Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia

Powell, Susan B.; Sejnowski, Terrence J.; Behrens, M. Margarita

doi:10.1016/j.neuropharm.2011.01.049

Cited by 164Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia

Open access

Powell, Susan B., Sejnowski, Terrence J., Behrens, M. Margarita·2012·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.01.049PMC PMC3106123

Open this paper in CoChat — free account

Abstract

Oxidative stress, in response to the activation of the superoxide-producing enzyme Nox2, has been implicated in the schizophrenia-like behavioral dysfunction that develops in animals that were subject to either neonatal NMDA receptor-antagonist treatment or social isolation. In both of these animal models of schizophrenia, an environmental insult occurring during the period of active maturation of the fast-spiking parvalbumin-positive (PV+) interneuronal circuit leads to a diminished expression of parvalbumin in GABA-inhibitory neurons when animals reach adulthood. The loss of PV+ interneurons in animal models had been tentatively attributed to the death of these neurons. However, present results show that for the perinatal NMDA-R antagonist model these interneurons are still alive when animals are 5-6 weeks of age even though they have lost their phenotype and no longer express parvalbumin. Alterations in parvalbumin expression and sensory-evoked gamma-oscillatory activity, regulated by PV+ interneurons, are consistently observed in schizophrenia. We propose that cortical networks consisting of faulty PV+ interneurons interacting with pyramidal neurons may be responsible for the aberrant oscillatory activity observed in schizophrenia. Thus, oxidative stress during the maturation window for PV+ interneurons by alteration of normal brain development, leads to the emergence of schizophrenia-like behavioral dysfunctions when subjects reach early adulthood.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2011.01.049

Cites

161 of 161 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inhibition of NMDARs during early life causes a persistent decrease in the number of parvalbumin-immunoreactive cells without cell death, suggesting that disruption of NMDAR-mediated signaling impairs maturation of these cells.
“Inhibition of NMDARs during early life causes a persistent decrease in number of parvalbumin-immunoreactive cells without cell death (Powell et al., 2012), suggesting that disruption of NMDAR-mediated signaling impairs maturation of these cells.”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Powell et al., 2012
Parvalbumin interneurons are especially vulnerable to NMDAR hypofunction during development.
“However, PVI are especially vulnerable to NMDAR hypofunction during development (Abekawa et al., 2007; Powell et al., 2012; Wang et al., 2008; Wang et al., 2013).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Powell et al., 2012
In NOX-2 knockout mice, parvalbumin interneurons are protected from postnatal ketamine treatment, indicating a crucial role of NOX in parvalbumin interneuron impairment following early-life NMDAR blockade.
“In NOX-2 knockout mice, PVI are protected from a postnatal ketamine treatment, indicating a crucial role of NOX in the PVI impairment following early-life blockade of NMDAR (Powell et al., 2012).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Powell et al., 2012
Some human and animal data suggest that PV-INs may remain present but cease to express PV, although a definitive conclusion cannot yet be drawn.
“Some human and animal model data suggest that formerly PV-INs are still present but cease to express PV, though a definitive conclusion cannot be drawn at this point [7,[18][19][20].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [18]
Redox dysregulation/oxidative stress halts normal PVI maturation in the prefrontal cortex without causing their death, possibly via epigenetic mechanisms.
“Based on the fact that a peripubertal antioxidant treatment can abolish oxidative stress and rescue PVI/PNN deficit in the NVHL rat model,41 we propose a hypothesis in which redox dysregulation/oxidative stress halts normal PVI maturation in the prefrontal cortex without causing their death,82 possibly via epigenetic mechanisms.102, 103”
From Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia (2017) · cites this paper as [82]

