The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index.
Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: A target to modulate cardiovascular risk?
Open accessAbstract
Background Epicardial adipose tissue (EAT) is a risk factor for cardiovascular diseases. Glucagon-like peptide 1 analogs (GLP-1A) may have beneficial cardiovascular effects and reduce EAT, possibly throughout targeting GLP-1 receptor (GLP-1R). Nevertheless, the role of EAT GLP-1R, GLP-2R and their interplay with EAT genes involved in adipogenesis and fatty acid (FA) metabolism are unknown. We analyzed whether EAT transcriptome is related to GLP-1R/GLP-2R gene expression, and GLP-1/GLP-2 plasma levels in coronary artery disease patients (CAD).Methods EAT was collected from 17 CAD patients undergoing CABG for microarray analysis of GLP-1R, GLP-2R and genes involved in FA metabolism and adipogenesis. EAT thickness was measured by echocardiography. GLP-1 and GLP-2 levels were quantified by ELISA in CAD and healthy subjects (CTR).Results EAT GLP-1R was directly correlated with genes promoting beta-oxidation and white-to-brown adipocyte differentiation, and inversely with pro-adipogenic genes. GLP-2R was positively correlated with genes involved in adipogenesis and lipid synthesis, and inversely with genes promoting beta-oxidation. GLP-1 and GLP-2 levels were higher in CAD than CTR and in patients with greater EAT thickness.Conclusions GLP-1 analogs may target EAT GLP-1R and therefore reduce local adipogenesis, improve fat utilization and induce brown fat differentiation. As EAT lies in direct contiguity to myocardium and coronary arteries, the beneficial effects of GLP-1 activation may extent to the heart. The increased levels of circulating GLP-1 and GLP-2 and EAT GLP-2R may be compensatory mechanisms related to CAD and also EAT expansion, but the meaning of these observations needs to be further investigated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, a correlation between epicardial fat GLP-1R and genes encoding for brown fat activity and fatty acid oxidation has been recently reported [26].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
Marso, S. P., Daniels, G. H., Brown-Frandsen, K., Kristensen, P., Mann, J. F. E., Nauck, M. A., Nissen, S. E., Pocock, S., Poulter, N. R., Ravn, L. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603827 · Cited by 7,629
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Marso, S. P., Bain, S. C., Consoli, A., Eliaschewitz, F. G., Jódar, E., Leiter, L. A., Lingvay, I., Rosenstock, J., Seufert, J., Warren, M. L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1607141 · Cited by 6,900
Browning, L. M., Hsieh, S. D., & Ashwell, M. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000144 · Cited by 1,400
Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features
Iacobellis, G., & Bianco, A. C. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.07.003 · Cited by 612
Self-citationLocal and systemic effects of the multifaceted epicardial adipose tissue depot
Iacobellis, G. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.58 · Cited by 605
Self-citationSvegliati‐Baroni, G., Saccomanno, S., Rychlicki, C., Agostinelli, L., De Minicis, S., Candelaresi, C., Faraci, G., Pacetti, D., Vivarelli, M., Nicolini, D., et al. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02462.x · Cited by 405
Ørskov, C., Holst, J. J., & Nielsen, O. V. (1988) · Endocrinology · doi:10.1210/endo-123-4-2009 · Cited by 396
Effects of GLP-1 on appetite and weight
Shah, M., & Vella, A. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9289-5 · Cited by 352
Schmidt, W. E., Siegel, E. G., & Creutzfeldt, W. (1985) · Diabetologia · doi:10.1007/bf00291980 · Cited by 323
GLP-1 Receptor Expression Within the Human Heart
Baggio, L. L., Yusta, B., Mulvihill, E. E., Cao, X., Streutker, C. J., Butany, J., Cappola, T. P., Margulies, K. B., & Drucker, D. J. (2018) · Endocrinology · doi:10.1210/en.2018-00004 · Cited by 312
The Double Role of Epicardial Adipose Tissue as Pro- and Anti-inflammatory Organ
