Circular RNA circPTK2 regulates oxygen-glucose deprivation-activated microglia-induced hippocampal neuronal apoptosis via miR-29b-SOCS-1-JAK2/STAT3-IL-1β signaling

Natural RNA circles function as efficient microRNA sponges

Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985 · see citing works

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

Li, J.-H., Liu, S., Zhou, H., Qu, L., & Yang, J.-H. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1248 · Cited by 5,587 · see citing works

Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures

Sanger, H. L., Klotz, G., Riesner, D., Gross, H. J., & Kleinschmidt, A. K. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3852 · Cited by 2,296 · see citing works

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

Zheng, Q., Bao, C., Guo, W., Li, S., Chen, J., Chen, B., Luo, Y., Lyu, D., Li, Y., Shi, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms11215 · Cited by 2,045 · see citing works

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

Piwecka, M., Glažar, P., Hernandez-Miranda, L. R., Memczak, S., Wolf, S. A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C. A., Fenske, P., et al. (2017) · Science · doi:10.1126/science.aam8526 · Cited by 1,210 · see citing works

Signaling through the JAK/STAT pathway, recent advances and future challenges

Kisseleva, T., Bhattacharya, S., Braunstein, J., & Schindler, C. (2002) · Gene · doi:10.1016/s0378-1119(02)00398-0 · Cited by 1,158 · see citing works

Cytokine Signaling in 2002

O’Shea, J. J., Gadina, M., & Schreiber, R. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00701-8 · Cited by 1,119 · see citing works

INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology

Arend, W. P., Malyak, M., Guthridge, C. J., & Gabay, C. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.27 · Cited by 1,071 · see citing works

Circular RNAs function as ceRNAs to regulate and control human cancer progression

Zhong, Y., Du, Y., Yang, X. F., Mo, Y., Fan, C., Xiong, F., Ren, D., Ye, X., Li, C., Wang, Y., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0827-8 · Cited by 1,008 · see citing works

MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984 · see citing works

Circular RNAs are miRNA sponges and can be used as a new class of biomarker

Kulcheski, F. R., Christoff, A. P., & Margis, R. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.09.011 · Cited by 739 · see citing works

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

Yoshikawa, H., Matsubara, K., Qian, G.-S., Jackson, P. E., Groopman, J. D., Manning, J. E., Harris, C. C., & Herman, J. G. (2001) · Nature Genetics · doi:10.1038/ng0501-29 · Cited by 724 · see citing works

Microglia: biology and pathology

Graeber, M. B., & Streit, W. J. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0622-0 · Cited by 720 · see citing works

miRcode: a map of putative microRNA target sites in the long non-coding transcriptome

Jeggari, A., Marks, D., & Larsson, E. (2012) · Bioinform. · doi:10.1093/bioinformatics/bts344 · Cited by 696 · see citing works

Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

Yamasaki, Y., Matsuura, N., Shozuhara, H., Onodera, H., Itoyama, Y., & Kogure, K. (1995) · Stroke · doi:10.1161/01.str.26.4.676 · Cited by 573 · see citing works

Migration and differentiation of neural precursor cells can be directed by microglia

Aarum, J., Sandberg, K., Haeberlein, S. L. B., & Persson, M. A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237050100 · Cited by 450 · see citing works

Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma

Qin, M., Liu, G., Huo, X., Tao, X., Sun, X., Ge, Z., Yang, J., Fan, J., Liu, L., & Qin, W. (2016) · Cancer Biomarkers · doi:10.3233/cbm-150552 · Cited by 441 · see citing works

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL‐6 signal transduction

Nicholson, S. E., Willson, T. A., Farley, A., Starr, R., Zhang, J., Baca, M., Alexander, W. S., Metcalf, D., Hilton, D. J., & Nicola, N. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.2.375 · Cited by 407 · see citing works

Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer

Wang, L., Tong, X., Zhou, Z., Wang, S., Lei, Z., Zhang, T., Liu, Z., Zeng, Y., Li, C., Zhao, J., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0889-7 · Cited by 344 · see citing works

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

Samavati, L., Rastogi, R., Du, W., Hüttemann, M., Fite, A., & Franchi, L. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.02.018 · Cited by 255 · see citing works

The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis

Bauer, J., Huitinga, I., Zhao, W., Lassmann, H., Hickey, W. F., & Dijkstra, C. D. (1995) · Glia · doi:10.1002/glia.440150407 · Cited by 226 · see citing works

miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosisPreprint

Kole, A. J., Swahari, V., Hammond, S. M., & Deshmukh, M. (2011) · Genes & Development · doi:10.1101/gad.1975411 · Cited by 220 · see citing works

Emerging Functions of Circular RNAs.