Neurons rely on astrocytes to provide extrinsic support because of relatively weak intrinsic antioxidant defences.
“Another consequence of relatively weak intrinsic antioxidant defences is that neurons rely on astrocytes to provide extrinsic support 82 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [82]
Neurons express little NRF2, a transcription factor and master regulator of antioxidant defence genes.
“Indeed, they express little nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2), a transcription factor and master regulator of antioxidant defence genes 81,82 (Figure 5).”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [82]
NFE2L2-dependent gene expression is activated by mild oxidative stress.
“However, this deprives neurons of a useful adaptive response, since NFE2L2-dependent gene expression is activated by mild oxidative stress 82,84,85 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [82]
Several NFE2L2-activating compounds have efficacy in preclinical models of neurodegenerative disease.
“Several NFE2L2-activating compounds have efficacy in preclinical models of neurodegenerative disease 82”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [82]
NFE2L2 activators promote neuronal resistance to oxidative stress via non-cell-autonomous mechanisms involving NFE2L2 activation in astrocytes, including human astrocytes.
“NFE2L2 activators promote neuronal resistance to oxidative stress via non cell-autonomous mechanisms involving NF22L2 activation in astrocytes, including human astrocytes 82,108”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [82]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Estimation of nuclear population from microtome sections
Abercrombie, M. (1946) · The Anatomical Record · doi:10.1002/ar.1090940210 · Cited by 4,363 · see citing works
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606 · see citing works
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603 · see citing works
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323 · see citing works
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works
The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M., & Kaila, K. (1999) · Nature · doi:10.1038/16697 · Cited by 2,152 · see citing works
Abnormal neural oscillations and synchrony in schizophrenia
Uhlhaas, P. J., & Singer, W. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2774 · Cited by 2,120 · see citing works
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070 · see citing works
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605 · see citing works
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498 · see citing works
Correlated neuronal activity and the flow of neural information
Salinas, E., & Sejnowski, T. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35086012 · Cited by 1,333 · see citing works
Self-citation
Prediction of Psychosis in Youth at High Clinical Risk: A Multisite Longitudinal Study in North America
Cannon, T. D., Cadenhead, K., Cornblatt, B., Woods, S. W., Addington, J., Walker, E., Seidman, L. J., Perkins, D., Tsuang, M., McGlashan, T., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.3 · Cited by 1,269 · see citing works
Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition
Pouille, F., & Scanziani, M. (2001) · Science · doi:10.1126/science.1060342 · Cited by 1,097 · see citing works
NMDA receptor hypofunction model of schizophrenia
Olney, J. W., Newcomer, J. W., & Farber, N. B. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00029-1 · Cited by 1,020 · see citing works
The neurodevelopmental model of schizophrenia: update 2005
Rapoport, J. L., Addington, A. M., Frangou, S., & Psych, M. R. C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001642 · Cited by 993 · see citing works
Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex
Hensch, T. K., Fagiolini, M., Mataga, N., Stryker, M. P., Baekkeskov, S., & Kash, S. F. (1998) · Science · doi:10.1126/science.282.5393.1504 · Cited by 910 · see citing works
Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders
Fone, K. C. F., & Porkess, M. V. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.003 · Cited by 864 · see citing works
The Neurodevelopmental Hypothesis of Schizophrenia, Revisited
Fatemi, S. H., & Folsom, T. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn187 · Cited by 860 · see citing works
Physiological, morphological, and histochemical characterization of three classes of interneurons in rat neostriatum
Kawaguchi, Y. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-11-04908.1993 · Cited by 814 · see citing works
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Belforte, J. E., Zsiros, V., Sklar, E. R., Jiang, Z., Yu, G., Li, Y., Quinlan, E. M., & Nakazawa, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2447 · Cited by 752 · see citing works
Molecular and Physiological Diversity of Cortical Nonpyramidal Cells
Cauli, B., Audinat, E., Lambolez, B., Angulo, M. C., Ropert, N., Tsuzuki, K., Hestrin, S., & Rossier, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03894.1997 · Cited by 738 · see citing works
To Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test
Lipska, B. K. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00137-8 · Cited by 650 · see citing works
Experience and Activity-Dependent Maturation of Perisomatic GABAergic Innervation in Primary Visual Cortex during a Postnatal Critical Period
Chattopadhyaya, B., Di Cristo, G., Higashiyama, H., Knott, G. W., Kuhlman, S. J., Welker, E., & Huang, Z. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1851-04.2004 · Cited by 596 · see citing works
Ketamine-Induced Loss of Phenotype of Fast-Spiking Interneurons Is Mediated by NADPH-Oxidase
Behrens, M. M., Ali, S. S., Dao, D. N., Lucero, J., Shekhtman, G., Quick, K. L., & Dugan, L. L. (2007) · Science · doi:10.1126/science.1148045 · Cited by 585 · see citing works
Self-citation
GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia
González‐Burgos, G., & Lewis, D. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn070 · Cited by 568 · see citing works
N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized, Placebo-Controlled Trial
Berk, M., Copolov, D., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Judd, F., Katz, F., Katz, P., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.004 · Cited by 552 · see citing works
Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo
Do, K. Q., Trabesinger, A. H., Kirsten‐Krüger, M., Lauer, C. J., Dydak, U., Hell, D., Holsboer, F., Boesiger, P., & Cuénod, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00229.x · Cited by 540 · see citing works
Neural synchrony and the development of cortical networks
Uhlhaas, P. J., Roux, F., Rodriguez, E., Rotarska-Jagiela, A., & Singer, W. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.12.002 · Cited by 532 · see citing works
Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat
Weiss, I. C., Pryce, C. R., Jongen-Rêlo, A. L., Nanz-Bahr, N. I., & Feldon, J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.10.015 · Cited by 512 · cited 2× · see citing works
“, 1996), deficits in fear learning (Weiss et al., 2004; Voikar et al., 2005) and deficits visual learning and memory (e.”
Background
Switch in the expression of rat GABAA-receptor subtypes during postnatal development: an immunohistochemical study
Fritschy, J., Paysan, J., Enna, A., & Möhler, H. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05302.1994 · Cited by 506 · see citing works
Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling
Fazzari, P., Paternain, A. V., Valiente, M., Pla, R., Luján, R., Lloyd, K., Lerma, J., Marín, O., & Rico, B. (2010) · Nature · doi:10.1038/nature08928 · Cited by 501 · see citing works
Local circuit neurons immunoreactive for calretinin, calbindin D‐28k or parvalbumin in monkey prefronatal cortex: Distribution and morphology
Condé, F., Lund, J. S., Jacobowitz, D. M., Baimbridge, K. G., & Lewis, D. A. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410109 · Cited by 500 · see citing works
A Loss of Parvalbumin-Containing Interneurons Is Associated with Diminished Oscillatory Activity in an Animal Model of Schizophrenia
Lodge, D. J., Behrens, M. M., & Grace, A. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5419-08.2009 · Cited by 488 · see citing works
Self-citation
Total number and ratio of excitatory and inhibitory synapses converging onto single interneurons of different types in the CA1 area of the rat hippocampus
Gulyás, A. I., Megı́as, M., Emri, Z., & Freund, T. F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-22-10082.1999 · Cited by 476 · see citing works
Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice
Meyer, U., Nyffeler, M., Yee, B. K., Knuesel, I., & Feldon, J. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.09.012 · Cited by 457 · see citing works
Immunochemical characterization of inhibitory mouse cortical neurons: Three chemically distinct classes of inhibitory cells
Xu, X., Roby, K. D., & Callaway, E. M. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22229 · Cited by 429 · see citing works
Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors
Haddad, J. J. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(02)00053-0 · Cited by 427 · see citing works
Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains
Torrey, E. F., Barci, B. M., Webster, M. J., Bartko, J. J., Meador-Woodruff, J. H., & Knable, M. B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.019 · Cited by 426 · see citing works
Cortical Enlightenment: Are Attentional Gamma Oscillations Driven by ING or PING?
Tiesinga, P. H. E., & B, T. J. S. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.009 · Cited by 421 · see citing works
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans
Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704774104 · Cited by 417 · see citing works
Destruction and Creation of Spatial Tuning by Disinhibition: GABAABlockade of Prefrontal Cortical Neurons Engaged by Working Memory
Rao, S. G., Williams, G. V., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00485.2000 · Cited by 407 · see citing works
Redox dysregulation, neurodevelopment, and schizophrenia
Do, K. Q., Cabungcal, J. H., Frank, A., Steullet, P., & Cuenod, M. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.001 · Cited by 384 · see citing works
Lhx6Activity Is Required for the Normal Migration and Specification of Cortical Interneuron Subtypes
Liodis, P., Denaxa, M., Grigoriou, M., Akufo-Addo, C., Yanagawa, Y., & Pachnis, V. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3055-06.2007 · Cited by 377 · see citing works
Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia
Geyer, M. A., Wilkinson, L. S., Humby, T., & Robbins, T. W. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90180-l · Cited by 377 · see citing works
Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Beasley, C. L., Zhang, Z. J., Patten, I., & Reynolds, G. P. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01360-4 · Cited by 374 · see citing works
Glutathione Precursor, N-Acetyl-Cysteine, Improves Mismatch Negativity in Schizophrenia Patients
Lavoie, S., Murray, M. M., Deppen, P., Knyazeva, M. G., Berk, M., Boulat, O., Bovet, P., Bush, A. I., Conus, P., Copolov, D., et al. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301624 · Cited by 371 · see citing works
Long‐term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences
Võikar, V., Polus, A., Vasar, E., & Rauvala, H. (2004) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2004.00106.x · Cited by 359 · see citing works
The development of neural synchrony reflects late maturation and restructuring of functional networks in humans
Uhlhaas, P. J., Roux, F., Singer, W., Haenschel, C., Sireteanu, R., & Rodriguez, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900390106 · Cited by 356 · see citing works
A critical period for social isolation in the rat
Einon, D. F., & Morgan, M. J. (1977) · Developmental Psychobiology · doi:10.1002/dev.420100205 · Cited by 342 · see citing works
Decreased dendritic spine density on prefrontal cortical and hippocampal pyramidal neurons in postweaning social isolation rats
Silva-Gómez, A. B., Rojas, D., Juárez, I., & Flores, G. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03042-7 · Cited by 336 · see citing works
A Specific Role for NR2A-Containing NMDA Receptors in the Maintenance of Parvalbumin and GAD67 Immunoreactivity in Cultured Interneurons
Kinney, J. W., Davis, C. N., Tabarean, I., Conti, B., Bartfai, T., & Behrens, M. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4722-05.2006 · Cited by 329 · see citing works
Self-citation
Sensory Processing in Schizophrenia: Neither Simple nor Intact
Javitt, D. C. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp110 · Cited by 328 · see citing works
Altered glutathione redox state in schizophrenia.
Yao, J. K., Leonard, S., & Reddy, R. (2006) · Disease Markers · doi:10.1155/2006/248387 · Cited by 321 · see citing works
Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence
Gysin, R., Kraftsik, R., Sandell, J., Bovet, P., Chappuis, C., Conus, P., Deppen, P., Preisig, M., Ruiz, V., Steullet, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706778104 · Cited by 309 · see citing works
Transcriptional and Electrophysiological Maturation of Neocortical Fast-Spiking GABAergic Interneurons
Okaty, B. W., Miller, M. N., Sugino, K., Hempel, C. M., & Nelson, S. B. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0105-09.2009 · Cited by 309 · see citing works
Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex.
