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Effect of prenatal stress on memory, nicotine withdrawal and 5HT1A expression in raphe nuclei of adult rats

Said, N., Lakehayli, S., Khachibi, M. El, Ouahli, M. El, Nadifi, S., Hakkou, F., Tazi, A.·2015·International Journal of Developmental Neuroscience
DOI 10.1016/j.ijdevneu.2015.04.008
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Abstract

Maternal distress has often been associated with cognitive deficiencies and drug abuse in rats. This study examined these behavioral effects in offspring of mothers stressed during gestation. To this end, pregnant dams were subjected to daily electric foot shocks during the last 10 days of pregnancy. We measured litter parameters and body weights of the descendants after weaning (21 days) and at adulthood (80 days). Afterwards, prenatally stressed and control rats' performances in the novel object recognition test were compared in order to evaluate their memory while others underwent the Water consumption test to assess the nicotine withdrawal intensity after perinatal manipulations. Meanwhile, another set of rats were sacrificed and 5HT 1A receptors' mRNA expression was measured in the raphe nuclei by quantitative Real Time PCR. We noticed no significant influence of maternal stress on litter size and body weight right after weaning. However, control rats were heavier than the stressed rats in adulthood. The results also showed a significant decrease in the recognition score in rats stressed in utero compared to the controls. Moreover, a heightened anxiety symptom was observed in the prenatally stressed offspring following nicotine withdrawal. Additionally, the Real Time PCR method revealed that prenatal stress induced a significant decrease in 5HT 1A receptors’ levels in the raphe nuclei. Nicotine had a similar effect on these receptors’ expression in both nicotine‐treated control and prenatally stressed groups. Taken together, these findings suggest that the cognitive functions and drug dependence can be triggered by early adverse events in rats.

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Research works printed but not linked: 64