Cortés-López, M., & Miura, P. (2016) · Europe PMC (PubMed Central) · Cited by 204 · see citing works

Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

Baek, S. H., Ko, J., Lee, H., Jung, J., Kong, M., Lee, J.-W., Lee, J., Chinnathambi, A., Zayed, M., Alharbi, S. A., et al. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.02.011 · Cited by 185 · see citing works

Brain Under Surveillance: The Microglia Patrol

Fetler, L., & Amigorena, S. (2005) · Science · doi:10.1126/science.1114852 · Cited by 168 · see citing works

Tumour necrosis factor alpha‐induced neuronal loss is mediated by microglial phagocytosis

Neniškytė, U., Vilalta, A., & Brown, G. C. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.05.046 · Cited by 151 · see citing works

Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells

Guadagno, J., Swan, P., Shaikh, R., & Cregan, S. P. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.151 · Cited by 150 · see citing works

Neutralization of interleukin‐1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice

Clausen, F., Hånell, A., Israelsson, C., Hedin, J., Ebendal, T., Mir, A. K., Gram, H., & Marklund, N. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07723.x · Cited by 148 · see citing works

The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor

Zhang, L., Dong, L.-Y., Li, Y., Hong, Z., & Wei, W. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-211 · Cited by 147 · see citing works

Both the Suppressor of Cytokine Signaling 1 (SOCS-1) Kinase Inhibitory Region and SOCS-1 Mimetic Bind to JAK2 Autophosphorylation Site: Implications for the Development of a SOCS-1 Antagonist

Waiboci, L. W., Ahmed, C. M. I., Mujtaba, M. G., Flowers, L. O., Martin, J. P., Haider, M. I., & Johnson, H. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5058 · Cited by 122 · see citing works

Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury1

Wang, X., Kong, K., Wei-li, Q., Wei-lian, Y. E., & Pei-song, S. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00152.x · Cited by 122 · see citing works

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP

Yang, X., Ren, H., Wood, K., Li, M., Qiu, S., Shi, F., Ma, C., & Liu, Q. (2018) · The FASEB Journal · doi:10.1096/fj.201700833rr · Cited by 115 · see citing works

miR‐21 represses FasL in microglia and protects against microglia‐mediated neuronal cell death following hypoxia/ischemia

Zhang, L., Dong, L., Li, Y., Hong, Z., & Wei, W. (2012) · Glia · doi:10.1002/glia.22404 · Cited by 103 · see citing works

The Pro-Inflammatory Cytokines IL-1β and TNFα Are Neurotrophic for Enteric Neurons

Gougeon, P., Lourenssen, S. R., Han, T., Nair, D. G., Ropeleski, M. J., & Blennerhassett, M. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3564-12.2013 · Cited by 102 · see citing works

miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells

Amodio, N., Bellizzi, D., Leotta, M., Raimondi, L., Biamonte, L., D’Aquila, P., Martino, M. T. D., Calimeri, T., Rossi, M., Lionetti, M., et al. (2013) · Cell Cycle · doi:10.4161/cc.26585 · Cited by 99 · see citing works

Amyloid-β Induces Hepatic Insulin Resistance by Activating JAK2/STAT3/SOCS-1 Signaling Pathway

Zhang, Y., Zhou, B. Z., Zhang, F., Wu, J., Hu, Y., Liu, Y., & Zhai, Q. (2012) · Diabetes · doi:10.2337/db11-0499 · Cited by 93 · see citing works

Circular RNA hsa_circ_0003221 (circPTK2) promotes the proliferation and migration of bladder cancer cells

Xu, Z., Yang, M., Liu, H., & Su, C. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26492 · Cited by 92 · see citing works

Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms

Gao, S., Chen, C., Wang, L., Hong, L., Wu, J., Dong, P., & Yu, F. (2012) · Experimental Hematology · doi:10.1016/j.exphem.2012.10.012 · Cited by 86 · see citing works

MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax and Sirt2.