Wilson, F. A. W., ÓScalaidhe, S. P., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4009 · Cited by 303 · see citing works
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
Wen, L., Lu, Y.-S., Zhu, X.-H., Li, X.-M., Woo, R., Chen, Y., Yin, D., Lai, C., Terry, A. V., Vazdarjanova, A. I., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910302107 · Cited by 302 · see citing works
Relations between brain chemistry and problem-solving among rats raised in enriched and impoverished environments.
Krech, D., Rosenzweig, M. R., & Bennett, E. L. (1962) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0044220 · Cited by 271 · see citing works
Phencyclidine animal models of schizophrenia: Approaches from abnormality of glutamatergic neurotransmission and neurodevelopment
Mouri, A., Noda, Y., Enomoto, T., & Nabeshima, T. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.019 · Cited by 267 · see citing works
Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing TruncatedDisc1
Shen, S., Lang, B., Nakamoto, C., Zhang, F., Pu, J., Kuan, S. L., Chatzi, C. A., He, S., Mackie, I., Brandon, N. J., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3299-08.2008 · Cited by 250 · see citing works
Reactive Oxygen Species and Regulation of Gene Expression
Turpaev, K. T. (2002) · Biochemistry (Moscow) · doi:10.1023/a:1014819832003 · Cited by 249 · see citing works
Postnatal Differentiation of Basket Cells from Slow to Fast Signaling Devices
Doischer, D., Aurel Hosp, J., Yanagawa, Y., Obata, K., Jonas, P., Vida, I., & Bartos, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2890-08.2008 · Cited by 248 · see citing works
Interleukin-6 Mediates the Increase in NADPH-Oxidase in the Ketamine Model of Schizophrenia
Behrens, M. M., Ali, S. S., & Dugan, L. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4457-08.2008 · Cited by 241 · see citing works
Self-citation
Cell Type- and Input-Specific Differences in the Number and Subtypes of Synaptic GABAAReceptors in the Hippocampus
Klausberger, T., Roberts, J. D. B., & Somogyi, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02513.2002 · Cited by 239 · see citing works
A Pharmacological Model for Psychosis Based on N-methyl-D-aspartate Receptor Hypofunction: Molecular, Cellular, Functional and Behavioral Abnormalities
Rujescu, D., Bender, A., Keck, M. E., Hartmann, A. M., Ohl, F., Ræder, H., Giegling, I., Genius, J., McCarley, R. W., Möller, H., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.029 · Cited by 239 · see citing works
Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene
Tosic, M., Ott, J., Barral, S., Bovet, P., Deppen, P., Gheorghita, F., Matthey, M.-L., Parnas, J., Preisig, M., Saraga, M., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/507566 · Cited by 234 · see citing works
Gestational methylazoxymethanol acetate administration: A developmental disruption model of schizophrenia
Lodge, D. J., & Grace, A. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.031 · Cited by 215 · see citing works
Calcium Microdomains in Aspiny Dendrites
Goldberg, J. H., Tamas, G., Aronov, D., & Yuste, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00714-1 · Cited by 212 · see citing works
Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats
Schiavone, S., Sorce, S., Dubois-Dauphin, M., Jaquet, V., Colaianna, M., Zotti, M., Cuomo, V., Trabace, L., & Krause, K.-H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.033 · Cited by 208 · see citing works
Redox Dysregulation Affects the Ventral But Not Dorsal Hippocampus: Impairment of Parvalbumin Neurons, Gamma Oscillations, and Related Behaviors
Steullet, P., Cabungcal, J.-H., Kulak, A., Kraftsik, R., Chen, Y., Dalton, T. P., Cuenod, M., & Do, K. Q. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3857-09.2010 · Cited by 202 · see citing works
Cell Type-Specific Development of NMDA Receptors in the Interneurons of Rat Prefrontal Cortex
Wang, H.-X., & Gao, W. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.20 · Cited by 198 · see citing works
Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review
Weiss, I. C., & Feldon, J. (2001) · Psychopharmacology · doi:10.1007/s002130100800 · Cited by 194 · see citing works
Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus
Bianchi, M., Fone, K. C. F., Azmi, N., Heidbreder, C. A., Hagan, J. J., & Marsden, C. A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05170.x · Cited by 191 · see citing works
Region-Specific Reduction in Entorhinal Gamma Oscillations and Parvalbumin-Immunoreactive Neurons in Animal Models of Psychiatric Illness
Cunningham, M. O., Hunt, J., Middleton, S. J., LeBeau, F. E. N., Gillies, M. J., Davies, C. H., Maycox, P. R., Whittington, M. A., & Racca, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5054-05.2006 · Cited by 187 · see citing works
Dlx5andDlx6Regulate the Development of Parvalbumin-Expressing Cortical Interneurons
Wang, Y., Dye, C. A., Sohal, V. S., Long, J. E., Estrada, R. C., Roztocil, T., Lufkin, T., Deisseroth, K. A., Baraban, S. C., & Rubenstein, J. L. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5963-09.2010 · Cited by 186 · see citing works
Determinants of quality of life at first presentation with schizophrenia
Browne, S., Clarke, M., Gervin, M., Waddington, J. L., Larkin, C., & O’Callaghan, E. (2000) · The British Journal of Psychiatry · doi:10.1192/bjp.176.2.173 · Cited by 184 · see citing works
Changing Properties of GABAAReceptor–Mediated Signaling During Early Neocortical Development
Owens, D. F., Liu, X., & Kriegstein, A. R. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.2.570 · Cited by 182 · see citing works
Resocialisation of isolation-reared rats does not alter their anxiogenic profile on the elevated X-maze model of anxiety
Wright, I. K., Upton, N., & Marsden, C. A. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90572-6 · Cited by 177 · see citing works
Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome
Meechan, D. W., Tucker, E. S., Maynard, T. M., & LaMantia, A.-S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905696106 · Cited by 173 · see citing works
IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase
Dugan, L. L., Ali, S. S., Shekhtman, G., Roberts, A. J., Lucero, J., Quick, K. L., & Behrens, M. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005518 · Cited by 165 · see citing works
Self-citation
Gamma oscillations mediate stimulus competition and attentional selection in a cortical network model
Börgers, C., Epstein, S., & Kopell, N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809511105 · Cited by 165 · see citing works
Region-Specific Changes in Gamma and Beta2 Rhythms in NMDA Receptor Dysfunction Models of Schizophrenia
