Cited by 456Diet and metabolism studiesFatty Acid Research and HealthCoconut Research and Applications

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Medium-chain triglycerides

Marten, Berit, Pfeuffer, Maria, Schrezenmeir, Jürgen·2006·International Dairy Journal

DOI 10.1016/j.idairyj.2006.06.015

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Abstract

Medium-chain fatty acids (MCFAs) comprise saturated fatty acids with 6-10 carbons. Besides synthetic medium-chain triglyceride (MCT) oils there are natural sources, like coconut oil and dairy fat. Compared with long-chain fatty acids (LCFAs), the chemical and physical properties of MCFAs show substantial metabolic differences. MCFAs do not require binding to proteins such as fatty-acid binding protein, fatty acid transport protein, and/or fatty acid translocase (FAT, homolog to human platelet CD36). MCFAs are a preferred source of energy (β-oxidation). MCFAs are also incorporated into adipose tissue triglycerides, and may influence adipose tissue and other systemic functions more substantially than previously assumed. MCTs reduce fat mass, through down-regulation of adipogenic genes as well as peroxisome proliferator activated receptor-γ. Recent studies confirmed the potential of MCFAs to reduce body weight and particularly body fat. This effect was not transient. MCFAs reduce lipoprotein secretion and attenuate postprandial triglyceride response. It was, however, frequently observed that MCTs increase fasting cholesterol and triglyceride levels. But, given in moderate amounts, in diets with moderate fat supply, MCFAs may actually reduce fasting lipid levels more than oils rich in mono- or polyunsaturated fatty acids. The same is true for glucose levels. MCTs improved several features contributing to enhanced insulin sensitivity. Under certain in vitro conditions, MCTs exert…

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Authors: Marten, B., Pfeuffer, M., & Schrezenmeir, J.
Corresponding author: Pfeuffer, Maria
ORCID: Schrezenmeir, Jürgen
Venue: International Dairy Journal
Publisher: Elsevier BV
Published: 2006-11
Volume: 16
Issue: 11
Pages: 1374-1382
ISSN: 0958-6946 (ISSN-L)
DOI: 10.1016/j.idairyj.2006.06.015
OpenAlex: W2010109211
Cited by: 456
References: 85
Citations by year: 2026: 16 · 2025: 20 · 2024: 22 · 2023: 28 · 2022: 43 · 2021: 39 · 2020: 47 · 2019: 28 · 2018: 26 · 2017: 36 · 2016: 34 · 2015: 17 · 2014: 11 · 2013: 21 · 2012: 15
FWCI: 5.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Dairy Journal (publishedVersion)
OpenAgrar (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Agricultural and Biological Sciences › Food Science › Coconut Research and Applications
Keywords: medium-chain triglycerides, medium-chain fatty acids, coconut oil, milk fat, fatty acid metabolism, adipose tissue, PPARγ, lipoprotein secretion, postprandial triglycerides, insulin sensitivity, glucose metabolism, pro-inflammatory effects, hepatotoxicity, intestinal injury, fat loss

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