Recent advances on polydeoxyribonucleotide extraction and its novel application in cosmeceuticals
Abstract
Polydeoxyribonucleotide (PDRN) is a registered DNA-derived proprietary drug containing a mixture of DNA fragments of molecular weights of 50 and 1500 kDa extracted mainly from salmon with a highly pure active substance (>95 %). It has many valuable medicinal effects and multi-functions related to cosmeceuticals. In-vivo tests and even clinical trials have confirmed this substance as non-toxic. Its promising bioactivities and safety profile have prompted increasing research and discovery of this active ingredient. However, most previous review papers have only focused on the bioactivities of PDRN in medicine and mainly evaluated the efficiency of salmon-derived sources. Only one review has elucidated the capacity of PDRN as promising anti-aging without mentioning other effects in cosmeceuticals. Thus, an overview of novel sources for the extraction of PDRN and their functions in the cosmeceuticals field is lacking, and is the main topic of discussion in this review. Besides general information about PDRN, this review evaluated the advantages and disadvantages of different novel sources and procedures for PDRN extraction. The bioactivities of PDRN regarding cosmeceuticals are also elucidated comprehensively. This review aims to supply worthy scientific information for further studies on PDRN extraction and its bioactivity in cosmeceuticals.
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PDRN-based injectable pharmaceuticals are frequently used in dermatological practice because of multifactorial benefits, including tissue regeneration, dermal rejuvenation, hypopigmentation, wound healing, anti-inflammatory effects, anti-aging properties, and promotion of hair regrowth.
“PDRN-based injectable pharmaceuticals are frequently used in dermatological practice because of their multifactorial benefits, including tissue regeneration, dermal rejuvenation, hypopigmentation, wound healing, anti-inflammatory effects, anti-aging properties, and promotion of hair regrowth [23,147].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [147]
The commercialization of Placentex® catalyzed advancements in DNA purification technologies.
“and catalyzed advancements in DNA purification technologies [147,148,168].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [147]
The commercialization of Placentex® in the early 1990s marked a significant milestone in the therapeutic use of PDRN.
“The commercialization of Placentex® in the early 1990s marked a significant milestone in the therapeutic use of PDRN”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [147]
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Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Nguyen, T. H., Wang, S.-L., & Nguyen, V. B.
- Affiliations
- Tamkang University (TW)
- Tay Nguyen University (VN)
- Corresponding author
- Wang, San-Lang
- Nguyen, Van Bon
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2024-12
- Volume
- 282
- Issue
- Pt 3
- Pages
- 137051
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W4403929870
- Cited by
- 21
- References
- 7
- Citations by year
- 2026: 10 · 2025: 11
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Tamkang University Institutional Repository (TKUIR) (submittedVersion)
- Funders
- National Science and Technology Council (NSTC 112-2923-B-032-001)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- polydeoxyribonucleotide, cosmeceuticals, anti-aging, biological activity, skin care
- MeSH terms
- Cosmeceuticals, Animals, Cosmetics, Humans, Polydeoxyribonucleotides
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