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Structure and functional roles of Epac2 (Rapgef4)
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“Several lines of evidence has conceived that EPAC2 plays significant roles in the liver45,71,96, endocrine glands and brain97–99.”
From ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver (2025) · cites this paper as [98]
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Cites
Dynamics of Insulin Secretion by the Perfused Rat Pancreas
CURRY, D. L., BENNETT, L. L., & GRODSKY, G. M. (1968) · Endocrinology · doi:10.1210/endo-83-3-572 · Cited by 601
Kim, M., Platt, M. J., Shibasaki, T., Quaggin, S. E., Backx, P. H., Seino, S., Simpson, J. A., & Drucker, D. J. (2013) · Nature Medicine · doi:10.1038/nm.3128 · Cited by 514 · cited 1×
“In this process, Epac2 is shown to link activation of the GLP-1 receptor and ANP secretion through PLCdependent signals in cardiomyocytes (Kim et al., 2013).”
BackgroundSelf-citationPhysiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease
Sandoval, D. A., & D'Alessio, D. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00013.2014 · Cited by 498
Kang, G., Joseph, J. W., Chepurny, O. G., Monaco, M., Wheeler, M. B., Bos, J. L., Schwede, F., Genieser, H.-G., & Holz, G. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211682200 · Cited by 298
De Marinis, Y. Z., Salehi, A., Ward, C. E., Zhang, Q., Abdulkader, F., Bengtsson, M., Braha, O., Braun, M., Ramracheya, R., Amisten, S., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.007 · Cited by 257 · cited 2×
“Adrenaline stimulates glucagon secretion by L-type Ca2+ channeldependent exocytosis through activation of Epac2 as well as PKA via a large increase in intracellular cAMP levels by binding to the Gs-coupled β-adrenergic receptors on α-cells (De Marinis et al., 2010).”
BackgroundSelf-citationBarg, S., Eliasson, L., Renström, E., & Rorsman, P. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s74 · Cited by 227 · cited 1×
“The first and second phases are associated with exocytosis of insulin granules from the RRP and a reserve pool (RP), respectively (Henquin, 2000; Barg et al., 2002; Bratanova-Tochkova et al., 2002).”
BackgroundEpac2 induces synapse remodeling and depression and its disease-associated forms alter spines
Woolfrey, K. M., Srivastava, D. P., Photowala, H., Yamashita, M., Barbolina, M. V., Cahill, M. E., Xie, Z., Jones, K. A., Quilliam, L. A., Prakriya, M., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2386 · Cited by 161
Gromada, J., Dissing, S., Bokvist, K., Renström, E., Frøkjær-Jensen, J., Wulff, B. S., & Rorsman, P. (1995) · Diabetes · doi:10.2337/diab.44.7.767 · Cited by 125
Bacchelli, E., Blasi, F., Biondolillo, M., Lamb, J. A., Bonora, E., Barnby, G., Parr, J., Beyer, K. S., Klauck, S. M., Poustka, A., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001340 · Cited by 117
Dzhura, I., Chepurny, O. G., Kelley, G. G., Leech, C. A., Roe, M. W., Dzhura, E., Afshari, P., Malik, S., Rindler, M. J., Xu, X., et al. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.198424 · Cited by 67 · cited 1×
“PLC-ε has a domain structure containing two RA domains at its carboxy-terminus (Kelley et al., 2001), and PLC-ε is activated by the association of the active form of Rap to a RA domain (Schmidt et al., 2001; Song et al., 2002; Dzhura et al., 2010).”
