Nutrition, dietary recommendations, and supplements for patients with congenital heart disease
Open accessAbstract
Nutrition is the cornerstone of a healthy life and is crucial for the prevention of cardiovascular disease. Patients with congenital heart disease (CHD) are prone to nutrition disorders, including abnormalities in body composition such as overweight or obesity which, along with other classic cardiovascular risk factors, places our increasing and aging adult CHD (ACHD) population at a higher risk for acquired cardiovascular disease. These patients are also at risk of cachexia or sarcopenia as well as macronutrient and micronutrient deficiencies derived from the development of heart failure as a complication of their underlying cardiac disease. In this paper, we review different dietary recommendations and supplementation with specific macronutrients and micronutrients. We also discuss some special scenarios in ACHD patients and the importance of the microbiota, a new therapeutical target as yet underexplored in this patient population.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some cardiovascular populations are disproportionately affected by nutritional abnormalities, such as patients with a Fontan circulation who frequently experience protein-losing enteropathy.
“Some cardiovascular populations are disproportionately affected by nutritional abnormalities such as patients with a Fontan circulation who frequently experience protein-losing enteropathy.6”
From Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association (2026) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afy169 · Cited by 13,818 · see citing works
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
Bhatt, D. L., Steg, P. G., Miller, M., Brinton, E. A., Jacobson, T. A., Ketchum, S. B., Doyle, R. T., Juliano, R. A., Jiao, L., Granowitz, C., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812792 · Cited by 3,317 · see citing works
ESPEN Guidelines for Nutrition Screening 2002
Kondrup, J. (2003) · Clinical Nutrition · doi:10.1016/s0261-5614(03)00098-0 · Cited by 3,159 · see citing works
2020 ESC Guidelines for the management of adult congenital heart disease
Baumgartner, H., Backer, J. F. A. D., Babu‐Narayan, S. V., Budts, W., Chessa, M., Diller, G., Lung, B., Kluin, J., Lang, I. M., Meijboom, F. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa554 · Cited by 2,417 · see citing works
Self-citationEngelman, D. T., Ben Ali, W., Williams, J. B., Perrault, L. P., Reddy, V. S., Arora, R. C., Roselli, E. E., Khoynezhad, A., Gerdisch, M., Levy, J. H., et al. (2019) · JAMA Surgery · doi:10.1001/jamasurg.2019.1153 · Cited by 1,225 · see citing works
Diller, G., Kempny, A., Alonso-González, R., Swan, L., Uebing, A. S., Li, W., Babu‐Narayan, S. V., Wort, S. J., Dimopoulos, K., & Gatzoulis, M. Α. (2015) · Circulation · doi:10.1161/circulationaha.115.017202 · Cited by 643 · see citing works
de van der Schueren, M. A. E., Guaitoli, P. R., Jansma, E. P., & de Vet, H. C. W. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.04.008 · Cited by 527 · see citing works
Microbial modulation of cardiovascular disease
Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.149 · Cited by 440 · see citing works
Nutrition and Cardiovascular Health
Casas, R. M., Castro‐Barquero, S., Estruch, R., & Sacanella, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123988 · Cited by 344 · see citing works
Nutrition Screening Tools for Hospitalized Patients
Anthony, P. S. (2008) · Nutrition in Clinical Practice · doi:10.1177/0884533608321130 · Cited by 262 · see citing works
Albumin Levels Predict Survival in Patients with Heart Failure and Preserved Ejection Fraction
Liu, M., Chan, C.-P., Yan, B. P., Zhang, Q., Lam, Y., Li, R., Sanderson, J. E., Coats, A. J. S., Sun, J., Yip, G. W., et al. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr154 · Cited by 221 · see citing works
Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure
Selvaraj, S., Kelly, D. P., & Margulies, K. B. (2020) · Circulation · doi:10.1161/circulationaha.119.045033 · Cited by 193 · see citing works