  1. Abrahamyan S.S., 2011, Brain plasticity of rats exposed to prenatal immobilization stress, Biopolym. Cell, 5, 339, 10.7124/bc.00011E · DOI
  2. 10.1016/0091-3057(94)90433-2 · DOI
  3. 10.1016/j.pbb.2007.11.005 · DOI
  4. 10.1007/s002130000390 · DOI
  5. 10.1016/S0278-5846(00)00129-9 · DOI
  6. Chigr F., 2014, Modulation of orexigenic and anorexigenic peptides gene expression in the rat DVC and hypothalamus by acute immobilization stress, Front. Cell. Neurosci., 8, 1
  7. 10.1016/0006-8993(92)91383-P · DOI
  8. 10.1016/S0924-977X(98)00032-7 · DOI
  9. 10.1016/j.neulet.2009.10.038 · DOI · Paper page
  10. 10.1016/j.pbb.2004.07.007 · DOI
  11. 10.1016/j.bbr.2005.04.003 · DOI
  12. 10.1016/j.ijdevneu.2006.03.001 · DOI
  13. 10.1037/0735-7044.112.6.1423 · DOI
  14. 10.1016/j.neuron.2012.08.016 · DOI · Paper page
  15. 10.1016/S0736-5748(98)00028-8 · DOI · Paper page
  16. 10.1016/S0006-8993(97)01135-9 · DOI · Paper page
  17. 10.1016/0892-0362(92)90020-B · DOI
  18. 10.1016/j.ntt.2004.08.001 · DOI
  19. 10.1016/S0091-3057(00)00449-4 · DOI · Paper page
  20. 10.1016/j.ejphar.2005.04.032 · DOI · Paper page
  21. 10.1016/j.bbr.2008.08.018 · DOI
  22. 10.1046/j.0953-816x.2001.01501.x · DOI
  23. 10.1038/sj.npp.1301447 · DOI
  24. 10.1016/j.bbr.2004.05.030 · DOI
  25. 10.1016/j.neulet.2015.02.015 · DOI
  26. 10.1016/j.psyneuen.2012.02.010 · DOI
  27. 10.1016/j.brainres.2007.04.042 · DOI · Paper page
  28. 10.1006/meth.2001.1262 · DOI · Paper page
  29. 10.1523/JNEUROSCI.15-01-00110.1995 · DOI
  30. Markham J.A., 2010, Characterization of the cognitive impairments induced by prenatal exposure to stress in the rat, Front. Behav. Neurosci., 4, 1, 10.3389/fnbeh.2010.00173 · DOI
  31. 10.1002/syn.20664 · DOI
  32. 10.1016/j.neures.2011.02.002 · DOI
  33. 10.1016/j.physbeh.2014.02.040 · DOI
  34. 10.1111/j.1460-9568.2003.03070.x · DOI · Paper page
  35. Morley‐Fletcher S., 2004, Chronic treatment with imipramine reverses immobility behaviour, hippocampal corticosteroid receptors and cortical 5‐HT1A receptor mRNA in prenatally stressed rats, Neuropharmacology, 47, 841, 10.1016/j.neuropharm.2004.06.011 · DOI
  36. 10.1007/s00213-011-2280-x · DOI
  37. 10.1016/j.pneurobio.2007.01.001 · DOI
  38. Murphy D.L., 1990, A comparative examination of a role for serotonin in obsessive compulsive disorder, panic disorder, and anxiety, J. Clin. Psychiatry, 51, 53
  39. 10.1016/j.physbeh.2007.06.021 · DOI
  40. 10.1016/j.devbrainres.2005.09.010 · DOI
  41. 10.1016/0091-3057(82)90353-7 · DOI
  42. 10.1002/(SICI)1098-2396(199710)27:2<145::AID-SYN5>3.0.CO;2-E · DOI
  43. Rasmussen K., 2000, The novel 5‐hydroxytryptamine(1A) antagonist LY426965: effects on nicotine withdrawal and interactions with fluoxetine, J. Pharmacol. Exp. Ther., 294, 688, 10.1016/S0022-3565(24)39123-2 · DOI
  44. 10.1055/s-0029-1210877 · DOI
  45. 10.1046/j.1460-9568.1998.00438.x · DOI
  46. 10.1210/edrv-7-3-284 · DOI · Paper page
  47. 10.1038/sj.mp.4001118 · DOI
  48. 10.1016/S0306-4530(03)00025-8 · DOI
  49. 10.1016/S0301-0082(97)00060-9 · DOI
  50. 10.1016/0166-4328(94)90100-7 · DOI
  51. 10.1016/0006-8993(92)90809-N · DOI
  52. 10.1016/S0306-4530(98)00024-9 · DOI
  53. Tazi A., 1992, Potentiation of behavioural effects of a calcium channel antagonist, nifedipine, by ipsapirone, Behav. Pharmacol., 3, 269, 10.1097/00008877-199206000-00012 · DOI
  54. 10.1007/s00213-009-1470-2 · DOI · Paper page
  55. 10.1038/263242a0 · DOI
  56. 10.1523/JNEUROSCI.17-07-02626.1997 · DOI
  57. Van den Hove D.L.A., 2006, Prenatal stress in the rat alters 5‐HT1A receptor binding in the ventral hippocampus, Brain Res., 23, 29, 10.1016/j.brainres.2006.03.057 · DOI
  58. 10.1111/j.1460-9568.2006.04973.x · DOI
  59. 10.1007/s00213-009-1765-3 · DOI
  60. 10.1016/S0031-9384(00)00270-5 · DOI
  61. 10.1016/S0892-0362(98)00060-9 · DOI
  62. Zohar I., 2011, Differential effect of prenatal stress on the expression of corticotrophin‐releasing hormone and its receptors in the hypothalamus and amygdala in male and female rats, J. Neuroendocrinol., 23, 320, 10.1111/j.1365-2826.2011.02117.x · DOI
  63. Zohar I., 2014, Sex dependent reduction by prenatal stress of the expression of the 5HT1A receptors in the prefrontal cortex and CRF type 2 receptors in the raphe nuclei in rats: reversal by ciralopram, Psychopharmacology, 232, 1643, 10.1007/s00213-014-3803-z · DOI
  64. Zuena A.R., 2008, Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in males and female rats, PLoS One, 3, 2170, 10.1371/journal.pone.0002170 · DOI

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Metadata

Authors
Said, N., Lakehayli, S., Khachibi, M. E., Ouahli, M. E., Nadifi, S., Hakkou, F., & Tazi, A.
Affiliations
  • Laboratory of Pharmacology Faculty of Medicine and Pharmacy of Casablanca 19 Rue Tarik Bnou Ziad Casablanca Morocco
  • Genetics and Molecular Pathology Laboratory Faculty of Medicine and Pharmacy of Casablanca 19 Rue Tarik Bnou Ziad Casablanca Morocco
  • Sultan My Slimane University Fac Sciences &amp; Tecniques Beni‐Mellal Life Sciences Morocco
Venue
International Journal of Developmental Neuroscience
Publisher
Wiley
Published
2015-04-17
Volume
43
Issue
1
Pages
92-98
ISSN
  • 0736-5748
  • 1873-474X
DOI
10.1016/j.ijdevneu.2015.04.008
Cited by
16
References
5
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
Association for the Development of Scientific Research

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