Optimal exercise to improve physical ability and performance in older adults with sarcopenia: a systematic review and network meta-analysis
Open accessAbstract
Objective The study aimed to pool and analyze the effects of different forms of exercise on muscle strength (handgrip strength [HGS]), and physical performance (timed up and go test [TUGT], gait speed [GS] and chair stand test [CS]) in older adults with sarcopenia. Methods The effect sizes of all studies retrieved and included by the four databases were analyzed using the network meta-analysis and expressed as standardized mean differences (SMD) and the corresponding 95% confidence intervals (CI). Results Twenty studies were included in this study with 1347 older adults with sarcopenia. Compared with control and other intervention groups, resistance training (RT) improved HGS [SMD=3.8, 95% CI (1.3, 6.0), p Conclusion In older adults with sarcopenia, RT could improve HGS and TUGT, CT and CT_SM could improve TUGT. There were no significant changes in CS and GS with any of the exercise training modes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Resistance training improves gait speed compared with no exercise (CTRL) in healthy adults.
“Compared with CTRL, gait speed was impacted by standard RT (17,30,32,33,36–38,47,53,152–155).”
Resistance training improves chair stand test performance compared with no exercise (CTRL) in healthy adults.
“Compared with CTRL, chair stand performance was impacted by standard RT (30,32,33,36,50,152).”
Resistance training improves timed up-and-go performance compared with no exercise (CTRL) in healthy adults.
“Compared with CTRL, TUG was impacted by standard RT (30,32,33,36,38,47,50,152,154,156).”
Cites
Cadore, E. L., Rodríguez-Mañas, L., Sinclair, A., & Izquierdo, M. (2013) · Rejuvenation Research · doi:10.1089/rej.2012.1397 · Cited by 954 · see citing works
Tai chi and postural stability in patients with Parkinson's disease
Li, F., Harmer, P., Fitzgerald, K., Eckstrom, E., Stock, R., Galver, J., Maddalozzo, G., & Batya, S. S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107911 · Cited by 890 · see citing works
Kim, H. K., Suzuki, T., Saito, K., Yoshida, H., Kobayashi, H., Kato, H., & Katayama, M. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03776.x · Cited by 551 · see citing works
Network meta-analysis: application and practice using R software
Shim, S. R., Kim, S.-J., Lee, J., & Rücker, G. (2019) · Epidemiology and Health · doi:10.4178/epih.e2019013 · Cited by 483 · see citing works
Liao, C.-D., Tsauo, J.-Y., Lin, L.-F., Huang, S.-W., Ku, J.-W., Chou, L.-C., & Liou, T.-H. (2017) · Medicine · doi:10.1097/md.0000000000007115 · Cited by 201 · see citing works
Liao, C.-D., Tsauo, J.-Y., Huang, S.-W., Ku, J.-W., Hsiao, D.-J., & Liou, T.-H. (2018) · Scientific Reports · doi:10.1038/s41598-018-20677-7 · Cited by 180 · see citing works
Zhu, L.-Y., Chan, R., Kwok, T., Cheng, K. C.-C., Ha, A., & Woo, J. (2019) · Age and Ageing · doi:10.1093/ageing/afy179 · Cited by 179 · see citing works
Wu, P.-Y., Huang, K.-S., Chen, K.-M., Chou, C.-P., & Tu, Y.-K. (2021) · Maturitas · doi:10.1016/j.maturitas.2020.12.009 · Cited by 168 · see citing works
Lozano-Montoya, I., Correa-Pérez, A., Abraha, I., Soiza, R. L., Cherubini, A., O'Mahony, D., & Cruz-Jentoft, A. J. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s132496 · Cited by 130 · see citing works
Nutrition and exercise in sarcopenia
Anton, S. D., Hida, A., Mankowski, R., Layne, A., Solberg, L. M., Mainous, A. G., & Buford, T. (2018) · Current Protein & Peptide Science · doi:10.2174/1389203717666161227144349 · Cited by 113 · see citing works
The neural basis of sustained and transient attentional control in young adults with ADHD
Banich, M. T., Burgess, G. C., Depue, B. E., Ruzic, L., Bidwell, L. C., Hitt-Laustsen, S., Du, Y. P., & Willcutt, E. G. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.07.005 · Cited by 100 · see citing works
Park, J., Kwon, Y., & Park, H. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.39065 · Cited by 94 · see citing works
Cadore, E. L., & Izquierdo, M. (2015) · AGE · doi:10.1007/s11357-015-9800-2 · Cited by 93 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
CURRIER, B. S., D’SOUZA, A. C., SINGH, M. A. F., LOWISZ, C. V., RAWSON, E. S., SCHOENFELD, B. J., SMITH-RYAN, A. E., STEEN, J. P., THOMAS, G. A., TRIPLETT, N. T., et al. (2026) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003897 · Cited by 55 · see citing works
“Compared with CTRL, TUG was impacted by standard RT (30,32,33,36,38,47,50,152,154,156).”
Liao, C.-D., Huang, S.-W., Chen, H.-C., Huang, M.-H., Liou, T.-H., & Lin, C.-L. (2024) · Nutrients · doi:10.3390/nu16070941 · Cited by 45 · see citing works
Training modalities for elder sarcopenic obesity: a systematic review and network meta-analysis
Qiu, H., Zheng, W., Zhou, X., Liu, Q., & Zhao, X. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1537291 · Cited by 17 · see citing works
Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians
Afsar, B., Afsar, R. E., Caliskan, Y., Lentine, K. L., & Edwards, J. C. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05043-8 · Cited by 15 · see citing works
- Authors
- Zeng, D., Ling, X.-Y., Fang, Z.-L., & Lu, Y.-F.
- Affiliations
- Beijing Sport University (CN)
- ORCID
- Zeng, Dan
- Venue
- Geriatric Nursing
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 52
- Pages
- 199-207
- ISSN
- 0197-4572 (ISSN-L)
- OpenAlex
- W4382794980
- Cited by
- 16
- References
- 13
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Geriatric Nursing (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2020YFC2002902)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Keywords
- sarcopenia, older adults, exercise intervention, resistance training, comprehensive training, self-management, grip strength, physical performance, Timed Up and Go test, walking speed, chair stand test
- MeSH terms
- Aged, Postural Balance, Humans, Time and Motion Studies, Exercise, Hand Strength, Muscle Strength, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