Roopun, A. K., Cunningham, M. O., Racca, C., Alter, K., Traub, R. D., & Whittington, M. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn059 · Cited by 163 · see citing works
Neuregulin-1 Modulates Hippocampal Gamma Oscillations: Implications for Schizophrenia
Fisahn, A., Neddens, J., Yan, L., & Buonanno, A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn107 · Cited by 162 · see citing works
Postnatal Phencyclidine Administration Selectively Reduces Adult Cortical Parvalbumin-Containing Interneurons
Wang, C. Z., Yang, S. F., Xia, Y., & Johnson, K. M. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301647 · Cited by 161 · see citing works
Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
Cristo, G. D., Wu, C., Chattopadhyaya, B., Ango, F., Knott, G. W., Welker, E., Svoboda, K., & Huang, Z. J. (2004) · Nature Neuroscience · doi:10.1038/nn1334 · Cited by 161 · see citing works
Does schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex?
Behrens, M. M., & B, T. J. S. A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.002 · Cited by 160 · see citing works
Self-citation
Neural basis of psychosis-related behaviour in the infection model of schizophrenia
Meyer, U., & Feldon, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.022 · Cited by 158 · see citing works
Transient N-methyl-D-aspartate receptor blockade in early development causes lasting cognitive deficits relevant to schizophrenia
Stefani, M. R., & Moghaddam, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.031 · Cited by 157 · see citing works
Protracted Developmental Trajectories of GABAA Receptor α1 and α2 Subunit Expression in Primate Prefrontal Cortex
Hashimoto, T., Nguyen, Q. L., Rotaru, D., Keenan, T., Arion, D., Beneyto, M., Gonzalez-Burgos, G., & Lewis, D. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.004 · Cited by 151 · see citing works
Calcium binding protein markers of GABA deficits in schizophrenia — post mortem studies and animal models
Reynolds, G. P., Abdul-Monim, Z., Neill, J. C., & Zhang, Z. (2004) · Neurotoxicity Research · doi:10.1007/bf03033297 · Cited by 150 · see citing works
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders
Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I. N., Sawa, A., Margolis, R. L., Cadet, J. L., Mori, S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2009.144 · Cited by 148 · see citing works
Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats
Harte, M., Powell, S. B., Swerdlow, N. R., Geyer, M. A., & Reynolds, G. P. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0627-6 · Cited by 146 · see citing works
Self-citation
A Neonatal Ventral Hippocampal Lesion Causes Functional Deficits in Adult Prefrontal Cortical Interneurons
Tseng, K. Y., Lewis, B. L., Hashimoto, T., Sesack, S. R., Kloc, M., Lewis, D. A., & O'Donnell, P. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4166-08.2008 · Cited by 144 · see citing works
Prefrontal Microcircuits: Membrane Properties and Excitatory Input of Local, Medium, and Wide Arbor Interneurons
Krimer, L. S., & Goldman-Rakic, P. S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03788.2001 · Cited by 141 · see citing works
GABAergic neuronal subtypes in the human frontal cortex — development and deficits in schizophrenia
Reynolds, G. P., & Beasley, C. L. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00113-2 · Cited by 138 · see citing works
Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood
Ibi, D., Nagai, T., Koike, H., Kitahara, Y., Mizoguchi, H., Niwa, M., Jaaro-Peled, H., Nitta, A., Yoneda, Y., & Nabeshima, T. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.08.027 · Cited by 137 · cited 1× · see citing works
“additive effect on reduced PV-IR with PolyI:C on PND 2e6 (Ibi et al., 2010) No data available”
Background
Functional development of the dorsolateral prefrontal cortex: An analysis utilizing reversible cryogenic depression
Alexander, G. E., & Goldman, P. S. (1978) · Brain Research · doi:10.1016/0006-8993(78)90566-8 · Cited by 134 · see citing works
Rapid Developmental Maturation of Neocortical FS Cell Intrinsic Excitability
Goldberg, E. M., Jeong, H.-Y., Kruglikov, I., Tremblay, R., Lazarenko, R. M., & Rudy, B. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq138 · Cited by 132 · see citing works
Developmental expression of parvalbumin mRNA in the cerebral cortex and hippocampus of the rat
Lecea, L. D., del Ri´o, J., & Soriano, E. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00056-x · Cited by 130 · see citing works
Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle
Day-Wilson, K. M., Jones, D. N. C., Southam, E., Cilia, J., & Totterdell, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.048 · Cited by 129 · see citing works
Multidirectional and multizonal tangential migration of GABAergic interneurons in the developing cerebral cortex
Tanaka, D. H., Maekawa, K., Yanagawa, Y., Obata, K., & Murakami, F. (2006) · Development · doi:10.1242/dev.02382 · Cited by 128 · see citing works
Decrease in parvalbumin‐expressing neurons in the hippocampus and increased phencyclidine‐induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia
Penschuck, S., Flagstad, P., Didriksen, M., Leist, M., & Michael-Titus, A. T. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04536.x · Cited by 127 · see citing works
Spatial Memory Deficits Induced by Perinatal Treatment of Rats with PCP and Reversal Effect of D-Serine
Andersen, J. D., & Pouzet, B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300394 · Cited by 126 · see citing works
Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone
Scaccianoce, S., Bianco, P. D., Paolone, G., Caprioli, D., Modafferi, A. M. E., Nencini, P., & Badiani, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.04.024 · Cited by 122 · see citing works
Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice
Neddens, J., & Buonanno, A. (2009) · Hippocampus · doi:10.1002/hipo.20675 · Cited by 121 · see citing works
Postnatal Development of Prefrontal Inhibitory Circuits and the Pathophysiology of Cognitive Dysfunction in Schizophrenia
Lewis, D. A., Cruz, D. A., Eggan, S. M., & Erickson, S. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.008 · Cited by 121 · see citing works
Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism
Braun, I., Genius, J., Grunze, H., Bender, A., Möller, H., & Rujescu, D. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.05.005 · Cited by 121 · see citing works
Subcellular compartmentalization of glutathione: Correlations with parameters of oxidative stress related to genotoxicity
M.Green, R., Graham, M., O’Donovan, M. R., Chipman, J. K., & Hodges, N. J. (2006) · Mutagenesis · doi:10.1093/mutage/gel043 · Cited by 119 · see citing works
Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine in postpubertal rats
