Eight-year trends of cardiometabolic morbidity and mortality in patients with schizophrenia
Open accessAbstract
Objective We examined cardiometabolic disease and mortality over 8 years among individuals with and without schizophrenia.Method We compared 65,362 patients in the Veteran Affairs (VA) health system with schizophrenia to 65,362 VA patients without serious mental illness (non-SMI) matched on age, service access year and location. The annual prevalence of diagnosed cardiovascular disease, diabetes, dyslipidemia, hypertension, obesity, and all-cause and cause-specific mortality was compared for fiscal years 2000-2007. Mean years of potential life lost (YPLLs) were calculated annually.Results The cohort was mostly male (88%) with a mean age of 54 years. Cardiometabolic disease prevalence increased in both groups, with non-SMI patients having higher disease prevalence in most years. Annual between-group differences ranged from <1% to 6%. Annual mortality was stable over time for schizophrenia (3.1%) and non-SMI patients (2.6%). Annual mean YPLLs increased from 12.8 to 15.4 in schizophrenia and from 11.8 to 14.0 for non-SMI groups.Conclusions VA patients with and without schizophrenia show increasing but similar prevalence rates of cardiometabolic diseases. YPLLs were high in both groups and only slightly higher among patients with schizophrenia. The findings highlight the complex population served by the VA while suggesting a smaller mortality impact from schizophrenia than previously reported.
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People with schizophrenia and other psychotic disorders die earlier than their peers in the general population, by around 15-20 years according to recent estimates.
“People with schizophrenia and other psychotic disorders die earlier than their peers in the general population, with recent estimates suggesting by around 15–20 years.1–10”
From Mortality in Schizophrenia and Other Psychoses: A 10-Year Follow-up of the ӔSOP First-Episode Cohort (2015) · cites this paper as [7]
Evidence as to whether excess mortality in psychotic disorders is predominantly due to unnatural or natural causes remains equivocal.
“Evidence as to whether excess mortality is predominantly due to unnatural or natural causes of death remains equivocal.2,7,9,12”
From Mortality in Schizophrenia and Other Psychoses: A 10-Year Follow-up of the ӔSOP First-Episode Cohort (2015) · cites this paper as [7]
Consistent evidence has accrued that people with psychotic disorder have higher mortality rates than the general population.
“Over the past decades, consistent evidence has accrued that people with psychotic disorder have higher mortality rates than the general population.1–9”
From Mortality in Schizophrenia and Other Psychoses: A 10-Year Follow-up of the ӔSOP First-Episode Cohort (2015) · cites this paper as [7]
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- Authors
- Morden, N. E., Lai, Z., Goodrich, D. E., MacKenzie, T., McCarthy, J. F., Austin, K., Welsh, D. E., Bartels, S., & Kilbourne, A. M.
- Affiliations
- Dartmouth College (US)
- University of Michigan (US)
- Corresponding author
- Kilbourne, Amy M.
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 34
- Issue
- 4
- Pages
- 368-379
- ISSN
- 0163-8343 (ISSN-L)
- PMC
- PMC3383866
- OpenAlex
- W2073104319
- Cited by
- 44
- References
- 48
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 8 · 2013: 4 · 2012: 1
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- General Hospital Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- VA Ann Arbor HSR&D Center for Clinical Management Research, the VA National Serious Mental Illness Treatment Resource and Evaluation Center, and the Health Services Research and Development Program
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- schizophrenia, cardiometabolic disease, cardiovascular disease, diabetes mellitus, dyslipidemia, hypertension, obesity, mortality, years of potential life lost, veterans, severe mental illness, temporal trends
- MeSH terms
- Adult, Aged, Cardiovascular Diseases, Female, Humans, Male, Metabolic Diseases, Middle Aged, Mortality, Schizophrenia, United States, United States Department of Veterans Affairs, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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