Cited by 334Treatment of Major DepressionPhysical Activity and HealthNeural and Behavioral Psychology Studies

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Exercise effects on depression: Possible neural mechanisms

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Gujral, Swathi, Aizenstein, Howard, Reynolds, Charles F., Butters, Meryl A., Erickson, Kirk I.·2017·General Hospital Psychiatry

DOI 10.1016/j.genhosppsych.2017.04.012PMC PMC6437683

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Abstract

Depression is a syndrome of stress- and emotion-dysregulation, involving compromised structural integrity of frontal-limbic networks. Meta-analytic evidence indicates that volumetric reductions in the hippocampus, anterior cingulate cortex, prefrontal cortex, striatum, and amygdala, as well as compromised white matter integrity are frequently observed in depressed adults. Exercise has shown promise as an effective treatment for depression, but few studies have attempted to characterize or identify the neural mechanisms of these effects. In this review, we examined the overlap between structural brain abnormalities in depression and the effects of exercise on brain structure in adults, to highlight possible neural mechanisms that may mediate the positive effects of exercise on depressive symptoms. The prefrontal cortex, anterior cingulate cortex, hippocampus, and corpus callosum emerged as structural neural markers that may serve as targets for exercise-based treatments for depression. These findings highlight the need for randomized exercise interventions to test these proposed neurobiological mechanisms of exercise on depression.

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Authors: Gujral, S., Aizenstein, H., Reynolds, C. F., Butters, M. A., & Erickson, K. I.
Affiliations: University of Pittsburgh (US)
Corresponding author: Gujral, Swathi
ORCID: Gujral, Swathi
Aizenstein, Howard
Reynolds, Charles F.
Butters, Meryl A.
Erickson, Kirk I.
Venue: General Hospital Psychiatry
Publisher: Elsevier BV
Published: 2017-11
Volume: 49
Pages: 2-10
ISSN: 0163-8343 (ISSN-L)
DOI: 10.1016/j.genhosppsych.2017.04.012
PMC: PMC6437683
OpenAlex: W2767771037
Cited by: 334
References: 97
Citations by year: 2026: 33 · 2025: 42 · 2024: 55 · 2023: 67 · 2022: 40 · 2021: 34 · 2020: 40 · 2019: 12 · 2018: 10
FWCI: 2.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 371 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: General Hospital Psychiatry (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation (P30 MH090333, R01 DK095172, P30 AG024827, P30 MH90333, P50 AG005133, 2014192810)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: physical activity, depression, neural mechanisms, brain structure, hippocampus, anterior cingulate cortex, prefrontal cortex, corpus callosum, white matter integrity, structural brain abnormalities, neuroplasticity
MeSH terms: Adult, Aged, Aged, 80 and over, Brain, Depression, Depressive Disorder, Exercise Therapy, Humans, Middle Aged, Young Adult

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Exercise effects on depression: Possible neural mechanisms

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