Li, S., Lv, X., Zhai, K., Xu, R., Zhang, Y., Zhao, S., Qin, X., Yin, L., & Lou, J. (2016) · PubMed Central · Cited by 84 · see citing works

Intra-parenchymal injection of tumor necrosis factor-? and interleukin 1-? produces dopamine neuron loss in the rat

Carvey, P. M., Chen, E.-Y., Lipton, J. W., Tong, C. W., Chang, Q. A., & Ling, Z. D. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0222-z · Cited by 83 · see citing works

Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1β to promote neuronal death

Yin, L., Dai, Q., Jiang, P., Zhu, L. D., Dai, H., Yao, Z., Liu, H., Ma, X., Qu, L., & Jiang, J. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.04.001 · Cited by 80 · see citing works

A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells

Shen, W., Chen, C., Guan, Y., Song, X., Jin, Y., Wang, J., Hu, Y., Xin, T., Jiang, Q., & Li, Z. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.06.078 · Cited by 43 · see citing works

PPARγ alleviated hepatocyte steatosis through reducing SOCS3 by inhibiting JAK2/STAT3 pathway

Bi, J., Sun, K., Wu, H., Chen, X., Tang, H., & Mao, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.110 · Cited by 27 · see citing works

Interleukin-1β regulation of N-type Ca2+ channels in cortical neurons

Zhou, C. Y., Ye, H., Wang, S., & Chai, Z. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.043 · Cited by 24 · see citing works

MicroRNA-29b alleviates oxygen and glucose deprivation/reperfusion-induced injury via inhibition of the p53‑dependent apoptosis pathway in N2a neuroblastoma cells

Cao, L., Zhang, Y., Zhang, S., Jiang, T., Chen, L., Liu, J., & Zhou, S. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5410 · Cited by 24 · see citing works

miR-146a down-regulation alleviates H2O2-induced cytotoxicity of PC12 cells by regulating MCL1/JAK/STAT pathway

Yang, X., Mao, X., Ding, X., Guan, F., Jia, Y., Luo, L., Li, B., Tan, H., & Cao, C. (2018) · Cell Biology and Toxicology · doi:10.1007/s10565-018-9424-2 · Cited by 15 · see citing works

The American Trotting-Horse

Galton, F. (1883) · Nature · doi:10.1038/028029c0 · Cited by 2 · see citing works

Role of circular RNAs in brain development and CNS diseases

Mehta, S. L., Dempsey, R. J., & Vemuganti, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101746 · Cited by 281 · see citing works

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works

Epigenetic Regulation of Neuroinflammation in Parkinson’s Disease

Rasheed, M., Liang, J., Wang, C., Deng, Y., & Chen, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094956 · Cited by 94 · see citing works

Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia

Lian, L., Zhang, Y., Liu, L., Yang, L., Cai, Y., Zhang, J., & Xu, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.612439 · Cited by 83 · see citing works

Downregulation of circular RNA HECTD1 induces neuroprotection against ischemic stroke through the microRNA-133b/TRAF3 pathway

Dai, Q.-D., Ma, Y., Xu, Z., Zhang, L., Yang, H., Liu, Q., & Wang, J.-Z. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118626 · Cited by 74 · see citing works

CircRNA–miRNA networks in regulating bone disease

Huang, W., Wu, Y., Qiao, M., Xie, Z., Cen, X. B., Huang, X., & Zhao, Z. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30625 · Cited by 56 · see citing works

Recent insights into the roles of circular RNAs in human brain development and neurologic diseases

Najafi, S., Zarch, S. M. A., Majidpoor, J., Pordel, S., Aghamiri, S., Rasul, M. F., Asemani, Y., Vakili, O., Mohammadi, V., Movahedpour, A., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.11.166 · Cited by 55 · see citing works

Noncoding RNA crosstalk in brain health and diseases

Mehta, S. L., Chokkalla, A. K., & Vemuganti, R. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105139 · Cited by 47 · see citing works

