Cited by 44Schizophrenia research and treatmentCardiac Health and Mental HealthMental Health Treatment and Access

Eight-year trends of cardiometabolic morbidity and mortality in patients with schizophrenia

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Morden, Nancy E., Lai, Zongshan, Goodrich, David E., MacKenzie, Todd, McCarthy, John F., Austin, Karen, Welsh, Deborah E., Bartels, Stephen +1 more·2012·General Hospital Psychiatry

Abstract

Objective We examined cardiometabolic disease and mortality over 8 years among individuals with and without schizophrenia.Method We compared 65,362 patients in the Veteran Affairs (VA) health system with schizophrenia to 65,362 VA patients without serious mental illness (non-SMI) matched on age, service access year and location. The annual prevalence of diagnosed cardiovascular disease, diabetes, dyslipidemia, hypertension, obesity, and all-cause and cause-specific mortality was compared for fiscal years 2000-2007. Mean years of potential life lost (YPLLs) were calculated annually.Results The cohort was mostly male (88%) with a mean age of 54 years. Cardiometabolic disease prevalence increased in both groups, with non-SMI patients having higher disease prevalence in most years. Annual between-group differences ranged from <1% to 6%. Annual mortality was stable over time for schizophrenia (3.1%) and non-SMI patients (2.6%). Annual mean YPLLs increased from 12.8 to 15.4 in schizophrenia and from 11.8 to 14.0 for non-SMI groups.Conclusions VA patients with and without schizophrenia show increasing but similar prevalence rates of cardiometabolic diseases. YPLLs were high in both groups and only slightly higher among patients with schizophrenia. The findings highlight the complex population served by the VA while suggesting a smaller mortality impact from schizophrenia than previously reported.

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Crossref · 10.1016/j.genhosppsych.2012.02.009

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Authors
Morden, N. E., Lai, Z., Goodrich, D. E., MacKenzie, T., McCarthy, J. F., Austin, K., Welsh, D. E., Bartels, S., & Kilbourne, A. M.
Affiliations
  • Dartmouth College (US)
  • University of Michigan (US)
Corresponding author
Kilbourne, Amy M.
Venue
General Hospital Psychiatry
Publisher
Elsevier BV
Published
2012-07
Volume
34
Issue
4
Pages
368-379
ISSN
0163-8343 (ISSN-L)
OpenAlex
W2073104319
Cited by
44
References
48
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 8 · 2013: 4 · 2012: 1
FWCI
5.03
Type
journal article
Language
en
Open access
Locations
  • General Hospital Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
VA Ann Arbor HSR&D Center for Clinical Management Research, the VA National Serious Mental Illness Treatment Resource and Evaluation Center, and the Health Services Research and Development Program
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
schizophrenia, cardiometabolic disease, cardiovascular disease, diabetes mellitus, dyslipidemia, hypertension, obesity, mortality, years of potential life lost, veterans, severe mental illness, temporal trends
MeSH terms
Adult, Aged, Cardiovascular Diseases, Female, Humans, Male, Metabolic Diseases, Middle Aged, Mortality, Schizophrenia, United States, United States Department of Veterans Affairs, Cohort Studies

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