Abekawa, T., Ito, K., Nakagawa, S., & Koyama, T. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0729-8 · Cited by 118 · see citing works
Activity‐dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond
Huang, Z. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.168211 · Cited by 115 · see citing works
Development of calcium‐permeable AMPA receptors and their correlation with NMDA receptors in fast‐spiking interneurons of rat prefrontal cortex
Wang, H. X., & Gao, W. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.187591 · Cited by 109 · see citing works
Prolonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex
Zhang, Y., Behrens, M. M., & Lisman, J. E. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00079.2008 · Cited by 107 · see citing works
Self-citation
Rationale for the study of early intervention
Wyatt, R. J., & Henter, I. D. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00242-0 · Cited by 106 · see citing works
Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
Möller, M., du Preez, J. L., Emsley, R. A., & Harvey, B. H. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.09.006 · Cited by 103 · see citing works
Blockade of Phencyclidine-Induced Cortical Apoptosis and Deficits in Prepulse Inhibition by M40403, a Superoxide Dismutase Mimetic
Wang, C., McInnis, J., West, J. B., Bao, J., Anastasio, N. C., Guidry, J. A., Ye, Y., Salvemini, D., & Johnson, K. M. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041798 · Cited by 98 · see citing works
The NADPH Oxidase NOX2 Controls Glutamate Release: A Novel Mechanism Involved in Psychosis-Like Ketamine Responses
Sorce, S., Schiavone, S., Tucci, P., Colaianna, M., Jaquet, V., Cuomo, V., Dubois‐Dauphin, M., Trabace, L., & Krause, K. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1491-10.2010 · Cited by 92 · see citing works
Individual Housing From Rearing Modifies the Performance of Young Rats on the Elevated Plus-Maze Apparatus
SILVA, N. L. D., Ferreira, V. M. M., Carobrez, A. P., & Morato, G. S. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00254-5 · Cited by 90 · see citing works
Region specific changes in forebrain 5-hydroxytryptamine1a and 5-hydroxytryptamine2a receptors in isolation-reared rats: an in vitro autoradiography study
Preece, M., Dalley, J. W., Theobald, D. E. H., Robbins, T. W., & Reynolds, G. P. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.008 · Cited by 88 · see citing works
Desynchronization of Neocortical Networks by Asynchronous Release of GABA at Autaptic and Synaptic Contacts from Fast-Spiking Interneurons
Manseau, F., Marinelli, S., Méndez, P., Schwaller, B., Prince, D. A., Huguenard, J. R., & Bacci, A. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000492 · Cited by 86 · see citing works
Models of Neurodevelopmental Abnormalities in Schizophrenia
Powell, S. B. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_57 · Cited by 84 · see citing works
Self-citation
Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats: Relevance to schizophrenia
Cabungcal, J.-H., Preissmann, D., Delseth, C., Cuénod, M., Kim, Q., & Schenk, F. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.03.001 · Cited by 83 · see citing works
The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain
Lipska, B. K., Lerman, D. N., Khaing, Z. Z., & Weinberger, D. R. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03047.x · Cited by 78 · see citing works
The postweaning social isolation in C57BL/6 mice: preferential vulnerability in the male sex
Pietropaolo, S., Singer, P., Feldon, J., & Yee, B. K. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1081-3 · Cited by 77 · see citing works
Decreased glutathione levels and altered antioxidant defense in an animal model of schizophrenia: Long-term effects of perinatal phencyclidine administration
Radonjić, N. V., Knežević, I. D., Vilimanovich, U., Kravić-Stevović, T., Marina, L. V., Nikolić, T., Todorović, V., Bumbaširević, V., & Petronijević, N. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.009 · Cited by 75 · see citing works
Early social deprivation disrupts attentional, but not affective, shifts in rats
Schrijver, N. C., & Würbel, H. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.437 · Cited by 70 · see citing works
Isolation rearing of mice induces deficits in prepulse inhibition of the startle response
Varty, G. B., Powell, S. B., Masten, V. L., Buell, M. R., & Geyer, M. A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.11.025 · Cited by 70 · see citing works
Self-citation
Selective reorganization of GABAergic transmission in neonatal ventral hippocampal-lesioned rats
François, J., Ferrandon, A., Koning, E., Angst, M.-J., Sandner, G., & Nehlig, A. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009985 · Cited by 68 · see citing works
Evaluation of a neurodevelopmental model of schizophrenia—Early postnatal PCP treatment in attentional set-shifting
Broberg, B. V., Dias, R., Glenthoj, B. Y., & Olsen, C. K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.020 · Cited by 65 · see citing works
Genetic Dysregulation of Glutathione Synthesis Predicts Alteration of Plasma Thiol Redox Status in Schizophrenia
Gysin, R., Kraftsik, R., Boulat, O., Bovet, P., Conus, P., Comte-Krieger, E., Polari, A. R., Steullet, P., Preisig, M., Bellier-Teichmann, T., et al. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3463 · Cited by 62 · see citing works
Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex
Graterón, L., Sánchez, S. C., Marcos, P., Mohedano‐Moriano, A., Serrano, A. M. I., Muñoz, M., Jiménez, M. D. M. A., Martı́nez-Marcos, A., Artacho‐Pérula, E., Blaizot, X., et al. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.09.005 · Cited by 61 · see citing works
Effect of MK-801 and ketamine on hydroxyl radical generation in the posterior cingulate and retrosplenial cortex of free-moving mice, as determined by in vivo microdialysis
Zuo, D., Wu, Y., Yao, W.-X., Cao, Y., Wu, C., & Tanaka, M. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.05.010 · Cited by 61 · see citing works
Neonatal lipopolysaccharide induces pathological changes in parvalbumin immunoreactivity in the hippocampus of the rat
Jenkins, T. A., Harte, M. K., Stenson, G., & Reynolds, G. P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.014 · Cited by 61 · see citing works
Neonatal Phencyclidine Treatment in Mice Induces Behavioral, Histological and Neurochemical Abnormalities in Adulthood
Nakatani-Pawlak, A., Yamaguchi, K., Tatsumi, Y., Mizoguchi, H., & Yoneda, Y. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1576 · Cited by 61 · see citing works
Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons
Zhang, Z., & Sun, Q. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20844 · Cited by 59 · see citing works
Altered cortico‐striatal synaptic plasticity and related behavioural impairments in reeler mice