Non-Coding RNA in Microglia Activation and Neuroinflammation in Alzheimer’s Disease

He, C., Li, Z., Yang, M., Yu, W., Luo, R., Zhou, J., He, J., Chen, Q., Song, Z., & Cheng, S. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s422114 · Cited by 49 · see citing works

Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects

Zhang, Z., Ge, M., Wu, D., Li, W., Chen, W., Liu, P., Zhang, H., & Yang, Y. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.121916 · Cited by 48 · see citing works

Circular RNA MYLK promotes tumour growth and metastasis via modulating miR‐513a‐5p/VEGFC signalling in renal cell carcinoma

Li, J., Huang, C., Zou, Y., Yu, J., & Gui, Y. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15308 · Cited by 45 · see citing works

Functional roles of circular RNAs in Alzheimer’s disease

Huang, J.-L., Su, M., & Wu, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101058 · Cited by 45 · see citing works

CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis

Li, M., Hu, J., Peng, Y., Li, J., & Ren, R. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00305-3 · Cited by 44 · see citing works

Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes

Yuan, J., Zhang, Y., Zhang, Y., Mo, Y., & Zhang, Q. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-021-00405-2 · Cited by 43 · see citing works

Insights into the multifaceted role of circular RNAs: implications for Parkinson’s disease pathogenesis and diagnosis

Doxakis, E. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-021-00265-9 · Cited by 43 · see citing works

Long non‐coding RNA H19 promotes leukocyte inflammation in ischemic stroke by targeting the miR‐29b/C1QTNF6 axis

Li, G., Ma, X., Zhao, H., Fan, J., Liu, T., Luo, Y., & Guo, Y. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13829 · Cited by 38 · see citing works

Differential Expression and Bioinformatics Analysis of circRNA in Non-small Cell Lung Cancer

Sun, Q., Li, X., Xu, M., Zhang, L., Zuo, H., Xin, Y., Zhang, L., & Gong, P. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.586814 · Cited by 36 · see citing works

Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-κB axis

Cai, L., Ge, B., Xu, S., Chen, X., & Yang, H. (2021) · Aging · doi:10.18632/aging.203468 · Cited by 34 · see citing works

Circular RNAs in the Central Nervous System

Li, M., Wang, W., & Jin, Z. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.629593 · Cited by 31 · see citing works

CircPRKCI-miR-545/589-E2F7 axis dysregulation mediates hydrogen peroxide-induced neuronal cell injury

Cheng, Q., Cao, X., Xue, L., Xia, L., & Xu, Y. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.131 · Cited by 29 · see citing works

Expression and function of circular RNAs in the mammalian brain

Xu, K., Zhang, Y., & Li, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03780-3 · Cited by 27 · see citing works

Progress in circRNA-Targeted Therapy in Experimental Parkinson’s Disease

(2023) · doi:10.3390/pharmaceutics15082035 · Cited by 26 · see citing works

The emerging roles of circular RNAs in CNS injuries

Qu, X., Li, Z., Chen, J., & Hou, L. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24591 · Cited by 20 · see citing works

CircRNAs in Alzheimer's disease: What are the prospects?

Beylerli, O., Beilerli, A., Ilyasova, T., Shumadalova, A. V., Shi, H., & Sufianov, A. A. (2023) · Non-coding RNA Research · doi:10.1016/j.ncrna.2023.11.011 · Cited by 16 · see citing works

Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization

Huang, X., Yang, Q., Xie, L., & Lei, S. (2022) · Bioengineered · doi:10.1080/21655979.2022.2036892 · Cited by 15 · see citing works

The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease

Abed, S., Ebrahimi, A., Fattahi, F., Kouchakali, G., Khaniani, M. S., & Derakhshan, S. M. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02262-y · Cited by 16 · see citing works

Hsa_circ_0031608: A Potential Modulator of VSMC Phenotype in the Rupture of Intracranial Aneurysms

Wang, C., Luo, Y., Tang, H., Yan, Y., Chang, X., Zhao, R., Li, Q., Yang, P., Hong, B., Xu, Y., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.842865 · Cited by 15 · see citing works

Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis

Huang, K., Yang, C., Zheng, J., Liu, X., Liu, J., Che, D., Xue, Y., An, P., Wang, D., Ruan, X., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00507-y · Cited by 14 · see citing works

Non-coding RNAs and Exosomal Non-coding RNAs in Traumatic Brain Injury: the Small Player with Big Actions

Mohamadzadeh, O., Hajinouri, M., Moammer, F., Zadeh, S. S. T., Shafiei, G. O., Jafari, A., Ostadian, A., Talaei, S. A., Hamblin, M. R., Yazdi, A. J., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03321-y · Cited by 12 · see citing works

Investigation of the Circular Transcriptome in Alzheimer’s Disease Brain

Gao, Y., Xu, S.-M., Cheng, Y., Takenaka, K., Lindner, G., & Janitz, M. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02236-0 · Cited by 11 · see citing works

Hypoxia-Induced circRNAs in Human Diseases: From Mechanisms to Potential Applications

Huang, Q. Q., Yang, J., Goh, R. M., You, M., Wang, L., & Ma, Z. (2022) · Cells · doi:10.3390/cells11091381 · Cited by 10 · see citing works

Inhibition of MicroRNA-122-5p Relieves Myocardial Ischemia-Reperfusion Injury via SOCS1

Zhang, J., Fu, L., Zhang, J., Zhou, B., Tang, Y., Zhang, Z., & Gu, T. (2023) · Hämostaseologie · doi:10.1055/a-2013-0336 · Cited by 10 · see citing works

The Phytochemical Agathisflavone Modulates miR146a and miR155 in Activated Microglia Involving STAT3 Signaling

dos Santos, B. L., dos Santos, C. C., da Silva, K. C., Nonaka, C. K. V., Souza, B. S. D. F., David, J. M., de Oliveira, J. V. R., Costa, M. D. F. D., Butt, A. M., da Silva, V. D. A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052547 · Cited by 11 · see citing works

Overexpression of circ PTK2 suppresses the progression of nonalcoholic fatty liver disease via the miR ‐200c/ SIK2 / PI3K /Akt axis

Li, Y., Cen, C., Liu, B., Zhou, L., Huang, X., & Liu, G. (2022) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12568 · Cited by 9 · see citing works

HIF-1-Induced hsa-miR-429: Understanding Its Direct Targets as the Key to Developing Cancer Diagnostics and Therapies

Bartoszewska, S., Sławski, J., Collawn, J. F., & Bartoszewski, R. (2023) · Cancers · doi:10.3390/cancers15112903 · Cited by 9 · see citing works

CircRtn4 Acts as the Sponge of miR-24-3p to Promote Neurite Growth by Regulating CHD5

Qi, Y., Ma, N., Chen, X., Wang, Y., Zhang, W., & Wan, J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.660429 · Cited by 9 · see citing works

Non-coding RNA biomarkers in Alzheimer’s disease

Mohammadpour, M., Saeidi, K., Ferdosi, F., Khanifar, H., Dadgostar, E., Zakizadeh, F., Abdolghaderi, S., & Khatami, S. H. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120427 · Cited by 8 · see citing works

The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation

Gu, X., Li, L., Chen, B., Zhang, Y., Zhou, Y., Liu, K., Xia, W., Li, X., Zhang, Z., Shi, H., et al. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2304087 · Cited by 8 · see citing works

circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-κB Pathway

Guo, K., Chang, Y., Jin, Y., Yuan, H., & Che, P. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02018-6 · Cited by 8 · see citing works

A Narrative Review of Circular RNAs in Brain Development and Diseases of Preterm Infants

Gu, Q., Liu, H., Ma, J., Yuan, J., Li, X., & Qiao, L. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.706012 · Cited by 7 · see citing works

CircRNA-Based Therapeutics: a New Frontier in Neuroinflammation Treatment

Muhammed, T. M., Jasim, S. A., Uthirapathy, S., Mandaliya, V. B., Ballal, S., Kalia, R., Arya, R., Nakash, P., Mustafa, Y. F., & Ahmed, J. K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05258-w · Cited by 5 · see citing works

Overexpression of Circ_0005585 Alleviates Cerebral Ischemia Reperfusion Injury via Targeting MiR-16-5p

Zhuang, Y., Fan, W. P., & Yan, H. (2023) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-023-05857-4 · Cited by 5 · see citing works

Role of circRNA in pathogenesis of Alzheimer's disease.