Jenkins, D., Sievenpiper, J. L., & Jones, P. J. H. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1809971 · Cited by 181 · see citing works
Ezekowitz, J. A., Colin-Ramirez, E., Ross, H., Escobedo, J., Macdonald, P., Troughton, R., Saldarriaga, C., Alemayehu, W., McAlister, F. A., Arcand, J., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00369-5 · Cited by 179 · see citing works
Broberg, C. S., Bax, B. E., Okonko, D. O., RAMPLING, M. W., Bayne, S., Harries, C., Davidson, S. J., Uebing, A. S., Khan, A. A., Thein, S. L., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.03.040 · Cited by 176 · see citing works
Lean Mass Abnormalities in Heart Failure: The Role of Sarcopenia, Sarcopenic Obesity, and Cachexia
Carbone, S., Billingsley, H., Rodriguez‐Miguelez, P., Kirkman, D. L., Garten, R. S., Franco, R. L., Lee, D.-C., & Lavie, C. J. (2019) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2019.03.006 · Cited by 169 · see citing works
Iliceto, S., Scrutinio, D., Bruzzi, P., DʼAmbrosio, G., Boni, L., Biase, M. D., Biasco, G., Hugenholtz, P. G., & Rizzon, P. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)80010-e · Cited by 165 · see citing works
Radman, M. R., Mack, R. A., Barnoya, J., Castañeda, A. R., Rosales, M., Azakie, A., Mehta, N. M., Keller, R. L., Datar, S. A., Oishi, P. E., et al. (2013) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2013.03.023 · Cited by 148 · see citing works
Tay, E. L. W., Peset, A. M., Papaphylactou, M., Inuzuka, R., Alonso-González, R., Giannakoulas, G. A., Tzifa, A., Goletto, S., Broberg, C. S., Dimopoulos, K., et al. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.05.066 · Cited by 146 · see citing works
Stoppe, C., Goetzenich, A., Whitman, G., Ohkuma, R., Brown, T., Hatzakorzian, R., Kristof, A., Meybohm, P., Mechanick, J., Evans, A., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1690-5 · Cited by 138 · see citing works
Nutrition Assessment and Dietary Interventions in Heart Failure
Driggin, E., COHEN, L. P., Gallagher, D., Karmally, W., Maddox, T. M., Hummel, S. L., Carbone, S., & Maurer, M. S. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.02.025 · Cited by 134 · see citing works
The wasting continuum in heart failure: from sarcopenia to cachexia
von Haehling, S. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115002438 · Cited by 130 · see citing works
Manzanares, W., Langlois, P. L., Dhaliwal, R., Lemieux, M., & Heyland, D. K. (2015) · Critical Care · doi:10.1186/s13054-015-0888-7 · Cited by 116 · see citing works
Casas, R. M., Urpí-Sardà, M., Sacanella, E., Arranz, S., Corella, D., Castañer, O., Lamuela-Raventós, R. M., Salas‐Salvadó, J., Lapetra, J., Portillo, M. P., et al. (2017) · Mediators of Inflammation · doi:10.1155/2017/3674390 · Cited by 114 · see citing works
Prognostic value of nutritional screening tools for patients scheduled for cardiac surgery
Ломиворотов, В. В., Efremov, S. M., Александрович, Б. В., Nikolaev, D. A., Vedernikov, P. E., Deryagin, M. N., Ломиворотов, В. В., & Karaskov, A. M. (2013) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivs549 · Cited by 100 · see citing works
Intermittent fasting for the prevention of cardiovascular disease
Allaf, M., Elghazaly, H., Mohamed, O. G., Fareen, M. F. K., Zaman, S., Salmasi, A.-M., Tsilidis, K., & Dehghan, A. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013496.pub2 · Cited by 98 · see citing works
Iron deficiency is associated with adverse outcome in Eisenmenger patients
Bruaene, A. V. D., Delcroix, M., Pasquet, A., Backer, J. F. A. D., Pauw, M. D., Naeije, R., Vachiéry, J.-L., Paelinck, B. P., Morissens, M., & Budts, W. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr130 · Cited by 97 · see citing works
Thiamine Supplementation for the Treatment of Heart Failure: A Review of the Literature
DiNicolantonio, J. J., Niazi, A. K., Lavie, C. J., O’Keefe, J. H., & Ventura, H. O. (2013) · Congestive Heart Failure · doi:10.1111/chf.12037 · Cited by 95 · see citing works
Kaemmerer, H. M., Fratz, S., Braun, S. L., Kölling, K., Eicken, A., Brodherr-Heberlein, S., Pietrzik, K. F., & Hess, J. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.06.014 · Cited by 70 · see citing works
