Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease
Open accessAbstract
OBJECTIVE: To explore the transcriptome of epicardial adipose tissue (EAT) as compared to subcutaneous adipose tissue (SAT) and its modifications in a small number of patients with coronary artery disease (CAD) versus valvulopathy. METHODS: SAT and EAT samples were obtained during elective cardiothoracic surgeries. The transcriptome of EAT was evaluated, as compared to SAT, using an unbiased, whole-genome approach in subjects with CAD (n = 6) and without CAD (n = 5), where the patients without CAD had cardiac valvulopathy. RESULTS: Relative to SAT, EAT is a highly inflammatory tissue enriched with genes involved in endothelial function, coagulation, immune signaling, potassium transport, and apoptosis. EAT is lacking in expression of genes involved in protein metabolism, tranforming growth factor-beta (TGF-beta) signaling, and oxidative stress. Although underpowered, in subjects with severe CAD, there is an expression trend suggesting widespread downregulation of EAT encompassing a diverse group of gene sets related to intracellular trafficking, proliferation/transcription regulation, protein catabolism, innate immunity/lectin pathway, and ER stress. CONCLUSIONS: The EAT transcriptome is unique when compared to SAT. In the setting of CAD versus valvulopathy, there is possible alteration of the EAT transcriptome with gene suppression. This pilot study explores the transcriptome of EAT in CAD and valvulopathy, providing new insight into its physiologic and pathophysiologic roles.
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EAT has a unique transcriptome enriched in genes involved in coagulation, endothelial function, phospholipase activity, apoptosis, and immune signaling, and a secretome that may be influenced by environmental, epigenetic, and genetic factors.
“EAT has a unique transcriptome enriched in genes involved in coagulation, endothelial function, phospholipase activity, apoptosis, and immune signaling, and a secretome that may be influenced by environmental, epigenetic, and genetic factors [43,44,45].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [43]
EAT activity can be downregulated in advanced chronic diseases, as observed in severe coronary artery disease.
“Epicardial adipose tissue activity can be downregulated in advanced chronic diseases, as we observed in severe coronary artery disease [3].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [3]
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- Authors
- McAninch, E. A., Fonseca, T. L., Poggioli, R., Panos, A. L., Salerno, T. A., Deng, Y., Li, Y., Bianco, A. C., & Iacobellis, G.
- Affiliations
- Rush University Medical Center (US)
- University of Miami (US)
- Corresponding author
- Iacobellis, Gianluca
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2015-05-09
- Volume
- 23
- Issue
- 6
- Pages
- 1267-1278
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC5003780
- OpenAlex
- W1643881813
- Cited by
- 130
- References
- 37
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 18 · 2023: 19 · 2022: 11 · 2021: 9 · 2020: 11 · 2019: 15 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 1
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Joslin Diabetes Center
- Broad Institute
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065055, R01DK077148)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- epicardial adipose tissue, subcutaneous adipose tissue, coronary artery disease, valvulopathy, transcriptome, gene expression, inflammation, endothelial function, coagulation, immune signaling, oxidative stress, endoplasmic reticulum stress, TGF-beta signaling, gene downregulation
- MeSH terms
- Adipose Tissue, Coronary Artery Disease, Female, Gene Expression Regulation, Humans, Male, Pericardium, Pilot Projects, Transcriptome
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