Shen, X., He, Y., & Ge, C. (2022) · PubMed Central · doi:10.11817/j.issn.1672-7347.2022.210729 · Cited by 4 · see citing works

The circRNA and Role in Alzheimer’s Disease: From Regulation to Therapeutic and Diagnostic Targets

Li, W., & Jin, G. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.99893 · Cited by 2 · see citing works

Subcytotoxic Exposure to Avobenzone and Ethylhexyl Salicylate Induces microRNA Modulation and Stress-Responsive PI3K/AKT and MAPK Signaling in Differentiated SH-SY5Y Cells

Graziosi, A., Ghelli, L., Corrieri, C., Iacenda, L., Manfredi, M. C., Angelini, S., Sita, G., Hrelia, P., & Morroni, F. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031134 · Cited by 1 · see citing works

The emerging role of circular RNAs in neurodegenerative diseases and viral infections

Medina, F., & Bellizzi, A. (2026) · Journal of NeuroVirology · doi:10.1007/s13365-026-01324-8 · Cited by 1 · see citing works

TERT silencing alters the expression of ARG1, GLUL, VIM, NES genes and hsa-miR-29b-3p in the T98G cell line

González‐Giraldo, Y., Fonseca, Á. Y. G., & Aristizábal-Pachón, A. F. (2022) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2022.2155301 · Cited by 1 · see citing works

Circular RNAs — a modern perspective on the molecular mechanisms of neurologic diseases in humans and prospects for therapeutic agents

Shabanov, P. D., Иванович, В. В., Savelieva, L. P., & Romashova, Y. E. (2023) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf334925 · Cited by 1 · see citing works

Long noncoding RNA H19 promotes leukocyte inflammation in ischaemic stroke by targeting the miR-29b/C1QTNF6 axisPreprint

Li, G., Ma, X., Zhao, H., Fan, J., Liu, T., Luo, Y., & Guo, Y. (2024) · doi:10.22541/au.170667660.03895240/v1

Additional file 2 of Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes

Yuan, J., Zhang, Y., Zhang, Y., Mo, Y., & Zhang, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14251857

Additional file 1 of Long Non-coding RNA H19 Deteriorates Hypoxic-Ischemic Brain Damage by Interacting with MicroRNA-140-5p and STAT3

Lu, Q., Hou, H. M., Li, S., Yuan, J., Liu, H., & Xu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19522713

Additional file 1 of Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes

Yuan, J., Zhang, Y., Zhang, Y., Mo, Y., & Zhang, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14251854

Anti-inflammatory activity of an IL-6 missense variant against crystal-induced inflammatory response

Li, Y., Leng, J., Wen, N., Han, H., Wang, H., Song, Z., Liu, Q., Lu, X., & Gao, B. (2026) · Cytokine · doi:10.1016/j.cyto.2026.157202

Circular RNA _NLRP1 targets mouse microRNA-199b-3p to regulate apoptosis and pyroptosis of hippocampal neuron under oxygen-glucose deprivation exposure

Sun, B., Liu, X., Peng, H., Xiang, X., & Yang, H. (2021) · Bioengineered · doi:10.1080/21655979.2021.1947443 · Cited by 11 · see citing works

CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis

Li, M., Hu, J., Peng, Y., Li, J., & Ren, R. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00305-3 · Cited by 44 · see citing works

CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p

Qiu, L., He, J., Chen, H., Xu, X., & Tao, Y. (2021) · Journal of Molecular Histology · doi:10.1007/s10735-021-10036-8 · Cited by 20 · see citing works

Knockdown of circ_0007290 alleviates oxygen-glucose deprivation-induced neuronal injury by regulating miR-496/PDCD4 axis

Wang, F., Liu, J., Wang, D., Yu, Y., & Jiao, X. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-021-00900-7 · Cited by 14 · see citing works

Downregulation of circAsxl2 Relieves Neuronal Injury Induced by oxygen-glucose deprivation/reperfusion

Zhang, W., Liu, D., Yi, J., & Fan, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03532-3 · Cited by 5 · see citing works