2016.44.2.100 · Cited by 2 · see citing works
Rodriguez, K. W., & Meier, K. K. (2025) · Biochemistry · doi:10.1021/acs.biochem.5c00123 · Cited by 1 · see citing works
Das, S., Omondi, E. C., Hinson, P. O., Nguyen, K. D., Olson, R., Beelman, R., Bitzer, Z. T., Sun, D., Zinati, G. M., Smith, A., et al. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.102661 · Cited by 1 · see citing works
Key genes for ergothioneine biosynthesis and stress adaptation in Schizophyllum commune
Chen, J., Leng, S., Zeng, S., Xue, Y.-R., & Liu, C.-H. (2026) · Fungal Biology · doi:10.1016/j.funbio.2026.101750 · Cited by 1 · see citing works
Halliwell, B. B. (2026) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2026.101488 · Cited by 1 · see citing works
Machado, M. J., Jacinavicius, F. R., Dextro, R. B., Feitosa, A. M. T., Silva, L. D. S. E., Alves, F. A. D. S., Pinto, E., Fiore, M. F., & Schneider, M. P. C. (2026) · Phycology · doi:10.3390/phycology6030074 · Cited by 1 · see citing works
Lanthanide utilization in Methylobacterium aquaticum strain 22A
Juma, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13307-7.00006-2
Chen, Z., He, Y., Wu, X., Wang, L., Dong, Z., & Chen, X. (2022) · Figshare · doi:10.6084/m9.figshare.19728307
Liu, K., Xiang, G., Li, L., Liu, T., Ke, J., Xiong, L., Wei, D., & Wang, F. (2024) · Figshare · doi:10.6084/m9.figshare.25815083
Rieder, G. S., Zeppilli, D., Nogara, P. A., Aschner, M., Tinkov, A. A., Adedara, I. A., de Souza, D. O. G., de Souza, D. G., Orian, L., & Rocha, J. B. T. (2026) · Advances in neurotoxicology · doi:10.1016/bs.ant.2025.08.001
Tian, T., Chen, L., Dong, Z., & Yang, C. (2026) · Food Frontiers · doi:10.1002/fft2.70207
Rodriguez, K. W., Tao, P. H. N., Kurmi, K., & Meier, K. K. (2026) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-026-02167-8
Gołaś, E., & Maciejczyk, M. (2026) · Antioxidants · doi:10.3390/antiox15091118
Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease
Yi, G., Yao, D., Dong, C., Tu, X., Liao, G., Long, M., & Xie, Y. (2026) · MedComm · doi:10.1002/mco2.70947
Bui, T., Jamil, E., Nguyen, H., Doyle, S., Fitzpatrick, D. A., Bayram, Ö. S., & Bayram, Ö. (2026) · Food Chemistry · doi:10.1016/j.foodchem.2026.151245
Self-citationDi, Z., Huo, Y., Li, B., & Zhuang, Y. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.110083
Kodchasee, P., Kumla, J., Kathongthung, C., Senwanna, C., Singsalood, S., Duangkon, N., & Suwannarach, N. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.103406
- Authors
- Jones, G. W., Doyle, S., & Fitzpatrick, D. A.
- Affiliations
- National University of Ireland, Maynooth (IE)
- Corresponding author
- Fitzpatrick, David A.
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 549
- Issue
- 1
- Pages
- 161-170
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2015375628
- Cited by
- 79
- References
- 36
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 9 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 1
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Maynooth University ePrints and eTheses Archive (Maynooth University) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- ergothioneine, ergothioneine biosynthesis, gene cluster evolution, EGTA, Mycobacterium smegmatis, Neurospora crassa, horizontal gene transfer, gene fusion, actinobacteria, fungal distribution, prokaryotic genomes, phylogenetic analysis, antioxidants
- MeSH terms
- Bacteria, Bacterial Proteins, Ergothioneine, Fungal Proteins, Fungi, Multigene Family, Phylogeny, Genome, Bacterial, Genome, Fungal, Evolution, Molecular, Gene Transfer, Horizontal, Gene Fusion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