Marrone, M. C., Marinelli, S., Biamonte, F., Keller, F., Sgobio, C., Ammassari‐Teule, M., Bernardi, G., & Mercuri, N. B. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05083.x · Cited by 58 · see citing works
Effect of subchronic phencyclidine administration on sucrose preference and hippocampal parvalbumin immunoreactivity in the rat
Jenkins, T. A., Harte, M., & Reynolds, G. P. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.028 · Cited by 57 · see citing works
The 5-HT 1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice
Sakaue, M., Ago, Y., Baba, A., & Matsuda, T. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1515-x · Cited by 57 · see citing works
Nitric Oxide Signaling in the Medial Prefrontal Cortex is Involved in the Biochemical and Behavioral Effects of Phencyclidine
Fejgin, K., Pålsson, E., Wass, C., Svensson, L., & Klamer, D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301587 · Cited by 56 · see citing works
The effects of social isolation on the forced swim test in Fawn hooded and Wistar rats
Hall, F. S., Huang, S., Fong, G., & Pert, A. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00155-6 · Cited by 55 · see citing works
PROSPECTIVE OBSERVATIONS OF EMERGING PSYCHOSIS
Rosen, J. L., Woods, S., Miller, T. J., & McGlashan, T. (2002) · Journal of Nervous and Mental Disease · doi:10.1097/00005053-200203000-00001 · Cited by 54 · see citing works
Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting
Broberg, B. V., Glenthoj, B. Y., Dias, R., Larsen, D. B., & Olsen, C. K. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1540-5 · Cited by 53 · see citing works
Maturation of medial temporal lobe memory functions in rodents, monkeys, and humans
Bachevalier, J., & Beauregard, M. (1993) · Hippocampus · doi:10.1002/hipo.1993.4500030723 · Cited by 51 · see citing works
Isolation rearing-induced deficits in prepulse inhibition and locomotor habituation are not potentiated by water deprivation
Powell, S. B., Swerdlow, N. R., Pitcher, L., & Geyer, M. A. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00817-x · Cited by 49 · see citing works
Self-citation
Impact of postnatal blockade of N-methyl-d-aspartate receptors on rat behavior: A search for a new developmental model of schizophrenia
Wędzony, K., Fijał, K., Maćkowiak, M., Chocyk, A., & Zajaczkowski, W. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.016 · Cited by 45 · see citing works
Effects of postweaning social isolation and re-socialization on the expression of vasoactive intestinal peptide (VIP) and dendritic development in the medial prefrontal cortex of the rat
Pascual, R., Zamora-León, S. P., & Valero‐Cabré, A. (2006) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2006-1582 · Cited by 44 · see citing works
Recruitment of Early Postnatal Parvalbumin-Positive Hippocampal Interneurons by GABAergic Excitation
Sauer, J., & Bartos, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4125-09.2010 · Cited by 42 · see citing works
Social Isolation Stress Significantly Enhanced the Disruption of Prepulse Inhibition in Mice Repeatedly Treated with Methamphetamine
Dai, H., OKUDA, H., Iwabuchi, K., et al. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.032 · Cited by 42 · see citing works
NR2A and NR2B subunit containing NMDA receptors differentially regulate striatal output pathways
Fantin, M., Marti, M., Auberson, Y. P., & Morari, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04966.x · Cited by 42 · see citing works
Pharmacological challenge reveals long-term effects of perinatal phencyclidine on delayed spatial alternation in rats
Wiley, J. L., Bühler, K. G., LaVecchia, K. L., & Johnson, K. M. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00146-5 · Cited by 39 · see citing works
Social Isolation Rearing Affects Prefrontal Cortical Response To Ventral Tegmental Area Stimulation
Peters, Y. M., & O’Donnell, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.011 · Cited by 38 · see citing works
Reelin haploinsufficiency reduces the density of PV+ neurons in circumscribed regions of the striatum and selectively alters striatal-based behaviors
Ammassari‐Teule, M., Sgobio, C., Biamonte, F., Marrone, C., Mercuri, N. B., & Keller, F. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1483-x · Cited by 35 · see citing works
Developmental markers of psychiatric disorders as identified by sensorimotor gating
Powell, S., & Geyer, M. (2009) · Neurotoxicity research · doi:10.1080/10298420290030578 · Cited by 32 · see citing works
Self-citation
It's about time for thalamocortical circuits
Hull, C., & Scanziani, M. (2007) · Nature Neuroscience · doi:10.1038/nn0407-400 · Cited by 30 · see citing works
A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.
Steullet, P., Lavoie, S., Kraftsik, R., Guidi, R., Gysin, R., Cuenod, M., & Do, K. (2008) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2007.12.006 · Cited by 29 · see citing works
Neonatal NMDA receptor antagonist treatments have no effects on prepulse inhibition of postnatal day 25 Sprague–Dawley rats
Boctor, S. Y., & Ferguson, S. A. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.10.011 · Cited by 23 · see citing works
Decline in age‐dependent, MK801‐induced injury coincides with developmental switch in parvalbumin expression: Somatosensory and motor cortex
Tomé, C. M. L., Miller, R., Bauer, C. T., Smith, C. M., Blackstone, K., Leigh, A., Busch, J., & Turner, C. P. (2008) · Developmental Psychobiology · doi:10.1002/dev.20325 · Cited by 21 · see citing works
The Missing Piece in the "Use It or Lose It" Puzzle: Is Inhibition Regulated by Activity or Does it Act on its Own Accord?
Sun, Q. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.3-4.295 · Cited by 20 · see citing works
Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors
du Bois, T. M., Newell, K. A., Han, M., Deng, C., & Huang, X. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.001 · Cited by 19 · see citing works
Opposite effect of phencyclidine on activity-regulated cytoskeleton-associated protein (Arc) in juvenile and adult limbic rat brain regions
Thomsen, M. S., Hansen, H. H., & Mikkelsen, J. D. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.10.011 · Cited by 17 · see citing works
Effects of isolation-rearing on serotonin-1A and M1-muscarinic receptor messenger RNA expression in the hipocampal formation of rats
Bel, E. A. D., Joca, S. R. L., Padovan, C. M., & Guimarães, F. S. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00933-3 · Cited by 17 · see citing works
Neonatal treatment with a competitive NMDA antagonist results in response-specific disruption of conditioned fear in preweanling rats
Hunt, P. S. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0291-1 · Cited by 7 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