Mirzai, S., Eck, B., Chen, P., Estep, J. D., & Tang, W. H. W. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.121.009322 · Cited by 64 · see citing works
Coenzyme Q10 for heart failure
Saadi, T. A., Assaf, Y., Farwati, M., Turkmani, K., Al-Mouakeh, A., Shebli, B., Khoja, M. T., Essali, A., & Madmani, M. E. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008684.pub3 · Cited by 62 · see citing works
Body mass index in adult congenital heart disease
Brida, M., Dimopoulos, K., Kempny, A., Liodakis, E., Alonso-González, R., Swan, L., Uebing, A. S., Baumgartner, H., Gatzoulis, M. Α., & Diller, G. (2017) · Heart · doi:10.1136/heartjnl-2016-310571 · Cited by 61 · see citing works
Protein-losing enteropathy and plastic bronchitis after the Fontan procedure
Sharma, V. J., Iyengar, A. J., Zannino, D., Gentles, T. L., Justo, R. N., Celermajer, D. S., Bullock, A. M., Winlaw, D. S., Wheaton, G. R., Burchill, L. J., et al. (2020) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2020.07.107 · Cited by 56 · see citing works
Dietary Patterns in Secondary Prevention of Heart Failure: A Systematic Review
Padilha, G. D. R., d’Almeida, K. S. M., Spillere, S. R., & Souza, G. C. (2018) · Nutrients · doi:10.3390/nu10070828 · Cited by 55 · see citing works
Ogawa, M., Izawa, K. P., Satomi‐Kobayashi, S., Kitamura, A., Ono, R., Sakai, Y., & Okita, Y. (2016) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0552-3 · Cited by 52 · see citing works
Micronutrient Depletion in Heart Failure: Common, Clinically Relevant and Treatable
Cvetinovic, N., Loncar, G., Isakovic, A. M., von Haehling, S., Doehner, W., Lainščak, M., & Farkaš, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225627 · Cited by 43 · see citing works
Wu, C. C. N., Kato, T., Ji, R., Zizola, C. F., Brunjes, D. L., Deng, Y. W., Akashi, H., Armstrong, H. F., Kennel, P. J., Thomas, T. A., et al. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002073 · Cited by 41 · see citing works
Blanche, C., Alonso-González, R., Uribarri, A., Kempny, A., Swan, L., Price, L., Wort, S. J., Beghetti, M., & Dimopoulos, K. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.05.062 · Cited by 34 · see citing works
Protein-Losing Enteropathy Following Fontan Palliation
Balushi, A. A., & Mackie, A. S. (2019) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.07.625 · Cited by 34 · see citing works
Pulmonary Arterial Hypertension: Iron Matters
Ramakrishnan, L., Pedersen, S. L., Toe, Q. K., Quinlan, G. J., & Wort, S. J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00641 · Cited by 31 · see citing works
Role and mechanism of action of butyrate in atherosclerotic diseases: a review
Xiao, Y., Guo, Z., Li, Z., Ling, H., & Song, C. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14906 · Cited by 30 · see citing works
Mas‐Peiró, S., Papadopoulos, N., Walther, T., Zeiher, A. M., Fichtlscherer, S., & Vasa‐Nicotera, M. (2019) · Cardiology Journal · doi:10.5603/cj.a2019.0038 · Cited by 28 · see citing works
Spehlmann, M. E., Rangrez, A. Y., Dhotre, D. P., Schmiedel, N., Chavan, N., Bang, C., Müller, O. J., Shouche, Y. S., Franke, A., Frank, D., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10040809 · Cited by 27 · see citing works
Bartholomew, C. L., Muhlestein, J. B., Anderson, J. L., May, H. T., Knowlton, K. U., Bair, T. L., Le, V. T., Bailey, B. W., & Horne, B. D. (2020) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaa050 · Cited by 24 · see citing works
The microbiome’s relationship with congenital heart disease: more than a gut feeling
Feng, D., Christensen, J. T., Yetman, A. T., Lindsey, M. L., Singh, A. B., & Salomon, J. (2021) · Journal of Congenital Cardiology · doi:10.1186/s40949-021-00060-4 · Cited by 19 · see citing works
Kanoh, M., Inai, K., Shinohara, T., Tomimatsu, H., & Nakanishi, T. (2017) · Heart and Vessels · doi:10.1007/s00380-017-1015-2 · Cited by 15 · see citing works
Martínez‐Quintana, E., Sánchez-Matos, M. M., Estupiñán-León, H., Rojas-Brito, A. B., González-Martín, J. M., Rodríguez‐González, F., & Tugores, A. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.09.026 · Cited by 11 · see citing works
Mediterranean diet adherence in patients with congenital heart disease.