Iacobellis, G., & Bárbaro, G. (2008) · Hormone and Metabolic Research · doi:10.1055/s-2008-1062724 · Cited by 285
Self-citationDutour, A., Abdesselam, I., Ancel, P., Kober, F., Mrad, G., Darmon, P., Ronsin, O., Pradel, V., Lesavre, N., Martin, J. C., et al. (2016) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12680 · Cited by 262
Liraglutide causes large and rapid epicardial fat reduction
Iacobellis, G., Mohseni, M., Bianco, S. D., & Banga, P. K. (2017) · Obesity · doi:10.1002/oby.21718 · Cited by 251
Self-citationVendrell, J., El Bekay, R., Peral, B., García-Fuentes, E., Megia, A., Macias-Gonzalez, M., Real, J. F., Jimenez-Gomez, Y., Escoté, X., Pachón, G., et al. (2011) · Endocrinology · doi:10.1210/en.2011-1070 · Cited by 173
Seufert, J., & Gallwitz, B. (2014) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12251 · Cited by 156
Tashiro, Y., Sato, K., Watanabe, T., Nohtomi, K., Terasaki, M., Nagashima, M., & Hirano, T. (2014) · Peptides · doi:10.1016/j.peptides.2013.12.015 · Cited by 149
Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease
McAninch, E. A., Fonseca, T. L., Poggioli, R., Panos, A. L., Salerno, T. A., Deng, Y., Li, Y., Bianco, A. C., & Iacobellis, G. (2015) · Obesity · doi:10.1002/oby.21059 · Cited by 130
Self-citationHuman epicardial fat expresses glucagon-like peptide 1 and 2 receptors genes
Iacobellis, G., Camarena, V., Sant, D., & Wang, G. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-109563 · Cited by 112
Self-citationValverde, I., Mérida, E., Delgado, E., Trapote, M. A., & Villanueva‐Peñacarrillo, M. L. (1993) · Endocrinology · doi:10.1210/endo.132.1.8380388 · Cited by 96
Vianello, E., Dozio, E., Arnaboldi, F., Marazzi, M. G., Martinelli, C., Lamont, J. V., Tacchini, L., Sigrüener, A., Schmitz, G., & Romanelli, M. M. C. (2016) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.12.005 · Cited by 81
Self-citationGLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility
Guan, X., Shi, X., Li, X., Chang, B. H., Wang, Y., Li, D., & Chan, L. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00245.2012 · Cited by 79
The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis
Guan, X. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00096.2014 · Cited by 70
Epicardial Adipose Tissue and Intracoronary Adrenomedullin Levels in Coronary Artery Disease
Iacobellis, G., Gioia, C. R. T. D., Vito, M. D., Petramala, L., Cotesta, D., Santis, V. D., Vitale, D., Tritapepe, L., & Letizia, C. (2009) · Hormone and Metabolic Research · doi:10.1055/s-0029-1231081 · Cited by 68
Self-citationCamarena, V., Sant, D., Mohseni, M., Salerno, T., Zaleski, M. L., Wang, G., & Iacobellis, G. (2017) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.05.010 · Cited by 67
Self-citationGLP2: an underestimated signal for improving glycaemic control and insulin sensitivity
Amato, A., Baldassano, S., & Mulè, F. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0035 · Cited by 66
Mérida, E., Delgado, E., Molina, L., Villanueva‐Peñacarrillo, M. L., & Valverde, I. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263154 · Cited by 65
Benedini, S., Dozio, E., Invernizzi, P. L., Vianello, E., Banfi, G., Terruzzi, I., Luzi, L., & Romanelli, M. M. C. (2017) · Journal of Diabetes Research · doi:10.1155/2017/1039161 · Cited by 63
Self-citationInfluence of glucagon-like peptide 2 on energy homeostasis
Baldassano, S., Amato, A., & Mulè, F. (2016) · Peptides · doi:10.1016/j.peptides.2016.09.010 · Cited by 50
Dozio, E., Vianello, E., Briganti, S., Fink, B., Malavazos, A. E., Scognamiglio, E. T., Dogliotti, G., Sigrüener, A., Schmitz, G., & Romanelli, M. M. C. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.04.045 · Cited by 45
Self-citationDozio, E., Malavazos, A. E., Vianello, E., Briganti, S., Dogliotti, G., Bandera, F., Giacomazzi, F., Castelvecchio, S., Menicanti, L., Sigrüener, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090960 · Cited by 41