Melle I Larsen TK Haahr U Friis S Johannesen JO Opjordsmoen S Rund BR Simonsen E Vaglum P McGlashan T Prevention of negative symptom psychopathologies in first-episode schizophrenia: two-year effects of reducing the duration of untreated psychosis Arch Gen Psychiatry 2008 65 634 640 18519821
Sircar R Rudy JW Repeated neonatal phencyclidine treatment impairs performance of a spatial task in juvenile rats Ann N Y Acad Sci 1998 844 303 309 9668687

Sorted by citations

Perineuronal nets protect fast-spiking interneurons against oxidative stress
Cabungcal, J.-H., Steullet, P., Morishita, H., Kraftsik, R., Cuenod, M., Hensch, T. K., & Do, K. Q. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300454110 · Cited by 512 · see citing works
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
Steullet, P., Cabungcal, J.-H., Coyle, J., Didriksen, M., Gill, K., Grace, A. A., Hensch, T. K., LaMantia, A.-S., Lindemann, L., Maynard, T. M., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.47 · Cited by 360 · see citing works
Has an Angel Shown the Way? Etiological and Therapeutic Implications of the PCP/NMDA Model of Schizophrenia
Javitt, D. C., Zukin, S. R., Heresco-Levy, U., & Umbricht, D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs069 · Cited by 322 · see citing works
Neuroinflammation in schizophrenia especially focused on the role of microglia
Monji, A., Kato, T. A., Mizoguchi, Y., Horikawa, H., Seki, Y., Kasai, M., Yamauchi, Y., Yamada, S., & Kanba, S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.002 · Cited by 314 · see citing works
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works
Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology?
Steullet, P., Cabungcal, J. H., Monin, A., Dwir, D., O'Donnell, P., Cuenod, M., & Do, K. Q. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.021 · Cited by 262 · see citing works
Early-Life Insults Impair Parvalbumin Interneurons via Oxidative Stress: Reversal by N-Acetylcysteine
Cabungcal, J.-H., Steullet, P., Kraftsik, R., Cuenod, M., & Do, K. Q. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.020 · Cited by 232 · see citing works
Parvalbumin interneuron vulnerability and brain disorders
Ruden, J. B., Dugan, L. L., & Konradi, C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-0778-9 · Cited by 194 · see citing works
Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Piekarski, D. J., Johnson, C. M., Boivin, J. R., Thomas, A. W., Lin, W. C., Delevich, K., M. Galarce, E., & Wilbrecht, L. (2017) · Brain Research · doi:10.1016/j.brainres.2016.08.042 · Cited by 175 · see citing works
Downregulation of Parvalbumin at Cortical GABA Synapses Reduces Network Gamma Oscillatory Activity
Volman, V., Behrens, M. M., & Sejnowski, T. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3041-11.2011 · Cited by 164 · see citing works
Self-citation
Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats
Zamberletti, E., Beggiato, S., Steardo, L., Prini, P., Antonelli, T., Ferraro, L., Rubino, T., & Parolaro, D. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.028 · Cited by 147 · see citing works
Early interventions in risk groups for schizophrenia: what are we waiting for?
Sommer, I. E., Bearden, C. E., van Dellen, E., Breetvelt, E. J., Duijff, S. N., Maijer, K., van Amelsvoort, T., de Haan, L., Gur, R. E., Arango, C., et al. (2016) · npj Schizophrenia · doi:10.1038/npjschz.2016.3 · Cited by 140 · see citing works
Characterization of GABAergic Marker Expression in the Chronic Unpredictable Stress Model of Depression
Banasr, M., Lepack, A., Fee, C., Duric, V., Maldonado-Aviles, J., DiLeone, R., Sibille, E., Duman, R. S., & Sanacora, G. (2017) · Chronic Stress · doi:10.1177/2470547017720459 · Cited by 135 · see citing works
Towards a cognitive neuroscience of self-awareness
Lou, H. C., Changeux, J. P., & Rosenstand, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.004 · Cited by 131 · see citing works
Social Isolation Exacerbates Schizophrenia-Like Phenotypes via Oxidative Stress in Cortical Interneurons
Jiang, Z., Rompala, G. R., Zhang, S., Cowell, R. M., & Nakazawa, K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.004 · Cited by 128 · see citing works
Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons
Morishita, H., Cabungcal, J.-H., Chen, Y., Do, K. Q., & Hensch, T. K. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.026 · Cited by 92 · see citing works
Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders
Barnes, S. A., Pinto-Duarte, A., Kappe, A., Zembrzycki, A., Metzler, A., Mukamel, E. A., Lucero, J., Wang, X., Sejnowski, T. J., Markou, A., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.113 · Cited by 92 · see citing works
Self-citation
Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain
Komitova, M., Xenos, D., Salmaso, N., May Tran, K., Brand, T., Schwartz, M. L., Ment, L., & Vaccarino, F. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5286-12.2013 · Cited by 88 · see citing works
Parvalbumin immunoreactivity in the auditory cortex of a mouse model of presbycusis.
Martin del Campo, H. N., Measor, K. R., & Razak, K. A. (2012) · Hearing Research · doi:10.1016/j.heares.2012.08.017 · Cited by 76 · see citing works
Inhibitory Interneurons, Oxidative Stress, and Schizophrenia
Sullivan, E. M., & O'Donnell, P. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs052 · Cited by 71 · see citing works
Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons
Povysheva, N. V., & Johnson, J. W. (2012) · Journal of Neurophysiology · doi:10.1152/jn.01017.2011 · Cited by 62 · see citing works
Age-Related Deterioration of Perineuronal Nets in the Primary Auditory Cortex of Mice
Brewton, D. H., Kokash, J., Jimenez, O., Pena, E. R., & Razak, K. A. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00270 · Cited by 54 · see citing works
Hippocampal temporal-parietal junction interaction in the production of psychotic symptoms: a framework for understanding the schizophrenic syndrome
Wible, C. G. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00180 · Cited by 56 · see citing works
How Nox2-Containing NADPH Oxidase Affects Cortical Circuits in the NMDA Receptor Antagonist Model of Schizophrenia
Wang, X., Pinto-Duarte, A., Sejnowski, T. J., & Behrens, M. M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4907 · Cited by 46 · see citing works
Self-citation
Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia
Morishita, H., Kundakovic, M., Bicks, L., Mitchell, A., & Akbarian, S. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.03.005 · Cited by 42 · see citing works
Oxygen levels regulate the development of human cortical radial glia cells
Ortega, J. A., Sirois, C. L., Memi, F., Glidden, N., & Zecevic, N. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw194 · Cited by 37 · see citing works

Authors: Powell, S. B., Sejnowski, T. J., & Behrens, M. M.
Affiliations: University of California San Diego (US)
Salk Institute for Biological Studies (US)
Corresponding author: Behrens, M. Margarita
ORCID: Powell, Susan B.
Behrens, M. Margarita
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2012-03
Volume: 62
Issue: 3
Pages: 1322-1331
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.01.049
PMC: PMC3106123
OpenAlex: W2132951361
Cited by: 164
References: 161
Citations by year: 2026: 5 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 12 · 2019: 9 · 2018: 8 · 2017: 12 · 2016: 15 · 2015: 19 · 2014: 20 · 2013: 15 · 2012: 16
FWCI: 12.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH091407-01)
Howard Hughes Medical Institute
NARSAD
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, oxidative stress, parvalbumin interneurons, NMDA receptor antagonists, social isolation, NOX2, superoxide, GABAergic neurons, gamma oscillations, perinatal brain development, rodent models, neurochemical changes
MeSH terms: Animals, Cerebral Cortex, Disease Models, Animal, Humans, Interneurons, Motor Activity, Parvalbumins, Rodentia, Schizophrenia, Oxidative Stress, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Record

About these checks