Martínez‐Quintana, E., Rojas-Brito, A. B., Estupiñán-León, H., & Rodríguez‐González, F. (2020) · Europe PMC (PubMed Central) · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [1]Bendich A. Deckelbaum R.J. Preventive nutrition 2010 Humana Press Totowa, NJ
- [8]Deen J.F. Krieger E v Slee A.E. Arslan A. Arterburn D. Stout K.K. Metabolic syndrome in adults with congenital heart disease [cited 2022 Dec 5] http://ahajournals.org PMC4802435 26873680
- [27]Goudarzi S. Memar Montazerin S. Najafi H. Shojaei F. Chi G. Effect of vitamins and dietary supplements on cardiovascular health. Critical pathways in Cardiology J Evid Base Med 19 3 2020 Sep 11 153 159 32053519
- [47]Engelman D.T. ben Ali W. Williams J.B. Perrault L.P. Reddy V.S. Arora R.C. Guidelines for perioperative care in cardiac surgery JAMA Surg 154 8 2019 755 31054241
Cited by
Sorted by citations
Vest, A. R., DiDomenico, R. J., Lichtenstein, L., Slater, T., Ekpo, E., Damluji, A. A., Bohula, E., Alviar, C. L., on behalf of the American Heart Association Acute Cardiac Care and General Cardiology Committee of the Council on Clinical Cardiology, & Council on Cardiovascular and Stroke Nursing (2026) · Circulation · doi:10.1161/cir.0000000000001405 · Cited by 15 · see citing works
Congenital Heart Disease After Mid-Age: From the “Grown-Up” to the Elderly
Bonanni, F., Servoli, C., Spaziani, G., Bennati, E., Filippo, C. D., Cirri, G. K., Giaccardi, M., Olivotto, I., & Favilli, S. (2025) · Diagnostics · doi:10.3390/diagnostics15040481 · Cited by 5 · see citing works
The Unique Challenge of Coronary Artery Disease in Adult Patients with Congenital Heart Disease
Borrelli, N., Merola, A., Barracano, R., Palma, M., Altobelli, I., Abbate, M., Papaccioli, G., Ciriello, G. D., Liguori, C., Sorice, D., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13226839 · Cited by 4 · see citing works
A change of heart: Empowering adults with congenital heart disease for a healthy change
Rosa, S. D., Brida, M., & Gatzoulis, M. Α. (2023) · International Journal of Cardiology Congenital Heart Disease · doi:10.1016/j.ijcchd.2023.100484 · Cited by 4 · see citing works
Damani, R., Usman, M. A., & Samiullah, F. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.07.023 · Cited by 2 · see citing works
Ye, E., Wu, E., Tang, T., & La, X. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1601620 · Cited by 1 · see citing works
Radhika, M., Mohan, D. S., Singh, H. J., Kadwe, P., Prajapati, J. B., Mansuri, S. H., & Sonis, J. J. (2026) · Cureus · doi:10.7759/cureus.105305 · Cited by 1 · see citing works
Văn, S. Đ., Guzman, J. S. D., Trần, T. M., & Trung, N. N. T. (2024) · Tạp chí Tim Mạch Học Việt Nam · doi:10.58354/jvc.112e.2024.862
Verma, S., & Sumana, A. (2025) · International Journal of Nutrition and Dietetics · doi:10.17654/2347527725003
- Authors
- Lorente, M., Azpiroz, M. J., Guedes, P., Burgos, R., Lluch, A., & Dos, L.
- Affiliations
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario de Canarias (ES)
- Instituto de Salud Carlos III (ES)
- Venue
- International Journal of Cardiology Congenital Heart Disease
- Publisher
- Elsevier BV
- Published
- 2023-06
- Volume
- 12
- Pages
- 100449
- ISSN
- 2666-6685 (ISSN-L)
- PMC
- PMC11657916
- OpenAlex
- W4327718593
- Cited by
- 9
- References
- 48
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Cardiology Congenital Heart Disease (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- congenital heart disease, adult congenital heart disease, nutrition, dietary recommendations, dietary supplements, macronutrients, micronutrients, obesity, overweight, body composition, cachexia, sarcopenia, heart failure, cardiovascular risk, gut microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review