Self-citationDozio, E., Briganti, S., Vianello, E., Dogliotti, G., Barassi, A., Malavazos, A. E., Ermetici, F., Morricone, L. F., Sigrüener, A., Schmitz, G., et al. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.08.012 · Cited by 41
Self-citationDozio, E., Vianello, E., Briganti, S., Lamont, J. V., Tacchini, L., Schmitz, G., & Romanelli, M. M. C. (2015) · Journal of Diabetes Research · doi:10.1155/2016/2327341 · Cited by 39
Self-citationGlucagon-like peptide-2 treatment improves glucose dysmetabolism in mice fed a high-fat diet
Baldassano, S., Amato, A., Caldara, G., & Mulè, F. (2016) · Endocrine · doi:10.1007/s12020-016-0871-3 · Cited by 38
Influence of endogenous glucagon-like peptide-2 on lipid disorders in mice fed a high-fat diet
Baldassano, S., Amato, A., Rappa, F., Cappello, F., & Mulè, F. (2016) · Endocrine Research · doi:10.3109/07435800.2016.1141950 · Cited by 30
Dozio, E., Dogliotti, G., Malavazos, A. E., Bandera, F., Cassetti, G., Vianello, E., Zelaschi, R., Barassi, A., Pelissero, G., Solimene, U., et al. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500418 · Cited by 13
Self-citationon behalf of the LEADER Investigators, Rutten, G. E. H. M., Tack, C. J., Pieber, T. R., Çömlekçi, A., Ørsted, D. D., Baeres, F. M. M., Marso, S. P., & Buse, J. B. (2016) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-016-0153-5 · Cited by 11
Li, F., Lu, L., Yu, P., Zhang, Y., Gao, J., Zhou, D., Zhou, D., Sheng, H., & Qu, S. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.77 · Cited by 8
Flagged first, then by citations
2 of the 41 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Epicardial adipose tissue in contemporary cardiology
Iacobellis, G. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00679-9 · Cited by 797
Self-citationSignaling pathways in obesity: mechanisms and therapeutic interventions
Wen, X., Zhang, B., Wu, B., Xiao, H., Li, Z., Li, R., Xu, X., & Li, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01149-x · Cited by 490
Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation
McLean, B. A., Wong, C. K., Campbell, J. E., Hodson, D. J., Trapp, S., & Drucker, D. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa032 · Cited by 289
Iacobellis, G., & Villasante Fricke, A. C. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvz042 · Cited by 168
Self-citationMalavazos, A. E., Iacobellis, G., Dozio, E., Basilico, S., Di Vincenzo, A., Dubini, C., Menicanti, L., Vianello, E., Meregalli, C., Ruocco, C., et al. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad050 · Cited by 100
Self-citation
Metadata
- Authors
- Dozio, E., Vianello, E., Malavazos, A. E., Tacchini, L., Schmitz, G., Iacobellis, G., & Corsi Romanelli, M. M.
- Affiliations
- University of Milan (IT)
- IRCCS Policlinico San Donato (IT)
- University of Regensburg (DE)
- University of Miami (US)
- Corresponding author
- Dozio, Elena
- ORCID
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 292
- Pages
- 218-224
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2937422733
- Cited by
- 118
- References
- 41
- Citations by year
- 2026: 15 · 2025: 28 · 2024: 20 · 2023: 15 · 2022: 14 · 2021: 9 · 2020: 11 · 2019: 5
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Funders
- Fondazione E. A. Fiera Internazionale di Milano
- Italian Ministry of Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Pharmacology (medical) › Apelin-related biomedical research
- Keywords
- epicardial adipose tissue, GLP-1 receptor, GLP-2 receptor, glucagon-like peptide-1, glucagon-like peptide-2, coronary artery disease, fatty acid beta-oxidation, adipogenesis, lipogenesis, EAT thickness, cardiovascular risk, GLP-1 analogues
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Acetyl-CoA C-Acyltransferase, Adult, Aged, Anthropometry, Adipose Tissue, Brown, Cardiovascular Diseases, Enoyl-CoA Hydratase, Female, Humans, Male, Middle Aged, Pericardium, Risk Factors, 3-Hydroxyacyl CoA Dehydrogenases, Carbon-Carbon Double Bond Isomerases, Racemases and Epimerases, Adipose Tissue, White
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