Background
Research works printed but not linked: 88
- Ahren, 2009, Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes, Nat. Rev. Drug Discov., 8, 369, 10.1038/nrd2782 · DOI
- Baukrowitz, 1998, PIP2 and PIP as determinants for ATP inhibition of KATP channels, Science, 282, 1141, 10.1126/science.282.5391.1141 · DOI
- Beavo, 2002, Cyclic nucleotide research — still expanding after half a century, Nat. Rev. Mol. Cell Biol., 3, 710, 10.1038/nrm911 · DOI
- Bers, 2008, Calcium cycling and signaling in cardiac myocytes, Annu. Rev. Physiol., 70, 23, 10.1146/annurev.physiol.70.113006.100455 · DOI
- Bos, 2006, Epac proteins: multi-purpose cAMP targets, Trends Biochem. Sci., 31, 680, 10.1016/j.tibs.2006.10.002 · DOI
- Bratanova-Tochkova, 2002, Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion, Diabetes, 51, S83, 10.2337/diabetes.51.2007.S83 · DOI
- Christensen, 2003, cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension, J. Biol. Chem., 278, 35394, 10.1074/jbc.M302179200 · DOI
- Consonni, 2012, cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane, Proc. Natl. Acad. Sci. U. S. A., 109, 3814, 10.1073/pnas.1117599109 · DOI
- de Heer, 2008, Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas, Diabetologia, 51, 2263, 10.1007/s00125-008-1149-y · DOI
- de Rooij, 2000, Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs, J. Biol. Chem., 275, 20829, 10.1074/jbc.M001113200 · DOI
- de Rooij, 1998, Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP, Nature, 396, 474, 10.1038/24884 · DOI
- Drucker, 2006, The biology of incretin hormones, Cell Metab., 3, 153, 10.1016/j.cmet.2006.01.004 · DOI · Paper page
- Dzhura, 2011, Phospholipase C-epsilon links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans, Islets, 3, 121, 10.4161/isl.3.3.15507 · DOI
- El-Armouche, 2009, Beta-adrenergic stimulation and myocardial function in the failing heart, Heart Fail. Rev., 14, 225, 10.1007/s10741-008-9132-8 · DOI
- Emery, 2014, Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells, J. Biol. Chem., 289, 10126, 10.1074/jbc.M113.529321 · DOI
- Enserink, 2002, A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK, Nat. Cell Biol., 4, 901, 10.1038/ncb874 · DOI · Paper page
- Fernandes, 2015, Epac2 mediates cAMP-dependent potentiation of neurotransmission in the hippocampus, J. Neurosci., 35, 6544, 10.1523/JNEUROSCI.0314-14.2015 · DOI
- Frische, 2010, Rap1, a mercenary among the Ras-like GTPases, Dev. Biol., 340, 1, 10.1016/j.ydbio.2009.12.043 · DOI
- Fu, 2011, Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway, Proc. Natl. Acad. Sci. U. S. A., 108, 1403, 10.1073/pnas.1018376108 · DOI
- Fujimoto, 2002, Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis, J. Biol. Chem., 277, 50497, 10.1074/jbc.M210146200 · DOI
- Gekel, 2008, Application of an Epac activator enhances neurotransmitter release at excitatory central synapses, J. Neurosci., 28, 7991, 10.1523/JNEUROSCI.0268-08.2008 · DOI
- Gelinas, 2008, Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus, Learn. Mem., 15, 403, 10.1101/lm.830008 · DOI
- Gloerich, 2011, Regulating Rap small G-proteins in time and space, Trends Cell Biol., 21, 615, 10.1016/j.tcb.2011.07.001 · DOI
- Henquin, 2000, Triggering and amplifying pathways of regulation of insulin secretion by glucose, Diabetes, 49, 1751, 10.2337/diabetes.49.11.1751 · DOI · Paper page
- Hoivik, 2013, DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms, PLoS One, 8, 10.1371/journal.pone.0067925 · DOI
- Holz, 2006, Cell physiology of cAMP sensor Epac, J. Physiol., 577, 5, 10.1113/jphysiol.2006.119644 · DOI
- Holz, 1999, cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37), J. Biol. Chem., 274, 14147, 10.1074/jbc.274.20.14147 · DOI · Paper page
- Hothi, 2008, Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart, Pflugers Arch., 457, 253, 10.1007/s00424-008-0508-3 · DOI
- Kai, 2013, Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop beta-cell dysfunction and metabolic syndrome, FASEB J., 27, 4122, 10.1096/fj.13-230433 · DOI
- Kang, 2001, cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells, J. Physiol., 536, 375, 10.1111/j.1469-7793.2001.0375c.xd · DOI
- Kang, 2006, cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells, J. Physiol., 573, 595, 10.1113/jphysiol.2006.107391 · DOI
- Kashima, 2001, Critical role of cAMP-GEFII–Rim2 complex in incretin-potentiated insulin secretion, J. Biol. Chem., 276, 46046, 10.1074/jbc.M108378200 · DOI
- Kawasaki, 1998, A family of cAMP-binding proteins that directly activate Rap1, Science, 282, 2275, 10.1126/science.282.5397.2275 · DOI
- Kelley, 2001, Phospholipase C(epsilon): a novel Ras effector, EMBO J., 20, 743, 10.1093/emboj/20.4.743 · DOI
- Kiermayer, 2005, Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells, Mol. Biol. Cell, 16, 5639, 10.1091/mbc.e05-05-0432 · DOI
- Li, 2006, The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane, J. Biol. Chem., 281, 2506, 10.1074/jbc.M508165200 · DOI
- Liu, 2008, Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2, Mol. Cell. Biol., 28, 7109, 10.1128/MCB.01060-08 · DOI
- Metrich, 2010, Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway, Cell. Signal., 22, 1459, 10.1016/j.cellsig.2010.05.014 · DOI
- Metrich, 2008, Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy, Circ. Res., 102, 959, 10.1161/CIRCRESAHA.107.164947 · DOI
- Montague, 1972, The mode of action of adenosine 3′:5′-cyclic monophosphate in mammalian islets of Langerhans. Preparation and properties of islet-cell protein phosphokinase, Biochem. J., 129, 551, 10.1042/bj1290551 · DOI
- Morel, 2005, cAMP-binding protein Epac induces cardiomyocyte hypertrophy, Circ. Res., 97, 1296, 10.1161/01.RES.0000194325.31359.86 · DOI
- Murray, 2008, Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration, Mol. Cell. Neurosci., 38, 578, 10.1016/j.mcn.2008.05.006 · DOI
- Nauck, 2009, Unraveling the science of incretin biology, Am. J. Med., 122, S3, 10.1016/j.amjmed.2009.03.012 · DOI
- Niimura, 2009, Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function, J. Cell. Physiol., 219, 652, 10.1002/jcp.21709 · DOI · Paper page
- Nijholt, 2008, Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation, Cell. Signal., 20, 1715, 10.1016/j.cellsig.2008.05.001 · DOI
- Ostroveanu, 2010, Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval, Hippocampus, 20, 1018, 10.1002/hipo.20700 · DOI
- Ozaki, 2000, cAMP-GEFII is a direct target of cAMP in regulated exocytosis, Nat. Cell Biol., 2, 805, 10.1038/35041046 · DOI · Paper page
- Park, 2012, Glucagon-like peptide-1 enhances glucokinase activity in pancreatic beta-cells through the association of Epac2 with Rim2 and Rab3A, Endocrinology, 153, 574, 10.1210/en.2011-0259 · DOI
- Parnell, 2015, The future of EPAC-targeted therapies: agonism versus antagonism, Trends Pharmacol. Sci., 36, 203, 10.1016/j.tips.2015.02.003 · DOI
- Penzes, 2011, Epac2-mediated dendritic spine remodeling: implications for disease, Mol. Cell. Neurosci., 46, 368, 10.1016/j.mcn.2010.11.008 · DOI
- Pereira, 2013, Epac2 mediates cardiac beta1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia, Circulation, 127, 913, 10.1161/CIRCULATIONAHA.12.148619 · DOI
- Pereira, 2015, Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes, Proc. Natl. Acad. Sci. U. S. A., 112, 3991, 10.1073/pnas.1416163112 · DOI
- Pereira, 2012, Epac enhances excitation-transcription coupling in cardiac myocytes, J. Mol. Cell. Cardiol., 52, 283, 10.1016/j.yjmcc.2011.10.016 · DOI
- Qiao, 2002, Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP, J. Biol. Chem., 277, 26581, 10.1074/jbc.M203571200 · DOI
- Quesada, 2008, Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes, J. Endocrinol., 199, 5, 10.1677/JOE-08-0290 · DOI
- Rehmann, 2012, Epac2: a sulfonylurea receptor?, Biochem. Soc. Trans., 40, 6, 10.1042/BST20110640 · DOI
- Rehmann, 2008, Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B, Nature, 455, 124, 10.1038/nature07187 · DOI
- Rehmann, 2006, Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state, Nature, 439, 625, 10.1038/nature04468 · DOI
- Renstrom, 1997, Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic β-cells, J. Physiol., 502, 105, 10.1111/j.1469-7793.1997.105bl.x · DOI · Paper page
- Roscioni, 2008, Epac: effectors and biological functions, Naunyn Schmiedeberg's Arch. Pharmacol., 377, 345, 10.1007/s00210-007-0246-7 · DOI
- Sakaba, 2001, Preferential potentiation of fast-releasing synaptic vesicles by cAMP at the calyx of Held, Proc. Natl. Acad. Sci. U. S. A., 98, 331, 10.1073/pnas.98.1.331 · DOI
- Schmidt, 2013, Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions, Pharmacol. Rev., 65, 670, 10.1124/pr.110.003707 · DOI
- Schmidt, 2001, A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase, Nat. Cell Biol., 3, 1020, 10.1038/ncb1101-1020 · DOI
- Schwede, 2015, Structure-guided design of selective Epac1 and Epac2 agonists, PLoS Biol., 13, 10.1371/journal.pbio.1002038 · DOI
- Seino, 2011, Dynamics of insulin secretion and the clinical implications for obesity and diabetes, J. Clin. Invest., 121, 2118, 10.1172/JCI45680 · DOI · Paper page
- Seino, 2010, GIP and GLP-1, the two incretin hormones: similarities and differences, J. Diabetes Investig., 1, 8, 10.1111/j.2040-1124.2010.00022.x · DOI · Paper page
- Shibasaki, 2004, Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis, J. Biol. Chem., 279, 7956, 10.1074/jbc.M309068200 · DOI
- Shibasaki, 2007, Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP, Proc. Natl. Acad. Sci. U. S. A., 104, 19333, 10.1073/pnas.0707054104 · DOI · Paper page
- Song, 2002, Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon, Oncogene, 21, 8105, 10.1038/sj.onc.1206003 · DOI
- Srivastava, 2012, Social, communication, and cortical structural impairments in Epac2-deficient mice, J. Neurosci., 32, 11864, 10.1523/JNEUROSCI.1349-12.2012 · DOI
- Srivastava, 2012, An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice, PLoS Biol., 10, 10.1371/journal.pbio.1001350 · DOI
- Ster, 2009, Epac mediates PACAP-dependent long-term depression in the hippocampus, J. Physiol., 587, 101, 10.1113/jphysiol.2008.157461 · DOI
- Takahashi, 2015, Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion, Diabetes, 64, 1262, 10.2337/db14-0576 · DOI
- Takahashi, 2013, Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A, Sci. Signal., 6, 10.1126/scisignal.2004581 · DOI
- Thorens, 1992, Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1, Proc. Natl. Acad. Sci. U. S. A., 89, 8641, 10.1073/pnas.89.18.8641 · DOI · Paper page
- Tsalkova, 2011, Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs, Assay Drug Dev. Technol., 9, 88, 10.1089/adt.2010.0338 · DOI
- Tsuboi, 2003, Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells, Biochem. J., 369, 287, 10.1042/bj20021288 · DOI
- Uenishi, 2013, Actin dynamics regulated by the balance of neuronal Wiskott–Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion, J. Biol. Chem., 288, 25851, 10.1074/jbc.M113.464420 · DOI
- Ueno, 2001, Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform, Genomics, 78, 91, 10.1006/geno.2001.6641 · DOI · Paper page
- Ulucan, 2007, Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy, Am. J. Physiol. Heart Circ. Physiol., 293, H1662, 10.1152/ajpheart.00159.2007 · DOI
- Usdin, 1993, Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain, Endocrinology, 133, 2861, 10.1210/endo.133.6.8243312 · DOI · Paper page
- Vliem, 2008, 8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue, Chembiochem, 9, 2052, 10.1002/cbic.200800216 · DOI
- Wang, 2007, Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion, J. Biol. Chem., 282, 9536, 10.1074/jbc.M610553200 · DOI · Paper page
- Yamada, 1995, Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA, Genomics, 29, 773, 10.1006/geno.1995.9937 · DOI
- Yang, 2012, EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation, Neuron, 73, 774, 10.1016/j.neuron.2012.02.003 · DOI
- Yasuda, 2010, Rim2alpha determines docking and priming states in insulin granule exocytosis, Cell Metab., 12, 117, 10.1016/j.cmet.2010.05.017 · DOI · Paper page
- Zhang, 2009, The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs, Science, 325, 607, 10.1126/science.1172256 · DOI
- Zhong, 2005, cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction, J. Neurosci., 25, 208, 10.1523/JNEUROSCI.3703-04.2005 · DOI
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Chen, J., Huang, H., Chen, C., Xia, G., Huang, H., Xiong, Y., Luo, P., Chen, Y., Li, J., Wen, L., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08818-x · Cited by 1
Metadata
- Authors
- Sugawara, K., Shibasaki, T., Takahashi, H., & Seino, S.
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 575
- Issue
- 2
- Pages
- 577-583
- ISSN
- 0378-1119
- PMC
- PMC6636354
- Cited by
- 59
- References
- 10
- Language
- en
- Funders
- National Institutes of Health (GM089820, GM114833)
- Ministry of Education, Culture, Sport, Science and Technology (24229007)
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